- |||||||||| Duragesic (fentanyl) / J&J, Targin (oxycodone/naloxone ER) / Shionogi, Purdue, Mundipharma
[VIRTUAL] Prolonged release (PR) oxycodone/naloxone (OXN) for cancer pain (CP) & its impact on bowel function, safety & quality of life (QoL): Systematic review (On-Demand e-Poster Display) - Oct 8, 2020 - Abstract #ESMOAsia2020ESMO_Asia_946;
Systematic review of literature from PubMed and EMBASE that evaluated analgesia, bowel function, adverse events (AE) and QoL after OXN PR or oral oxycodone (OXY)/morphine/tapentadol PR, or transdermal fentanyl, in adults with moderate-severe CP...Although limited, this meta-analysis confirms existing evidence on OXN’s efficacy and tolerability in patients with moderate-severe CP and highlights that few data on OXN in CP is available. Mundipharma Singapore Holding Pte Ltd.
- |||||||||| Duragesic (fentanyl) / J&J, Targin (oxycodone/naloxone ER) / Shionogi, Purdue, Mundipharma
[VIRTUAL] Prolonged release (PR) oxycodone/naloxone (OXN) for cancer pain (CP) & its impact on bowel function, safety & quality of life (QoL): Systematic review (On-Demand e-Poster Display) - Oct 8, 2020 - Abstract #ESMOAsia2020ESMO_Asia_580;
Systematic review of literature from PubMed and EMBASE that evaluated analgesia, bowel function, adverse events (AE) and QoL after OXN PR or oral oxycodone (OXY)/morphine/tapentadol PR, or transdermal fentanyl, in adults with moderate-severe CP...Although limited, this meta-analysis confirms existing evidence on OXN’s efficacy and tolerability in patients with moderate-severe CP and highlights that few data on OXN in CP is available. Mundipharma Singapore Holding Pte Ltd.
- |||||||||| fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Prescription Opioid Distribution after the Legalization of Recreational Marijuana in Colorado. (Pubmed Central) - Oct 7, 2020
The most prevalent opioids by morphine equivalents were oxycodone and methadone. Due to rapid and pronounced changes in prescription opioid distribution over the past decade, additional study with more states is needed to determine whether cannabis policy was associated with reductions in opioids used for chronic pain.
- |||||||||| fentanyl citrate / Generic mfg., ketamine / Generic mfg., sevoflurane / Generic mfg.
Journal: The use of multimodal low-opioid anesthesia for coronary artery bypass grafting surgery in conditions of artificial blood circulation. (Pubmed Central) - Oct 7, 2020
Group II: dexketoprofen trometamol (50 mg), intravenous lidocaine (1% - 1 mg/kg bolus) and continuous lidocaine infusion (1.5-2 mg/kg/h), propofol, ketamine (0.5 mg/kg), magnesia sulfate, minimal doses of fentanyl...Mean arterial pressure changes in group I were characterized by a significant reduction at the stage of induction, support and sternum reduction, whereas in group II it was relatively at the same level during the entire anesthetic management and significantly differed from baseline only at the stage of induction. Multimodal low-opioid anesthesia during coronary artery bypass surgery with artificial blood circulation allows one to ensure adequate analgesia and avoid the intraoperative usage of routine doses of fentanyl, as indicated by the absence of hemodynamic and endocrine-metabolic changes.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Does carrier fluid reduce low flow drug infusion error from syringe size? (Pubmed Central) - Oct 7, 2020
With carrier fluid, larger syringes were associated with significantly less drug delivery, less total volume delivered, and other flow problems in our low flow drug model. Carrier fluid should not be used to compensate for inappropriately large syringes in critical low flow drug infusions.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Esophagoduodenoscopy or colonoscopy: which should be done first? (Pubmed Central) - Oct 7, 2020
All patients received standard anesthesia with 1 µg/kg fentanyl and 1 mg/kg propofol...Total procedure duration and esophagoduodenoscopy duration were statistically significant longer in Group E. Complication frequency was higher in Group E. Endoscopist and patient satisfaction were lower in Group E. There was no difference in time to reach the cecum and the recovering period. Additional propofol dose was increased in Group E. Regarding shorter procedural duration, lower consumption amount of propofol and fewer complications, it could be a better choice to start bidirectional procedure with colonoscopy first.
