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39 Diseases |  |
5 Trials |
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5 Trials |  |
18506 News |  |
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- | fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Quantifying enhanced risk from alcohol and other factors in polysubstance-related deaths. (Pubmed Central) - Feb 10, 2021
Co-ingestion of alcohol, multiple opioids or stimulants were associated with significantly decreased predicted concentrations of commonly identified opioids in drug deaths. Further evidence is provided for enhanced risks from polysubstance use with opioids, which has important public health implications.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Predicted Versus Non-Predicted Opioid Administration Using Preoperative Pain Sensitivity in Patients Undergoing Gynecological Surgery: A Randomized-Controlled Trial. (Pubmed Central) - Feb 10, 2021
Patients were treated with a higher or lower (15 or 10 μg/mL) dose of fentanyl via intravenous patient-controlled analgesia...However, opioid consumptions were lower in the predicted group compared to the control group (median 406.0 vs. 526.5 μg; p = 0.042). This study showed that offering a predicted dose of opioids according to pain sensitivity did not affect the incidence of nausea and pain scores.
- || fentanyl citrate / Generic mfg.
Clinical: Mass @ASAMorg Pearls for Practice @TraciCGreen1 fascinating talk TMTC takehomes: Locally XYLAZINE (veterinarian mega clonidine-like tranquilizer) common adulterant of ops/#fentanyl; Existence of Section 35 inhibits calling 911, countering good samaritan laws. (Twitter) - Feb 9, 2021
- | fentanyl citrate / Generic mfg., remifentanil / Generic mfg., sevoflurane / Generic mfg.
Clinical, Journal: Incidence of residual neuromuscular blockade in children below 3 years after a single bolus of cisatracurium 0.1 mg/kg A quality assurance study. (Pubmed Central) - Feb 9, 2021
This study showed that offering a predicted dose of opioids according to pain sensitivity did not affect the incidence of nausea and pain scores. We found that 8 % of the children had residual neuromuscular blockade (TOF ratio < 0.9) after administration of a single bolus of cisatracurium 0.1 mg/kg but we cannot exclude that the true proportion is around 20%.
- | fentanyl citrate / Generic mfg.
Journal: Effect of witnessing an overdose on the use of drug checking services among people who use illicit drugs in Vancouver, Canada. (Pubmed Central) - Feb 9, 2021
Our findings suggest that witnessing an overdose may motivate PWUD to use drug checking services. Given that only a small proportion of PWUD in the study reported using drug checking services, our findings highlight the need to continue to scale-up a range of overdose prevention interventions.
- | ketorolac / Generic mfg.
Journal: Compatibility of acetaminophen with central nervous system medications during simulated Y-site injection. (Pubmed Central) - Feb 9, 2021
Given that only a small proportion of PWUD in the study reported using drug checking services, our findings highlight the need to continue to scale-up a range of overdose prevention interventions. Nine of 15 common CNS medications in critical care tested with acetaminophen were physically incompatible for 24 hours.
- | fentanyl citrate / Generic mfg.
Journal: Effects of Massage on Postoperative Pain in Infants With Complex Congenital Heart Disease. (Pubmed Central) - Feb 9, 2021
This study provides beginning evidence that postoperative massage may reduce pain and improve physiological parameters in infants with congenital heart disease. This nonpharmacological adjunct to pain management may provide a particular benefit for this population by reducing demand on the cardiorespiratory system.
- || fentanyl citrate / Generic mfg.
People may better understand this concept of potency making the analogy with various opioids, fentanyl analogs and other opioid research chemicals. Right? Or perhaps I’m missing something. (Twitter) - Feb 8, 2021
- || fentanyl citrate / Generic mfg., paracetamol / Generic mfg.
Clinical, Journal: A randomised controlled comparison of serratus anterior plane, pectoral nerves and intercostal nerve block for post-thoracotomy analgesia in adult cardiac surgery. (Pubmed Central) - Feb 7, 2021
The SAPB group had the highest time to 1 rescue analgesic requirement in contrast to the other groups. SAPB and Pecs II blocks are simple single-shot effective alternatives to ICNB with a prolonged analgesic duration following thoracotomy and can potentially enhance pain-free recovery after cardiac surgery.
