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Journal: Inhibition of Protein kinase A and GIRK channel reverses fentanyl-induced respiratory depression. (Pubmed Central) - Apr 11, 2019 A phosphodiesterase 4 (PDE4) inhibitor and cyclic adenosine monophosphate (cAMP) analogs did not affect fentanyl-induced respiratory depression. These findings suggest that PKA and GIRK may be involved in fentanyl-induced respiratory depression and could represent useful therapeutic targets for the treatment of fentanyl-induced ventilatory depression.
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Journal: Challenges of helicopter mountain rescue missions by human external cargo: need for physicians onsite and comprehensive training. (Pubmed Central) - Apr 11, 2019 Serratus anterior plane block may be used to reduce pain and opioid use after thoracoscopic lung surgery. As these interventions have to be performed in challenging terrain, with reduced personnel resources, and limited monitoring, our results point out the need for physicians onsite who are clinically experienced in these procedures and specially and intensively trained for the specific characteristics and challenges of HEC rescue missions.
- |||||||||| Clinical, Review, Journal: Management of pain in end-stage renal disease patients: Short review. (Pubmed Central) - Apr 10, 2019
Methadone, fentanyl, and buprenorphine are the ideal analgesics in ESRD. However, complex pain syndrome requires multidrug analgesic regimen comprising opioids, non-opioids, and adjuvant medication, which should be individualized to the patient to achieve adequate pain control.
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Journal: Quantification of U-47700 and its metabolites in plasma by LC-MS/MS. (Pubmed Central) - Apr 9, 2019 ...NSO have gained popularity in the illicit drug market and have brought about an increase in fentanyl and its derivatives, as well as other chemically unrelated opioid agonists...Postmortem whole blood samples (n = 15) were analyzed with the validated method. U-47700, N-desmethyl-U-47700 and N,N-didesmethyl-U-47700 concentration ranges were 1.1-1367 ng/mL, 4.0-1400 ng/mL and 0.7-658 ng/mL, respectively.
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Journal: Trends in Medical Use of Opioids in the U.S., 2006-2016. (Pubmed Central) - Apr 7, 2019 U-47700, N-desmethyl-U-47700 and N,N-didesmethyl-U-47700 concentration ranges were 1.1-1367 ng/mL, 4.0-1400 ng/mL and 0.7-658 ng/mL, respectively. With the exception of buprenorphine, used to treat an opioid use disorder, prescription opioid use has been decreasing over the past 5 years in the U.S. Further efforts are needed to continue to optimize the balance between appropriate opioid access for acute pain while minimizing diversion and treating opioid addiction.
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Journal: Analgesia Nociception Index Monitoring During Supratentorial Craniotomy. (Pubmed Central) - Apr 5, 2019 In neurosurgical patients undergoing elective supratentorial craniotomy, ANI measures response to noxious stimuli with at least as much reliability as hemodynamic variables and changes in ANI parallel the changes in HR and MAP. ANI is superior to RE for measurement of response to noxious stimuli.
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Journal: Opioid Analgesic Prescribing: Facts vs Assumptions. (Pubmed Central) - Apr 3, 2019 ...Opioid analgesic prescribing and associated overdose deaths both peaked around 2011 and are in long-term decline; the sharp overdose increase recorded in 2014 was driven by illicit fentanyl and heroin. Nonmethadone prescription opioid analgesic deaths, in the absence of co-ingested benzodiazepines, alcohol, or other central nervous system/respiratory depressants, are infrequent...No abstract available
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Journal: Propofol and fentanyl sedation for laser treatment of retinopathy of prematurity to avoid intubation. (Pubmed Central) - Apr 3, 2019 Nonmethadone prescription opioid analgesic deaths, in the absence of co-ingested benzodiazepines, alcohol, or other central nervous system/respiratory depressants, are infrequent...No abstract available The good level of anesthesia and analgesia achieved sustains the efficacy of sedation with propofol during laser photocoagulation to avoid intubation and mechanical ventilation during and after the procedure.
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Retrospective data, Journal: Identification of opioids in surface and wastewaters by LC/QTOF-MS using retrospective data analysis. (Pubmed Central) - Mar 30, 2019 The concentrations of individual opioids in surface water and wastewater effluent varied from 8.8 (EDDP) to 1640 (tramadol) ngL and from 12 (dihydrocodeine) to 1288 (tramadol) ngL, respectively. The opioids with higher overall frequency detections were tramadol, dextromethorphan and its metabolite, dextrorphan.
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Pricing, Retrospective data, Journal, HEOR: Efficacy and cost savings with the use of a minimal sedation / anxiolysis protocol for intra-articular corticosteroid injections in children with juvenile idiopathic arthritis: a retrospective review of prospectively collected data. (Pubmed Central) - Mar 29, 2019 Conclusion Clopidogrel dose-adjusted plasma concentration in STEMI patients, as well as multivessel coronary artery disease, showed significance in predicting an unfavorable composite clinical outcome after 40-month follow-up. A minimal sedation/anxiolysis protocol (including nitrous oxide, intranasal fentanyl, a topical numbing agent, acetaminophen, ibuprofen, ondansetron and child life intervention), provides safe and effective analgesia for intra-articular corticosteroid injection in a subset of patients with juvenile idiopathic arthritis and offers a lower cost alternative to general anesthesia.
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