fentanyl citrate / Generic mfg. 
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  • ||||||||||  Duragesic (fentanyl) / J&J
    Journal:  Fentanyl patches: Use and Misuse. (Pubmed Central) -  Dec 1, 2020   
    It is also an opioid that is widely abused. Acute clinicians need to be aware of the methods by which fentanyl patches may be used both therapeutically and illicitly as well as the impact this can have in managing a patient's period of intoxication.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Delayed Norfentanyl Clearance During Pregnancy. (Pubmed Central) -  Dec 1, 2020   
    Acute clinicians need to be aware of the methods by which fentanyl patches may be used both therapeutically and illicitly as well as the impact this can have in managing a patient's period of intoxication. This case highlights the importance of acknowledging pregnancy, genetic, or medication-induced changes to fentanyl pharmacokinetics when interpreting urine tests, especially given the potential sequelae of a false-positive urine test result.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market. (Pubmed Central) -  Nov 28, 2020   
    U-47700 represents a classic example of how chemical entities from the medicinal chemistry or patent literature can be diverted for use in recreational drug markets. Lessons learned from the experiences with U-47700 can inform scientists, clinicians, and policymakers who are involved with responding to the spread and impact of NSOs.
  • ||||||||||  ketamine / Generic mfg., ibuprofen / Generic mfg.
    Clinical, Journal:  Opioid-Sparing Anesthetic Technique for Pediatric Patients Undergoing Adenoidectomy: A Pilot Study. (Pubmed Central) -  Nov 28, 2020   
    The perioperative regimen included oral dextromethorphan (1 mg/kg) and acetaminophen (15 mg/kg) plus single boluses of intraoperative dexmedetomidine (0.5 μg/kg) and ketamine (0.5 mg/kg)...Patients with a pain score >4 received fentanyl as needed...Postoperatively, patients were instructed to use oral acetaminophen or ibuprofen every 6 hours as needed for pain...This opioid-sparing approach provided safe and effective pain control as well as parental satisfaction following adenoidectomy in children. Additional prospective studies are needed to determine whether this regimen is effective in a larger cohort of patients with and for other otolaryngology procedures.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Lumbar Epidural: Anatomical and Clinical Study in Dogs Submitted to Ovariohysterectomy. (Pubmed Central) -  Nov 28, 2020   
    The conclusion of the anatomical study was that L1-L2 epidural bupivacaine dispersion is lower in canine thawed cadavers than in alive dogs. Conclusion of the clinical study was that lumbar epidural anesthesia improved postoperative analgesia and produced longer postoperative sedation when compared to fentanyl.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  Opportunities to Offer Harm Reduction to People who Inject Drugs During Infectious Disease Encounters: Narrative Review. (Pubmed Central) -  Nov 28, 2020   
    Major target areas include (1) teaching and distribution of materials related to safer injection practice such as sterile injection supplies, fentanyl test strips, and naloxone; (2) increased screening and access to pre-exposure prophylaxis and postexposure prophylaxis; and (3) initiation of medications for opioid use disorder. Incorporating these strategies in various treatment settings can expand treatment access, improve patient outcomes, and reduce stigma associated with IDU.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Comparison of hospital consumption of immediate-release fentanyl: use or abuse? (Pubmed Central) -  Nov 28, 2020   
    No significant change was seen in MV days, ICU length of stay, or self-extubation rates. The use of immediate-release fentanyl in the hospital setting has considerably increased in comparison to 2014, as well as its off-label use.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Situating the Continuum of Overdose Risk in the Social Determinants of Health: A New Conceptual Framework. (Pubmed Central) -  Nov 28, 2020   
    The use of immediate-release fentanyl in the hospital setting has considerably increased in comparison to 2014, as well as its off-label use. Without recognizing the full drug-use continuum and the role of social determinants, the current responses to drug overdose will continue to aggravate the problem they are trying to solve.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Fentanyl analogues potency: what should be known. (Pubmed Central) -  Nov 26, 2020   
    Moreover, an additional analytical challenge is represented by the emergence of newly synthesized derivatives. In this concern, the harmonization of international guidelines, the adoption of common legal responses and the enforcement of international collaboration is desirable to face this alarming public health threat.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Preclinical, Journal:  Changes in fentanyl demand following naltrexone, morphine, and buprenorphine in male rats. (Pubmed Central) -  Nov 25, 2020   
    We conclude that the use of therapeutic plasmapheresis with plasma associated with the introduction of rituximab was effective in obtaining prolonged complete remission in this patient with acute and severe PTT. These results indicate that fentanyl demand is sensitive to blockade or activation of opioid receptors by the drug classes used for MAT in humans.
