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- | fentanyl citrate / generics
Journal: Quantification of U-47700 and its metabolites in plasma by LC-MS/MS. (Pubmed Central) - Apr 9, 2019
...NSO have gained popularity in the illicit drug market and have brought about an increase in fentanyl and its derivatives, as well as other chemically unrelated opioid agonists...Postmortem whole blood samples (n = 15) were analyzed with the validated method. U-47700, N-desmethyl-U-47700 and N,N-didesmethyl-U-47700 concentration ranges were 1.1-1367 ng/mL, 4.0-1400 ng/mL and 0.7-658 ng/mL, respectively.
- ||| fentanyl citrate / generics
Clinical: Your child is 19 and is injecting heroin, has overdosed 2x. Offered a friend’s bupe vs still injecting heroin/fentanyl. Takes the bupe, is not dopesick, feels simply normal. Do we think she should go to jail for this? Or maybe can she get expedited access to tx if she wants? (Twitter) - Apr 9, 2019
- ||| fentanyl citrate / generics
“Its misleading& harmful 2lump all opioids, prescription& illicit, together. While conflating the 2may help create better headlines& fuel the hysteria. illicit fentanyl/heroin, r major drivers in alarming increase in addiction& overdose, not prescription opioids,” Ziegler wrote. (Twitter) - Apr 9, 2019
- || fentanyl citrate / generics
Meant it to read decriminalize BUPE. Herion and fentanyl are killing people daily bupe doesn't I gotta learn to read my tweets BEFORE I hit reply or tweet lol I'm still learning 🤷♂️ (Twitter) - Apr 9, 2019
- || Duragesic (fentanyl) / J&J
And don't mess with my pain control along the way! My fentanyl patches are not your fentanyl-laced heroin, etc. Don't criminalize pain. (Twitter) - Apr 8, 2019
- || fentanyl citrate / generics
Why is it such a HORRIBLE thing to divert? BY DIVERTING THEY ARE POTENTIALLY SAVING A LIFE!!!! it's crazy that this is the only reason I keep hearing to not decriminalize heroin and fentanyl are KILLING PEOPLE!!!! BUPE DOESN'T!!! It's literally saving lives!!!! (Twitter) - Apr 8, 2019
- | fentanyl citrate / generics
Journal: Trends in Medical Use of Opioids in the U.S., 2006-2016. (Pubmed Central) - Apr 7, 2019
U-47700, N-desmethyl-U-47700 and N,N-didesmethyl-U-47700 concentration ranges were 1.1-1367 ng/mL, 4.0-1400 ng/mL and 0.7-658 ng/mL, respectively. With the exception of buprenorphine, used to treat an opioid use disorder, prescription opioid use has been decreasing over the past 5 years in the U.S. Further efforts are needed to continue to optimize the balance between appropriate opioid access for acute pain while minimizing diversion and treating opioid addiction.
- | fentanyl citrate / generics, ketamine / generics, sevoflurane / generics
Clinical, Journal: Induction techniques for pediatric patients with congenital heart disease undergoing noncardiac procedures are influenced by cardiac functional status and residual lesion burden. (Pubmed Central) - Apr 7, 2019
Use of etomidate, ketamine or opioids was more associated with inotrope use, but there was not significant difference in respiratory events among different induction agents. Causative association needs to be examined in the future.
- | fentanyl citrate / generics
Journal: Reframing the Prevention Strategies of the Opioid Crisis: Focusing on Prescription Opioids, Fentanyl, and Heroin Epidemic. (Pubmed Central) - Apr 7, 2019
Finally, Tier 3 focuses on making buprenorphine more available for chronic pain management as well as for medication-assisted treatment. Opioid epidemic, fentanyl and heroin epidemic, prescription opioids, National All Schedules Prescription Electronic Reporting Act (NASPER), Prescription Drug Monitoring Programs (PDMPs).
- | tramadol / Fortress
Clinical, Journal: Effects of intraoperative propofol-based total intravenous anesthesia on postoperative pain in spine surgery: Comparison with desflurane anesthesia - a randomised trial. (Pubmed Central) - Apr 7, 2019
Opioid epidemic, fentanyl and heroin epidemic, prescription opioids, National All Schedules Prescription Electronic Reporting Act (NASPER), Prescription Drug Monitoring Programs (PDMPs). Patients anesthetized with propofol-based TIVA reported less pain during coughing and consumed less daily and total PCA fentanyl after lumbar spine surgery.
