- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Journal: Breakthrough Cancer Pain in Patients Receiving Low Doses of Opioids for Background Pain. (Pubmed Central) - Jun 22, 2021 It has its own peculiarities: less frequent, lower intensity, faster onset, longer time to meaningful pain relief, and less satisfaction with medication. Many patients were prescribed fentanyl preparations, which are normally reserved for patients receiving higher doses of opioids.
- |||||||||| tramadol hydrochloride / Generic mfg.
Journal: Alleviation of Pain After Femur and Tibia Shaft Fractures Using Nothing Stronger Than Codeine and Tramadol. (Pubmed Central) - Jun 22, 2021 Many patients were prescribed fentanyl preparations, which are normally reserved for patients receiving higher doses of opioids. Alleviation of pain can be achieved in most patients with femoral and tibial shaft fractures, including multiply injured patients, with one-on-one patient support and by using nothing stronger than codeine and tramadol.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Morphine-induced respiratory depression is independent of ß-arrestin2 signalling. (Pubmed Central) - Jun 22, 2021 Sustained presence of fentanyl may influence response to neurological examination at 12 hours post discontinuation in patients receiving the drug as an infusion as part of TTM. Our findings do not support the original suggestion that ß-arrestin2 signalling plays a key role in opioid-induced respiratory depression and call into question the concept of developing G protein-biased μ-opioid receptor agonists as a strategy for the development of safer opioid analgesic drugs.
- |||||||||| fentanyl citrate / Generic mfg.
Clinical, Journal: Opioid Overdoses for Recently Incarcerated Individuals: Toxicology Results and Risk Evaluations. (Pubmed Central) - Jun 22, 2021 Background: The opioid epidemic continues to challenge the United States, fueled by illicitly manufactured fentanyl...Substance risk assessment tools should drive referral for treatment while in prison and at time of release. These results provide better insight into the opioid epidemic and may help guide medical care, specifically for recently incarcerated individuals.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Activation of μ opioid receptors by MT-45 and its fluorinated derivatives. (Pubmed Central) - Jun 22, 2021 Fluorinated derivatives of MT-45 are potent μ receptor agonists and this may pose a danger to illicit opioid users. Inhibition of NMDA receptors by a metabolite of MT-45 may contribute to the reported dissociative effects.
- |||||||||| fentanyl citrate / Generic mfg.
Preclinical, Journal: Evaluation of a dual fentanyl/heroin vaccine on the antinociceptive and reinforcing effects of a fentanyl/heroin mixture in male and female rats. (Pubmed Central) - Jun 22, 2021 For comparison, continuous treatment with a naltrexone dose (0.032 mg/kg/h) shown previously to produce clinically relevant plasma-naltrexone levels decreased the antinociceptive potency of fentanyl, heroin, and the 1:27 fentanyl/heroin mixture by approximately 20-fold...These data demonstrate that a vaccine can simultaneously attenuate the thermal antinociceptive effects of two structurally dissimilar opioids. However, the vaccine did not attenuate fentanyl/heroin mixture self-administration, suggesting a greater magnitude of vaccine responsiveness is required to decrease opioid reinforcement relative to antinociception.
- |||||||||| methionine enkephalin (IRT-101) / Immune Therap, Cytocom
Journal: Voltage modulates the effect of μ receptor activation in a ligand-dependent manner. (Pubmed Central) - Jun 22, 2021 However, the vaccine did not attenuate fentanyl/heroin mixture self-administration, suggesting a greater magnitude of vaccine responsiveness is required to decrease opioid reinforcement relative to antinociception. Our results indicate a strong ligand-dependent modulation of MOP activity by the membrane potential, suggesting preferential activity of morphine in neurons with high neuronal activity.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Multiscale Modeling of Skin Electroporation. (Pubmed Central) - Jun 22, 2021 The release of fentanyl through this model is compared with the available experimental results...This multiscale modelling framework provides valuable insight at molecular and macroscopic level to design the electroporation experiments. The framework can be utilized as a design tool for skin electroporation applications.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Potential Energy Function for Fentanyl-Based Opioid Pain Killers. (Pubmed Central) - Jun 22, 2021 We find that fluorination alters the electronic ground state properties of fentanyl. As a consequence, fentanyl and NFEPP have distinct torsional and electrostatic properties likely to impact how they bind to receptors.
