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39 Diseases |  |
5 Trials |
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5 Trials |  |
18506 News |  |
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- || midazolam hydrochloride / Generic mfg., bupropion / Generic mfg.
Clinical, Journal: Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine. (Pubmed Central) - Jul 10, 2021
In these cases, bupropion overdose resulted in a clinical presentation consistent with serotonin syndrome, with the first having a temporal improvement after treatment with cyproheptadine. Physicians need to be aware of the potential serotonergic activity of bupropion for accurate assessment and treatment of this dangerous condition.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: The Role of Tourniquet Placement in Management of a Patient With Status Epilepticus. (Pubmed Central) - Jul 10, 2021
After imaging, purposeful movements were noted in the right lower extremity distal to the tourniquet despite the initiation of standard dose post-intubation sedation with fentanyl (0.5 μg/kg/h) and propofol (20 μg/kg/min)...WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: The observations made support the use of temporally limited tourniquet placement during paralytic administration to assess patient seizure status and sedation levels. Mindful tourniquet use in this manner permits a more effective sedation and management protocol for SE patients coming into the ED and may outweigh the minor risks associated with short-term hypoperfusion.
- || midazolam hydrochloride / Generic mfg., palonosetron intravenous / Generic mfg.
Clinical, Journal: Comparison of efficacy between palonosetron-midazolam combination and palonosetron alone for prevention of postoperative nausea and vomiting in patients undergoing breast surgery and patient controlled analgesia: A prospective, randomized, double-blind study: A CONSORT-compliant study. (Pubmed Central) - Jul 10, 2021
Mindful tourniquet use in this manner permits a more effective sedation and management protocol for SE patients coming into the ED and may outweigh the minor risks associated with short-term hypoperfusion. The combination therapy of palonosetron with midazolam did not lead to a greater reduction in the incidence of PONV than monotherapy in patients undergoing breast surgery and receiving IV-PCA containing fentanyl.
- ||| fentanyl citrate / Generic mfg.
In @AAAP1985 AJA our @ColumbiaPsych research group reports on the feasibility of a single-day induction onto buprenorphine extended-release injection for fentanyl users. With fentanyl overdose deaths rising, novel treatment approaches are needed. https://t.co/gC7xPL0Nja (Twitter) - Jul 9, 2021
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Endogenous opioid peptides in the descending pain modulatory circuit. (Pubmed Central) - Jul 9, 2021
Further emphasis on understanding the complex regulation of endogenous opioids will help to make rational decisions with regard to the use of opioids for pain. We also include a discussion of the actions of endogenous opioids in the amygdala, an upstream brain structure that has reciprocal connections to the PAG that contribute to the brain's response to pain.
- | fentanyl citrate / Generic mfg., methadone / Generic mfg.
Preclinical, Journal: Female rats self-administer heroin by vapor inhalation. (Pubmed Central) - Jul 9, 2021
There was an initial increase in non-medical use of prescription opioids around 2002, followed later by increased heroin use and then most recently fentanyl...Non-contingent exposure to heroin or methadone vapor produced anti-nociceptive efficacy in male and female rats...In sum, these studies show that rewarding and anti-nociceptive effects of heroin are produced in rats by vapor inhalation using e-cigarette technology. Importantly, self-administration models by this route can be deployed to determine health effects of inhaled heroin or other opioids.
- || midazolam hydrochloride / Generic mfg.
Clinical, Journal: Efficiency and Safety of Balloon-Assisted Gastrostomy. (Pubmed Central) - Jul 8, 2021
Balloon-assisted gastrostomy is a safe and effective technique for large bore gastrostomy placement. Patients required less sedation, allowing for faster recovery and discharge time in outpatients at our institution.
- | fentanyl citrate / Generic mfg.
Journal: The Rise and Fall of Isotonitazene and Brorphine: Two Recent Stars in the Synthetic Opioid Firmament. (Pubmed Central) - Jul 8, 2021
Both isotonitazene and brorphine remained in circulation for over a year, each contributing to hundreds of deaths and adverse events. By detailing the life-cycles of these opioids from their earliest synthesis as described in scientific literature to their subsequent rise and fall on recreational markets, this review illustrates the new characteristic life-cycle of synthetic opioids in the 'post-fentanyl-analogue' era.
