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- fentanyl citrate / Generic mfg.
[VIRTUAL] Feasibility and Safety of ENB Guided Microwave Ablation for Lung Cancer: A Preliminary Report (ePoster Hall) - Dec 17, 2020 - Abstract #IASLCWCLC2020IASLC_WCLC_430;
After pathway planning using the procedure-planning software, ENB procedure were performed under conscious sedation with a combination of midazolam and fentanyl...One of the ENB guided ablation has mild hemoptysis and pneumonia after treatment, after intravenous antibiotic and coagulation treatment, the patient recovered. Conclusion Our preliminary experience shows ENB guided microwave ablation is safe and feasible, bronchus sign on CT seems a important factor for accurate navigation.
- | fentanyl citrate / Generic mfg.
Journal: Identification and Confirmation of Fentanyls on Paper using Portable Surface Enhanced Raman Spectroscopy and Paper Spray Ionization Mass Spectrometry. (Pubmed Central) - Dec 17, 2020
The commercial nature of both instruments moves this technology from the academic realm to a setting where the criminal justice system can realistically utilize it. The capabilities of this single-substrate dual-analyzer technique are further examined by sampling a variety of surfaces of forensic interest.
- | Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma
Preclinical, Journal: Assessment of structure-activity relationships and biased agonism at the Mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform. (Pubmed Central) - Dec 17, 2020
The developed bio-assays allow to gain insight into the βarr2 or G protein recruitment potential of NSO, which may eventually help to better understand why certain opioids are associated with higher toxicity. Adding to the recent discussion about the relevance of the biased agonism concept for opioids, we did not observe a significant bias for any of the evaluated compounds, including TRV130.
- || ketamine / Generic mfg.
Clinical, Journal: Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial. (Pubmed Central) - Dec 17, 2020
P3
We expect to complete the recruitment by 31 December 2020. The findings of this pilot trial will likely justify further investigation for the role of adjunct low-dose ketamine infusion as an analgo-sedative agent in a larger, multicenter, randomized controlled trial.
- | Selincro (nalmefene oral) / Lundbeck, Acorda
Preclinical, Journal: GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats. (Pubmed Central) - Dec 17, 2020
Moreover, the recovery of motor coordination of the KFD + PNF group was faster than that of the KFD group. In summary, our results suggest the potential application of the PNF combination as an antagonistic treatment strategy for anesthesia.
- | fentanyl citrate / Generic mfg.
Retrospective data, Journal: Implementation of the Obturator Nerve Block into a Supra-Inguinal Fascia Iliaca Compartment Block Based Analgesia Protocol for Hip Arthroscopy: Retrospective Pre-Post Study. (Pubmed Central) - Dec 17, 2020
The cumulative opioid (fentanyl) consumption at 24 hours after surgery was significantly lower in the group FO compared with the group N (N: 678.5 (444.0-890.0) µg; FO: 482.8 (305.8-635.0) µg; p = 0.014), whereas the group F did not show a significant difference (F: 636.0 (426.8-803.0) µg). Our findings suggest that implementing obturator nerve block into SI-FICB can reduce postoperative opioid consumption in hip arthroscopy.
- || fentanyl citrate / Generic mfg.
It’s so bad. The half life of fentanyl is too long. With straight heroin, you can wait the 24-36 hrs. before starting Bupe and the transition is manageable. However, the 24-36 hrs. is nowhere close to long enough when using fentanyl. Precipitous withdrawal is a certainty! #BRUTAL (Twitter) - Dec 17, 2020
- || fentanyl citrate / Generic mfg.
Bupe was great, until fentanyl hit. Now it is almost impossible to go from illicit drugs to Bupe. A low dose short acting opioid is needed to bridge the fentanyl to the Bupe. Unfortunately NO clinics are doing this. Once again, Dr’s refuse to listen to us drug users! (Twitter) - Dec 17, 2020
- || fentanyl citrate / Generic mfg., methadone / Generic mfg.
Agree! Avoiding withdrawal in microdosing depends on so many factors; I’ve found with anyone on high doses of fentanyl or methadone, it’s harder to avoid withdrawal entirely. To answer the original question then, maybe that folks on bup have 40% less risk of dying at one year (Twitter) - Dec 17, 2020
- | fentanyl citrate / Generic mfg.
