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39 Diseases |  |
5 Trials |
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5 Trials |  |
18506 News |  |
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- || fentanyl citrate / Generic mfg.
Clinical, Journal: Transversus Abdominis Plane Block Reduced Early Postoperative Pain after Robot-assisted Prostatectomy: a Randomized Controlled Trial. (Pubmed Central) - Nov 12, 2020
These results indicated that subcostal TAP block by anesthesiologists of varied level of training reduced postoperative pain immediate after RALP. TAP block had fundamental analgesic effect, but this benefit was too small to reduce postoperative 24-hour fentanyl consumption.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl-induced block of hERG channels is exacerbated by hypoxia, hypokalemia, alkalosis, and the presence of hERG1b. (Pubmed Central) - Nov 12, 2020
SIGNIFICANCE STATEMENT: This work demonstrates that heterologously expressed hERG1a/1b channels, which more closely resemble I in the human heart, are blocked by fentanyl with a 3-fold greater potency than the previously studied hERG1a expressed alone. Additionally, chronic hypoxia, hypokalemia, and alkalosis can increase the block of hERG current by fentanyl, potentially increasing the risk of cardiac arrhythmias and sudden death.
- | Journal: Spinal opioid tolerance depends upon platelet-derived growth factor receptor-β signaling, not mu-opioid receptor internalization. (Pubmed Central) - Nov 12, 2020
Here we present conclusive evidence that opioid tolerance occurs independently of MOR internalization, and is selectively mediated by platelet-derived growth factor receptor signaling. This novel hypothesis suggests that dangerous opioid side effects can be selectively targeted and blocked, improving the safety and efficacy of opioids.
- | fentanyl citrate / Generic mfg.
Journal: Exploration of the STOP Act and Opioid Deaths in North Carolina, 2010-2018. (Pubmed Central) - Nov 12, 2020
Results were stratified by heroin-fentanyl deaths and other opioid deaths.Results...Published online ahead of print August 20, 2020: e1-e5. doi:10.2105/AJPH.2020.305748).
- | fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
Journal: Potential Relationship between Cerebral Fractional Tissue Oxygen Extraction (FTOE) and the Use of Sedative Agents during the Perioperative Period in Neonates and Infants. (Pubmed Central) - Nov 11, 2020
There was no association with 0.5 quantile regression. We observed the suggestive positive association of decreased fractional cerebral tissue oxygen extraction and the use of sedative agents in neonates and infants undergoing surgery.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Efficacy and Safety in Combining Primary Palatoplasty and Myringotomy in Patients with Cleft Palate. (Pubmed Central) - Nov 11, 2020
This study documents decreased postoperative care unit time and anesthesia drug exposure without increased length of stay or perioperative complications in patients undergoing combined PP and BMT. These results support combining PP and BMT to reduce exposure to potentially neurotoxic medications and to increase efficient utilization of hospital resources.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: A randomised controlled trial to evaluate the peri-operative role of intraoperative dexmedetomidine infusion in robotic-assisted laparoscopic oncosurgeries. (Pubmed Central) - Nov 11, 2020
Study drug titration, fentanyl boluses, and changes in minimum alveolar concentration (MAC) of inhalational agent were protocolised...Intraoperative dexmed (bolus of 1 μg/kg followed by 0.2 μg/kg/h infusion) has an opioid and inhalational anaesthetic sparing role during robotic oncosurgeries. However, no benefit of the infusion is seen in the postoperative period.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Efficacy of premixed versus succedent administration of fentanyl and bupivacaine in subarachnoid block for lower limb surgeries: A randomised control trial. (Pubmed Central) - Nov 11, 2020
All statistical calculations were done using SPSS 21 version statistical program for Microsoft Windows. The mean time for onset of sensory and motor block was least in group C followed by group B. The duration of sensory and motor block was prolonged in groups B and C. Patients in group A experienced more hypotension as compared to groups B and C. Administering hyperbaric bupivacaine first followed by fentanyl leads to an early onset and prolonged duration of sensory and motor block.