- || fentanyl citrate / Generic mfg.
Clinical, PK/PD data, Journal: Characterizing Fentanyl Variability using Population Pharmacokinetics in Pediatric Burn Patients. (Pubmed Central) - Jul 8, 2021
This study confirmed the high variability in pediatric burn patient fentanyl pharmacokinetics and demonstrates similarities and differences to other populations reported in literature. Further research is needed with a larger number of patients to extensively investigate the impact of burns, genetic polymorphisms and other factors on fentanyl efficacy and patient outcomes.
- | fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Investigating opioid-related fatalities in southern Sweden: contact with care-providing authorities and comparison of substances. (Pubmed Central) - Jul 8, 2021
The studied population is characterised by extensive contact with care-providing authorities, thus providing numerous opportunities for authorities to reach this group with preventive and other interventions. Few differences emerged between groups with regard to which opioid had contributed to the death.
- | fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: Stimulant safe supply: a potential opportunity to respond to the overdose epidemic. (Pubmed Central) - Jul 8, 2021
The promise of similar opioid-focused approaches in addressing both overdose-related risks and experiences related to vulnerability underscores the need to advance safe supply approaches targeted towards people who use stimulants. Given the current overdose crisis and rising stimulant use across North America, the implementation and evaluation of such novel stimulant-focused interventions should be a public health priority.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Addressing overdose risk among unstably housed women in San Francisco, California: an examination of potential fentanyl contamination of multiple substances. (Pubmed Central) - Jul 8, 2021
The presence of fentanyl metabolites in this population was almost entirely among women who also reported using heroin or opioid pills. These data do not support the hypothesis that fentanyl is being routinely added to stimulants as an adulterant on a large scale in this region.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Evaluating networked drug checking services in Toronto, Ontario: study protocol and rationale. (Pubmed Central) - Jul 8, 2021
These data do not support the hypothesis that fentanyl is being routinely added to stimulants as an adulterant on a large scale in this region. This study addresses evidence gaps on the emerging continuum of overdose prevention responses and will generate critical evidence on a novel approach to reducing the ongoing high incidence of drug-related morbidity and mortality in Canada and elsewhere.
- | fentanyl citrate / Generic mfg.
Journal: A dynamic model of the opioid drug epidemic with implications for policy. (Pubmed Central) - Jul 8, 2021
No single intervention significantly reduces both PWOUD and overdose deaths, but a combination strategy can do so. Entering the 2020 s, only protective measures like naloxone expansion could significantly reduce overdose deaths.
- | fentanyl citrate / Generic mfg.
Journal: A novel vaccine that blunts fentanyl effects and sequesters ultrapotent fentanyl analogs. (Pubmed Central) - Jul 8, 2021
In vivo, immunization shifted the antinociceptive dose-response curve of fentanyl to higher doses. Collectively, these pre-clinical results showcased the desired traits of a potential vaccine against fentanyl and demonstrated the feasibility of immunization to combat fentanyl-induced effects.
- | fentanyl citrate / Generic mfg.
Journal: Illicit synthetic opioid consumption in Asia and the Pacific: Assessing the risks of a potential outbreak. (Pubmed Central) - Jul 8, 2021
With the exception of Australia, many countries in the region fail to properly record overdose deaths or monitor changes in local drug markets. Early assessment and monitoring can give officials a better understanding of these changing threats.
- | fentanyl citrate / Generic mfg.
Only in your fentanyl-addled cracker mind (Twitter) - Jul 7, 2021
- || Nucynta (tapentadol) / Collegium Pharma, Grunenthal, Relistor (methylnaltrexone bromide) / Ono Pharma, Progenics, Bausch Health
Review, Journal: Opioid receptors beyond pain control: The role in cancer pathology and the debated importance of their pharmacological modulation. (Pubmed Central) - Jul 7, 2021
Moreover, various pathological processes of human cancer are affected by opioid receptor agonists, such as tumour growth, angiogenesis and immunosuppression. These findings highlight the functional value of opioid receptors in human cancer, and a potential double role of opioid receptor agonists and antagonists in human cancer treatment.