- || fentanyl citrate / generics
So nobody cares. CDC already knows that restricting access to rX opioids led directly to heroin and illicit fentanyl. (Twitter) - Apr 6, 2019
- ||| fentanyl citrate / generics
IMHO the parsing of whether it’s a fentanyl death or prescribed opioid death is probably unhelpful. Anyways most are polysubstance events. The arrival of heroin and fentanyl exacerbated and shifted an existing crisis of prescription opioid addiction. Let’s not kid ourselves! (Twitter) - Apr 6, 2019
- || fentanyl citrate / generics
Going into a room with fentanyl: (Twitter) - Apr 5, 2019
- | fentanyl citrate / generics
Journal: Analgesia Nociception Index Monitoring During Supratentorial Craniotomy. (Pubmed Central) - Apr 5, 2019
In neurosurgical patients undergoing elective supratentorial craniotomy, ANI measures response to noxious stimuli with at least as much reliability as hemodynamic variables and changes in ANI parallel the changes in HR and MAP. ANI is superior to RE for measurement of response to noxious stimuli.
- ||| fentanyl citrate / generics
Clinical: The article makes a powerful case for why Health Departments should provide wide spread distribution of fentanyl detection strips to the public. https://t.co/2DMAgDh5VU via @vice (Twitter) - Apr 5, 2019
- |||| fentanyl citrate / generics
dr. Adena Greenbaum from #Baltimore City health Dept sets the stage for #opioidcrisis. Baltimore has even major increase in deaths, fentanyl and prescription meds remain a major issue. 90% of those with #opioid use disorder do not get evidence based MAT #SAGES2019 (Twitter) - Apr 5, 2019
- | fentanyl citrate / generics
Clinical, Journal: Comparison of the Efficacy of Ultrasound-Guided Serratus Anterior Plane Block, Pectoral Nerves II Block, and Intercostal Nerve Block for the Management of Postoperative Thoracotomy Pain After Pediatric Cardiac Surgery. (Pubmed Central) - Apr 5, 2019
ANI is superior to RE for measurement of response to noxious stimuli. SAPB and Pecs II fascial plane blocks are equally efficacious in post-thoracotomy pain management compared with ICNB, but they have the additional benefit of being longer lasting and are as easily performed as the traditional ICNB.
- | ibuprofen / generics
Journal: Preemptive intravenous ibuprofen application reduces pain and opioid consumption following thyroid surgery. (Pubmed Central) - Apr 5, 2019
To use preemptive a single dose IV ibuprofen decreases pain scores and postoperative opioid consumption in patients following thyroidectomy. Additionally, this application increase the patient comfort reducing nausea and vomiting in early postoperative period.
- |||| fentanyl citrate / generics
Clinical: Nasal fentanyl improved dyspnea at rest and dyspnea and distance after 6 min walk in cancer patients #hpm https://t.co/BgGSZdclAn (Twitter) - Apr 5, 2019
- || fentanyl citrate / generics
Illicit fentanyl NOT Rx fentanyl (Twitter) - Apr 5, 2019
- |||| fentanyl citrate / generics
Clinical: 3/ oral fluid fentanyl testing likely helpful if practice already incorporated oral fluid drug testing; not the case yet for OBOT at Montefiore but we are looking into this especially for anuric pts! (Twitter) - Apr 4, 2019
- || fentanyl citrate / generics
2/ "off-label" use of fentanyl test strips originally intended for urine tox is a valuable harm reduction tool https://t.co/9gmJ9I5sAb (Twitter) - Apr 4, 2019
- | fentanyl citrate / generics
Retrospective data, Review, Journal: Effectiveness of Perioperative Auricular Therapy on Postoperative Pain after Total Hip Arthroplasty: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. (Pubmed Central) - Apr 4, 2019
...The intraoperative body mass-adjusted fentanyl amount in the AT group was also lower than that of the control group in two trials...Regression analysis found that the prolonged time after the operation decreased the difference in VAS between the two groups. Although all the outcomes were assessed as very low to low in the GRADE system, evidence on the effectiveness of perioperative AT in pain treatment after total hip replacement was positive.
- ||| fentanyl citrate / generics, methadone / generics
Methadone superior to fentanyl for neuropathic pain #hpm #pallonc https://t.co/C48b8rkVt7 (Twitter) - Apr 3, 2019
- | fentanyl citrate / generics, methadone / generics
Journal: Opioid Analgesic Prescribing: Facts vs Assumptions. (Pubmed Central) - Apr 3, 2019
...Opioid analgesic prescribing and associated overdose deaths both peaked around 2011 and are in long-term decline; the sharp overdose increase recorded in 2014 was driven by illicit fentanyl and heroin. Nonmethadone prescription opioid analgesic deaths, in the absence of co-ingested benzodiazepines, alcohol, or other central nervous system/respiratory depressants, are infrequent...No abstract available
- | fentanyl citrate / generics
Journal: Propofol and fentanyl sedation for laser treatment of retinopathy of prematurity to avoid intubation. (Pubmed Central) - Apr 3, 2019
Nonmethadone prescription opioid analgesic deaths, in the absence of co-ingested benzodiazepines, alcohol, or other central nervous system/respiratory depressants, are infrequent...No abstract available The good level of anesthesia and analgesia achieved sustains the efficacy of sedation with propofol during laser photocoagulation to avoid intubation and mechanical ventilation during and after the procedure.