Journal: Use of Dexmedetomidine in Transfemoral Transcatheter Aortic Valve Implantation (tf-TAVI) Procedures. (Pubmed Central) - Dec 17, 2020
In this series, sedation with dexmedetomidine for TAVI procedures with femoral access was proven effective and safe. Dexmedetomidine may be a valid alternative to general anesthesia in high-risk older patients undergoing transfemoral TAVI.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Nasal fentanyl alone plus buccal midazolam: an open-label, randomised, controlled feasibility study in the dying. (Pubmed Central) - Dec 16, 2020
P4
Study participation in a hospice population of the dying was acceptable. The results will help guide future community study planning.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: The Haemodynamic Response to Endotracheal Intubation at Different Time of Fentanyl Given During Induction: A Randomised Controlled Trial. (Pubmed Central) - Dec 16, 2020
Confounding factors such as smoking, hypertension, diabetes mellitus and preoperative intravenous fluid supplement were analysed. In conclusion, fentanyl injection 2 minutes before intubation is recommended in order to obtain the most stable haemodynamic status.
- || fentanyl citrate / Generic mfg.
Review, Journal: Opioids for breathlessness: a narrative review. (Pubmed Central) - Dec 16, 2020
We have no long-term data on immune or endocrine function. There are promising data regarding prophylaxis for exertion-related breathlessness, but given the risks associated with transmucosal fentanyl, caution is needed with regard to clinical use pending longer term, robust safety data.
- | fentanyl citrate / Generic mfg.
Journal: Endogenous opioids facilitate intrinsically-rewarded birdsong. (Pubmed Central) - Dec 16, 2020
Furthermore, infusion of siRNA targeting MORs specifically in mPOA both suppresses gregarious song and disrupts the positive association between affective state and singing behavior, as revealed using CPP tests of song-associated reward. Results strongly implicate opioids in gregarious song and suggest that endogenous opioids in the mPOA may facilitate song by influencing an individual's intrinsic reward state.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Determination of 37 fentanyl analogues and novel synthetic opioids in hair by UHPLC-MS/MS and its application to authentic cases. (Pubmed Central) - Dec 16, 2020
Furthermore, the method was successfully applied to the detection and quantification of fentanyl and sufentanil in hair samples from two authentic cases. Thus, this method has great potential for detecting fentanyl analogues and novel synthetic opioids in forensic work.
- | fentanyl citrate / Generic mfg.
Journal: Dexmedetomidine reduces the amount of benzodiazepines and opioids administered during moderate conscious sedation for dental treatment. (Pubmed Central) - Dec 16, 2020
Thus, this method has great potential for detecting fentanyl analogues and novel synthetic opioids in forensic work. The addition of DEX to the anesthetic regimen results in a reduction of overall medications administered.
- |||| fentanyl citrate / Generic mfg.
There are 25 other viral proteins that also make SARS-CoV-2 dangerous. The same account melted down when @RyanMarino, a toxicologist, told them there’s no way their friend accidentally OD’d on fentanyl by touching a rental car. Mercifully alt agency accts have run their course. (Twitter) - Dec 16, 2020
- | fentanyl citrate / Generic mfg.
Journal: Genetic variation regulates opioid-induced respiratory depression in mice. (Pubmed Central) - Dec 16, 2020
The diversion and misuse of prescription opioids along with increased use of drugs like heroin and fentanyl, has led to an epidemic in addiction and overdose deaths...We used DO mice treated with morphine to map quantitative trait loci for respiratory depression, recovery time and survival time. Trait mapping and integrative functional genomic analysis in GeneWeaver has allowed us to implicate Galnt11, an N-acetylgalactosaminyltransferase, as a gene that regulates OIRD.
- | fentanyl citrate / Generic mfg.
Journal: Effects of perioperative magnesium sulfate with controlled hypotension on intraoperative bleeding and postoperative ecchymosis and edema in open rhinoplasty. (Pubmed Central) - Dec 16, 2020
Trait mapping and integrative functional genomic analysis in GeneWeaver has allowed us to implicate Galnt11, an N-acetylgalactosaminyltransferase, as a gene that regulates OIRD. Magnesium sulfate with controlled hypotension can lower ecchymosis and edema of the upper and lower eyelids in rhinoplasty surgery by reducing bleeding.
- | fentanyl citrate / Generic mfg., methadone / Generic mfg.
