fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / generics
    Preclinical, Journal:  Efficacy-Based Perspective to Overcome Reduced Opioid Analgesia of Advanced Painful Diabetic Neuropathy in Rats. (Pubmed Central) -  Apr 27, 2019   
    ...Herein, we examined the antinociceptive and antiallodynic actions of a novel opioid agonist 14-O-methymorphine-6-O-sulfate (14-O-MeM6SU), fentanyl and morphine in rats with streptozocin-evoked DNP of 9-12 weeks following their systemic administration...In conclusion, the reduction in the analgesic action of opioids in DNP might be a consequence of MOR reduction, particularly in the spinal cord. Therefore, developing opioids of high efficacy might provide analgesia exceeding that of currently available opioids.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Higher doses of naloxone are needed in the synthetic opiod era. (Pubmed Central) -  Apr 26, 2019   
    A rapid competition is required by naloxone to out-compete large numbers of opioid receptors occupied by fentanyl in the CNS. Taken together, we propose that higher doses of naloxone are needed to combat the new era of overdoses due to the more potent synthetic opioids such as fentanyl.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Negotiating space & drug use in emergency shelters with peer witness injection programs within the context of an overdose crisis: A qualitative study. (Pubmed Central) -  Apr 24, 2019   
    Vancouver, Canada is experiencing an overdose crisis due to the proliferation of fentanyl and related analogues and novel overdose response interventions are being implemented across multiple high overdose risk environments, including emergency shelters...Findings reveal that the implementation of this intervention reduced stigma and shame through the normalization of drug use in shelter spaces, and yet underlying social norms and material constraints led people to inject alone in non-designated injecting spaces. Whereas these spatial dynamics of injection drug use potentially increased overdose vulnerability, an emerging sense of collective responsibility in relation to the overdose crisis led to the routinization of peer witnessing practices across the shelter environment to extend the impact of the intervention.
  • ||||||||||  fentanyl citrate / generics, ketamine / generics
    Clinical, Journal:  Predrawn prehospital medications are microbiologically safe for up to 48 hours. (Pubmed Central) -  Apr 24, 2019   
    Whereas these spatial dynamics of injection drug use potentially increased overdose vulnerability, an emerging sense of collective responsibility in relation to the overdose crisis led to the routinization of peer witnessing practices across the shelter environment to extend the impact of the intervention. Predrawing of the eight studied medications for urgent prehospital procedures appears to be a microbiologically safe practice with syringe dwell times up to 48 hours.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Sedation effects by dexmedetomidine versus propofol in decreasing duration of mechanical ventilation after open heart surgery. (Pubmed Central) -  Apr 21, 2019   
    There was significant difference between both the groups in midazolam and fentanyl dose requirement and financial costs with a value of P < 0.05. Dexmedetomidine is safer and equally effective agent for the sedation of mechanically ventilated patients admitted to the ICU after cardiovascular surgery compared to the patients receiving propofol, with good hemodynamic stability, and equally rapid extubation time.
  • ||||||||||  fentanyl citrate / generics
    Preclinical, Journal:  Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantifying Fentanyl and 22 Analogs and Metabolites in Whole Blood, Urine, and Hair. (Pubmed Central) -  Apr 20, 2019   
    Average urine concentrations were 47.7 ± 39.3 and 417 ± 296 μg/L for cyclopropylfentanyl and cyclopropyl norfentanyl, respectively (n = 11), 995 ± 908 μg/L for methoxyacetylfentanyl, (n = 3), 1,874 ± 1,710 and 6,582 ± 3,252 μg/L for acetylfentanyl and acetyl norfentanyl, respectively (n = 5), 146 ± 318 and 300 ± 710 μg/L for fentanyl (n = 5) and norfentanyl (n = 6), respectively, 84.0 and 23.0 μg/L for furanylfentanyl and furanyl norfentanyl, respectively (n = 1), and 50.5 ± 50.9 μg/L for 4-ANPP (n = 10). Average hair concentrations were 2,670 ± 184 and 82.1 ± 94.7 ng/g for fentanyl and norfentanyl, respectively (n = 2), and 10.8 ± 0.57 ng/g for 4-ANPP (n = 2).
  • ||||||||||  Journal:  Prescription opioid analgesic use in France: trends and impact on morbidity-mortality. (Pubmed Central) -  Apr 19, 2019   
    In 2004-2017, prescription opioid use in France at least doubled and oxycodone use increased particularly, associated with a non-trivial increase in opioid-related morbidity-mortality. Although giving no indication for an "opioid epidemic", these findings call for proper monitoring of opioid use.
  • ||||||||||  fentanyl citrate / generics
    Journal:  A preliminary study of different methods of anesthesia for painless bronchoscopy (Pubmed Central) -  Apr 16, 2019   
    Propofol combined with sufentanil could achieve better painless effect, improve patient comfort and tolerance, and reduce intraoperative memory, but was prone to causing hypoxemia and hypotension. The decline of intraoperative SpO(2) could be corrected by establishing artificial airway, while the decrease of blood pressure could be corrected by applying vasoactive drugs, which were relatively safe.
  • ||||||||||  fentanyl citrate / generics
    Clinical, Journal:  Simultaneous explantation and implantation of intrathecal pumps: a case series. (Pubmed Central) -  Apr 13, 2019   
    ...Of the 17 patients, 14 (82.4%) had baclofen pumps to treat spasticity and 3 (17.6%) had fentanyl pumps to treat chronic pain...The current standard of care for deep pump infections requires pump explantation and a course of antibiotics prior to reimplantation of the IDDD. The authors demonstrate the effectiveness of a procedure involving simultaneous explantation of an infected pump and implantation of a new pump on the contralateral side in the treatment of IDDD infections.
  • ||||||||||  fentanyl citrate / generics
    Retrospective data, Journal:  Propofol Sedation by Pediatric Gastroenterologists for Endoscopic Procedures: A Retrospective Analysis. (Pubmed Central) -  Apr 12, 2019   
    ...The addition of fentanyl significantly decreased propofol dosage needed to provide optimal sedation, p < 0.001...All the procedures were successfully completed and all patients were discharged home. We conclude that our approach is safe in children as it is in adults and can be implemented for children with ASA I, II.