- | fentanyl citrate / Generic mfg., diazepam / Generic mfg., paracetamol / Generic mfg.
Retrospective data, Journal: Incidence and risk factors for acute delirium in older patients with a hip fracture: A retrospective cohort study. (Pubmed Central) - Jul 7, 2021
Multivariate logistic regression analysis determined comorbidity and cognitive impairment as independent risk factors for the development of delirium. This study demonstrates the importance of evaluation of medications prescribed in the perioperative period as modifiable risk factors, in order to identify patients at high risk of delirium and enable targeted monitoring and treatment during patients' hospitalisation.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Journal: Association between intraoperative and postoperative epidural or intravenous patient-controlled analgesia and pancreatic fistula after distal pancreatectomy. (Pubmed Central) - Jul 7, 2021
Intraoperative and postoperative epidural analgesia and IV-PCA are not associated with clinical POPF after DP. Our results suggest that morphine and fentanyl can be used as IV-PCA or epidural analgesia.
- | fentanyl citrate / Generic mfg.
Journal: Sedation and Analgesia for Liver Cancer Percutaneous Radiofrequency Ablation: Fentanyl and Oxycodone Comparison. (Pubmed Central) - Jul 7, 2021
More patients in the FEN group displayed unwanted body movement and respiratory depression. Both oxycodone and fentanyl can be applied for liver cancer percutaneous radiofrequency ablation; however, oxycodone provides a better patient experience, lower postoperative pain, less respiratory depression and stable haemodynamic fluctuations.
- || fentanyl citrate / Generic mfg., methadone / Generic mfg.
Clinical, Journal: Deficiencies with the Use of Prescription Drug Monitoring Program in Cancer Pain Management: A Report of Two Cases. (Pubmed Central) - Jul 7, 2021
The PDMP erroneously reported that he had filled methadone, thereby impacting the provider-patient relationship...The patient was wearing a fentanyl patch that was found only on physical examination during a clinic visit, because it was not noted in the PDMP...Enhanced real-time reporting of opioid prescribing information, increased integration into electronic health systems, and universal interstate sharing of prescribing data are some of the ways to improve their effectiveness. More research is needed to further examine the deficiencies and improve on its utility in routine chronic opioid therapy.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Lack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats. (Pubmed Central) - Jul 7, 2021
More research is needed to further examine the deficiencies and improve on its utility in routine chronic opioid therapy. Results extend the range of conditions across which pain-related manipulations fail to increase opioid seeking in rats and suggest that enhanced opioid-addiction risk in humans with chronic pain involves factors other than enhanced opioid reinforcement and relapse.
- | ketamine / Generic mfg., tranexamic acid oral / Generic mfg.
Journal: Ketamine Use in Operation Enduring Freedom. (Pubmed Central) - Jul 7, 2021
Results extend the range of conditions across which pain-related manipulations fail to increase opioid seeking in rats and suggest that enhanced opioid-addiction risk in humans with chronic pain involves factors other than enhanced opioid reinforcement and relapse. This study demonstrates increasing use of ketamine by the U.S. Military on the battlefield and effectiveness of clinical practice guidelines in influencing practice patterns.
- || lidocaine topical / Generic mfg.
Clinical, Review, Journal: Lidocaine for postoperative pain after cardiac surgery: a systematic review. (Pubmed Central) - Jul 7, 2021
This study demonstrates increasing use of ketamine by the U.S. Military on the battlefield and effectiveness of clinical practice guidelines in influencing practice patterns. Due to the favorable risk profile of topical lidocaine and the need for further advancements in the postoperative care of adults after cardiac surgery, topically administered lidocaine could be considered for incorporation into established postoperative recovery protocols.