- || fentanyl citrate / generics
Yet haven't we seen net rise in OD deaths overall, with fentanyl/heroin Third Wave still increasing and Rx opioids decreasing @DanCiccarone? Perhaps not causation yet correlation? (Twitter) - Apr 3, 2019
- | fentanyl citrate / generics
Retrospective data, Journal, Adverse events, Serious adverse event: Serious Adverse Events Associated with Off-Label Use of Azithromycin or Fentanyl in Children in Intensive Care Units: A Retrospective Chart Review. (Pubmed Central) - Apr 3, 2019
Off-label use of fentanyl appears to be more frequently associated with respiratory depression when used off-label by both age and indication in pediatric ICUs. Prospective studies should be undertaken to assess the safety and efficacy of fentanyl in the pediatric population so that data can be added to the FDA labeling.
- | fentanyl citrate / generics
Clinical, Journal: Clinical Benefits of Direct-to-Definitive Testing for Monitoring Compliance in Pain Management. (Pubmed Central) - Apr 3, 2019
Direct-to-definitive LC-MS/MS testing has several clinical benefits, including reduction of false positive results, improved assessment of patient compliance, decreased TAT, and increased detection of drug use and abuse. Cost savings were also realized using this approach.
- ||| fentanyl citrate / generics
Clinical: #medtwitter please educate me regarding oral/saliva testing for fentanyl in clinical outpatient medical practice. Found this article but anything more UTD? @adfoxMD @RyanMarino @TiffanyLuMD Thanks https://t.co/g2bPbUpjlh (Twitter) - Apr 2, 2019
- || fentanyl citrate / generics
U.S. welcomes China's expanded clampdown on fentanyl https://t.co/6CVxmsByJl (Twitter) - Apr 1, 2019
- | fentanyl citrate / generics
100 fentanyl,30 mg oxy hard act to follow Im afraid... (Twitter) - Apr 1, 2019
- | fentanyl citrate / generics
Averick: Fentanyl is long-lasting, but the current antidotes aren't--that's where his new nanoparticles come in #ACSOrlando (Twitter) - Apr 1, 2019
- || fentanyl citrate / generics
Why The Latest Fentanyl Surge Is Hitting Some Communities Harder Than Others https://t.co/BasnJBarry with @tracicgreen1 @drptw (Twitter) - Mar 30, 2019
- | fentanyl citrate / generics, methadone / generics
Retrospective data, Journal: Identification of opioids in surface and wastewaters by LC/QTOF-MS using retrospective data analysis. (Pubmed Central) - Mar 30, 2019
The concentrations of individual opioids in surface water and wastewater effluent varied from 8.8 (EDDP) to 1640 (tramadol) ngL and from 12 (dihydrocodeine) to 1288 (tramadol) ngL, respectively. The opioids with higher overall frequency detections were tramadol, dextromethorphan and its metabolite, dextrorphan.
- || fentanyl citrate / generics
Plus if deaths due to fentanyl often happen in less time, might there be identifiers observable during autopsy? E. g. immediate collapse to the floor God rest the souls (Twitter) - Mar 30, 2019
- | clopidogrel / generics
Clinical, Clinical data, Journal: The association of clopidogrel and 2-oxo-clopidogrel plasma levels and the 40Â months clinical outcome after primary PCI. (Pubmed Central) - Mar 29, 2019
The decrease in dose-adjusted clopidogrel unit for each ng/ml/mg increases the risk 21.7 times (p < 0.05). Conclusion Clopidogrel dose-adjusted plasma concentration in STEMI patients, as well as multivessel coronary artery disease, showed significance in predicting an unfavorable composite clinical outcome after 40-month follow-up.
- | Instanyl (fentanyl) / Takeda
Pricing, Retrospective data, Journal, HEOR: Efficacy and cost savings with the use of a minimal sedation / anxiolysis protocol for intra-articular corticosteroid injections in children with juvenile idiopathic arthritis: a retrospective review of prospectively collected data. (Pubmed Central) - Mar 29, 2019
Conclusion Clopidogrel dose-adjusted plasma concentration in STEMI patients, as well as multivessel coronary artery disease, showed significance in predicting an unfavorable composite clinical outcome after 40-month follow-up. A minimal sedation/anxiolysis protocol (including nitrous oxide, intranasal fentanyl, a topical numbing agent, acetaminophen, ibuprofen, ondansetron and child life intervention), provides safe and effective analgesia for intra-articular corticosteroid injection in a subset of patients with juvenile idiopathic arthritis and offers a lower cost alternative to general anesthesia.
