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39 Diseases |  |
5 Trials |
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5 Trials |  |
18506 News |  |
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- | fentanyl citrate / Generic mfg.
Journal: Analytical method for the simultaneous determination of a broad range of opioids in influent wastewater: Optimization, validation and applicability to monitor consumption patterns. (Pubmed Central) - Jun 9, 2021
All biomarkers showed high benchtop stability with the exception of buprenorphine, EDDP, fentanyl and normorphine...The highest population-normalized mass loads were found for tramadol, O-desmethyltramadol and codeine. The proposed methodology was able to evaluate spatial differences in opioid use.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl overdose causing hippocampal ischemia followed by delayed leukoencephalopathy. (Pubmed Central) - Jun 8, 2021
The proposed methodology was able to evaluate spatial differences in opioid use. No abstract available
- | fentanyl citrate / Generic mfg.
Journal: Xylazine, a Veterinary Tranquilizer, Detected in 42 Accidental Fentanyl Intoxication Deaths. (Pubmed Central) - Jun 8, 2021
Detection of xylazine may help the forensic pathologist distinguish illicit from prescribed fentanyl, and law enforcement agents track the illicit drugs to a specific drug supplier. Because of its lack of response to naloxone, emergency medicine physicians need to be aware of its potential presence as it may affect therapy.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Parturient Controlled Epidural Analgesia with and without Basal Infusion of Ropivacaine and Fentanyl: A Randomized Trial. (Pubmed Central) - Jun 8, 2021
In PCEA + BI group, Visual Analog Scale (VAS) score was 0.07 ± 0.35 at 60 min and 0.06 ± 0.33 at 120 min, whereas in PCEA group, VAS was 0.32 ± 0.62 at 60 min and 0.26 ± 0.50 at 120 min (P = 0.05), respectively. BI when added to PCEA, it significantly reduces breakthrough labor pain and demand boluses without prolonging labor duration but at the cost of increased requirement of drug volume when compared to PCEA only group.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
Preclinical, Journal: Impact of Morphine Dependence and Withdrawal on the Reinforcing Effectiveness of Fentanyl, Cocaine, and Methamphetamine in Rats. (Pubmed Central) - Jun 8, 2021
The current studies provide direct evidence that the reinforcing effects of fentanyl are increased in opioid-withdrawn rats and reduced in opioid-dependent rats, relative to rats that are not physically dependent on opioids. These findings suggest that motivations to use opioids are dependent on the state of the individual whereas stimulants retain their reinforcing effects regardless of whether the individual is in an opioid-dependent or withdrawn state.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Journal: Chronic High Risk Prescription Opioid Use Among Persons With HIV. (Pubmed Central) - Jun 8, 2021
Our findings show that despite opioid prescribing guidelines and monitoring systems, additional efforts are needed to prevent chronic high risk prescriptions in patients with comorbid conditions, including pain-related, mental health and substance use disorders. Evidence about the risk for chronic high risk use based on prescribing patterns could better inform pain management and opioid prescribing practices for patients receiving HIV care.
- || fentanyl citrate / Generic mfg., paracetamol / Generic mfg.
Then we have fentanyl in Tylenol (Twitter) - Jun 7, 2021
- |||| fentanyl citrate / Generic mfg.
Clinical: They should give u then fentanyl since that seems to work!! I'm so so sick about this! They have blood on their hands @CDCgov @CDCDirector you will have to answer to God about all the lives lost due to pain! Help God's people! We r in pain not drug addict! It's not rocket science (Twitter) - Jun 6, 2021
- ||| fentanyl citrate / Generic mfg.
Clinical: Illegal fentanyl heroin cocaine meth cause vast majority of OverDose deaths esp when mixed. CDC combined #s of illegal drug ODs with Rx ODs falsely blaming Rx opiates for Crisis. @EWErickson @ericbolling @EricTrump @HeatherChilders @Franklin_Graham @US_FDA @frankgaffney @US4MF (Twitter) - Jun 5, 2021
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Clinical utility of a targeted smartphone application to aid veterinary students in calculating constant rate infusions and perioperative fluid drip rates. (Pubmed Central) - Jun 5, 2021
TSPAs are more efficient and accurate when calculating CRIs and FDR compared with conventional methods. Medical mathematics must be emphasised during the veterinary curriculum.
- | methylphenidate tablet / Generic mfg.