- || labetalol / Generic mfg., dexmedetomidine / Generic mfg.
Clinical, Journal: To Compare the Efficacy of Dexmedetomidine Versus Labetalol in Providing Controlled Hypotension in Functional Endoscopic Sinus Surgery. (Pubmed Central) - Jul 6, 2021
The first analgesic request time was significantly longer in the group D (50.2 ± 9.1) compared to group L (24.8 ± 5.1) (P-value < 0.05). Dexmedetomidine provided better hemodynamic stability and operative field visibility as compared to labetalol during FESS.
- | midazolam hydrochloride / Generic mfg.
Journal: Impact of class III obesity on outcomes and complications of transvaginal ultrasound-guided oocyte pickup. (Pubmed Central) - Jul 6, 2021
There was no increased risk of complications for women with class III obesity undergoing OPU with conscious sedation. However, the operator was more likely to encounter difficult access and to incompletely aspirate follicles through a transvaginal approach.
- | senicapoc (ICA-17043) / SpringWorks Therap, UC Davis Health
Preclinical, Journal: Effect of the KCa3.1 blocker, senicapoc, on cerebral edema and cardiovascular function after cardiac arrest - A randomized experimental rat study. (Pubmed Central) - Jul 6, 2021
Senicapoc enhanced the PaO/FiO ratio significantly 4 h after resuscitation. Senicapoc was successfully administered intravenously after resuscitation, but did not reduce cerebral edema or increase mean arterial pressure in the early post-resuscitation period.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Early cytotoxic lymphocyte localization to the brain following resuscitation in a porcine model of asphyxial cardiac arrest: A pilot study. (Pubmed Central) - Jul 6, 2021
In eight of the animals, this was followed by induction of asphyxial OHCA via fentanyl bolus and concurrent airway occlusion...CD8 single positive cells made up 0.473 +/- 0.24% of detected cells in animals that achieved ROSC, 0.395 +/- 0.062% in animals that did not achieve ROSC, and 0.19 +/- 0.014% in sham animals (No ROSC vs Sham, p = 0.012). These data suggest that cytotoxic lymphocytes may be localizing to the brain during cardiac arrest resuscitation.
- ||| fentanyl citrate / Generic mfg.
Fresenius Kabi Introduces New Simplist® Fentanyl Citrate Injection, USP 50 mcg per 1 mL in Ready-to-Administer Prefilled Syringe https://t.co/wl3pQhW9Dw (Twitter) - Jul 6, 2021
- |||| fentanyl citrate / Generic mfg.
Clinical: Good point Sam. I do most of mine with midaz/fentanyl sedation 3-6 min. Once a month I do a propofol list in an outreach hospital. Intubation times are slightly faster there (1.5 to 2.5 min). (Twitter) - Jul 5, 2021
- || Clinical, Journal: Effect of total intravenous anesthesia or inhalation anesthesia on postoperative quality of recovery in patients undergoing total laparoscopic hysterectomy: A randomized controlled trial. (Pubmed Central) - Jul 4, 2021
The choice of intravenous or inhalation maintenance anesthesia did not affect overall postoperative recovery as measured by the QoR-40 in patients undergoing total laparoscopic hysterectomy. Reducing the duration of pneumoperitoneum and improving sleep quality were conducive to postoperative recovery.
- || Rapinyl (fentanyl) / Kyowa Kirin, Orexo, Zydus Cadila
Clinical, Journal: Procedural pain in patients with cancer: a Delphi expert management consensus. (Pubmed Central) - Jul 3, 2021
Reducing the duration of pneumoperitoneum and improving sleep quality were conducive to postoperative recovery. These results provide updated expert-based recommendations on the definition, prevention and treatment of moderate to severe procedural pain, which could inform specialists involved in pain management of patients with cancer.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Efficacy of transmuscular quadratus lumborum block in the multimodal regimen for postoperative analgesia after total laparoscopic hysterectomy: A prospective randomised double-blinded study. (Pubmed Central) - Jul 3, 2021
The ultrasound-guided TQLB provides effective postoperative analgesia after TLH surgery in a multimodal analgesia approach. It reduces the fentanyl consumption and improves the visual analogue scale (VAS) score.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Efficacy of ultrasound-guided erector spinae plane block following breast surgery - A double-blinded randomised, controlled study. (Pubmed Central) - Jul 3, 2021
There was no statistically significant difference in intraoperative fentanyl consumption. Ultrasound-guided ESP block with general anaesthesia offers superior post-operative analgesia compared to general anaesthesia alone in patients undergoing unilateral nonreconstructive breast cancer surgeries.
