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39 Diseases |  |
5 Trials |
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5 Trials |  |
18506 News |  |
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- || fentanyl citrate / Generic mfg.
No fucking shit! But it's not gonna happen with the political climate right now. This is a possible step to stop manufacturers to stop making a chemical that's makes fentanyl. Do you or do you not want less illicit fentanyl on the streets? (Twitter) - Jul 31, 2021
- || fentanyl citrate / Generic mfg.
one cannot 'stop fentanyl' prohibition = increased danger sex work, substances, abortion when banned, anything is more harmful https://t.co/9IhHgyoXsm (Twitter) - Jul 31, 2021
- ||| fentanyl citrate / Generic mfg.
Clinical: It's a way to stop the fentanyl so people stop dying. I'm anti drug war, prohibition don't work. Less fentanyl to kill ppl who take any drug. Ofc there needs to be safe supply, but we need to be realistic with what can happen ASAP. Save as many lives as possible (Twitter) - Jul 31, 2021
- | fentanyl citrate / Generic mfg.
Clinical, Journal: The Effect of Pre-emptive Dexketoprofen Administration on Postoperative Pain Management in Patients with Ultrasound Guided Interscalene Block in Arthroscopic Shoulder Surgery. (Pubmed Central) - Jul 31, 2021
Pre-emptive IV dexketoprofen may be a good option for arthroscopic shoulder surgery and provides effective analgesia.
- | fentanyl citrate / Generic mfg.
Journal: Trends in opioid initiation among people who use opioids in three US cities. (Pubmed Central) - Jul 31, 2021
Pre-emptive IV dexketoprofen may be a good option for arthroscopic shoulder surgery and provides effective analgesia. Our study highlights women and PWUO initiating with NMPO as key risk groups amid the changing landscape of opioid use and overdose, and discusses implications for targeted prevention and treatment.
- || fentanyl citrate / Generic mfg., ketamine / Generic mfg., dexmedetomidine / Generic mfg.
Clinical, Journal: Efficacy of dexmedetomidine-ketamine vs. fentanylketamine on saturated oxygen, hemodynamic responses and sedation in cystoscopy: a doubleblinded randomized controlled clinical trial. (Pubmed Central) - Jul 31, 2021
Therefore, dexmedetomidine-ketamine is recommended to be employed for pain relief in subjects undergoing cystoscopy. The study was approved by Ethical Committee of Arak University of Medical Sciences with IR.ARAKMU.REC.1397.108 on July 2, 2018, and registered in Iranian Registry Clinical Trial center with code IRCT20141209020258N105 on April 21, 2019.
- || Clinical, Journal: Drug-drug interactions in neonatal intensive care: A prospective cohort study. (Pubmed Central) - Jul 31, 2021
Neonates in intensive care have a high exposure to DDIs and the occurrence of major DDIs is related specifically to the prescription of fentanyl. The number of prescribed drugs, gestational age, cesarean delivery and low APGAR score in the first minute were identified as risk factors for DDIs in NICU.
- | Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma, pethidine / Samaritan
Journal: A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity. (Pubmed Central) - Jul 31, 2021
DS21980956 had potent analgesic activity in the mouse acetic acid writhing test or tail flick test without agonistic activity at the µ opioid receptor (MOR). The mechanism of analgesic action of DS21980956 was considered to differ from a biased ligand, for example, TRV-130 (3, oliceridine).
- || fentanyl citrate / Generic mfg.
I love the idea, but won't happen. Let's at least keep bringing up that the DEA and US gov know which labs make the chemical components to make fentanyl. Why haven't they pressured them?!?!?! (Twitter) - Jul 30, 2021
- | clonidine / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Comparison of effect of intraperitoneal instillation of additional dexmedetomidine or clonidine along with bupivacaine for post-operative analgesia following laparoscopic cholecystectomy. (Pubmed Central) - Jul 30, 2021
Total amount of rescue fentanyl given in groups BD (16.8 ± 29.0 μg) and BC (15 ± 26.4 μg) was significantly less than B (35.7 ± 40.0 μg); P < 0.05). The addition of alpha-2 agonists to bupivacaine reduces the post-operative opioid consumption, and dexmedetomidine appears to be superior to clonidine in prolonging time to first analgesic request.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Hemodynamic impact of increasing time between fentanyl and propofol administration during anesthesia induction: a randomised, clinical trial. (Pubmed Central) - Jul 30, 2021
The addition of alpha-2 agonists to bupivacaine reduces the post-operative opioid consumption, and dexmedetomidine appears to be superior to clonidine in prolonging time to first analgesic request. Increasing the time between the administration of fentanyl and propofol by up to two minutes results in greater hypotension in patients over 55 years.
- |||| fentanyl citrate / Generic mfg.