Journal: Patch Problems? Characteristics of Transdermal Drug Delivery System Exposures Reported to the National Poison Data System. (Pubmed Central) - Jun 3, 2021
Overall, single-substance TDDS exposures decreased over the duration of this study and typically resulted in no or mild effects. However, exposures involving fentanyl resulted in higher rates of major or moderate medical outcomes and were associated with multiple deaths.
- | fentanyl citrate / Generic mfg.
Journal: Naloxone Dosing After Opioid Overdose in the Era of Illicitly Manufactured Fentanyl. (Pubmed Central) - Jun 3, 2021
There were no significant differences in the dose of naloxone required to treat opioid overdose patients with UDS evidence of exposure to fentanyl, opiates, or both. Further evaluation of naloxone stocking and dosing protocols is needed.
- | fentanyl citrate / Generic mfg.
Journal: Adequacy of Anesthesia Guidance for Colonoscopy Procedures. (Pubmed Central) - Jun 3, 2021
In patients undergoing CPs under ISA using propofol and FNT, as compared to standard practice, intraprocedural SE monitoring reduced the rate of IAwR and IPP, with no influence on the rate of PPP, PONV, or patients' and endoscopists' satisfaction. AoA guidance on propofol and FNT titration, as compared to SE monitoring only, did not reduce the occurrence of the aforementioned studied parameters, imposing an unnecessary extra cost.
- || fentanyl citrate / Generic mfg.
Like they didn’t know this. Damage control game now. Let’s discuss the elephant in the room. Wuhan lab biggest producer of FENTANYL!! Spread worldwide. Causes hypoxia. Add vent = ⚰️ (Twitter) - Jun 2, 2021
- ||| fentanyl citrate / Generic mfg.
@9NEWS spoke with our CEO @RobValuck about the surge in opioid overdose deaths - especially fentanyl - in Colorado last year. https://t.co/rg6C7UcRRj (Twitter) - Jun 2, 2021
- || Emestop (ramosetron hydrochloride) / Samyang Group
Clinical, Journal: The effectiveness of ramosetron and ondansetron for preventing postoperative nausea and vomiting after arthroscopic rotator cuff repair: a randomized controlled trial. (Pubmed Central) - Jun 2, 2021
AoA guidance on propofol and FNT titration, as compared to SE monitoring only, did not reduce the occurrence of the aforementioned studied parameters, imposing an unnecessary extra cost. Ramosetron use led to a lower incidence, mild severity of nausea, and reduced use of rescue antiemetic drug after arthroscopic rotator cuff repair during the 6- to 24-h postoperative period than the control.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl and fentanyl analogs in the illicit stimulant supply: Results from U.S. drug seizure data, 2011-2016. (Pubmed Central) - Jun 2, 2021
Although relatively uncommon, the presence of fentanyl in the stimulant supply increased significantly between 2011 and 2016, with the greatest increases occuring between 2015-2016; the presence of these products was concentrated in the U.S. Northeast. Given these trends, strengthening community-based drug checking programs and surveillance within the public health infrastructure could help promote timely responses to novel threats posed by rapid shifts in the drug supply that may lead to inadvertent exposures.
- ||| fentanyl citrate / Generic mfg.
Clinical: Fentanyl/Midaz also likely would make patient retain a lot less of what you tell them after procedure, compared to awake or prop. (Twitter) - Jun 1, 2021
- ||| fentanyl citrate / Generic mfg.
CEO @RobValuck weighed in on @denverpost article about the dramatic increase in fentanyl OD deaths in Colorado https://t.co/a56uMnOhmS (Twitter) - Jun 1, 2021
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Platelets and poppies: Do morphine and fentanyl differ? (Pubmed Central) - Jun 1, 2021
Given these trends, strengthening community-based drug checking programs and surveillance within the public health infrastructure could help promote timely responses to novel threats posed by rapid shifts in the drug supply that may lead to inadvertent exposures. No abstract available
- || fentanyl citrate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Clinical, Journal: Hydromorphone Compared to Fentanyl in Patients Receiving Extracorporeal Membrane Oxygenation. (Pubmed Central) - Jun 1, 2021
Patients receiving hydromorphone required less MME compared to fentanyl without any differences in sedative requirements, or agitation-sedation scores at 48 hours. Prospective studies should be completed to validate these findings.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Epidural Naloxone Attenuates Fentanyl Induced PONV in Patients Undergoing Lower Limb Orthopaedic Surgeries. a Prospective Randomized Double-Blind Comparative Study. (Pubmed Central) - Jun 1, 2021
The mean WBS score for pain also showed significant reduction in Group N at 6 hours, postoperatively. Concomitant use of low dose epidural naloxone and fentanyl is effective in attenuating PONV, besides enhancing analgesia in the earlypostoperative period.