- || fentanyl citrate / Generic mfg.
Clinical, Journal, Video: Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial. (Pubmed Central) - Jul 3, 2021
Our results indicated that incorporating a QR code within additional video education leads to proper use of a fentanyl transdermal patch and relieves pain and anxiety levels in patients with cancer. Based on this, we recommend a new style of education during care of cancer patients who first use a fentanyl transdermal patch.
- || fentanyl citrate / Generic mfg.
Clinical, Journal, Video: Should the dosage of propofol be higher and independent of immunosuppressive therapy in adult cystic fibrosis patients undergoing sedation during flexible video bronchoscopy? (Pubmed Central) - Jul 3, 2021
Based on this, we recommend a new style of education during care of cancer patients who first use a fentanyl transdermal patch. Adult CF patients not receiving immunosuppressive therapy require higher propofol dose per kg of body weight compared to non-CF, independently on bronchopulmonary disease stage showing a narrow therapeutic window for propofol in CF group.
- || fentanyl citrate / Generic mfg., paracetamol / Generic mfg.
Clinical, Journal: Efficacy of Truncal Plane Blocks in Pediatric Patients Undergoing Subcutaneous Implantable Cardioverter-Defibrillator Placement. (Pubmed Central) - Jul 3, 2021
Adult CF patients not receiving immunosuppressive therapy require higher propofol dose per kg of body weight compared to non-CF, independently on bronchopulmonary disease stage showing a narrow therapeutic window for propofol in CF group. TTMP block combined with SAPB in pediatric S-ICD placement could provide effective analgesia.
- | fentanyl citrate / Generic mfg.
Journal: "People need them or else they're going to take fentanyl and die": A qualitative study examining the 'problem' of prescription opioid diversion during an overdose epidemic. (Pubmed Central) - Jul 3, 2021
Our study provides an alternative perspective on the "problem" of diversion and demonstrate a positive effect in providing a safer drug supply to others during an overdose crisis. Given that drug policy, criminalization, and poverty created challenges, our findings demonstrate the need for strategies that engender greater safety, reduce harm, and alleviate the effects of these constraints, including through policies promoting safer drug supplies, decriminalization, and employment.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: The potential impacts of community drug checking within the overdose crisis: qualitative study exploring the perspective of prospective service users. (Pubmed Central) - Jul 3, 2021
These include increasing power and accountability within the illicit drug market, improving the health of communities, supporting safer supply initiatives and regulation of substances, and mitigating harms of criminalization. Evaluation of drug checking should consider potential impacts that extend beyond individual behaviour change and recognize lived realities and structural conditions.
- | fentanyl citrate / Generic mfg.
Journal: Quality of labor epidural analgesia at a high-volume tertiary care obstetric unit: a before-and-after study. (Pubmed Central) - Jul 2, 2021
A bundle of practice changes implemented in our clinical practice, including the PIEB regimen, has resulted in a significant improvement in the quality of labor analgesia. However, despite all the implemented changes, 30% of women still experience pain during labor and further optimization of our practice is warranted.
- || tranexamic acid IV / Generic mfg.