- ||| Penthrox (methoxyflurane) / Medical Developments International, Mundipharma
Clinical, Observational data: Agree. But there is a critical shortage of IN fentanyl stock, and there are very few non-inferior alternatives for prehospital use. Methoxyflurane safe/effective but not "COVID-safe". Good opportunity to compare fentanyl vs ketamine using observational data @VACAR_AV (Twitter) - Nov 10, 2020
- || fentanyl citrate / Generic mfg., ketamine / Generic mfg.
Better is often the enemy of good. For whatever convergence of reasons IN Fentanyl is not a viable option. So the true comparison is actually IN Ketamine versus IM fentanyl. (Twitter) - Nov 10, 2020
- ||| fentanyl citrate / Generic mfg.
Adverse events, Head-to-Head: Was just discussing this week in our ED. Interested in a comparison with IN fentanyl. All evidence I’ve seen so far does not point superiority and risk of adverse effect..@prof_cameron @EmergEdu @Biswadev_M @expensivecare (Twitter) - Nov 10, 2020
- | fentanyl citrate / Generic mfg.
The younger age groups really started ODing with the illicit fentanyl rises. (Twitter) - Nov 9, 2020
- fentanyl citrate / Generic mfg.
[VIRTUAL] The effect of sodium thiopental and fentanyl on mast cell degranulation in the mesentery in rats when modeling septaplasty () - Nov 9, 2020 - Abstract #ECP2020ECP_4746;
Conclusion Modeling of septoplasty under general anesthesia with fentanyl causes more pronounced phenomena of general inflammation and higher mast cell degranulation activity in the mesentery in rats than with sodium thiopental. Also, septoplasty itself provokes not only local inflammatory reactions, but also a systemic inflammatory response
- fentanyl citrate / Generic mfg.
[VIRTUAL] The effect of sodium thiopental and fentanyl on mast cell degranulation in the mesentery in rats when modeling septaplasty () - Nov 9, 2020 - Abstract #ECP2020ECP_3052;
Conclusion Modeling of septoplasty under general anesthesia with fentanyl causes more pronounced phenomena of general inflammation and higher mast cell degranulation activity in the mesentery in rats than with sodium thiopental. Also, septoplasty itself provokes not only local inflammatory reactions, but also a systemic inflammatory response
- fentanyl citrate / Generic mfg.
[VIRTUAL] The effect of sodium thiopental and fentanyl on mast cell degranulation in the mesentery in rats when modeling septaplasty () - Nov 9, 2020 - Abstract #ECP2020ECP_1378;
Conclusion Modeling of septoplasty under general anesthesia with fentanyl causes more pronounced phenomena of general inflammation and higher mast cell degranulation activity in the mesentery in rats than with sodium thiopental. Also, septoplasty itself provokes not only local inflammatory reactions, but also a systemic inflammatory response
- | fentanyl citrate / Generic mfg.
Clinical, Journal: Evaluation of pain management in medical transfer of trauma patients by air. (Pubmed Central) - Nov 7, 2020
Initial and subsequent dose(s) of analgesic had minimal effect on pain as assessed via numerical rating scale, likely due in part to inadequate dosing. Future research is required to determine and address the barriers to proper analgesia.
- |||| fentanyl citrate / Generic mfg.