Preclinical, Journal: Monoclonal antibodies counteract opioid-induced behavioral and toxic effects in mice and rats. (Pubmed Central) - Dec 16, 2020
In contrast to current pharmacotherapies (e.g., methadone, buprenorphine, naltrexone, and naloxone) for OUD and overdose, which target brain opioid receptors, mAbs and vaccine-generated polyclonal antibodies sequester the target opioid in the serum and reduce drug distribution to the brain...Using magnetic enrichment to isolate opioid-specific B cell lymphocytes prior to fusion with myeloma partners, this study identified a series of murine hybridoma cell lines expressing mAbs with high affinity for opioids of clinical interest, including oxycodone, heroin and its active metabolites, and fentanyl...Monoclonal antibodies (mAb) may provide acute protection from overdose by binding to circulating opioids in serum. Use of mAb prophylactically, or post-exposure in combination with naloxone, may reduce hospitalization and increase survival.
- | fentanyl citrate / Generic mfg.
Retrospective data, Journal: Assessing the Effectiveness of Combined Analgesics for Bilateral Ramus Osteotomies. (Pubmed Central) - Dec 16, 2020
From the multivariate analysis, the combination of NSAIDs-acetaminophen-fentanyl was an independent factor for no additional rescue analgesics during the first 1 hour after bilateral ramus osteotomies, indicating that the combination is significantly effective for bilateral ramus osteotomies compared with the other combinations. Considering that this study consisted of a small sample size, the results of this study suggest that some of the combinations, particularly NSAIDs-acetaminophen-fentanyl, are more effective than NSAIDs alone for postoperative pain control immediately following bilateral ramus osteotomy procedures.
- || lithium carbonate / Generic mfg., lithium / Generic mfg.
Clinical, Journal: Potentiation of Rocuronium Bromide by Lithium Carbonate: A Case Report. (Pubmed Central) - Dec 16, 2020
General anesthesia was induced with propofol, fentanyl, remifentanil, and sevoflurane...Following administration of sugammadex (200 mg) the TOF ratio increased to 95%...Thus, the effect of the remaining lithium may have been superimposed on the rocuronium neuromuscular blockade. Evaluation with a nerve stimulation device in patients taking lithium is crucial before extubation because of the risk of rocuronium potentiation.
- || fentanyl citrate / Generic mfg.
Well at least now I know what a colon looks like. That was brutal, to say the least. Also I declined Fentanyl (hate opioids and they started to push it when I was fading... I was like "ummm what's that?!) or Epi (❤️ stuff). Overall, not thrilled. (Twitter) - Dec 16, 2020
- ||| fentanyl citrate / Generic mfg.
Can’t stop using fentanyl enough to avoid ppt wd #bupmicroinduction low dose titrated up even if active use no ppt wd. https://t.co/gzgV4Ap8v6 to show pt starting tonight what 1/16th of 2/0.5 is (125 mcg) f/u call tomorrow. @adfoxMD @NYSAM_connect @acmtmedtox @DrMelissaWeimer (Twitter) - Dec 15, 2020
- | fentanyl citrate / Generic mfg.
Retrospective data, Journal: Shorter drug testing intervals are associated with improved drug misuse rates. (Pubmed Central) - Dec 15, 2020
Our findings suggest that clinical strategies that include serial testing conducted quarterly or sooner may be instrumental in decreasing drug misuse. Testing more frequently than "at least once annually" should be considered by clinicians monitoring potential drug misuse.
- | Ryanodex (dantrolene) / Eagle Pharma
Journal: Rhabdomyolysis during Perioperative Period after Cardiac Surgery (Pubmed Central) - Dec 15, 2020
It remained unclear which drug triggered rhabdomyolysis. When MH is suspected, we should consider the use of the clinical grading scale to predict its susceptibility and start dantrolene sodium hydrate infusion.
- | fentanyl citrate / Generic mfg.
fentanyl addict. criminal, left a lasting impression on some weak minded kin (Twitter) - Dec 15, 2020
- |||| fentanyl citrate / Generic mfg.
Clinical: What kind of thing? Everything I do is to end the lockdowns. - 46% cancers undiagnosed - 50% of chemo treatments missed - 50% of infant immunizations missed - 250K cases of child abuse likely missed - 300% rise in cardio myopathy. -50% increase in fentanyl overdoses (Twitter) - Dec 13, 2020
- || fentanyl citrate / Generic mfg.