  • ||||||||||  fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
    Journal:  Perseus A500 enables faster recovery from desflurane general anesthesia. (Pubmed Central) -  Nov 22, 2020   
    The method workflow is extremely dependable, relatively fast, sustainable, and leads to reproducible results that enable the high-throughput screening of various biological samples. We demonstrate in this study that Perseus enables the faster wash-out of anesthetics and faster recovery of patients after general anesthesia.
  • ||||||||||  Journal:  Opioid Preconditioning Modulates Repair Responses to Prevent Renal Ischemia-Reperfusion Injury. (Pubmed Central) -  Nov 21, 2020   
    Experimental protocol includes male rats with 45 min ischemia occluding the left renal hilum followed by 24 h of reperfusion with or without 60 min preconditioning with morphine/fentanyl...Opioid preconditioning decreased injury through modulation of angiogenic molecule expression. These are factors to consider when establishing strategies in pathophysiological and surgical processes.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Low dose fentanyl infusion versus 24% oral sucrose for pain management during laser treatment for retinopathy of prematurity-an open label randomized clinical trial. (Pubmed Central) -  Nov 21, 2020   
    There was no difference in other outcomes between the two groups. During laser for ROP, low dose fentanyl infusion was found to be efficacious in reducing pain as compared with 24% sucrose.What is Known:• Preterm infants undergoing laser photocoagulation for ROP suffer significant amount of pain.• Standard of care for pain relief in infants undergoing laser therapy in developed countries is general anesthesia (GA) or combination of sedation, analgesia, and paralysis (SAP).What is New:• During laser photocoagulation for ROP, fentanyl infusion at low dose (1 mcg/kg/hr) is efficacious in reducing pain as compared to 24% oral sucrose.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Perioperative Analgesic Modalities for Breast Cancer Surgeries: A Prospective Randomized Controlled Trial. (Pubmed Central) -  Nov 21, 2020   
    P=N/A
    Intraoperative hemodynamics and fentanyl consumption showed no difference between groups, whereas postoperative mean arterial blood pressure values at 2 and 4 hours were higher in the morphine group...SAPB and ESPB can be used as an effective and safe alternative to opioids with fewer side effects in breast cancer patients undergoing modified radical mastectomy. This trial was prospectively registered at Clinical Trials.gov on 22 January 2020 with registration number NCT04248608 (https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S0009JS5&selectaction=Edit&uid=U0004LIG&ts=7&cx=-81xkwa).
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] The Comparison of Postoperative Pain Between Umbilical and Suprapubic Incision in Laparoscopic Liver Resection () -  Nov 21, 2020 - Abstract #IHPBA2020IHPBA_881;    
    In 11 patients with umbilical incision and 8 patients with suprapubic incision, the operation time, bleeding volume, wound length, duration of continuous intravenous fentanyl infusion immediately after surgery and the number of flushes, and period of regular oral administration of NSAIDs were evaluated... In laparoscopic hepatectomy, extirpation of the specimen by umbilical incision is acceptable.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  High-dose buprenorphine for treatment of high potency opioid use disorder. (Pubmed Central) -  Nov 19, 2020   
    A 29-year-old woman presented to detox for treatment of an opioid use disorder with illicit fentanyl...She was given additional PRNs of buprenorphine/naloxone to a total daily dose of 40 mg, which helped to alleviate her symptoms of withdrawal and cravings. She was stabilised on buprenorphine/naloxone 40 mg daily without any side effects and was discharged to a rehabilitation centre.