Clinical: In the UK (unlike elsewhere) we cannot get access to get fentanyl without an anesthetist, so sedation cases here are midazolam/opiates. Wonder how this would affect hypercapnia @mcfinlay @DhirajGuptaBHRS (Twitter) - Nov 7, 2020
- || Clinical, Journal: A single-institution, randomized, pilot study evaluating the efficacy of gabapentin and methadone for patients undergoing chemoradiation for head and neck squamous cell cancer. (Pubmed Central) - Nov 7, 2020
Methadone may improve QOL compared with a regimen of short-acting opioids and fentanyl. However, pain was found to significantly worsen throughout treatment regardless of treatment arm, necessitating further studies to identify a more optimal regimen.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl but not Morphine Interacts with Non-Opioid Recombinant Human Neurotransmitter Receptors and Transporters. (Pubmed Central) - Nov 6, 2020
SIGNIFICANCE STATEMENT: The synthetic opioid, fentanyl, induces different clinical effects including rapid onset muscular rigidity, vocal cord closure and rapid death, than the heroin metabolite, morphine. Our data indicate for the first time that the two drugs have very different effects at recombinant human neurotransmitter receptors and transporters that might explain those clinical differences.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Postoperative Single-shot Epidural Fentanyl and Bupivacaine for Postoperative Analgesia After Lumbar Decompression: A Prospective, Double-blind Randomized Study. (Pubmed Central) - Nov 6, 2020
Our data indicate for the first time that the two drugs have very different effects at recombinant human neurotransmitter receptors and transporters that might explain those clinical differences. A postoperative bolus of Fentanyl and Bupivacaine is effective in reducing early postoperative pain without the related complications of opiod administration.
- || Clinical, Journal: Medication utilization in patients in New York hospitals during the COVID-19 pandemic. (Pubmed Central) - Nov 6, 2020
The increased utilization of supportive therapy drugs was consistent with the surge in patients with presumed or confirmed COVID-19 during the study period. These data and observations can help clinicians, health-system leaders, manufacturers, wholesalers, and policymakers understand the impact of current and future pandemics on the drug supply chain.
- Vecuron (vecuronium) / Sun Pharma
[VIRTUAL] Regional Cerebral Saturation in a Swine Model of Goal-directed Resuscitation of Prolonged Ventricular Fibrillation Cardiac Arrest () - Nov 6, 2020 - Abstract #AHA2020AHA_6168;
Thirty mixed-breed domestic pigs (mean weight: 25.0kg+/-2.0) were sedated (ketamine / xylazine), anesthetized (fentanyl), paralyzed (vecuronium) and mechanically ventilated...Group B animals received increasing rates and depth of CPR with epinephrine q3min... rSO2 measures differ between skin and skull though both correlate with MAP.
- || sevoflurane / Generic mfg.
Clinical, Journal: Comparison of Propofol and Sevoflurane on Cerebral Oxygenation Using Juglar Venous Oximetery (SjVo) in Patients Undergoing Surgery for Traumatic Brain Injury. (Pubmed Central) - Nov 5, 2020
However, significant reduction in MAP by propofol needs attention in patients with severe TBI. The decrease in IL-6 level reflects anti-inflammatory effect and probable neuroprotective potential of propofol and sevoflurane.
- || fentanyl citrate / Generic mfg.
A Comprehensive Approach to Targeted and Untargeted Screening Methodology for Emerging Synthetic Fentanyl Analogues Download the App Note PDF from @Agilent - https://t.co/9zseUShD2k (Twitter) - Nov 5, 2020
- Instanyl (fentanyl) / Takeda
[VIRTUAL] Optimizing Pain Management for Children with Sickle Cell Disease Vaso-Occlusive Crisis in the Emergency Department (Poster Hall (Virtual Meeting)) - Nov 5, 2020 - Abstract #ASH2020ASH_4192;
Standardized procedures to treat and reassess pain for sickle cell disease VOC patients in the PED resulted in check-in to first-dose time reduction by 24.6%. Further steps to sustain our results include guideline reinforcement and interventions with effective pharmacological i.e. intranasal fentanyl and non-pharmacological care.