- | Eladur (bupivacaine) / Amneal
Journal: Lower, Variable Intrathecal Opioid Doses, and the Incidence of Prolonged Fetal Heart Rate Decelerations After Combined Spinal Epidural Analgesia for Labor: A Quality Improvement Analysis. (Pubmed Central) - Jun 1, 2021
There were no differences in the rates of prolonged fetal decelerations (in order of increasing fentanyl dose: 4.4%, 2.3%, 7.6%, 3.0%, p-value = 0.11), emergent cesarean delivery, magnitude of pain reduction, pruritus, or maternal hypotension. In conclusion, the rates of prolonged fetal heart rate decelerations after combined spinal epidural with intrathecal bupivacaine and fentanyl does not differ for fentanyl doses of 15 mcg and below.
- || Ozalin (midazolam) / Primex Pharma, Sintetica
The BSG guidelines suggest not exceeding median doses of 5mg midazolam/100 fentanyl in <70yrs and 2mg/50 in 70+ are often mistaken to mean the maximum permissible dose. In fact, these are not evidence based and refer to the median, which I would be surprised if people exceed... (Twitter) - May 31, 2021
- || fentanyl citrate / Generic mfg.
Midaz+Fentanyl just before ISB .Dexmedetomedine infusion intraop . (Twitter) - May 31, 2021
- || fentanyl citrate / Generic mfg.
@GOPLeader @LeaderMcConnell @SenSchumer @SpeakerPelosi read this Kristof piece.@NickKristof write/work on targeted policies&work in a bipartisan way to solve our issues we create& Mother Nature creates.Kevin tweeted on fentanyl over the borders see its impacts ACT👍@MonicaGandhi9 (Twitter) - May 31, 2021
- |||| fentanyl citrate / Generic mfg., ketamine / Generic mfg.
Clinical: This is the way! It’s harder work than postop block GA & LMA/ETT. Surgical Anesthesia is the testing ground for RA. Multi injection ISB/SCB +SCP LIA at the port sites. TIVA (Propofol, Ketamine, Fentanyl) for those patients that prefer level of amnesia and sedation. (Twitter) - May 30, 2021
- midazolam hydrochloride / Generic mfg.
[VIRTUAL] Propriospinal myoclonus associated to Sars-Cov-2 respiratory infection (Raum2) - May 30, 2021 - Abstract #EAN2021EAN_1007;
We present the first case of propriospinal myoclonus in the context of SARS-CoV-2 infection. Clonazepam and levetiracetam in combination resulted in resolution of these movements.
- | ibuprofen / Generic mfg.
Journal: μ-Opioid receptors in primary sensory neurons are involved in supraspinal opioid analgesia. (Pubmed Central) - May 29, 2021
We generated Oprm1 conditional knockout (Oprm1-cKO) mice by crossing Advillin mice with Oprm1 mice...Intracerebroventricular injection of morphine or fentanyl produced a potent analgesic effect in wild-type mice, but such an effect was significantly attenuated in Oprm1-cKO mice...Our findings indicate that MORs expressed at primary afferent terminals in the spinal cord contribute to the supraspinal opioid analgesic effect. These presynaptic MORs in the spinal cord may serve as an interface between ascending inhibition and descending modulation that are involved in opioid analgesia.
- | fentanyl citrate / Generic mfg.
Journal: Synthesis and pharmacological evaluation of novel cis and trans 3-substituted anilidopiperidines. (Pubmed Central) - May 29, 2021
These presynaptic MORs in the spinal cord may serve as an interface between ascending inhibition and descending modulation that are involved in opioid analgesia. Of ten compounds tested for their antinociceptive activity, compound cis-4 is characterized by high potency, rapid beginning and short duration of action and due to this might be incorporated in different pharmaceutical forms.
- | fentanyl citrate / Generic mfg.
Journal: A synthetic opioid vaccine attenuates fentanyl-vs-food choice in male and female rhesus monkeys. (Pubmed Central) - May 29, 2021
These results translate fentanyl vaccine effectiveness from rats to rhesus monkeys to decrease fentanyl-vs-food choice, albeit with greater individual differences observed in monkeys. These results support the potential and further clinical evaluation of this fentanyl-targeted vaccine as a candidate Opioid Use Disorder medication.