  • ||||||||||  Zubsolv (buprenorphine/naloxone sublingual tablet) / Orexo, Mundipharma
    Clinical, Journal:  Initiation of injectable opioid agonist treatment in hospital: A case report. (Pubmed Central) -  Nov 19, 2020   
    We describe the case of a 47-year-old man with a severe, active opioid use disorder and daily use of illicitly manufactured fentanyl, who was re-admitted to hospital for post-operative management after leaving against medical advice due to uncontrolled opioid withdrawal. Intravenous hydromorphone was used to retain him in care, allowing for completion of his antibiotics and enrolment in ongoing community injectable opioid agonist treatment.
  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
    Clinical, Observational data, Journal:  Prediction of Postoperative Pain and Opioid Consumption Using Intraoperative Surgical Pleth Index After Surgical Incision: An Observational Study. (Pubmed Central) -  Nov 18, 2020   
    This prospective observational study was performed in 50 patients undergoing laparotomy under sevoflurane-based general anesthesia...Group H used higher fentanyl via patient control analgesia during postoperative 24 h (573 (253) µg vs 817 (305) µg, p=0.008)...Our finding suggests that the SPI response to nociceptive stimuli during surgery is closely related to the degree of patient postoperative pain and opioid requirements. This information may be used to provide proper intraoperative analgesia and individual postoperative pain management.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Fixed Dose versus Height-Adjusted Conventional Dose of Intrathecal Hyperbaric Bupivacaine for Caesarean Delivery: A Prospective, Double-Blinded Randomised Trial. (Pubmed Central) -  Nov 14, 2020   
    The fixed-dose group (FD) received a spinal block with 12.5 mg of hyperbaric bupivacaine with fentanyl, whereas the adjusted-dose group (AD) received a height-adjusted dose of bupivacaine (9-13 mg) with fentanyl...No differences were noted in terms of hypotension, bradycardia and nausea between the FD and AD groups. Compared to the height-adjusted dose regimen based on conventional doses of hyperbaric bupivacaine, the fixed dose regimen of 12.5 mg was equally effective and did not increase the risk of spinal block-related complications.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Perioperative effects of caudal block on pediatric patients in laparoscopic upper urinary tract surgery: a randomized controlled trial. (Pubmed Central) -  Nov 14, 2020   
    Compared to the height-adjusted dose regimen based on conventional doses of hyperbaric bupivacaine, the fixed dose regimen of 12.5 mg was equally effective and did not increase the risk of spinal block-related complications. Caudal block with 1.3 mL/kg of 0.15% ropivacaine reduced perioperative fentanyl use during laparoscopic upper urinary tract surgery on pediatric patients and produced good postoperative analgesia when compared with no caudal block and caudal block with 1.0 mL/kg of 0.15% ropivacaine.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Spinal and epidural sufentanil and fentanyl in early labour. (Pubmed Central) -  Nov 12, 2020   
    In terms of a reduction of VAS score at 20 minutes, epidural sufentanil or fentanyl provide 63% and 60% of the analgesic effect of the corresponding spinal analgesia. Epidural sufentanil or fentanyl could be used in situations in which spinal/CSE administration is not possible or desired.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal, Adverse events:  pK of opioid ligands as a discriminating factor for side effects. (Pubmed Central) -  Nov 12, 2020   
    The comparison of several fentanyl derivatives revealed a correlation between pK values and pH-dependent MOR activation, antinociception and side effects. An opioid ligand's pK value may be used as discriminating factor to design safer analgesics.
  • ||||||||||  morphine/oxycodone (Q8011) / QRxPharma
    Review, Journal:  Do All Opioid Drugs Share the Same Immunomodulatory Properties? A Review From Animal and Human Studies. (Pubmed Central) -  Nov 12, 2020   
    A search strategy was conducted in PubMed, Embase, and the Cochrane databases using the terms "immunosuppression," "immune system," "opioids," "Natural killer cells," "cytokines," and "lymphocytes." The results achieved concerning the effects of fentanyl, methadone, oxycodone, buprenorphine, remifentanil, tramadol, and tapentadol on immune responses in animal studies, in healthy volunteers and in patients are reported. With some limitations due to the different methods used to measure immune system parameters, the large range of opioid doses and the relatively scarce number of participants in the available studies, we conclude that it is not correct to generalize immunosuppression as a common side effect of all opioid molecules.