- || dexamethasone / Generic mfg.
Clinical, Journal: Effect of adding dexamethasone to ropivacaine for ultrasound-guided serratus anterior plane block in patients undergoing modified radical mastectomy: A preliminary trial. (Pubmed Central) - Feb 7, 2021
Intra-operative fentanyl requirement and postoperative diclofenac and tramadol requirements were comparable in both the groups. The incidence of postoperative nausea and vomiting was significantly more in Group P than Group D. Addition of dexamethasone to ropivacaine for SAP block increases the time to first rescue analgesic in the postoperative period.
- fentanyl citrate / Generic mfg., gabapentin / Generic mfg.
[VIRTUAL] Psychoactive Substances Update: Kratom, Cannabinoids, Fentanyl & More () - Feb 6, 2021 - Abstract #ASAM2021ASAM_159;
Recognize clinical clues to intoxication with emerging natural and synthetic substances, and ways to differentiate from other drug use. Discuss treatment of medical and psychiatric complications resulting from use of emerging substances of abuse.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Precipitated Opioid Withdrawal: When, Where and What to do Next () - Feb 6, 2021 - Abstract #ASAM2021ASAM_126;
Does the widespread use of fentanyl mandate a longer time of abstinence prior to buprenorphine initiation?...Review the existing evidence for management of precipitated opioid withdrawal from partial and full-opioid antagonists. Address precipitated opioid withdrawal concerns specific to buprenorphine initiation and strategies to reduce risk.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Opioid Overdose and the COVID-19 Pandemic () - Feb 6, 2021 - Abstract #ASAM2021ASAM_80;
This focused session aims to further delineate the characteristics of these colliding epidemics as it impacts patients, access to treatments, and healthcare systems. Learning Objectives: Upon completion the participant will be able to describe the trends in opioid overdose both before and during the COVID-19 pandemic Upon completion, the participant will be able to demonstrate an increased knowledge in the role of a healthcare provider in using MOUD to reduce opioid overdoses Upon completion, the participant will be able to describe the epidemiology and pharmacology of Fentanyl and its impact on the effectiveness of medications for OUD
- | fentanyl citrate / Generic mfg.
Journal: Quantitation of Fentanyl and Metabolites from Liver Tissue Using a Validated QuEChERS Extraction and LC-MS-MS Analysis. (Pubmed Central) - Feb 5, 2021
The range of norfentanyl concentrations were 1.9 to 50.0 μg/kg with a mean of 14.1 μg/kg (n = 10). The range of 4-ANPP concentrations were 3.2 to 23.7 μg/kg with a mean of 7.5 μg/kg (n = 7).
- | fentanyl citrate / Generic mfg.
Journal: Structure elucidation of urinary metabolites of fentanyl and five fentanyl analogues using LC-QTOF-MS, hepatocyte incubations and synthesized reference standards. (Pubmed Central) - Feb 5, 2021
Also, 3-OH-4-OMe was not detected in any hepatocyte samples, indicating a clear preference for the 4-OH-3-OMe, which was also found to be more abundant in urine compared to hepatocytes. The patterns appear to be consistent across all studied fentanyls and could serve as a starting point in the development of methods and synthesis of reference standards of novel fentanyl analogues where nothing is known about the metabolism.
- | fentanyl citrate / Generic mfg.
Journal: Drug checking to detect fentanyl and new psychoactive substances. (Pubmed Central) - Feb 5, 2021
Drug checking research and services largely focus on opioid consumers and nightclub and dance festival attendees, but more focus may be needed on the general population. Drug checking results can inform surveillance efforts, and more research is needed to overcome barriers to drug checking and to focus on whether test results indeed affect behavior change.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Global strategy for new psychoactive substances: an update. (Pubmed Central) - Feb 5, 2021
Although the rise of NPS is a cause for concern, World Drug Report suggests that the strategy to face the challenge should include updating international data collection systems, integrating scientific-based interventions for drug use, strengthening national monitoring, increasing research and forensic capabilities. The legal, regulatory framework and clinical guidelines should remain dynamic, whereas enforcement agencies should measure success by destroying drug networks as seizures rarely dismantle drug markets.