Clinical: @CDCDirector COVID cases up: vast majority have nothing more than cold. Natural immunity grows. COVID deaths hit a new Low.DC registered more homocides than CV deaths Biden distributes 2m illegals, many w COVID, to all 50 States.Crime UP, 90K deaths due to China/Cartel fentanyl (Twitter) - Jul 30, 2021
- | fentanyl citrate / Generic mfg.
Retrospective data, Review, Journal: Optimal Sequences of the Same-visit Bidirectional Endoscopy: A Systematic Review and Meta-analysis. (Pubmed Central) - Jul 30, 2021
However, there was no difference in polyp and adenoma detection. Therefore, the E-C group is the optimal sequence.
- | fentanyl citrate / Generic mfg.
Journal: A deadly trend in fentanyl fatalities (England, 1998-2017). (Pubmed Central) - Jul 30, 2021
The increasing availability of both pharmaceutical fentanyls and NPFDs represents a serious risk to public health. Unintentional misuse of these compounds in England is contributing to the exponential increase in fentanyl-associated deaths that is being observed at the global scale.
- | fentanyl citrate / Generic mfg.
Journal: Help me fix: The provision of injection assistance at an unsanctioned overdose prevention site in Toronto, Canada. (Pubmed Central) - Jul 30, 2021
Findings that women receiving assisted injecting are at higher odds of overdose within the supervised setting of the MP-OPS are consistent with previous literature on assisted injection in community settings. Rules banning assisted injection in supervised consumption services may be putting a group of people, particularly women and those injecting fentanyl, at higher risk of health harms by denying them access to a supervised space where prompt overdose response is available.
- | fentanyl citrate / Generic mfg.
Journal: "It's like super structural" - Overdose experiences of youth who use drugs and police in three non-metropolitan cities across British Columbia. (Pubmed Central) - Jul 30, 2021
Collaboration with police and local stakeholders is required to address the concerns of YWUD and to increase awareness and penetration of policies such as the GSDOA. Changes to policing cultures that prioritize health rather than criminalize YWUD may increase youth's trust of police and increase calls to 9-1-1.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Women's utilization of housing-based overdose prevention sites in Vancouver, Canada: An ethnographic study. (Pubmed Central) - Jul 30, 2021
Findings highlight how the low-barrier design and operation of HOPS can undermine women's engagement with HOPS. Overdose prevention strategies in SRAs should also include gender-specific models (e.g. women-only HOPS, women peer workers) to help mitigate barriers to these services within the context of the current overdose crisis.
- | fentanyl citrate / Generic mfg.
Journal: Exploring willingness to engage with law enforcement among syringe service program participants in New York City. (Pubmed Central) - Jul 30, 2021
Overdose prevention strategies in SRAs should also include gender-specific models (e.g. women-only HOPS, women peer workers) to help mitigate barriers to these services within the context of the current overdose crisis. Police investigations of both fatal and non-fatal drug overdose events have the potential to exacerbate mistrust of law enforcement and discourage emergency medical service utilization among PWUD.
- | fentanyl citrate / Generic mfg.
Journal: The protective effect of trusted dealers against opioid overdose in the U.S. (Pubmed Central) - Jul 30, 2021
Interpersonal relationships between individuals who use drugs and their suppliers strongly influence the risk and protective factors experienced by people who use drugs in today's opioid overdose epidemic. Evidence-based prevention strategies that are based on an awareness of-or even designed to harness-those positive and/or protective relationships that people who use drugs have already constructed for themselves are likely merited.
- || methadone / Generic mfg.
Clinical, Journal: The Effect of Intraoperative Methadone During Pediatric Cardiac Surgery on Postoperative Opioid Requirements. (Pubmed Central) - Jul 30, 2021
Use of intraoperative methadone appears to be a reasonable alternative to the use of fentanyl with potential other benefits both intra- and postoperatively of decreased total dose of opioids and other sedatives. Future studies will assess for any improvement in total postoperative opioid requirements during the total hospital stay, and potential use of methadone by the ICU team.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methadone / Generic mfg.
Reimbursement, Journal, Medicare: State Medical Cannabis Laws Associated With Reduction in Opioid Prescriptions by Orthopaedic Surgeons in Medicare Part D Cohort. (Pubmed Central) - Jul 30, 2021
Orthopaedic surgeons are among the highest prescribers of opioids, highlighting the importance of providing nonopioid analgesic alternatives in efforts to reduce opioid use in the patient cohort. This study is the first to examine the association between implementation of state cannabis laws and prescribing patterns for opioids by orthopaedic surgeons in Medicare Part D patients.
