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5 Trials |
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- || fentanyl citrate / Generic mfg.
Clinical, Journal: Delayed Post-Hypoxic Leukoencephalopathy Caused by Fentanyl Intoxication in a Healthy Woman. (Pubmed Central) - Jan 2, 2021
No abstract available
- || fentanyl citrate / Generic mfg.
I find it difficult to believe that 10-20 μg SA fentanyl as an adjunct for SAB in TJA have better analgesia on the ward than those without. (Twitter) - Jan 2, 2021
- || fentanyl citrate / Generic mfg.
Fentanyl? (Twitter) - Jan 2, 2021
- |||| fentanyl citrate / Generic mfg.
Clinical: I’ve not found a need for intrathecal opioids for orthopaedics for a number of years.(only used fentanyl in the olden days when I had to use v low dose Bupivacaine..itching was a big complaint from patients) (Twitter) - Jan 2, 2021
- ||| fentanyl citrate / Generic mfg.
Clinical: Most clinicians, I assume, wouldn’t give it prophylactically with a spinal for PONV prophylaxis or to prolong the duration. The generalised itch is probably the fentanyl that, for most spinals, is redundant. 😊 (Twitter) - Jan 2, 2021
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl Inhibits Lung Cancer Viability and Invasion via Upregulation of miR-331-3p and Repression of HDAC5. (Pubmed Central) - Jan 2, 2021
In addition, there was higher HDAC5 expression and lower miR-331-3p expression in tumor tissues which were isolated from patients with NSCLC compared to the adjacent normal tissues, and miR-331-3p was negatively correlated with HDAC5 in NSCLC tumor tissues. Fentanyl inhibits the viability and invasion of NSCLC cells by induction of miR-331-3p and reduction of HDAC5.
- | fentanyl citrate / Generic mfg.
Journal: Continuous suprascapular nerve block compared with single-shot interscalene brachial plexus block for pain control after arthroscopic rotator cuff repair. (Pubmed Central) - Jan 1, 2021
Fentanyl inhibits the viability and invasion of NSCLC cells by induction of miR-331-3p and reduction of HDAC5. C-SSNB was more effective than S-ISNB at 6-12 h after the surgery for postoperative analgesia after arthroscopic rotator cuff repair.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: The efficacy of ultrasound-guided erector spinae plane block after mastectomy and immediate breast reconstruction with a tissue expander: a randomized clinical trial. (Pubmed Central) - Jan 1, 2021
Intraoperative and cumulative PCA fentanyl consumption at 3, 6, 9, and 24 hours were also less in group E than in group P (P = 0.004, P = 0.048, P = 0.020, P = 0.036, and P < 0.001, respectively)...The incidences of PONV was similar. The ESPB decreased postoperative opioid consumption and increased patient satisfaction without significant complications after IBR with a tissue expander after mastectomy.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: The utility of the brain trauma evidence to inform paramedic rapid sequence intubation in out-of-hospital stroke. (Pubmed Central) - Dec 30, 2020
Rapid sequence intubation and related factors interact with stroke and TBI, which suggests that RSI effects stroke survival in a different way from TBI. If RSI impact survival differently for strokes compared to TBI, then perhaps the TBI evidence cannot be used for stroke RSI.
- | fentanyl citrate / Generic mfg.
Journal: A Novel Bioanalytical Method for the Determination of Opioids in Blood and Pericardial Fluid. (Pubmed Central) - Dec 30, 2020
An analytical methodology has been optimized and fully validated for the determination of codeine, morphine, 6-acetylmorphine, 6-acetylcodeine, oxycodone, oxymorphone and fentanyl in whole blood and pericardial fluid...The stability of the substances in the studied matrices was guaranteed, at least, 24 h in the autosampler, 4 h at room temperature and 30 days after three freeze/thaw cycles. This methodology was applied to real samples from the Laboratory of Chemistry and Forensic Toxicology, Centre Branch, of the National Institute of Legal Medicine and Forensic Sciences, Portugal.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Ultraviolet-Visible and High-Resolution Mass Spectrometry for the Identification of Cyclopropyl-Fentanyl in the First Fatal Case in Spain. (Pubmed Central) - Dec 30, 2020
This methodology was applied to real samples from the Laboratory of Chemistry and Forensic Toxicology, Centre Branch, of the National Institute of Legal Medicine and Forensic Sciences, Portugal. No abstract available
- || fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
Clinical, Journal: Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial. (Pubmed Central) - Dec 30, 2020
Despite absence of differences in fentanyl and morphine consumption during and after surgery, a 1.6-point improvement in postoperative pain scores was observed in the NOL-guided group. We attribute this to NOL-driven rather than BP- and HR-driven fentanyl dosing during anaesthesia.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: The big short(age): perioperative and patient-reported outcomes during a fentanyl shortage at a tertiary care facility. (Pubmed Central) - Dec 30, 2020
We attribute this to NOL-driven rather than BP- and HR-driven fentanyl dosing during anaesthesia. No abstract available
- || fentanyl citrate / Generic mfg.
