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Journal: Anesthesia recovery after ophthalmologic surgery at an ambulatory surgical center. (Pubmed Central) - Sep 13, 2020 Anesthesia recovery after ophthalmologic procedures at an ASC was associated primarily with the procedure and anesthesia type. Prolonged recoveries were associated with intraoperative fentanyl use, severe postoperative pain, and postoperative opioid requirements.
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Retrospective data, Journal: The efficacy of intra-articular fentanyl supplementation for knee arthroscopy: A meta-analysis of randomized controlled studies. (Pubmed Central) - Sep 13, 2020 Overall, compared with control group after knee arthroscopy, intra-articular fentanyl supplementation is associated with reduced pain scores at 1 h (standard mean difference (Std MD) = -3.50; 95% confidence interval (CI) = -5.68 to -1.32; p = 0.002), 2 h (Std MD = -4.73; 95% CI = -8.75 to -0.71; p = 0.02), and 8 h (Std MD = -5.02; 95% CI = -9.73 to -0.30; p = 0.04) but shows no substantial impact on pain scores at 4 h (Std MD = -3.94; 95% CI = -7.93 to 0.05; p = 0.05) or the supplementary analgesia (risk ratio = 0.56; 95% CI = 0.09-3.59; p = 0.54). Intra-articular fentanyl supplementation does benefit in pain control after knee arthroscopy.
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[VIRTUAL] Uncommon does not mean impossible: acute adrenal insufficiency. () - Sep 12, 2020 - Abstract #EUSEM2020EUSEM_1001; He was receiving treatment with Sintrom, Digoxina, Alopurinol, Rosuvastatina, omeprazol and lexatin and had no drug allergies...He was brought to the ED by ambulance, where was treated with fentanyl and metoclopramide for severe pain and nausea...We also believe the communication with his family was effective, delivering the news progressively. On the other hand, we did not include suprarrenal haemorrhage in the differential diagnosis and therefore we could have improved the treatment
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[VIRTUAL] Traumatic slipped upper femoral epiphysis (Delbet type 1 fracture). () - Sep 12, 2020 - Abstract #EUSEM2020EUSEM_988; He received appropriate dose of non steroidal anti-inflammatory medicine followed by intranasal fentanyl administration. Despite the rarity of the neck of femur fractures in children this case demonstrate importance of prompt diagnosis and treatment to avoid complications such as femoral head necrosis
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[VIRTUAL] Traumatic knee subluxation- a case report. () - Sep 12, 2020 - Abstract #EUSEM2020EUSEM_987; There are currently no published cases or studies involving traumatic knee subluxation, nor are there any management guidelines or recommendations specific to knee subluxations. Following reflection of this case and considering the evidence behind knee dislocations, logical reasoning suggests that traumatic subluxations should be treated similar to a dislocation, with considerations for early relocation if possible in the pre-hospital field.
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[VIRTUAL] Is there a place for another modified rapid sequence for acutely ill patients in ED? () - Sep 12, 2020 - Abstract #EUSEM2020EUSEM_674; Modified RSI method consisted from administration of oxygen (100%, 10-15 l/min), preoxygenation for 3 min, opioid Fentanyl (1-2 mcg/kg IBW), hypnotic drug Ketofol (mixture of 100mg Propofol + 25 mg Ketamine, 1 mg/kg IBW), muscle relaxant Rocuronium (1.2 mg/kg IBW). Although RSI is performed to secure the airway in patients at elevated risk of aspiration and acute illness, preparation of equipment, drugs, the team and the patient is essential.
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[VIRTUAL] Fentanyl Exposures Reported to the U.S. Poison Centers. () - Sep 12, 2020 - Abstract #EUSEM2020EUSEM_589; Our study demonstrated a significant proportion of fentanyl exposures associated with intentional abuse, suicide and a significantly increased mortality rate. Fentanyl exposure reports from acute care hospitals and EDs during the study increased
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[VIRTUAL] Assessment of knowledge of pain treatment methods in pre-hospital: survey for paramedical staff. () - Sep 12, 2020 - Abstract #EUSEM2020EUSEM_381; The use of morphine drugs was : 0.2 mg every 10 min in 5.88% ; 3mg first bolus then 2 mg in 11.76% ; 2mg divided in 5 to 10 minutes in 35.29% of cases The morphines available at the site of the intervention are Fentanyl for 76% of the responses and Sufentanyl for 17% of the responses...Regarding knowledge of the morphine antidote, 64.7% responded with Narcan (Naloxone), 29.9% responded with "I don't know" and 5.88% responded with Ephedrine...Analgesia treatment protocols should be in place for each prehospital emergency team. A practice assessment should be carried out regularly
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Journal: Quantitative Swab Touch Spray Mass Spectrometry for Oral Fluid Drug Testing. (Pubmed Central) - Sep 11, 2020 Most detection limits were below 5 ng/mL from the complex drug mixture in the biological matrix. Simulations of in vivo sampling were carried out and acceptable quantitative results were obtained even under these conditions, indicating the potential of this technique for fast and non-invasive point-of-care drug testing in clinical or forensic settings.