Clinical, Journal: Outcomes of combined use of topical and intravenous tranexamic acid on surgical field quality during functional endoscopic sinus surgery: A randomized controlled trial. (Pubmed Central) - Jul 2, 2021
However, despite all the implemented changes, 30% of women still experience pain during labor and further optimization of our practice is warranted. The combined use of topical and intravenous TA provided the best surgical field in FESS, less fentanyl consumption, and less recovery time without causing significant side effects.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Retrospective data, Journal: Retrospective study on the use of lumbosacral epidural analgesia during caesarean section surgery in 182 dogs: Impact on blood pressure, analgesic use and delays. (Pubmed Central) - Jul 2, 2021
The combined use of topical and intravenous TA provided the best surgical field in FESS, less fentanyl consumption, and less recovery time without causing significant side effects. LEA during caesarean section in dogs was associated with lower rates of opioid administration and did not exacerbate the incidence of hypotension.
- | fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Preclinical, Journal: A drug-vs-food "choice" self-administration procedure in rats to investigate pharmacological and environmental mechanisms of substance use disorders. (Pubmed Central) - Jul 2, 2021
LEA during caesarean section in dogs was associated with lower rates of opioid administration and did not exacerbate the incidence of hypotension. The concordance of behavioral results between rats and monkeys using the present drug-vs-food choice procedure supports its utility to improve our basic understanding of the expression and mechanisms of substance use disorders towards to development of more effective therapeutics.
- ||| fentanyl citrate / Generic mfg.
#AmericanGenocide they are causing people to die when they force them to go to the streets it’s a gamble every time you may get a grain of sand of fentanyl and lose your life because you were trying to save your life. Shame on @CDCgov @CDCDirector @POTUS @VP ‼️ (Twitter) - Jul 2, 2021
- || fentanyl citrate / Generic mfg.
Review, Journal: The fentanyl epidemic in Estonia: factors in its evolution and opportunities for a comprehensive public health response, a scoping review. (Pubmed Central) - Jul 1, 2021
The concordance of behavioral results between rats and monkeys using the present drug-vs-food choice procedure supports its utility to improve our basic understanding of the expression and mechanisms of substance use disorders towards to development of more effective therapeutics. Addressing illicitly manufactured fentanyl may serve as a public health learning experience for developing early detection and rapid response programs in rapidly changing drug use environments.
- | fentanyl citrate / Generic mfg., methamphetamine / Generic mfg., levamisole / Generic mfg.
Journal: Analytical findings in used syringes from a syringe exchange program. (Pubmed Central) - Jul 1, 2021
Addressing illicitly manufactured fentanyl may serve as a public health learning experience for developing early detection and rapid response programs in rapidly changing drug use environments. Analysis of samples collected from a drug street scenario allows the identification of new substances being injected and provides information to harm reduction programs to identify strategies to reduce drug abuse.
- | fentanyl citrate / Generic mfg.
Journal: The emerging role of fentanyl in antiplatelet therapy. (Pubmed Central) - Jul 1, 2021
The mechanism of this phenomenon is not fully understood. Similarly, the biological effects exerted by fentanyl on platelets and the presence of opioid receptors on the platelet surface remain an open question.
- || tranexamic acid oral / Generic mfg.
Clinical, Journal: Preoperative Correction of Anemia to Allow a 3000 ml Blood Loss Without Transfusion in a Jehovah's Witness Presenting for Explantation of an Infected Hip Joint Prosthesis: A Case Report. (Pubmed Central) - Jul 1, 2021
Spinal anesthesia was provided with a single shot hyperbaric bupivacaine and fentanyl...To further minimize blood loss, controlled hypotension to a mean blood pressure of 55 mm Hg was achieved with a propofol infusion and tranexamic acid was administered...Hb at the end of surgery was 13.3 g/dL; on postoperative day 5, 11.7 g/L. No blood products were utilized.
- | fentanyl citrate / Generic mfg.
Journal: The fentanyl phase of the opioid epidemic in Cuyahoga County, Ohio, United States. (Pubmed Central) - Jul 1, 2021
Toxicology data showed a decrease in mean morphine and 6-monoacetylmorphine concentrations when cointoxication with fentanyl occurred. Our study emphasizes the medical examiner's role as a public health data source and bridge between different stakeholders combating the opioid epidemic.