Clinical, Journal, Video: Serratus anterior plane block versus intercostal nerve block for postoperative analgesic effect after video-assisted thoracoscopic lobectomy: A randomized prospective study. (Pubmed Central) - Dec 30, 2020
No abstract available Results of the present study do not clarify whether SAPB or ICNB has a superior effect on reducing pain after VATS, thereby suggesting they may exert similar analgesic effects.
- | fentanyl citrate / Generic mfg.
Journal: Alpha-Methylfentanyl and Beta-Hydroxyfentanyl LC-MS-MS Quantification in Rat Plasma after Long-Term Ethanol Exposure. (Pubmed Central) - Dec 30, 2020
The validated assay indicated no significant differences in pharmacokinetic parameters (AUC0-t, Cmax and T1/2) derived from the assessment of A-F and B-F plasma concentrations between control and ethanol-exposed rats. This assay, for which the LOD was 3 pg/mL for A-F and B-F may help the forensic science field to determine fentanyl analogue-related causes of death and identify illicit drug tampering.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Objective Structured Clinical Examination Skill Station Is Effective for Assessing Acute Opioid Overdose Resuscitation. (Pubmed Central) - Dec 30, 2020
Introduction In recent decades, deaths related to heroin, illicit fentanyl, and prescription opioids have risen in the United States...Discussion Based on early medical student feedback (n=10), this OSCE skill station provides a promising competency-based assessment for opioid overdose resuscitation outside of the hospital setting. Its use could be expanded to other medical disciplines in undergraduate and graduate education.
- || Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Clinical, Journal, Real-World Evidence: Increasing Trends in Opioid Use From 2010 to 2018 in the Region of Valencia, Spain: A Real-World, Population-Based Study. (Pubmed Central) - Dec 29, 2020
The annual number of patients receiving at least one opioid prescription more than doubled, from 335,379 in 2010 to 722,838 in 2018. Even if proportions still seem far from epidemic, urgent research is warranted on the observed patterns of use, their appropriateness and their association with health and safety outcomes, especially for high-use and high-strength drugs.
- | fentanyl citrate / Generic mfg.
Fuck George Floyd! He was a drug addicted repeat felon who died of a fentanyl OD.. good riddance! (Twitter) - Dec 29, 2020
- |||| fentanyl citrate / Generic mfg.
Clinical: 2/illegal Heroin/Fentanyl are being given a free pass, while the Politicians,@US_FDA @CDCDirector @DEAWashingtonDC destroy pain patients lives, so they can sue Pharma who manuf. opioids for Billion$It’s a HUGE RACKET,Vets,Crippled, Disabled,diseased people are SUICIDING from PAIN (Twitter) - Dec 28, 2020
- | fentanyl citrate / Generic mfg.
Lesson: don’t take lethal doses of Fentanyl. (Twitter) - Dec 28, 2020
- || Subsys (fentanyl sublingual spray) / Insys Therap
Adverse events: ICYMI, FDA strengthened the REMS program for transmucosal immediate-release fentanyl products to help improve the ability to monitor for adverse events and ensure safe use of these medicines (Twitter) - Dec 28, 2020
- fentanyl citrate / Generic mfg.