- Venclexta (venetoclax) / Roche, AbbVie, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] Efficacy and Safety of Front-Line Venetoclax and Rituximab (VenR) for the Treatment of Young Patients with Chronic Lymphocytic Leukemia and an Unfavorable Biologic Profile. Preliminary Results of the Gimema Study ‘Veritas’ (Poster Hall (Virtual Meeting)) - Nov 5, 2020 - Abstract #ASH2020ASH_3940;
P2
Tumor lysis syndrome (TLS) prophylaxis measures included hydration, allopurinol, or rasburicase...Treatment was discontinued after the first dose of Ven in 1 patient with evidence of laboratory TLS associated with severe neurologic toxicity due to the concomitant administration of fentanyl...Grade ≥3 infection was recorded in 3 patients and was the reason for treatment discontinuation in 1 who developed COVID-19 pneumonia. In conclusion, the preliminary results of this study demonstrate the high efficacy of the front-line VenR combination, which resulted in a high proportion of CRs and responses with uMRD4 in young patients with CLL and an unfavorable biologic profile.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Reducing Dependence on General Anesthesia for Pediatric Oncology Outpatients Undergoing Repeated Lumbar Punctures (Poster Hall (Virtual Meeting)) - Nov 5, 2020 - Abstract #ASH2020ASH_1482;
GA is available in the oncology main clinic 3 days/week, and 73% of ALL/LL patients were using GA for LPs prior to the intervention. Since March 2020, nearly all patients with newly diagnosed ALL/LL are now undergoing LPs with no or mild/moderate sedation.
- || fentanyl citrate / Generic mfg.
Highlighting work from Dr Hui, + @edubru and @sureshkred @Reddysuppcare regarding use of fentanyl SL spray for refractory dyspnea which applied directly to a new referral I had yesterday. https://t.co/ClWQy6pbga Thanks @MDAndersonNews group for this research. #pallonc #supponc (Twitter) - Nov 5, 2020
- belzutifan (MK-6482) / Merck (MSD)
[VIRTUAL] ORAL HIF-2α INHIBITOR MK-6482 FOR VON HIPPEL-LINDAU (VHL) DISEASE–ASSOCIATED CLEAR CELL RENAL CELL CARCINOMA: EVALUATION OF RCC AND NON-RCC DISEASE () - Nov 4, 2020 - Abstract #SUO2020SUO_124;
P2
Five patients discontinued treatment: 3 patient decisions, 1 TRAE (grade 1 dizziness), 1 death (acute fentanyl toxicity). MK-6482 demonstrated durable efficacy in patients with VHL disease–associated ccRCC, pancreatic lesions, and hemangioblastomas by targeting the underlying pathophysiology of the disease; the safety profile is favorable.
- ||| fentanyl citrate / Generic mfg.
Clinical: We have some pregnant women coming in with opiate withdrawal. Concerned could be botched up self inductions while on fentanyl. We want to teach them to microdose but candidate selection and risks if they screw up seem prohibitive... (Twitter) - Nov 4, 2020
- | fentanyl citrate / Generic mfg.
Journal: Separation and Detection of Trace Fentanyl from Complex Mixtures Using Gradient Elution Moving Boundary Electrophoresis. (Pubmed Central) - Nov 4, 2020
In addition, GEMBE was successfully applied to a few adjudicated case samples of fentanyl-related mixtures exhibiting dyes and visible particulate. The short capillaries, contactless detection format utilized here, and continuous injection of sample allow for a small footprint platform that is easy-to-use for forensic analyses.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Comparison of Sufentanil- and Fentanyl-based Intravenous Patient-controlled Analgesia on Postoperative Nausea and Vomiting after Laparoscopic Nephrectomy: A Prospective, Double-blind, Randomized-controlled Trial. (Pubmed Central) - Nov 3, 2020
In conclusion, sufentanil- and fentanyl-based IV-PCA showed similar incidence of PONV with comparable analgesic effects after laparoscopic nephrectomy. Based on these results, we suggest that sufentanil and fentanyl may provide comparable effects for IV-PCA after laparoscopic nephrectomy.
- || fentanyl citrate / Generic mfg.
Retrospective data, Review, Journal: To the Editor. (Pubmed Central) - Nov 3, 2020
Based on these results, we suggest that sufentanil and fentanyl may provide comparable effects for IV-PCA after laparoscopic nephrectomy. No abstract available
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Dexmedetomidine Provides Fewer Respiratory Events Compared With Propofol and Fentanyl During Third Molar Surgery: A Randomized Clinical Trial. (Pubmed Central) - Nov 3, 2020
Using dexmedetomidine and midazolam for outpatient surgery resulted in fewer respiratory events requiring deliberate intervention compared with propofol, fentanyl, and midazolam. Ambulation and discharge times were not prolonged using dexmedetomidine.