- | fentanyl citrate / Generic mfg.
Journal: First report on brorphine: the next opioid on the deadly new psychoactive substances' horizon? (Pubmed Central) - Feb 5, 2021
Until recently, new synthetic opioids, which are among the most dangerous new psychoactive substances, primarily encompassed analogs of the potent analgesic fentanyl...The occurrence of brorphine is yet another example of how the illicit drug market is continuously evolving in an attempt to escape international legislation. Its high potency poses a serious and imminent health threat for any user.
- || sevoflurane / Generic mfg.
Clinical, Journal: Sufentanil Reduces Emergence Delirium in Children Undergoing Transthoracic Device Closure of VSD After Sevoflurane-Based Cardiac Anesthesia. (Pubmed Central) - Feb 5, 2021
Sufentanil can be safely used in sevoflurane-based fast-track cardiac anesthesia for transthoracic device closure of VSD in children. Compared to fentanyl, sufentanil is more effective in reducing postoperative emergence delirium, with lower analgesia scores and greater comfort.
- || nalbuphine / Endo
Clinical, Journal: Comparison of Postoperative Analgesic Effects Between Nalbuphine and Fentanyl in Children Undergoing Adenotonsillectomy: A Prospective, Randomized, Double-Blind, Multicenter Study. (Pubmed Central) - Feb 5, 2021
The other profiles observed from these two drug groups were similar. Nalbuphine provided better pain relief with minimal respiration depression than fentanyl in children undergoing Adenotonsillectomy.
- | ketamine / Generic mfg., ibuprofen / Generic mfg.
Preclinical, Journal: Efficacy comparison of intraperitoneal anaesthesia and post-operative analgesia regimens in laboratory rats. (Pubmed Central) - Feb 4, 2021
MK was shown to be a reliable, safe, and effective method of anesthesia. The TTI analgesia regimen is strongly recommended in light of these results.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Correlation of Fentanyl Positive Drug Screens with Other Medications in Patients from Pain, Rehabilitation and Behavioral Programs. (Pubmed Central) - Feb 4, 2021
In contrast, there was a definite increase in the presence of fentanyl with cocaine and methamphetamine. There was not a large increase over time associated with methadone, buprenorphine, and marijuana.
- | fentanyl citrate / Generic mfg.
Journal: Addition of Fentanyl or High-Dose Morphine to Bupivacaine Is Superior to Bupivacaine Alone during Single-Shot Spinal Anesthesia. (Pubmed Central) - Feb 4, 2021
There was not a large increase over time associated with methadone, buprenorphine, and marijuana. The addition of fentanyl or high-dose morphine to bupivacaine increases the efficacy and duration of SSSA in the active phase of progressing labor without increasing side effects.
- || MoxDuo IR (morphine + oxycodone) / QRxPharma, AbbVie
Clinical, Journal: Patterns of oxycodone controlled release use in older people with cancer following public subsidy of oxycodone/naloxone formulations: An Australian population-based study. (Pubmed Central) - Feb 4, 2021
The public subsidy of the oxycodone/naloxone CR formulation expanded the overall oxycodone CR market for DVA healthcare card holders with cancer. Our findings highlight the need for updated guidelines around risk management for opioid treatment in patients with cancer.
- | fentanyl citrate / Generic mfg.
Journal: Therapeutic and Prophylactic Vaccines to Counteract Fentanyl Use Disorders and Toxicity. (Pubmed Central) - Feb 4, 2021
Because of their selectivity, vaccines did not interfere with the pharmacological effects of commonly used anesthetics nor with methadone, naloxone, oxycodone, or heroin. These preclinical data support the translation of vaccines as a viable strategy to counteract fentanyl use disorders and toxicity.
- | fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Association between county level cannabis dispensary counts and opioid related mortality rates in the United States: panel data study. (Pubmed Central) - Feb 4, 2021
While the associations documented cannot be assumed to be causal, they suggest a potential association between increased prevalence of medical and recreational cannabis dispensaries and reduced opioid related mortality rates. This study highlights the importance of considering the complex supply side of related drug markets and how this shapes opioid use and misuse.
- ||| Ozalin (midazolam) / Primex Pharma, Sintetica
No barrier at all. Healthcare is funded through taxation in my country. The prep is fine. Entonox is fine. Midazolam and fentanyl are fine. Colonoscopies reduce my IBD and bowel cancer risks so I am happy to have them: better a bag than a coffin. (Twitter) - Feb 3, 2021
- | fentanyl citrate / Generic mfg.
Journal: The Value of a Post-induction Fentanyl Test in Identifying Severe Obstructive Sleep Apnea Syndrome. (Pubmed Central) - Feb 3, 2021
This study highlights the importance of considering the complex supply side of related drug markets and how this shapes opioid use and misuse. Our study showed that a post-induction fentanyl test had good predictive value in identifying severe obstructive sleep apnea syndrome and early postoperative adverse respiratory events, and could provide a reference for postoperative analgesia in children undergoing adenotonsillectomy.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Influence of infiltration anaesthesia on perioperative outcomes following lumbar discectomy under surgical pleth index-guided general anaesthesia: A preliminary report from a randomised controlled prospective trial. (Pubmed Central) - Feb 3, 2021
Our study showed that a post-induction fentanyl test had good predictive value in identifying severe obstructive sleep apnea syndrome and early postoperative adverse respiratory events, and could provide a reference for postoperative analgesia in children undergoing adenotonsillectomy. IA using RPV/FNT mixture significantly reduced SPP and postoperative demand for morphine in patients subjected to lumbar discectomy under GA.
- | Journal: Synthesis and Biological Characterization of Cyclic Disulfide-Containing Peptide Analogs of the Multifunctional Opioid/Neuropeptide FF Receptor Agonists That Produce Long-Lasting and Nontolerant Antinociception. (Pubmed Central) - Feb 3, 2021
In comparison to 0, cyclized peptide 6 exhibited sevenfold more potent μ-opioid receptor agonistic activity in vitro. Interestingly, the cyclized analog 6 possessed an improved stability in the brain and an increased blood-brain barrier permeability compared to the parent peptide 0 and produced more potent analgesia after supraspinal or subcutaneous administration with improved duration of action of 4 h. In addition, antinociceptive tolerance of analog 6 was greatly reduced after subcutaneous injection compared to fentanyl, as was the rewarding effect, withdrawal reaction, and gastrointestinal inhibition.
- ||| fentanyl citrate / Generic mfg.
Usually start w/propofol + low dose fentanyl. Then daily SATs & #A2Fbundle w shift to Fent + Dex (to get off GABA-ergic) using opioid primarily if deep RASS needed (ie, analgo-sedation as per MENDS, JAMA 2007). A template not carved in stone. #nurses #criticalcare #covid19 (Twitter) - Feb 2, 2021
- | fentanyl citrate / Generic mfg.
Journal: The Deadly Trio: Heroin, FentaNYL, and Carfentanil. (Pubmed Central) - Feb 2, 2021
Interestingly, the cyclized analog 6 possessed an improved stability in the brain and an increased blood-brain barrier permeability compared to the parent peptide 0 and produced more potent analgesia after supraspinal or subcutaneous administration with improved duration of action of 4 h. In addition, antinociceptive tolerance of analog 6 was greatly reduced after subcutaneous injection compared to fentanyl, as was the rewarding effect, withdrawal reaction, and gastrointestinal inhibition. No abstract available
- || fentanyl citrate / Generic mfg., dexamethasone IV / Generic mfg.