- |||||||||| fentanyl citrate / Generic mfg., pethidine / Samaritan
[VIRTUAL] Comprehensive Evaluation of Opioid Analgesic Use in Iran during 2000-2019 () - Oct 3, 2020 - Abstract #ISPOREU2020ISPOR-EU_1671;
We also have examined the possible reasons for this trend. CONCLUSIONS : Providing a comprehensive plan of opioid analgesics utilization in Iran, make it possible to improve rational prescription and use of analgesics by some appropriate interventions.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Drug Utilization Evaluation in a General Surgery Department of a Tertiary Healthcare Hospital () - Oct 3, 2020 - Abstract #ISPOREU2020ISPOR-EU_963;
General anesthesia (GA) used in 1010 patients included a combination of drugs like propofol, midazolam, fentanyl, atracurium and isoflurane whilst Local Anesthesia (LA)used in 700 mainly comprised of either bupivacaine or lidocaine...As per Schumack and Thornton Preventability assessment scale, 1810 (85%) ADR were probably preventable CONCLUSIONS : Anesthetics can induce potential ADRs which require prompt management and protocol reporting. Pharmacovigilance thus plays a crucial role in improving treatment outcomes, and would substantially reduce the financial pressure on patients.
- |||||||||| fentanyl citrate / Generic mfg.
Clinical, Journal: Out-of-hospital assessment and treatment of adults with atraumatic headache. (Pubmed Central) - Oct 3, 2020
Among patients receiving a single medication, Fentanyl was the most commonly administered (32.1%, 126)...Out-of-hospital pain scores were documented infrequently and less than one in five patients with initial pain scores >5 received medication. Additionally, adherence to evidence-based guidelines was infrequent.
- |||||||||| fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Modeling dynamics of fatal opioid overdose by state and across time. (Pubmed Central) - Oct 2, 2020
Rates of fatal opioid overdose vary across the states, but we identify some trends. Regional differences are identified in states with the highest overdose rates from all opioids combined.
- |||||||||| methadone / Generic mfg.
Clinical, Journal: From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care. (Pubmed Central) - Oct 1, 2020
Tramadol appears to play a key role in treating episodes of inconsolability in children with progressive neurologic, metabolic, or chromosomally based condition with impairment of the central nervous system. However, the recent 2017 United States Food and Drug Administration (FDA) warning against pediatric use of tramadol does not seem to be based on clinical evidence, and therefore puts children at risk for unrelieved pain or increased respiratory depression.
- |||||||||| Duragesic (fentanyl) / J&J
Journal: Complex Drug Delivery Systems: Controlling Transdermal Permeation Rates with Multiple Active Pharmaceutical Ingredients. (Pubmed Central) - Oct 1, 2020
Compared with the monolith, decreased opioid antagonist permeation while maintaining fentanyl permeation could be achieved using a bilayer design...Bilayer patch performance did not change over an 8-week period in accelerated stability storage conditions. In conclusion, modifying the patch design of a bilayer TDDS achieves an individualized permeation of each API while maintaining constant patch composition.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Driving Access to Care: Use of Mobile Units for Urine Specimen Collection During the Coronavirus Disease-19 (COVID-19) Pandemic. (Pubmed Central) - Oct 1, 2020
No statistically significant differences were found in substance use positivity rates in comparison to pre-coronavirus disease findings; however, some shifts in use included higher rates of fentanyl and opioid positivity and reductions in tetrahydrocannabinol and cocaine use in the mobile collections setting. Deployment of mobile collection services during the coronavirus disease-19 pandemic has shown to be an effective mechanism for supporting patients suffering from substance use disorder, allowing for access to care of this often stigmatized, vulnerable population.
- |||||||||| fentanyl citrate / Generic mfg.