- | fentanyl citrate / Generic mfg.
Journal: Comparison of preincisional and postincisional parasternal intercostal block on postoperative pain in cardiac surgery. (Pubmed Central) - Nov 3, 2020
Ambulation and discharge times were not prolonged using dexmedetomidine. Preoperative and postoperative parasternal intercostal block provide comparable pain relief during the postoperative period.
- || Instanyl (fentanyl) / Takeda
Retrospective data, Review, Journal: Intranasal ketamine for acute pain management in children: A systematic review and meta-analysis. (Pubmed Central) - Nov 3, 2020
Intranasal analgesic-dose ketamine may be considered as an alternative to opioids for acute pain management in children. Its accepted use will depend on the tolerability of non-serious adverse events and the desire to avoid opioids.
- || fentanyl citrate / Generic mfg.
Enig!! Og herefter fentanyl! Nye opioider har gjort rigtig meget skade - og ingen af dem har væsentlige fordele sammenlignet med morfin, som alle kender risikoen ved. (Twitter) - Nov 3, 2020
- || cefuroxime / Generic mfg.
Clinical, Journal: Efficacy of Periarticular Cocktail Injection in Rheumatoid Patients Undergoing Total Knee Replacement. (Pubmed Central) - Nov 3, 2020
Additional rescue agents used were significantly less at 6 h, at 12 h, and over the first 24 h after the surgery in group A when compared with group B. No cardiac or central nervous system toxicity was observed. Periarticular cocktail injection significantly reduces the requirements for post-operative analgesia and also improves patient satisfaction, with no apparent risks, following total knee arthroplasty in rheumatoid arthritis.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Upper Airway Nerve Block for Rigid Bronchoscopy in the Patients with Tracheal Stenosis: A Case Serie. (Pubmed Central) - Nov 3, 2020
15 patients received fentanyl, and only two patients did not need to intravenous sedation...There was one serious complication (laryngospasm) in one patient. The upper airway nerve block method is a suitable anesthesia technique for patients with tracheal stenosis who are candidates for the tracheal dilatation with rigid bronoscopy, especially when the patient has respiratory distress and has not been evaluated before surgery.
- || fentanyl citrate / Generic mfg., ketamine / Generic mfg.
Clinical, Journal: Comparison of the Combined Femoral and Lateral Femoral Cutaneous Nerve Block Plus Popliteal Block with Spinal Anesthesia for Thigh Tourniquet Pain During Foot or Ankle Surgery: A Randomized Clinical Trial. (Pubmed Central) - Nov 3, 2020
Spinal anesthesia is significantly more effective than the peripheral nerve block method in reducing thigh tourniquet pain. A combined femoral and lateral femoral cutaneous nerve block with popliteal block can improve thigh tourniquet tolerance if supplemented with intravenous analgesics.
- || fentanyl citrate / Generic mfg.
I have this dream where the @CDCDirector does a TV PSA where he acknowledges #ChronicPain as an epidemic & where he admits they got it all wrong - that the uptick in ODs was caused by bad policies & illicit #Fentanyl & the #opioid guidelines have been erroneously misapplied. (Twitter) - Nov 3, 2020
- fentanyl citrate / Generic mfg.
[VIRTUAL] Trends and Characteristics of Fentanyl Exposures Reported to the US Poison Centers () - Nov 2, 2020 - Abstract #ACEP2020ACEP_923;
Although between 2016 and 2017, more than 5 million prescriptions were dispensed, there is a paucity of nationally representative U.S. fentanyl overdose data. This study aims to examine the national trends in tramadol exposures reported to U.S. poison centers (PCs).
- ketamine / Generic mfg.
