fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg.
    Preclinical, Journal:  In vitro Pharmacology of Fentanyl Analogs at the Human Mu Opioid Receptor and Their Spectroscopic Analysis. (Pubmed Central) -  Jun 30, 2021   
    The reported spectra and chemical data will allow for easy identification of novel fentalogs in unknown or mixed samples. Taken together these data are useful for law enforcement and clinical workers as they will aid in identification of fentalogs in unknown samples and can potentially be used to predict physiological effects after exposure.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    Retrospective data, Journal:  Variation in opioid utilization among neonates with gastroschisis. (Pubmed Central) -  Jun 30, 2021   
    Understanding pain needs and standardization may improve opioid stewardship in infants with gastroschisis. 197/200 LEVEL OF EVIDENCE: Level III.
  • ||||||||||  pregabalin / Generic mfg., amitriptyline / Generic mfg., gabapentin / Generic mfg.
    [VIRTUAL] How is the Pharmacological Analgesic Ladder Being Portrayed in Social Media? () -  Jun 29, 2021 - Abstract #IASP2021IASP_821;    
    We focused on tweets containing the following keywords #Acetaminophen, #Paracetamol, #Tramadol, #Codeina, #Codeine, #Morphine, #Morfina, #Fentanyl, #Fentanilo, #Oxycodone, #Oxicodona, #Methadone, #Metadona , #Buprenorphine, #Buprenorfina, #Tapentadol, # Hydromorphone, #Hidromorfona, #Amitriptyline, #Amitriptilina, #Imipramine, #Imipramina, #Gabapentin, #Gabapentina, #Pregabalin and #Pregabalina. People from different backgrounds are turning to Twitter to discuss pain and analgesia issues.
  • ||||||||||  [VIRTUAL] Synthetic opioids cause more cellular damage in vitro than natural opioids. () -  Jun 29, 2021 - Abstract #IASP2021IASP_308;    
    In conclusion, the results demonstrated differences in opioid-induced toxicity and similar results were observed in all four cell cultures. The synthetic opioids methadone and fentanyl decreased mitochondrial activity and membrane function to the highest extent, followed by oxycodone and ketobemidone, and the least damage was caused by hydromorphone, and morphine.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    [VIRTUAL] Rapid Opioid Dose Titration in Patients with Moderate to Severe Cancer Pain () -  Jun 29, 2021 - Abstract #IASP2021IASP_261;    
    Administration of rapid opioid dose titration is effective and can provide pain relief to cancer patients. Giving an agent at the lowest effective dose and in a slow and proportional manner can provide significant pain relief and patient satisfaction with minimal adverse effects.
  • ||||||||||  methionine enkephalin (IRT-101) / Immune Therap, Cytocom
    [VIRTUAL] Opioid Signaling emerges late in Maturing Human iPSC-derived Nociceptors () -  Jun 29, 2021 - Abstract #IASP2021IASP_250;    
    Whereas pronociceptive PKA signaling develops already early after differentiation, opioid signaling requires extended periods of in vitro maturation. Defining such windows of pathway activity is a crucial prerequisite for the use of hiPSCdNs in pharmacological research and drug development.
  • ||||||||||  Carafate (sucralfate) / AbbVie
    [VIRTUAL] SUCRALFATE IN THE MANAGEMENT OF ODYNOPHAGIA DURING ALLOGENEIC HEMATOPOIETIC () -  Jun 29, 2021 - Abstract #MASCCISOO2021MASCC_ISOO_481;    
    Sucralfate group showed reduction in days (2.62vs6.64, p:0.001) and amount (3.347vs8.460 ml, p:0.001) of parenteral nutrition, Morphine (7.74vs12.56 ampoules, p:0.002), Patch Fentanil (0.36vs0.72, p:0.02) and Hexomedine (0.64vs0.92 bottles, p:0.003) use. Conclusions The administration of Sucralfate in suspension for the management of odynophagia reduced the use of parenteral nutrition, opioid and topical analgesics use during the acute phase of allo-HSCT.