- || fentanyl citrate / generics
Why? We have an illegal polydrug heroin fentanyl problem, not a presciption pain relief problem (Twitter) - Mar 29, 2019
- || fentanyl citrate / generics
Clinical: US FDA To Require Patient Registry For Transmucosal Fentanyl Products https://t.co/1W4LiUl7Eq #PinkSheet (Twitter) - Mar 29, 2019
- | fentanyl citrate / generics
What's the @US_FDA supposed to do? Invade Mexican druglords' fentanyl operations? Maybe divert some of their funding to @USBorderSec? (Twitter) - Mar 28, 2019
- | fentanyl citrate / generics, methadone / generics
Retrospective data, Journal: Opioid consumption in the Community of Madrid (Spain) between 2004 and 2014. (Pubmed Central) - Mar 28, 2019
Tramadol and fentanyl were the most prescribed of the stepII andIII analgesics, respectively. The role of morphine is diminishing in the prescription of opioids.
- || fentanyl citrate / generics
DEA SAC Bill Callahan and Diversion Investigator Dan Betzinger, @DEASTLOUISDiv and #FDA Special Agent Paul Cox @US_FDA talking drug dealing on the internet at Infragard St. Louis State of Cyber Conference. @DEAHQ @infragardnatl #FBI @FBIStLouis #cybersecurity #heroin #fentanyl (Twitter) - Mar 27, 2019
- | Duragesic (fentanyl) / J&J
Journal: Opioids delay healing of spinal fusion: a rabbit posterolateral lumbar fusion model. (Pubmed Central) - Mar 27, 2019
Systemic opioids led to an inferior quality fusion mass with delay in maturation and remodeling at six-weeks in this rabbit spinal fusion model. These preliminary results lay foundation for further research to investigate underlying cellular mechanisms, temporal fusion process, and dose-duration relationship of opioids responsible for our findings.
- | Bridion (sugammadex) / Merck (MSD)
Clinical, Retrospective data, Journal: Sugammadex affects emergence agitation in children undergoing strabismus surgery. (Pubmed Central) - Mar 27, 2019
In the propensity-matched analysis, patients in the sugammadex group showed rapid recovery, but there was no difference in the EA incidence or severity. Conclusion Sugammadex did not affect EA incidence or severity compared with conventional cholinesterase inhibitors, although it showed a favorable recovery profile in children undergoing strabismus surgery.
- || fentanyl citrate / generics
Green curve: prescriptions for opioids, showing that we addressed the Rx crisis a decade ago Blue line: overall opioid OD deaths Orange line: heroin deaths (took off in 2010) Silver line: fentanyl deaths (took off in 2010; exploded in 2013) (Twitter) - Mar 25, 2019
- || fentanyl citrate / generics
Exactly. See the attached slide, which demonstrates that although opioid prescriptions peaked 9 years ago, opioid overdose deaths continue to rise exponentially— because of illegal heroin, fentanyl use. (Twitter) - Mar 25, 2019
- | fentanyl citrate / generics
Clinical, Journal: Acetaminophen Does Not Reduce Postoperative Opiate Consumption in Patients Undergoing Craniotomy for Cerebral Revascularization: A Randomized Control Trial. (Pubmed Central) - Mar 24, 2019
Pain scores did not significantly differ between the IV acetaminophen group and the placebo group in postoperative hours 0-12 (Figure 2; p = 0.44) or 24 (Figure 3; p = 0.77). Conclusion Our study demonstrates that in patients receiving bilateral craniotomies for moyamoya disease, IV acetaminophen when given immediately after intubation and again 45 minutes prior to closure does not significantly decrease 12- or 24-hour postoperative opiate consumption.
- || fentanyl citrate / generics
Fuck off and go chug a bottle of fentanyl, you bullshit lying lobby garbage. I hope your org members all get cancer and go bankrupt (Twitter) - Mar 24, 2019
- | fentanyl citrate / generics
Clinical, Journal: Propofol for implantable cardioverter defibrillator implantation in patients with Brugada syndrome. (Pubmed Central) - Mar 23, 2019
ICD implantation without significant ECG changes or adverse outcomes is feasible under propofol sedation in patients with Brugada syndrome. However, because of significant hemodynamic changes and respiratory compromise, close monitoring and meticulous propofol dose titration is warranted.