[VIRTUAL] The impact of opioid administration on previously opioid naive intensive care unit survivors () - Dec 26, 2020 - Abstract #ASHP2020ASHP_5060;
Secondary outcomes are to see if these patients required scheduled or as needed opioid therapy after ICU discharge, determine if enteral or intravenous opioid therapy was utilized, determine if opioids were continued after hospital discharge, and evaluate if hospital length of stay was prolonged due to continuation of opioid therapy after ICU discharge. The following data will be collected from the electronic medical record: baseline demographics, length of mechanical ventilation days, length of continuous fentanyl administration, external fill history for prior opioid use, opioid dose, route of administration, and scheduling post ICU discharge, opioid detection in urine drug screen at admission if available, length of hospital stay, and completion of a medication reconciliation upon discharge from the hospital.
- Actemra IV (tocilizumab) / Roche, JW Pharma
[VIRTUAL] Impact of the COVID-19 pandemic on medication expenditure in a health-system () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4833;
In order to attempt to normalize medication expenditure for patient volume and patient acuity, total monthly medication expenditure was divided by case mix index adjusted discharge days (CMIAD). Descriptive statistics were used to compare monthly medication expenditures and medication expenditure to CMIAD ratios.
- Duragesic (fentanyl) / J&J
[VIRTUAL] Evaluation of fentanyl patch utilization in cancer patients with compromised renal function () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4635;
A comparison was made of therapy duration, patient pain scores, and quality of life (QoL) outcomes between the two groups. The Wilcoxon sign-rank statistical test was utilized to analyze the difference between two groups on pain intensity prior to and post fentanyl patch administration for each individual.
- fentanyl citrate / Generic mfg., dexmedetomidine / Generic mfg.
[VIRTUAL] Enteral Clonidine as a Strategy for Reducing Dexmedetomidine Usage in Critically Ill Patients () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4528;
All opiates will be converted to fentanyl equivalents. The secondary outcomes of the analysis are time to discontinuation of dexmedetomidine, clonidine dose required to discontinue dexmedetomidine, and occurrence of clonidine withdrawal symptoms.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Delirium occurrence between pre-and post analgosedation driven protocol utilizing fentanyl in comparison to other sedative agents in the medical intensive care unit () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4471;
Secondary outcomes include hospital length of stay, ICU length of stay, in-hospital mortality, and adverse events. The data will be utilized to optimize our selection of an agent for sedation in the ICU.
- Duragesic (fentanyl) / J&J
[VIRTUAL] The impact of pharmacy provided in-services on ketorolac and opioid utilization in the emergency department in a community teaching hospital () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4282;
The study protocol will be submitted for IRB approval prior to initiation. Results will be presented to the Pharmacy and Therapeutics Committee.
- fentanyl citrate / Generic mfg., dexmedetomidine / Generic mfg.
[VIRTUAL] Impact of pharmacy-driven education on inappropriate use of dexmedetomidine in a community medical/surgical intensive care unit () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4073;
The primary endpoint of this study is the percent difference in the number of patients inappropriately ordered dexmedetomidine pre- and post- pharmacy-driven education. As a secondary endpoint, the associated acquisition cost of dexmedetomidine pre- and post-education will be evaluated using the number of bags dispensed to assess percent cost reduction.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Fentanyl exposure in preterm infants: 5-year neurodevelopmental assessment () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4006;
As a secondary endpoint, the associated acquisition cost of dexmedetomidine pre- and post-education will be evaluated using the number of bags dispensed to assess percent cost reduction. Not applicable
- Duragesic (fentanyl) / J&J
[VIRTUAL] Evaluation of the appropriateness of fentanyl patch use in the inpatient setting () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3969;
Primary endpoints are the appropriateness of fentanyl dose initiation and titration. Secondary endpoints include appropriate indication, concomitant opioid use (for bridging), safety events (i.e., naloxone administration, rapid response team call) associated with the use of fentanyl, and prescribing patterns between disciplines.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Evaluation of pain and agitation practices in the intensive care unit of a community hospital () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3927;
Patients included in the study will be at least eighteen years old, mechanically ventilated, and have received the following continuous infusion sedative/analgesia: propofol, midazolam, fentanyl, and dexmedetomodine...Data showing if a pain medication was given before sedation began will be collected to determine if the correct treatment strategies are being used in accordance with the PADIS guidelines. Patient outcomes such as days on mechanical ventilation, length of ICU stay, and total medication cost will also be collected.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Evaluation of a revised protocol on paralytic usage in targeted temperature management () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3838;
Revisions of the protocol included: propofol and fentanyl administration instructions, a goal Richmond Agitation Sedation Scale (RASS) score, a change in maximum dosage of cisatracurium infusion, an IV push cisatracurium order and cisatracurium administration instructions based on the RASS and train of four (TOF) scores...The primary outcome was to assess the reduction of paralytic usage after protocol implementation. Secondary outcomes included medication and protocol compliance; hospitalization and ICU length of stay; and medication expenditure.
