fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., methadone / Generic mfg.
    [VIRTUAL] Expanding Buprenorphine Starts for People Experiencing Homelessness during COVID () -  Mar 20, 2021 - Abstract #ASAM2021ASAM_211;    
    Many PEH in San Francisco were started on buprenorphine since March 2020 despite COVID-related SIP restrictions. Retention in treatment was higher among those who accessed care at primary care sites including street-medicine open-access clinics.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Digital Health Intervention to Augment Outpatient Buprenorphine Treatment () -  Mar 20, 2021 - Abstract #ASAM2021ASAM_196;    
    Overall, adults engaged in outpatient buprenorphine treatment were receptive to an interactive computer- and text messaged-delivered personalized feedback intervention to support recovery. Incorporating thematic results on suggested structural changes may increase the usability of this intervention to improve treatment outcomes by reducing illicit opioid use, increasing adherence/retention, and preventing future overdose and other complications of illicit opioid use.
  • ||||||||||  fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
    [VIRTUAL] COVID-19 Decreases Syringe Service and Treatment Access for People Who Inject Drugs () -  Mar 20, 2021 - Abstract #ASAM2021ASAM_189;    
    72% reported experiencing homelessness in the preceding three months. The majority of participants reported that their most frequently injected substance was heroin/fentanyl (77%), followed by methamphetamine (12%), powder cocaine (7%), and crack cocaine (3%).
  • ||||||||||  Belbuca (buprenorphine BEMA) / BDSI
    [VIRTUAL] Buprenorphine Micro-Induction in Pregnancy () -  Mar 20, 2021 - Abstract #ASAM2021ASAM_181;    
    Pregnancy is not a barrier to microinduction. Theoretic downstream risks from neonatal abstinence syndrome have not been demonstrated in recent studies, and opioid replacement therapy should not be withheld in pregnancy.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Buprenorphine macro-dosing induction for OUD in the inpatient setting () -  Mar 20, 2021 - Abstract #ASAM2021ASAM_180;    
    Macro-dosing for patients receiving full opioid agonist therapy avoids the significant withdrawal required for standard buprenorphine induction and the 3-7 days required for micro-dosing. The role of concurrent fentanyl use needs to be further explored.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Protracted renal clearance of fentanyl in persons with opioid use disorder. (Pubmed Central) -  Mar 18, 2021   
    Fentanyl clearance in persons with OUD is considerably longer than the typical 2-4 day clearance of other short-acting opioids. The findings of this study might explain recent reports of difficulty in buprenorphine inductions for persons who use fentanyl, and point to a need to better understand the pharmacokinetics of fentanyl in the context of opioid withdrawal in persons who regularly use fentanyl.
  • ||||||||||  dexmedetomidine / Generic mfg.
    Clinical, Journal:  Cardioprotective effects of propofol-dexmedetomidine in open-heart surgery: A prospective double-blind study. (Pubmed Central) -  Mar 17, 2021   
    Furthermore, the PD group showed lower levels of myocardial enzymes (cTnI and CK-MB), decreased total fentanyl requirement, earlier postoperative extubation, and shorter ICU stay than the P(control) group. The use of propofol-dexmedetomidine in CPB surgeries offers more cardioprotective effects than the use of propofol alone.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Preclinical, Journal:  Aversion-resistant fentanyl self-administration in mice. (Pubmed Central) -  Mar 17, 2021   
    Quinine is detectable in fentanyl but mice will continue to respond for and consume fentanyl with quinine in both paradigms. These data support the use of these models in behavioral studies of compulsive-like opioid use.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Retrospective data, Journal:  Early Prediction of Extubation Failure in Patients with Severe Pneumonia: A Retrospective Cohort Study. (Pubmed Central) -  Mar 16, 2021   
    Patients were divided into extubation success and failure groups, and multivariate logistic regressions were performed to identify independent predictors for extubation failure. Results A total of 125 eligible patients were included, of which 82 and 43 patients had extubation success and failure, respectively. APACHE II score (odds ration (OR) 1.141, 95% confident interval (CI) 1.022-1.273, P = 0.019, cutoff at 17.5), blood glucose (OR 1.122, 95%CI 1.008-1.249, P = 0.035, cutoff at 9.87mmol/L), dose of fentanyl (OR 3.010, 95%CI 1.100-8.237, P = 0.032, cutoff at 1.135mg/d), and the need for red blood cell (RBC) transfusion (OR 2.774, 95%CI 1.062-7.252, P = 0.037) were independent risk factors for extubation failure. Conclusions In patients with severe pneumonia, APACHE II score > 17.5, blood glucose > 9.87mmol/L, fentanyl usage > 1.135mg/d, and the need for RBC transfusion might be associated with higher risk of extubation failure.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Diffuse subcortical white matter injury and bilateral basal ganglia neuronal loss after acute opioid overdose. (Pubmed Central) -  Mar 16, 2021   
    Here, we present the case of an otherwise high-functioning adolescent male who was found unresponsive after ingestion of approximately 3-4 fake oxycodone 10-325 mg pills laced with fentanyl...His neurological exam improved with supportive treatment over the course of his hospitalization. Although limited literature has shown leukoencephalopathy to be associated with opioid overdose, we present a case of additional involvement of subcortical gray matter.
  • ||||||||||  fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
    Review, Journal:  COVID-19 and the Opioid Epidemic: Two Public Health Emergencies That Intersect With Chronic Pain. (Pubmed Central) -  Mar 16, 2021   
    Despite increases in telehealth, outpatient services declined and only began returning towards normal at an extremely slow pace, accompanied by reduced productivity and increased practice costs. This review, therefore, emphasizes the devastating consequences of concurrent epidemics on chronic pain management and the need to develop best practice efforts to preserve access to treatment for chronic pain.