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Clinical, Journal: A Randomized Controlled Trial to Compare Pain Medications in Children Undergoing Strabismus Surgery. (Pubmed Central) - Sep 10, 2020 Simulations of in vivo sampling were carried out and acceptable quantitative results were obtained even under these conditions, indicating the potential of this technique for fast and non-invasive point-of-care drug testing in clinical or forensic settings. Results of this study can be used to change practice to minimize the pain levels both postoperatively and after discharge for children undergoing strabismus surgery.
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Review, Journal: Sex and Gender Differences in the Effects of Novel Psychoactive Substances. (Pubmed Central) - Sep 10, 2020 To date, more than 900 NPS have been identified, and can be catalogued in different pharmacological categories including synthetic cannabinoids, synthetic stimulants (cathinones and amphetamine-like), hallucinogenic phenethylamines, synthetic opioids (fentanyls and non-fentanyls), new benzodiazepines and dissociative anesthetics (i.e., methoxetamine and phencyclidine-derivatives). This work collects the little knowledge reached so far on the effects of NPS in male and female animal and human subjects, highlighting how much sex and gender differences in the effects of NPS has yet to be studied and understood.
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Review, Journal: The effects of cannabis and cannabinoids on anesthesia and analgesia during the perioperative period (Pubmed Central) - Sep 9, 2020 Besides the significantly increased requirement for propofol and fentanyl during anesthesia and for postoperative analgesia, a higher risk for tachycardia, pulmonary and cardiovascular complications was observed. With respect to these data, the authors recommend asking patients pre-operatively about recreational or medical cannabis use or cannabinoid-based medication.
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Journal: Ionic liquid-modified disposable electrochemical sensor strip for analysis of fentanyl. (Pubmed Central) - Sep 5, 2020 This CSWV profile facilitates rapid (one minute) identification of the target opioid at micromolar concentrations in the presence of other cutting agents commonly found in illicit drug formulations. The new protocol thus holds considerable promise for rapid decentralized fentanyl detection at the 'point of need'.
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Clinical, Journal: Does fentanyl epidural analgesia affect breastfeeding: A prospective cohort study. (Pubmed Central) - Sep 5, 2020 The new protocol thus holds considerable promise for rapid decentralized fentanyl detection at the 'point of need'. Our study did not find an association between fentanyl epidural analgesia in labour and rates of fully breastfeeding at discharge and at 6 weeks postpartum.
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Journal: "Everything is not right anymore": Buprenorphine experiences in an era of illicit fentanyl. (Pubmed Central) - Sep 5, 2020 The changing nature of heroin/NPF necessarily gives rise to new beliefs surrounding self-treatment attempts, treatment seeking behaviors, and harm reduction practices. While buprenorphine treatment continues to offer promising results for treating opioid use disorders, it is urgent to reconsider how the unpredictable biochemical mixture of NPFs circulating on the streets today may impact the initiation and success of treatment.
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Journal: Comparison between Epidural and Opioid Analgesia for Infants Undergoing Major Abdominal Surgery. (Pubmed Central) - Sep 4, 2020 Epidural placement does not preclude opioid exposure however, as opioids may be administered for indications other than nociceptive pain in the difficult-to-assess postoperative infant. Further prospective studies are warranted to better quantify the effect of epidural analgesia on intraoperative anesthetic exposure in infants.
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Review, Journal: Missouri's Fentanyl Problem: The China Connection. (Pubmed Central) - Sep 4, 2020 Based on reports from CDC Wonder data, county medical examiners, law enforcement agencies, and drug addiction prevention agencies, we conclude that IMF and related synthetic opioids arriving from China are primarily responsible for fatal narcotic overdoses in Missouri. Despite the COVID-19 disruption of fentanyl manufacturing and distribution centers in and around Wuhan, China early in the pandemic, preliminary 2020 data from medical examiners' offices show an upswing in opioid deaths, an indicator that Chinese fentanyl producers have restored the supply chain.
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