- ketamine / Generic mfg.
[VIRTUAL] Development of a medication utilization dashboard to rapidly inform dynamic sterile anticipatory compounding and distribution strategies for COVID-19 specific medications () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3752;
While data available to pharmacy leaders often exists in separate, incompatible reporting databases, the aggregation of information using an integrated database allowed for quick and seamless data visualization capabilities from three distinct datasets. In anticipation of a second COVID-19 surge, the Department of Pharmacy will maintain the functionality of the dashboard and will be readily reployed if required.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Comparison of fentanyl and hydromorphone for analgosedation in extracorporeal life support () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3719;
Secondary objectives are to describe and quantify any additional analgosedation medications required to achieve the appropriate level of sedation and analgesia (to a Critical Care Pain Observation Tool (CPOT) score < 3 and a Richmond Agitation-Sedation Scale (RASS) score < +1) and to evaluate the bolus requirements, dose adjustments, and frequency of refills needed for fentanyl compared to hydromorphone. Subgroup analyses will also be performed in specialized ECLS patient populations including those with Legionnaires’ disease, Sars-CoV-2, acute respiratory distress syndrome (ARDS), and H1N1 influenza, in addition to ECLS modalities (venoarterial vs. venovenous).
- fentanyl citrate / Generic mfg., epinephrine / Generic mfg.
[VIRTUAL] Utilization of medication products in a pediatric operating room () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3597;
The results determined what medications will be stocked in the OR automated dispensing cabinets and satellite pharmacies in the new WVU Medicine Children’s Hospital. The results of this medication use evaluation will initiate changes in standardization of medication doses to prevent unmeasurable doses and promote medication safety.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Stocking lower dose fentanyl vials in patient care areas reduces opioid waste and improves nurse satisfaction () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3540;
The results of this medication use evaluation will initiate changes in standardization of medication doses to prevent unmeasurable doses and promote medication safety. Stocking fentanyl 50 mcg/ml vials in addition to 100 mcg/2 ml vials is a successful way to decrease the amount of opioid waste (lowering the risk of diversion and waste documentation errors) and increase nursing satisfaction.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Opioid stewardship in the operating room: quality improvement evaluation of narcotic analgesics and anesthetics at a community-based hospital () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3442;
The implementation of automated dispensing cabinets (ADCs) or automated anesthesia carts within the surgical suites could help improve medication access and security, improve OR workflow, decrease restocking, and improve charge capturing. While discrepancies will still exist with automation, they will be easier to distinguish and correct.
- [VIRTUAL] Muscle Relaxers as Adjunctive Analgesics to Opioids () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3425;
The ideal muscle relaxer for reducing postoperative opioid consumption may be dependent upon the type of surgery, the chemical structure, and mechanism of the chosen drug. Further clinical trials are necessary to fully elucidate the most appropriate agent for the given procedure.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Evaluation of sedation and analgesia strategies implemented for mechanically ventilated patients in the emergency department and transitions of care to the intensive care unit () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3273;
This may have led to the rate of oversedation observed in patients transferring from the ED to the ICU. The rate of hypotension observed may have been a result of the frequent use of propofol and the infrequent documentation of RASS values in the ED.
- fentanyl citrate / Generic mfg., celecoxib oral / Generic mfg.
[VIRTUAL] Evaluation of postoperative opioid prescribing after total knee arthroplasty (TKA) at a large academic medical center () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3267;
Based on our findings, postoperative prescribing to patients who underwent TKA does show the appropriate theme of combination between non-opioid and opioid analgesics; however, when examining postoperative opioid prescribing alone, most opioid prescriptions exceeded the recommended surgery specific day supply and MME/day. Targeted prescriber education needs to be provided regarding appropriate postoperative opioid prescribing, MME/day and risk of overdose, and naloxone.