- || fentanyl citrate / Generic mfg., ticagrelor / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Journal: Comparison of the effect of morphine and fEntanyl in patients with acute coronary syndrome - The COMET randomized controlled trial. (Pubmed Central) - May 29, 2021
In patients with ACS, there was no significant difference between the use of fentanyl or morphine on the effect of ticagrelor on PA. (CTRI/2018/04/013423).
- | fentanyl citrate / Generic mfg., naltrexone / Generic mfg.
Preclinical, Journal: Discriminative stimulus effects of carfentanil in rats discriminating fentanyl: Differential antagonism by naltrexone. (Pubmed Central) - May 29, 2021
Differences in the effectiveness of naltrexone to attenuate the discriminative stimulus effects of carfentanil, compared with fentanyl and heroin, suggest that there may be differences in how carfentanil exerts its discriminative stimulus effects compared with other opioids. Further evaluation is needed of potential pharmacological and behavioral differences between carfentanil and other opioids, particularly in the context of toxicity.
- |||| Ozalin (midazolam) / Primex Pharma, Sintetica
Clinical: When it comes to dose of conscious sedation, the focus should be on the effect (patient comfort) rather than be rigid about dose itself as there are so many factors to consider. Some need very little, others a lot. Usual doses are up to 5 mg midazolam plus 100 mg fentanyl. (Twitter) - May 29, 2021
- || fentanyl citrate / Generic mfg., vancomycin / Generic mfg., ceftazidime / Generic mfg.
Clinical, Journal: Development of a Virtual Chinese Pediatric Population Physiological Model Targeting Specific Metabolism and Kidney Elimination Pathways. (Pubmed Central) - May 29, 2021
We anticipate the model to be a better representative of the pediatric Chinese population for drugs PK, offering greater clinical precision for medication given to the pediatric population, ultimately advancing clinical development of pediatric drugs. We can refine this model further by collecting more physiological parameters of Chinese children.
- | fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
Retrospective data, Journal: Ultrasound-guided, direct suprainguinal injection for fascia iliaca block for total hip arthroplasty: A retrospective study. (Pubmed Central) - May 29, 2021
We can refine this model further by collecting more physiological parameters of Chinese children. Ultrasound-guided, direct suprainguinal injection for fascia iliaca block led to faster recovery after general anesthesia and early postoperative pain relief in elderly patients undergoing total hip arthroplasty.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Knee Injury - Trip And Fall () - May 29, 2021 - Abstract #ACSM2021ACSM_1386;
No gross fractures. Non-specific thin lucency at the bone cement interface of the tibial component that could indicate loosening or infection.
- || pregabalin / Generic mfg.
Retrospective data, Review, Journal: Oral Pregabalin in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (Pubmed Central) - May 27, 2021
And we found that there were no significant differences between the two groups in extubation time (WMD: 17.24, 95% CI: -24.36-58.84, P = 0.42). Oral pregabalin for cardiac surgery patients can effectively reduce the patient's 24-hour morphine consumption after surgery, shorten the patient's hospital stay, and is more conducive to early postoperative recovery.
- | lorazepam / Generic mfg.
Journal: Pronounced Dead Twice: What Should an Attending Physician Do in Between? (Pubmed Central) - May 27, 2021
CONCLUSIONS What should an attending physician do in the rare case that the organ procurement team notices the patient is still alive? It is our opinion that: first, the organ procurement team should leave the room immediately and withdraw from the case, and second, the attending physician should let nature run its course and refrain from excessive medical intervention.
- gabapentin / Generic mfg.
[VIRTUAL] Patient and provider perspectives on a novel, low-threshold PrEP program for people who inject drugs and experience homelessness () - May 27, 2021 - Abstract #IASHIV2021IAS_HIV_685;
Our findings illustrate how innovative, culturally-competent strategies can help engage and retain PWID experiencing homelessness in low-threshold, outreach-based PrEP services. Specific elements of this program could be considered in a range of community-based settings, including syringe service programs and shelter to mitigate future outbreaks.
- fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
[VIRTUAL] Structural vulnerability and the impacts of the COVID-19 pandemic on HIV risk behaviors and prevention needs among people who inject drugs () - May 27, 2021 - Abstract #IASHIV2021IAS_HIV_661;
Despite initial SSP closures, expanded mobile outreach across this region helped PWID maintain access to sterile syringes. PWID narratives instead highlighted how COVID-19 exacerbated structural vulnerability by destabilizing access to essential services while intensifying stigma through the conflation of addiction, homelessness, and infectious diseases.
- || fentanyl citrate / Generic mfg.
Ben, are you using intrathecal fentanyl or just plain spinals with analgesic blocks?! (Twitter) - May 26, 2021
- || fentanyl citrate / Generic mfg.
1. You are making a causation / Correlation argument that isn’t in the study. A fire batch of fentanyl from mexico could have led to the excess murders and OD’s for example (Twitter) - May 26, 2021
- | metamizole / Generic mfg., tramadol hydrochloride / Generic mfg.
Journal: The preemptive effect of tramadol and metamizole on the intensity of postoperative pain. (Pubmed Central) - May 26, 2021
There was no significant difference in the intensity of pain when using these two analgesics (p=0.733). Conclusion The effect of preemptively administered tramadol prior to the introduction of general anaesthesia in postoperative pain is significantly more favourable than the effect of metamizole.
- || fentanyl citrate / Generic mfg., paracetamol / Generic mfg.
Clinical, Journal: Ultrasound-Guided Erector Spinae Plane Block vs. modified-Thoracolumbar Interfascial Plane Block for Lumbar Discectomy Surgery: A Randomized, Controlled Study. (Pubmed Central) - May 26, 2021
US-guided ESPB and mTLIP may provide adequate pain control after discectomy surgery. However, there is a non-superiority between ESPB and the mTLIP group.
- | fentanyl citrate / Generic mfg., dexmedetomidine / Generic mfg.
Biomarker, Journal: Effect of Opioid Versus Non-Opioid Analgesia on Surgical Pleth Index and Biomarkers of Surgical Stress During Neurosurgery for Brain Tumors: Preliminary Findings. (Pubmed Central) - May 26, 2021
There was no difference between the groups in the biomarkers of surgical stress-cortisol, blood glucose, and pH while leucocyte count was higher in the fentanyl group. The stress response to surgery during craniotomy for brain tumors is similar with opioid (fentanyl) and non-opioid (dexmedetomidine) analgesia as assessed by SPI and blood markers such as cortisol, glucose, and pH.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Pretreatment with Pectoral Nerve Block II Is Effective for Reducing Pain in Patients Undergoing Thoracoscopic Lobectomy: A Randomized, Double-Blind, Placebo-Controlled Trial. (Pubmed Central) - May 26, 2021
The primary endpoint was the total consumption of fentanyl...Mean arterial pressure (MAP) and heart rate (HR) of the PECS II group at chest entering (T1) were significantly lower than those in the placebo group (p < 0.05). Preconditioning of PECS II can stabilize the intraoperative circulation and significantly reduce pain and the consumption of opioids after operation.
- ||| fentanyl citrate / Generic mfg., levamisole / Generic mfg.
Levamisole, an anti-helminthic vet drug, is used as a colorless, odorless, adulterant to narcotics, cocaine, fentanyl, etc. Levamisole also causes ANCA+ Vasculitis (small to medium vessels), palpable purpura, agranulocytosis https://t.co/BKoDo2iemJ https://t.co/bSl0eYn0yO (Twitter) - May 25, 2021
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Does Surgical-site Multimodal Drug Injection After Palmar Plating of Distal Radius Fractures Improve Pain Scores? (Pubmed Central) - May 25, 2021
The high-potency opioids or other analgesia usually used for postoperative pain management have many side effects. Thus, reducing additional analgesia is as important as postoperative pain management and a surgical-site multimodal analgesic injection is one of the methods to achieve this a goal.
- | hydromorphone hydrochloride / Generic mfg.
Journal: "It's Helped Me a Lot, Just Like to Stay Alive": a Qualitative Analysis of Outcomes of a Novel Hydromorphone Tablet Distribution Program in Vancouver, Canada. (Pubmed Central) - May 25, 2021
Our findings indicate that the hydromorphone distribution program not only is effective in responding to the current overdose crisis by reducing people's use of illicit drugs but also addresses inequities stemming from the intersection of drug use and social inequality. Safe supply programs should be further implemented and evaluated in both urban and rural setting across North America as a strategy to reduce exposure to the toxic drug supply and fatal overdose.