Retrospective data, Review: Effects of Dexmedetomidine on Emergence Agitation and Recovery Quality Among Children Undergoing Surgery Under General Anesthesia: A Meta-Analysis of Randomized Controlled Trials. (Pubmed Central) - Dec 12, 2020
No significant differences were observed between the effects of dexmedetomidine and other drugs like midazolam, propofol, fentanyl, tramadol, and clonidine in terms of the emergence agitation incidence and other parameters, except for the requirement of rescue analgesic (RR 0.45; 95% CI 0.33-0.61; p < 0.00001). Dexmedetomidine can prevent emergence agitation, relieves postoperative pain, decreases the requirement of rescue analgesic, and decreases the postoperative nausea and vomiting events.
- || fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Agree. Prevention is vital. Street heroin laced with fentanyl and crystal methamphetamine use is surging (Twitter) - Dec 12, 2020
- | fentanyl citrate / Generic mfg.
Journal: Paper Spray Mass Spectrometry Utilized with a Synthetic Microporous Polyolefin Silica Matrix Substrate in the Rapid Detection and Identification of More than 190 Synthetic Fentanyl Analogs. (Pubmed Central) - Dec 10, 2020
The application of this novel synthetic substrate to PS-MS has been illustrated with a fentanyl analog screening kit (FAS Kit), which was designed by the Centers for Disease Control (CDC) for the screening of 212 evolving synthetic opioids, including more than 190 fentanyl analogs. The comparable fragmentation with precursor molecule mass data from this study can be useful in improving the accurate detection and structural characterization of complex samples with a minimum interference of the isobaric components.
- ||| fentanyl citrate / Generic mfg.
Here are some of the ongoing challenges we now face, says @Amy_Bohnert /13 : #COVID19 fentanyl (OD) how to taper equity in care (and discrimination) "Opioid refugees" Stigma (Twitter) - Dec 9, 2020
- ||| fentanyl citrate / Generic mfg.
@Amy_Bohnert gave an excellent talk just now. Not enough data to support a #causal link between opioid prescriptions and overdose. Fentanyl drives opioid overdoses and discontinuation of opioid prescriptions might even increase heroine use and overdose. #pain #opioids (Twitter) - Dec 9, 2020
- ||| fentanyl citrate / Generic mfg.
Interview: Good reporting on the overdose crisis and fentanyl in #LosAngeles from @kcrw by @JesseAHardman with interview of @DoingMedicine of @KECKSchool_USC https://t.co/8LPdoGYPcb (Twitter) - Dec 9, 2020
- || fentanyl citrate / Generic mfg.
Because illicit fentanyl is the problem. Otherwise the overdose rate would have dropped with the prescribing rate. Our sick are suffering for no reason. It won’t end until we address the real reasons for all of it. (Twitter) - Dec 9, 2020
- ||| fentanyl citrate / Generic mfg.
There are sufficient studies to show that it’s very rare. Drugs don’t cause addiction. Rx is down 40% and overdoses are up. This overdosing crisis has nothing to do w rx, but by denying people pain relief, you guys are sending people to the streets to overdose on illicit fentanyl (Twitter) - Dec 8, 2020
- || fentanyl citrate / Generic mfg.
Polypharmacy and illicit fentanyl deaths not "opioids" (Twitter) - Dec 7, 2020
- || fentanyl citrate / Generic mfg.
As badly as the CDC botched the response to the illicit fentanyl crisis i can imagine why anyone thought they wouldn't botch this (Twitter) - Dec 6, 2020
- ||| fentanyl citrate / Generic mfg.
Clinical: Sorry as a chronic pain patient I don't blame pharmaceutical companies for the opioid epidemic, I blame the cartels who put fentanyl in everything, bc it was cheap. We need to decriminalize all drugs. (Twitter) - Dec 5, 2020
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Comparing Analgesic Effect of Intravenous Fentanyl, Femoral Nerve Block and Fascia Iliaca Block During Spinal Anesthesia Positioning in Elective Adult Patients Undergoing Femoral Fracture Surgery: a Randomized Controlled Trial. (Pubmed Central) - Dec 5, 2020
Pan African Clinical Trial Registry, PACTR202006669166858, registered on June 19, 2020. https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=12127.
- | ketamine / Generic mfg.
Journal: The Impact of Vasopressor and Sedative Agents on Cerebrovascular Reactivity and Compensatory Reserve in Traumatic Brain Injury: An Exploratory Analysis. (Pubmed Central) - Dec 5, 2020
As such, this finding with regards to propofol remains "weak." This study indicates that commonly administered sedative and vasopressor agents with incremental dosing changes have no clinically significant influence on cerebrovascular reactivity or compensatory reserve in TBI. These results should be considered preliminary, requiring further investigation.