- |||||||||| fentanyl citrate / Generic mfg.
Clinical, Journal: Effect of Stellate Ganglion Block on Intraoperative Propofol and Fentanyl Consumption in Patients with Complex Regional Pain Syndrome Undergoing Surgical Repair of Brachial Plexus Injury: A Randomized, Double-blind, Placebo-controlled Trial. (Pubmed Central) - Jun 22, 2021 There was a significant reduction in the requirement of total intraoperative propofol (1659.7 ± 787.5 vs. 2500.7 ± 740.9 mg, P = 0.0003) and fentanyl (190.0 ± 82.5 vs. 327.3 ± 139.3, P = 0.0001) in Group B compared with Group S. Similarly, in Group B, the time to first analgesic was much longer (328 ± 219 vs. 64 ± 116 min, P = 0.000) and postoperative fentanyl requirement for 24 h was lesser compared to Group S (0.6 ± 1.1 vs. 2.1 ± 1.3 μg/kg, P = 0.000). SGB is effective in reducing the requirement of intraoperative propofol and fentanyl as well as decreasing opioid requirement in the postoperative period in patients with CRPS type II undergoing surgery.
- |||||||||| fentanyl citrate / Generic mfg.
Clinical, Journal: Determination of fentanyl and 19 derivatives in hair: Application to an Italian population. (Pubmed Central) - Jun 22, 2021 2 out of the 20 postmortem samples show positive one only for fentanyl, the other for furanyl fentanyl, acetyl fentanyl, methoxyacetyl fentanyl, methoxyacetyl norfentanyl, ocfentanil and 4-ANPP. Despite the relatively small number of samples, the results suggest that the method should be included in routine hair analyses for monitoring the new synthetic opioids potential intake by drug users.
- |||||||||| fentanyl citrate / Generic mfg., isoflurane / Generic mfg.
Journal: Optimised induction of on-demand focal hippocampal and neocortical seizures by electrical stimulation. (Pubmed Central) - Jun 22, 2021 Compared with FLK infusion, CRI of SLK at these doses decreased isoflurane requirements, decreased pain scores and improved recovery quality at extubation in dogs undergoing TECA-LBO. The proposed models provide an efficient method for the high-throughput screening of novel antiseizure therapies, including closed-loop stimulation paradigms, and are well-suited to in vivo investigations that require tight regulation of seizure timing under anaesthetised conditions, particularly neuroimaging studies aimed at understanding the development of epileptogenic networks.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Emulsion Effect on the Measurement of Standard Laboratory Blood Parameters. (Pubmed Central) - Jun 22, 2021 The in vitro studies indicate that results from certain assays of blood samples rich in lipid emulsion may not be accurate due to interference with optical, mechanical or ion selective electrode methodology. Although in vivo samples may be less impacted, there is still a risk of deviation from accuracy.
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Journal: The use of lateral flow immunoassays for the detection of fentanyl in seized drug samples and postmortem urine. (Pubmed Central) - Jun 22, 2021 Analysis of the fentanyl cassettes displayed a sensitivity, specificity, and efficiency of 100% for seized drug samples and a sensitivity of 100%, a specificity of 75%, and an efficiency of 92.9% for postmortem urine samples. These data point to the utility of LFIs as a quick and low resource-dependent option for presumptive detection of fentanyl in real-world situations.
- |||||||||| fentanyl citrate / Generic mfg.
Review, Journal: Carfentanil - from an animal anesthetic to a deadly illicit drug. (Pubmed Central) - Jun 22, 2021 The most prominent group of designer opioids consists of fentanyl and its analogues...This review presents current knowledge on pharmacological activity of carfentanil, prevalence and patterns of use, and analytical methods of its detection. Special emphasis is given to carfentanil-related non-fatal and lethal overdose cases.