Clinical, Journal: Evaluation of ultrasound-guided rhomboid intercostal nerve block for postoperative analgesia in breast cancer surgery: a prospective, randomized controlled trial. (Pubmed Central) - Feb 2, 2021
No abstract available In the current study, ultrasound-guided RIB promoted enhanced recovery and decreased opioid consumption after mastectomy surgery.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Continuous basal infusion versus programmed intermittent bolus for quadratus lumborum block after laparoscopic colorectal surgery: a randomized-controlled, double-blind study. (Pubmed Central) - Feb 2, 2021
In the current study, ultrasound-guided RIB promoted enhanced recovery and decreased opioid consumption after mastectomy surgery. Programmed intermittent boluses of local anesthetic for continuous QLB did not produce better analgesia or wider sensory blockade compared with continuous basal infusion in patients undergoing laparoscopic colorectal surgery.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: The effectiveness of the intramuscular quadratus lumborum block in postoperative analgesia after cesarean section with vertical incision: a randomized, double-blinded placebo-controlled study. (Pubmed Central) - Feb 2, 2021
Programmed intermittent boluses of local anesthetic for continuous QLB did not produce better analgesia or wider sensory blockade compared with continuous basal infusion in patients undergoing laparoscopic colorectal surgery. QLBi with the concentration and amount of local anesthetic used in the present study was clinically slightly effective, and the effect was limited for postoperative analgesia after cesarean section.
- Ovastat (treosulfan) / Medac
[VIRTUAL] DESCRIPTIVE ANALYSIS OF MUCOSITIS AMONG MAC VS RIC CONDITIONING REGIMENS () - Jan 30, 2021 - Abstract #APBMT2020APBMT_135;
Pain secondary to mucositis can be managed with adequate analgesia. Proper nutritional supplement during mucositis must be considered.
- | fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
Journal: Midazolam/fentanyl vs propofol/remifentanil in immediate postoperative with short-term mechanical ventilation (Pubmed Central) - Jan 30, 2021
In the midazolam-fentanyl group, respiratory depression was more frequent, although the percentage of adverse effects were similar in both groups. Both the combination of propofol-remifentanil and midazolam-fentanyl appear to be effective as a sedative-analgesic regimen for patients undergoing mechanical ventilation after surgery.
- ||| fentanyl citrate / Generic mfg.
🆕Increase from 1 to 2 #cannabis dispensaries in a county is associated with ~17% reduction in all opioid mortality. ~21% reduction in synthetic opioids (fentanyl) mortality rates. Although association is not causation, these are interesting findings! https://t.co/4lRFkl7CGp (Twitter) - Jan 28, 2021
- | fentanyl citrate / Generic mfg.
They do so you don't buy heroin and fentanyl (Twitter) - Jan 28, 2021
- ||| fentanyl citrate / Generic mfg.
Clinical: 95% of our TKA are done under spinal +/- intrathecal fentanyl and an ACB. Most of the time we have pt prepped, draped, and are waiting on the surgeon. When we first started doing the ACB it took slightly longer, that quickly resolved. Pts are up and moving with PT w/in hours. (Twitter) - Jan 28, 2021
- || fentanyl citrate / Generic mfg.
If I take fentanyl today, my problems today go away, but the big problems are just starting. Benefit ... cost. Save 1k lives today, lose 1M tomorrow. This is ridiculous that we have to talk about how silly it is to run around blindly from panic to panic. https://t.co/wNnKQ85DPN (Twitter) - Jan 28, 2021
- || Instanyl (fentanyl) / Takeda
Clinical, Journal: Combined intranasal fentanyl and dexmedetomidine plus inhaled nitrous oxide sedation in children needing myringotomy and ventilation tube insertion with a specific handheld device. (Pubmed Central) - Jan 28, 2021
Both the combination of propofol-remifentanil and midazolam-fentanyl appear to be effective as a sedative-analgesic regimen for patients undergoing mechanical ventilation after surgery. A combination of intranasal dexmedetomidine, fentanyl, and iNO could be considered as a possible option for procedural sedation in children with OME undergoing procedural sedation for tympanostomy tube placement in children with Solo TTD device.
- || fentanyl citrate / Generic mfg.