  • ||||||||||  [VIRTUAL] AN INTERNATIONAL SURVEY OF OPIOID ROTATION AND CONVERSION RATIOS USED BY PALLIATIVE CARE PROFESSIONALS () -  Jun 29, 2021 - Abstract #MASCCISOO2021MASCC_ISOO_328;    
    Although the median CR from intravenous to oral morphine varied significantly across regions (Europe 2.5, Canada 2, US 3), the variations with hydromorphone and fentanyl were more remarkable...Conclusions This survey provides unique insights into typical ORRs and CRs used in clinical practice internationally. It highlights the wide variation in ORR and CR among PC clinicians and the need for further research to standardize practice.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Policy Forum: Class-Wide Drug Scheduling Based on Chemical Structure: A Cautionary Tale () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_666;    
    Part II will include a panel discussion of the impact of classwide scheduling of fentanyl analogues on scientific research...Christopher Cunningham will consider the scheduling action from a chemist’s perspective, and Dr. Marco Pravetoni will describe the impact of classwide scheduling on development of vaccines.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Prevalence and Correlates of Requiring Assisted Injection Among People who Inject Drugs in Toronto, Canada () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_628;    
    A high proportion of sampled PWID in Toronto reported requiring assisted injection; this behaviour was associated with greater social vulnerability and specific substance use patterns. These findings highlight the need to provide safer self-injection education and dedicated supervised injection services to accommodate those subgroups requiring assisted injection.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Physiological Effects of Cyclopropylfentanyl, as Compared to Fentanyl and Heroin, in Rats () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_596;    
    Fentanyl and cyclopropylfentanyl showed significant cardiovascular effects at lower doses than heroin. The high potency of cyclopropylfentanyl reveals potential risks to users who are unknowingly exposed to this drug and highlights the need for further investigation into the pharmacology of fentanyl analogs found in recreational drug markets.
  • ||||||||||  fentanyl citrate / Generic mfg., methadone / Generic mfg.
    [VIRTUAL] Mobile Technology With Integrated Incentives to Promote Buprenorphine Treatment Enrollment and Adherence () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_569;    
    These results support translation of vaccines and mAb as medical interventions to prevent and reverse opioid overdose related to fentanyl and its analogs. The remote delivery of financial incentives can connect out-of-treatment adults with opioid use disorder to treatment, but additional supports may be needed to promote adherence to buprenorphine treatment.
  • ||||||||||  idazoxan (RX 781094) / Houston Pharma
    [VIRTUAL] The Primary Kratom Alkaloid Mitragynine as an In Vivo Adrenergic-Alpha2 Receptor Agonist in Rats () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_552;    
    Financial Support: Supported by NIDA grants DA23205 and DA48353 Aim: The primary kratom alkaloid mitragynine has received attention due to its µ-opioid receptor (MOR) activity; additionally, the antinociceptive effects of mitragynine in mice were blocked by the adrenergic-α2 receptor (Aα2R) antagonist idazoxan...In rats discriminating mitragynine (32mg/kg, i.p.) from vehicle, MOR agonists (morphine, fentanyl, and methadone), Aα2R agonists (lofexidine and clonidine), and Aα2R antagonists (yohimbine and atipamezole) produced up to 84%, 74%, and 40% drug-lever responding, respectively... These results suggest that mitragynine exerts its in vivo effects via dual agonism at µ-opioid and adrenergic-α2 receptors
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Effects of Daily Methocinnamox Treatment on Fentanyl Self-Administration in Rhesus Monkeys () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_475;    
    MCAM decreased self-administration of fentanyl, but not cocaine, and effects were maintained for the duration of treatment. Although antagonist effects of a relatively small dose were surmountable, MCAM produced sustained and selective attenuation of opioid self-administration, supporting the view that it could be an effective treatment for opioid use disorder.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Development of a Covalent Poly(Lactic Acid) Naloxone Nanoparticle for Extended Protection Against Fentanyl-Induced Renarcotization () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_474;    
    Although antagonist effects of a relatively small dose were surmountable, MCAM produced sustained and selective attenuation of opioid self-administration, supporting the view that it could be an effective treatment for opioid use disorder. These results suggest that NP-NLX could be an effective alternative to NLX to reverse fentanyl-induced overdose and prevent renarcotization, and that covalent poly(lactic acid-co-glycolic acid) nanoparticles are an attractive delivery platform for opioid antagonists or other small molecules used in treatment of toxicity.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Full-Oral Communication III: Fentanyl () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_473;    
    These results suggest that NP-NLX could be an effective alternative to NLX to reverse fentanyl-induced overdose and prevent renarcotization, and that covalent poly(lactic acid-co-glycolic acid) nanoparticles are an attractive delivery platform for opioid antagonists or other small molecules used in treatment of toxicity. "Dragon's Layer: The Fight Against Fentanyl"
  • ||||||||||  fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
    [VIRTUAL] Female Sex Hormones and Addiction: Preclinical and Clinical Studies () -  Jun 28, 2021 - Abstract #CPDD2021CPDD_467;    
    Collectively, these findings illustrate that ovarian hormone levels have a pronounced influence on susceptibility to problematic drug use. As such, this work has important implications for developing sex-specific prevention and treatment efforts for addiction, including the optimal timing of both neurobiological and behavioral interventions for women based on fluctuations in circulating sex hormones.