- ibuprofen / Generic mfg.
[VIRTUAL] Evaluation of Multimodal Pain Management at an Academic Medical Center: Role of the Pain Stewardship Pharmacist () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3259;
Areas to further promote multimodal pain therapy usage include increasing the use of non-steroidal anti-inflammatory agents and increase rates of acetaminophen prescribing in patients receiving opioids. Proper use of opioids should be ensured within all service lines.
- [VIRTUAL] Evaluating the efficacy and safety of calcium channel blockers as adjunctive analgesics to opioid therapy () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3204;
When compared, the studies came to varying conclusions demonstrating the need for more research regarding this topic. The literature retrieved demonstrated conflicting data regarding the use of calcium channel blockers as opioid adjuncts.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Day versus night analgesic and sedative infusion practices in two intensive care units at an academic medical center () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3154;
Our data supports other previous studies, demonstrating an increase in sedation during night shifts in relation to day shifts. We did not evaluate any complications of increased sedation (i.e. length of stay, duration of mechanical ventilation) in this cohort, so we cannot speak to the clinical significance of these findings.
- ketamine / Generic mfg.
[VIRTUAL] Retrospective drug use evaluation of ketamine use in an urban academic medical center emergency department () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2922;
There were no significant changes to the HR or BP seen with ketamine use after one hour of administration. Overall, the use of ketamine in Barnes-Jewish Hospital’s ED appeared in concordance with available literature.
- [VIRTUAL] Geriatric emergency medicine maximum (GEM-X) initial dosing quality improvement project (QIP) in a community hospital: review of actual versus recommended initial dosing () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2731;
In general, these patients received an average of two times the initial recommended dose. These findings indicate a need for a standardized ED dosing procedure.
- ibuprofen / Generic mfg.
[VIRTUAL] Comparative analysis of length of stay and opioid use in post-operative cesarean delivery patients treated with IV acetaminophen versus without () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2540;
Use of IV APAP was associated with a higher LOS and higher requirements for adjunctive NSAIDs and opioids, including PO APAP, ketorolac, morphine, and oxycodone. Given the lack of benefits, it is recommended to discontinue IV APAP use for post-operative C-section patients at Virtua Health.
- [VIRTUAL] Community hospital pharmacy evaluation of the barcode scanning administration (BCMA) process within the system () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2536;
Though the community hospital being studied has a BCMA process in place with an average medication scanning adherence rate of 96.71 percent, there are still high volumes of frequently used medications that are failing to meet the goal adherence rate. The identified primary source of error was nursing noncompliance and was addressed by pharmacy delivering nursing education specific to the frequently missed medications.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Assessment of opioid exposure during intensive care unit (ICU) visitations contributing to opioid epidemic post-discharge () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2499;
Although the results of this study may suggest a lack of association between opioids in the ICU and the current opioid epidemic, they cannot provide a concrete link between the two. Current pain management strategies utilized within ICU settings do not seem to contribute to opioid overuse post-discharge.
- fentanyl citrate / Generic mfg.
[VIRTUAL] The Comparison of Hydromorphone Continuous Infusion to Fentanyl Continuous Infusion in Achieving RASS (Richmond Agitation-Sedation Scale) Goals () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2384;
Secondary outcomes included time to achieve RASS goal, number of titrations to achieve RASS goal, total morphine milligram equivalents (MME) used, nonverbal pain scores, ventilator days, and cost of each therapy. Primary and secondary outcomes are expressed as comparative mean scores with 95% confidence intervals through the Mann-Whitney U-test and student t-test.
- fentanyl citrate / Generic mfg., methadone / Generic mfg.
[VIRTUAL] Retrospective chart review of an opioid withdrawal prevention algorithm in critically ill pediatric patients in a pediatric hospital () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2345;
The primary objective is to determine the average duration of opioid exposure when following the opioid withdrawal prevention algorithm. The secondary outcomes are to determine the level of adherence to the algorithm, measure the degree of withdrawal symptoms using a clinical assessment tool, determine whether oversedation occurred during the wean, and measure both PICU and hospital length of stays.