- | fentanyl citrate / Generic mfg.
New trial: SERAP: GERAP's Epidemiological Survey on Perioperative Hypersensitivity Reactions (clinicaltrials.gov) - Dec 3, 2020
P, N=3000, Recruiting, Sponsor: University Hospital, Strasbourg, France
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Deep sedation for transvenous lead extraction: a large single-centre experience. (Pubmed Central) - Dec 3, 2020
These results should be considered preliminary, requiring further investigation. Transvenous lead extraction under DS in the EP laboratory is a safe procedure with high success rates when performed by experienced staff.
- || fentanyl citrate / Generic mfg.
Clinical, Journal, Real-World Evidence: Assessing the limit of detection of Fourier-transform infrared spectroscopy and immunoassay strips for fentanyl in a real-world setting. (Pubmed Central) - Dec 3, 2020
Fentanyl immunoassay strips were able to consistently detect the presence of fentanyl in samples at lower concentrations than FTIR spectroscopy. Given that FTIR spectroscopy is able to quantify content, mixture and concentrations on an array of compounds beyond just fentanyl but requires concentrations generally greater than 10%, these findings provide evidence for use of FTIR spectroscopy and immunoassay strips in combination to compensate for the limitations of each technology alone.
- ||| fentanyl citrate / Generic mfg.
Retrospective data, Journal, Adverse events: Effect of Fentanyl-Based Intravenous Patient-Controlled Analgesia with and without Basal Infusion on Postoperative Opioid Consumption and Opioid-Related Side Effects: A Retrospective Cohort Study. (Pubmed Central) - Dec 3, 2020
The occurrence of overall opioid-related side effects was also significantly lower in the no basal group (at 24 hours: 31.0% vs 23.0%, OR=0.67, P=0.003, 95% CI=0.51 - 0.87; at 48 hours: 18.9% vs 11.0%, OR=0.48, P<0.001, 95% CI=0.31 - 0.75). Basal infusion of fentanyl-based IV-PCA was significantly associated with an increase in fentanyl consumption and the occurrence of opioid-related side effects in postsurgical patients.
- || fentanyl citrate / Generic mfg.
Yeah, definitely a billion dollar industry with 0 research under their belt. And why should we trust pharma again? W/ fentanyl & every other drug they’ve pushed despite insurmountable negative consequences, y’all just keep the propaganda train going. https://t.co/LU8gukT3DR (Twitter) - Dec 3, 2020
- || fentanyl citrate / Generic mfg.
Clinical, PK/PD data, Journal: An allometric pharmacokinetic model and minimum effective analgesic concentration of fentanyl in patients undergoing major abdominal surgery. (Pubmed Central) - Dec 2, 2020
Basal infusion of fentanyl-based IV-PCA was significantly associated with an increase in fentanyl consumption and the occurrence of opioid-related side effects in postsurgical patients. These results provide a scientific basis for the use of fentanyl for acute postoperative pain management in surgical patients.
- || fentanyl citrate / Generic mfg.
Review, Journal: Cerebrovascular Response to Propofol, Fentanyl, and Midazolam in Moderate/Severe Traumatic Brain Injury: A Scoping Systematic Review of the Human and Animal Literature. (Pubmed Central) - Dec 1, 2020
This review highlights the current knowledge gap surrounding the impact of commonly utilized sedative drugs in TBI care. This work supports the need for dedicated studies, both experimental and human-based, evaluating the impact of these drugs on CBF and cerebrovascular reactivity/response in TBI.
- || fentanyl citrate / Generic mfg.
Retrospective data, Review, Journal: Sufentanil versus fentanyl for pain relief in labor involving combined spinal-epidural analgesia: a systematic review and meta-analysis of randomized controlled trials. (Pubmed Central) - Dec 1, 2020
Thus the findings of this meta-analysis may provide additional evidence for future clinical practices of pain relief in labor involving CSEA. Stronger evidence supporting this conclusion will require data from more high-quality and multicenter randomized controlled trials.
- | fentanyl citrate / Generic mfg.
Journal: Opioid agonist treatment in the time of fentanyl: What can we learn from emerging evidence? (Pubmed Central) - Dec 1, 2020
Stronger evidence supporting this conclusion will require data from more high-quality and multicenter randomized controlled trials. No abstract available