- |||||||||| Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Clinical, Retrospective data, Journal: Opioids for chronic low back pain management: a Bayesian network meta-analysis. (Pubmed Central) - Jun 22, 2021 According to published level I evidence, oxymorphone, tapentadol and fentanyl were the most effective drugs in the treatment of chronic LBP. However, different formulation and pharmacokinetic characteristics need to be taken into consideration when choosing the ideal compound for a given patient.
- |||||||||| midazolam hydrochloride / Generic mfg.
Retrospective data, Journal: Nurse-Administered Propofol Continuous Infusion Sedation: A New Paradigm for Gastrointestinal Procedural Sedation. (Pubmed Central) - Jun 22, 2021 Thus, the developed method showed high sensitivity and good accuracy, which makes it suitable for the rapid detection of fentanyl analogues for customs and border service as well as pharmaceuticals. NAPCIS seems to be a safe, effective, and efficient means of providing moderate sedation for upper endoscopy and colonoscopy in low-risk patients.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: A New Library-Search Algorithm for Mixture Analysis Using DART-MS. (Pubmed Central) - Jun 22, 2021 This new approach for presumptive identification provides analysts with refined information about mixture components and will be of immediate importance in forensic analysis using DART-MS. A prototype implementation of the ILSA is available at https://github.com/asm3-nist/DART-MS-DST.
- |||||||||| fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
Biomarker, Clinical, Journal: Predictive factors for postoperative ıntensive care unit admission in pediatric patients undergoing scoliosis correction surgery. (Pubmed Central) - Jun 22, 2021 A smaller bodyweight percentile, neuromuscular etiology, abnormal findings in preoperative chest X-ray, additional comorbidities, and preoperative estimated risk for postoperative mechanical ventilation were among the risk factors for postoperative ICU stay. The age, height, weight, degree of the curvature, and the number of operated segments did not have an association with the postoperative outcomes.
- |||||||||| fentanyl citrate / Generic mfg.
Clinical, Journal: A Comparison of the Effect of Fractionated and Bolus Dose Injection on Spinal Anesthesia for Lower Limb Surgery: A Randomized Clinical Trial. (Pubmed Central) - Jun 22, 2021 The present study intended to compare the effect of fractionated and bolus dose injection of bupivacaine and fentanyl on spinal anesthesia for lower limb fracture surgeries...Moreover, the sensory blockage duration was longer (P = 0.035), and the highest level of sensory blockage was lower (P = 0.008) in Group B compared to Group A. Fractional spinal anesthesia led to a longer duration and more favorable levels of sensory blockage compared to the bolus method. In addition, hemodynamic changes and complications occurred less frequently following this procedure.
- |||||||||| fentanyl citrate / Generic mfg.
Preclinical, Journal: Operant Vapor Self-administration in Mice. (Pubmed Central) - Jun 22, 2021 This model can be used to study various aspects of opioid addiction including self-administration, escalation of drug intake, extinction, reinstatement, and drug seeking despite adversity. Further, this model bypasses the limitations of intravenous self-administration and allows the investigation of drug taking over extended periods of time and in conjunction with cutting-edge techniques such as calcium imaging and in vivo electrophysiology.
- |||||||||| ceftriaxone / Generic mfg.
What an Ethical Dilemma! Endoscopic Retrograde Cholangiopancreaticography (ERCP) on a 99-year-old? (Mezzanine 16AB) - Jun 20, 2021 - Abstract #ASA2021ASA_2933; Her past medical history includes atrial fibrillation on coumadin, coronary artery disease treated with multiple stents, transient ischemic attack, hypertension, pheochromocytoma, and hypothyroidism...She is started on Vancomycin and resuscitated with 1.5 liters of lactated ringers...What are the advantages and disadvantages of propofol-dexmedetomidine combination, propofol-ketamine combination, midazolam-fentanyl-Ketamine combination or Propofol alone when used for monitored anesthesia care?...4. What are the causes of pulmonary embolus during ERCP?
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