I did not realize until looking into it that Fentanyl originates in Wuhan as well. 👀 My contention is that an actual lockdown-as other countries have done-would have probably reduced ‘Deaths of Despair’ because, if successful, we’d have largely beat this as Wuhan has done. (Twitter) - Jan 27, 2021
- || fentanyl citrate / Generic mfg.
Deaths of Despair (opioid OD, suicide by gun, alcohol) occur more frequently in whites w/o BA, lowering life expectancy. Opioid ODs 2020 being used to argue that lockdowns lead to increased ODs. But trend already going up & fentanyl more likely culprit. https://t.co/4xEdAhQxwi (Twitter) - Jan 27, 2021
- || Duragesic (fentanyl) / J&J
Clinical, Review, Journal: Opioid rotation from transdermal fentanyl to continuous subcutaneous hydromorphone in a cachectic patient: A case report and review of the literature. (Pubmed Central) - Jan 27, 2021
Opioid toxicity eventually resolved with downward titration of hydromorphone to only 30% of the initially estimated equianalgesic dose. This case highlights the need for close follow-up of all patients undergoing opioid rotation from transdermal fentanyl and reinforces the need to reduce the initial dose of the new opioid by 30%-50% of the calculated MEDD, especially when rotating from a high dose of transdermal fentanyl, or if there are factors potentially impairing absorption from the patch such as age, cachexia and weight loss, or if rotation is performed for reasons other than uncontrolled pain.
- | fentanyl citrate / Generic mfg.
Journal: A Piriform-Orbitofrontal Cortex Pathway Drives Relapse to Fentanyl-Seeking after Voluntary Abstinence. (Pubmed Central) - Jan 27, 2021
This case highlights the need for close follow-up of all patients undergoing opioid rotation from transdermal fentanyl and reinforces the need to reduce the initial dose of the new opioid by 30%-50% of the calculated MEDD, especially when rotating from a high dose of transdermal fentanyl, or if there are factors potentially impairing absorption from the patch such as age, cachexia and weight loss, or if rotation is performed for reasons other than uncontrolled pain. No abstract available
- | fentanyl citrate / Generic mfg., paracetamol / Generic mfg.
Clinical, Journal: Thoracic continuous spinal anesthesia for high-risk comorbid older patients undergoing major abdominal surgery: one-year experience of an Italian geriatric hospital. (Pubmed Central) - Jan 26, 2021
TCSA may be a valid alternative to general anesthesia in high-risk older patients undergoing major abdominal surgery. Further studies are needed to confirm its safety and benefits.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Developing a clinical decision support for opioid use disorders: a NIDA center for the clinical trials network working group report. (Pubmed Central) - Jan 26, 2021
There is an urgent need for strategies to address the US epidemic of prescription opioid, heroin and fentanyl-related overdoses, misuse, addiction, and diversion...A semi-structured outline of clinical decision support for OUD was developed to facilitate implementation within the EHR. Further work for adaptation at specific sites and for testing is needed.
- | fentanyl citrate / Generic mfg.
Journal: Evaluating the Potential for Unintentional Occupational Exposure to Fentanyl and Fentanyl Analogues Among Medicolegal Death Investigators and Autopsy Technicians. (Pubmed Central) - Jan 26, 2021
The evaluation showed that this medical examiner's office had low potential for work-related exposure to fentanyls; its standard operating procedures and personal protective equipment requirements should reduce the potential for occupational exposure. Medicolegal death investigation agencies can develop and implement guidance to control exposures and provide workforce education and training to reduce the potential for work-related exposure to fentanyls.
- | dexmedetomidine / Generic mfg.
Retrospective data, Journal: The Effectiveness of Low-dose Dexmedetomidine Infusion in Sedative Flexible Bronchoscopy: A Retrospective Analysis. (Pubmed Central) - Jan 26, 2021
The co-administration of dexmedetomidine met the safety and recovery demands of flexible bronchoscopy. Compared to the conventional midazolam-propofol-fentanyl regimen, the application of dexmedetomidine improved sedative effectiveness with less procedural interruptions, shorter time to ambulation and higher bronchoscopist satisfaction.