  • ||||||||||  midazolam hydrochloride / Generic mfg.
    [VIRTUAL] ANESTHESIA AFFECTS FLIP MOTILITY BUT NOT DISTENSIBILITY OR DIAMETER (DDW Virtual) -  Mar 15, 2021 - Abstract #DDW2021DDW_4518;    
    However, those who underwent anesthesia compared to moderate sedation were less likely to exhibit normal motility patterns on FLIP. This is a potentially important finding and warrants further evaluation.
  • ||||||||||  midazolam hydrochloride / Generic mfg.
    [VIRTUAL] TRENDS OF FUNCTIONAL LUMEN IMAGING PROBE USE IN A HIGH-VOLUME PRACTICE (DDW Virtual) -  Mar 15, 2021 - Abstract #DDW2021DDW_4517;    
    Indications have changed with time, with earlier studies performed more for patients with achalasia and follow-up of abnormal manometries, whereas more recently, for patients with dysphagia and GERD. In current clinical practice, FLIP is often performed in conjunction with other tests or treatments, rather than in isolation.
  • ||||||||||  ketorolac / Generic mfg.
    [VIRTUAL] A RANDOMIZED CONTROLLED TRIAL OF ROPIVACAINE FOR POST-OPERATIVE PAIN IN POEM (DDW Virtual) -  Mar 15, 2021 - Abstract #DDW2021DDW_2957;    
    We currently use a multimodal approach to pain management with topical lidocaine, ketorolac and liquid acetaminophen...A mean of 87.5 mg of fentanyl in the placebo group (SD 46.0 mg) and a mean of 110.0 mg in the ropivacaine group (SD 62.6 mg) (p = 0.372) was used...2 and 4 hours postprocedural 1 patient in each group used 1mg of morphine...Half of the patients in this study were willing to have the procedure done as an outpatient. Future research should explore in whom a same-day discharge may be a safe and effective strategy.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Opioid Immunomodulation and Impact Within a Murine Sepsis Model () -  Mar 14, 2021 - Abstract #ATS2021ATS_4616;    
    In an opioid-naive murine model of sepsis induced via cecal-slurry injection, we evaluated the impact of concomitant in vivo fentanyl exposure in two phases...Our results demonstrate a significant impact of opioid exposure during sepsis on resulting immune response and secondary infection. Human studies are needed to evaluate the impact of opioids as supportive analgesia on clinical sepsis outcomes, including rates of re-infection subsequent to sepsis.
  • ||||||||||  ketamine / Generic mfg.
    [VIRTUAL] Low-Dose Cisatracurium Facilitates Sedation Reduction in an ARDS Patient () -  Mar 14, 2021 - Abstract #ATS2021ATS_4455;    
    She’s on continuous fentanyl infusion and augmentative therapies for pain...The use of “low-dose NMB” is common practice in Pediatric ICUs, where differences in metabolism and patient-communication make adequate sedation difficulty, in order to minimize the risk of self-extubation of airway trauma. This strategy may have a potential application in adults when sedation options are limited.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] A Clinically Relevant and Reliable Model for Preclinical Research of ARDS Syndrome () -  Mar 14, 2021 - Abstract #ATS2021ATS_3092;    
    Our large animal model of lung injury recapitulates the secondary inflammatory progression of a primary insult to the lungs with good reproducibility, low mortality and verified tissue damage. It is suitable for further research on the pathophysiology and management of the early stages of ARDS.
  • ||||||||||  fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
    [VIRTUAL] Wooden Chest Syndrome: Fentanyl Induced Chest Wall Rigidity () -  Mar 14, 2021 - Abstract #ATS2021ATS_2672;    
    Given the COVID-19 pandemic and surge in ICU admissions, analgesic fentanyl use is rising. Therefore, an understanding of this rare complication is necessary.
  • ||||||||||  fentanyl citrate / Generic mfg., piperacillin sodium/tazobactam sodium / Generic mfg., methadone / Generic mfg.
    [VIRTUAL] Infective Endocarditis Secondary to Skin Popping Complicated by Septic Emboli () -  Mar 14, 2021 - Abstract #ATS2021ATS_1061;    
    Urine toxicology was positive for opiates, fentanyl, and methadone...Blood cultures grew Pseudomonas aeruginosa, Streptococcus mitis, and Enterobacter cloacae complex E. and the patient’s antibiotics were narrowed to Zosyn for a 6-week course...It should also be considered an intravenous drug use equivalent that meets a minor criterion of the modified Duke Criteria. It is also important to obtain early transthoracic and transesophageal echocardiography for evaluation of the extent of the disease and whether cardiothoracic intervention is required to minimize systemic embolization.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Assessment of Change in Vasopressor Requirements During Sedation Hold in Mechanically Ventilated Patients () -  Mar 14, 2021 - Abstract #ATS2021ATS_720;    
    In patients that underwent SBT during DIS there was no association between vasopressor dose and liberation from mechanical ventilation. This finding is particularly important to consider in the context of guideline recommendations against weaning patients from mechanical ventilation unless they are hemodynamically stable without the need for vasoactive support.
  • ||||||||||  fentanyl citrate / Generic mfg., rocuronium / Generic mfg.
    Journal:  General anesthetics drug challenge tests: predictive value of skin tests. (Pubmed Central) -  Mar 11, 2021   
    After assessing risks and benefits and considering the importance of this group of drugs, we conclude that drug challenge testing with general anesthetics is necessary. We propose a protocol for perioperative drug reactions that enables us to make a highly accurate etiological diagnosis with minimum risk for the patient.