Clinical, Journal, Adverse events: Postoperative Thoracic Epidural Analgesia: Adverse Events from a Single-Center Series of 3126 Patients. (Pubmed Central) - Sep 30, 2020
Patients received continuous infusion TEA (0.2% ropivacaine and 2 µg ml fentanyl) to control postoperative pain...While serious complications were rare, minor complications occurred more often and affected the postoperative course negatively. A risk/benefit evaluation of each patient should be done before employing the technique.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Sleep, Circadian Rhythms and Substance Use Disorders - Chair () - Sep 30, 2020 - Abstract #ACNP2020ACNP_851;
Altering similar circadian-dependent pathways in mouse accumbal circuits leads to increased fentanyl seeking, craving, and relapse behaviors, and increased wakefulness, providing a molecular link between sleep, rhythms, and opioid addiction...The third talk will present unique findings showing withdrawal from cocaine disrupts REM sleep that is linked to relapse and the precise role of the specific cell-types in the lateral hypothalamus that are involved. The last talk will include unique data showing molecular changes in corticostriatal circuitry of human postmortem brains from subjects with opioid use disorder, including molecular rhythm changes that when manipulated in the mouse, lead to increased opioid seeking and tolerance.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Overlapping Neuron Subtype Mechanisms in Stress and Opioid Abstinence () - Sep 30, 2020 - Abstract #ACNP2020ACNP_720;
Pearson’s correlation, P<0.05 Social interaction after social defeat stress: n=15 water, n=12 fentanyl. Student’s t-test, P<0.05 RNA-seq: n=12 water (6 males and 6 females), n=12 fentanyl (6 males and 6 females), False Discovery Rate (FDR)<0.05; Weighted gene coexpression analysis, P<0.05 Exploratory No
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Sleep, Circadian Rhythms and Substance Use Disorders () - Sep 30, 2020 - Abstract #ACNP2020ACNP_685;
Altering similar circadian-dependent pathways in mouse accumbal circuits leads to increased fentanyl seeking, craving, and relapse behaviors, and increased wakefulness, providing a molecular link between sleep, rhythms, and opioid addiction...The third talk will present unique findings showing withdrawal from cocaine disrupts REM sleep that is linked to relapse and the precise role of the specific cell-types in the lateral hypothalamus that are involved. The last talk will include unique data showing molecular changes in corticostriatal circuitry of human postmortem brains from subjects with opioid use disorder, including molecular rhythm changes that when manipulated in the mouse, lead to increased opioid seeking and tolerance.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Female Rats are More Susceptible to High-Risk Addictive Behaviors Than Male Rats () - Sep 30, 2020 - Abstract #ACNP2020ACNP_668;
The data presented here demonstrates increased vulnerability to high-risk addictive behaviors in female rats as well as non-overlapping patterns of neuronal activation following presentation of drug-paired cues and contexts. Experiments are currently underway to further explore sex differences in drug- and cue-encoding by the C-BG, including fiber photometry recordings from the nucleus accumbens during heroin CPP and proteomic analysis of nucleus accumbens synaptosomes following heroin sensitization.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Cortical Mechanisms in Relapse to Fentanyl Seeking After Food Choice-Induced Voluntary Abstinence () - Sep 30, 2020 - Abstract #ACNP2020ACNP_452;
Our results identify the olfaction-related Pir and projections between Pir and OFC as a new motivation-related brain region and pathway critical to relapse to opioid seeking after voluntary abstinence. Current and future experiments will determine the causal role of Pir dopamine receptor signaling during fentanyl relapse and identify afferent projections to piriform cortex associated with relapse to fentanyl seeking.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Introducing NIDA's New National Drug Early Warning System. (Pubmed Central) - Sep 28, 2020
The novel PBPK models could be helpful to further investigate fentanyl pharmacokinetics in both adult and pediatric populations. No abstract available
- |||||||||| fentanyl citrate / Generic mfg., pethidine / Samaritan, methadone / Generic mfg.
Clinical, Journal: Opioids in patients with renal impairment (Pubmed Central) - Sep 26, 2020
Codeine and pethidine should be avoided entirely...Methadone, oxycodone and tramadol should be used with caution and in reduced doses. In this article we briefly explain the renal elimination processes, certain pharmacokinetic properties of the different opioids and the recommendations for clinical practice.
- |||||||||| Clinical, Journal: Opioid therapy in patients with liver cirrhosis (Pubmed Central) - Sep 26, 2020
In the following article, the relevant pharmacokinetic properties of the most common opioids in Switzerland and the resulting consequences regarding dose adjustment in liver cirrhosis are going to be discussed. Buprenorphine, fentanyl, hydromorphone, morphine, naloxone und tapentadol are drugs with a high first-pass effect, while the bioavailability of methadone, oxycodone and tramadol is > 70 %.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: "Something that actually works": Cannabis use among young people in the context of street entrenchment. (Pubmed Central) - Sep 26, 2020
Buprenorphine, fentanyl, hydromorphone, morphine, naloxone und tapentadol are drugs with a high first-pass effect, while the bioavailability of methadone, oxycodone and tramadol is > 70 %. In the context of the recent legalization of non-medical cannabis use in Canada and amid ongoing overdose and housing crises, it is imperative that future policy and programming interventions and provider education and training be responsive to the ways in which vulnerable youth in our setting are actively using cannabis to navigate their everyday lives and healthcare needs.
- |||||||||| fentanyl citrate / Generic mfg., epinephrine / Generic mfg.
Clinical, Journal: Primary wound care in children (Pubmed Central) - Sep 26, 2020
Laceration wounds, mainly those affecting the scalp, chin or forehead can be treated in the emergency room without general anesthesia. Extensive wounds, burns and animal bites often require wound care under anesthesia in children.
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