[VIRTUAL] Intranasal Ketamine for Acute Pain Management in Children: A Systematic Review and Meta-analysis () - Nov 2, 2020 - Abstract #ACEP2020ACEP_751;
This study aims to examine the national trends in tramadol exposures reported to U.S. poison centers (PCs). We conducted a systematic review and meta-analysis to assess the efficacy and safety of intranasal (IN) analgesic-dose ketamine as compared to IN fentanyl for pediatric acute pain management in the emergency department (ED).
- | fentanyl citrate / Generic mfg.
Journal: Racial differences in overdose events and polydrug detection in Indianapolis, Indiana. (Pubmed Central) - Nov 2, 2020
Recent racial disparities in overdose deaths are driven by a combination of fentanyl and cocaine, which disproportionally impacts African American drug users, but may be addressed through expanded harm reduction and community outreach services. Additionally, there is a need to assess the role of differing practices in overdose emergency service provision as a contributing factor to disparities.
- | fentanyl citrate / Generic mfg.
Journal: Leveraging crowdsourcing methods to collect qualitative data in addiction science: Narratives of non-medical prescription opioid, heroin, and fentanyl use. (Pubmed Central) - Nov 2, 2020
These findings support the feasibility and quality of qualitative data collected in online settings, broadly, and crowdsourced settings, specifically. Future work among people who use drugs may leverage crowdsourcing methods and the access to hard-to-sample populations to complement existing studies in the human laboratory and clinic as well as those using other digital technology methods.
- || Eladur (bupivacaine) / Amneal
Clinical, Journal: Comparative Study of Fentanyl vs Dexmedetomidine as Adjuvants to Intrathecal Bupivacaine in Cesarean Section: A Randomized, Double-Blind Clinical Trial. (Pubmed Central) - Nov 1, 2020
The two groups did not show significant differences in hemodynamic changes and other variables (P>0.05). Compared with fentanyl, it seems that adding 5 μg dexmedetomidine to bupivacaine has a better effect on postoperative pain management in cesarean section under spinal anesthesia.
- | Duragesic (fentanyl) / J&J
Journal: Predicting Transdermal Fentanyl Delivery Using Mechanistic Simulations for Tailored Therapy. (Pubmed Central) - Nov 1, 2020
Such computer-aided engineering tools also have great potential for in-silico design and precise control of drug delivery systems. Here, the validated mechanistic models can serve as a key building block for developing digital twins for transdermal drug delivery systems.
- || citalopram / Generic mfg., sertraline / Generic mfg., fluoxetine / Generic mfg.
Clinical, Journal: Prediction of Suicide-Related Events by Analyzing Electronic Medical Records from PTSD Patients with Bipolar Disorder. (Pubmed Central) - Nov 1, 2020
The use of Trazodone and Citalopram at baseline predicted the onset of SREs within one year...The model also provides feature decompositions to guide mechanism studies. The validation of this model with additional EMR datasets will be of great value in resource allocation and clinical decision making.
- | fentanyl citrate / Generic mfg.
Journal: Electrocortical changes associating sedation and respiratory depression by the opioid analgesic fentanyl. (Pubmed Central) - Oct 30, 2020
Interestingly, respiratory rate depression by fentanyl was significantly correlated with increased θ power (R = 0.61, P < 0.001), therefore showing a clear association between electrocortical activity and the magnitude of respiratory rate depression. Overall, we provide new evidence linking specific electrocortical changes to the severity of respiratory depression by opioids, which highlights the importance of considering the cortical and subcortical effects of opioids in addition to their impacts on breathing when evaluating opioid-induced respiratory depression.
- || fentanyl citrate / Generic mfg.
Clinical, P4 data, PK/PD data, Journal, Real-World Evidence: Development of a System for Post-marketing Population Pharmacokinetic and Pharmacodynamic Studies using Real-World Data from Electronic Health Records. (Pubmed Central) - Oct 30, 2020
Applying this system, we performed a fentanyl population PK analysis, resulting in comparable parameter estimates to a prior study. This new system makes the EHR data extraction and preparation process more efficient and accurate, and provides a powerful tool to facilitate post-marketing population PK/PD studies using information available in EHRs.