- | fentanyl citrate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Journal: Tackling the overdose crisis: The role of safe supply. (Pubmed Central) - Jul 30, 2021
In view of the persistent gaps in services and the limitations of available options, immediate scale-up of low-barrier opioid distribution programs are urgently needed. This includes "off-label" prescription of pharmaceutical grade opioids (e.g., hydromorphone) to disrupt the toxic drug supply and make safer opioids widely available to people at high risk of fatal overdose.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl self-testing in a community-based sample of people who inject drugs, San Francisco. (Pubmed Central) - Jul 30, 2021
Efforts to promote the use of FTS may have reached under half of PWID in San Francisco. Avenues need to be found to increase the role of FTS as a harm reduction approach to prevent overdose, particularly for older and Black/African American PWID.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Opioid Ontopolitics: Industrial Capitalism, Metabolic Rift, and the Power of Things. (Pubmed Central) - Jul 30, 2021
Do we consume drugs, or do drugs consume us, or both? Is there a Golden Rule in relationships between people and things-do the things with which we interact do to us what we do to them?
- || fentanyl citrate / Generic mfg., methadone / Generic mfg.
Clinical, Journal: One year of methadone maintenance treatment in a fentanyl endemic area: Safety, repeated exposure, retention, and remission. (Pubmed Central) - Jul 30, 2021
This study suggests MMT is safe despite repeated exposure to fentanyl while taking methadone. Remission is achievable, and MMT is protective against death among fentanyl-exposed patients while in treatment.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Elevated prevalence of self-reported unintentional exposure to fentanyl among women who use drugs in a Canadian setting: A cross-sectional analysis. (Pubmed Central) - Jul 30, 2021
Women were more than two times as likely to self-report they were unintentionally exposed to fentanyl compared to men. These findings highlight the urgent need to further understand experiences of gender-based risk differences and develop gender-focused interventions and policies aimed at preventing drug-related harm.
- | fentanyl citrate / Generic mfg.
Journal: Agency in the fentanyl era: Exploring the utility of fentanyl test strips in an opaque drug market. (Pubmed Central) - Jul 30, 2021
When fentanyl presence is assumed, people used fentanyl test strips in unexpected ways to gain some control over their drug use. Novel uses for fentanyl test strips strengthen existing strategies used to navigate the drug market and mitigate overdose risk, and highlight their potential to quickly disseminate valuable information about the local drug supply.
- || hydromorphone hydrochloride / Generic mfg.
Clinical, Journal: Motivations to initiate injectable hydromorphone and diacetylmorphine treatment: A qualitative study of patient experiences in Vancouver, Canada. (Pubmed Central) - Jul 30, 2021
Novel uses for fentanyl test strips strengthen existing strategies used to navigate the drug market and mitigate overdose risk, and highlight their potential to quickly disseminate valuable information about the local drug supply. Participants descriptions of their motivations to initiate HDM/DAM highlight how structural vulnerabilities shaped participants' experiences initiating injectable HDM/DAM.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Implementation of a Spinal Anesthesia and Sedation Protocol that Reliably Prolongs Infant Spinal Anesthesia: Case Series of 102 Infants who received Spinal Anesthesia for Urologic Surgery. (Pubmed Central) - Jul 30, 2021
We describe the successful implementation of an infant spinal anesthesia and sedation protocol and a technique that uniquely provides prolonged surgical anesthesia with a low failure rate. We also report shorter anesthesia time, surgical time, and recovery room length of stay in patients who received spinal anesthesia compared to general anesthesia.
- | fentanyl citrate / Generic mfg.
Journal: US drug overdose mortality: 2009-2018 increases affect young people who use drugs. (Pubmed Central) - Jul 30, 2021
We also report shorter anesthesia time, surgical time, and recovery room length of stay in patients who received spinal anesthesia compared to general anesthesia. Rapid changes in the demographics of overdose demonstrate distinct but overlapping US overdose sub-epidemics, and highlight the need for targeted interventions to reduce overdose risk in young people.
- | fentanyl citrate / Generic mfg., methamphetamine / Generic mfg., methadone / Generic mfg.
Journal: Supplying synthetic opioids during a pandemic: An early look at North America. (Pubmed Central) - Jul 30, 2021
Drug policy will need to evaluate market indicators as soon as they are available but responding now with expanded medication therapies, like methadone, may help save lives. The drug policy landscape could look different in a post-COVID world.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl analogs on the Swedish webforum flashback: Interest and impact of scheduling. (Pubmed Central) - Jul 30, 2021
The biggest effect sizes were from the narcotics scheduling of 2-Me-MAF, acryl, and acetyl fentanyl, while furanyl fentanyl saw the biggest reduction after health scheduling. The reductions were bigger for narcotics scheduling compared to health scheduling.
- | fentanyl citrate / Generic mfg.
Journal: Regional Anesthesia for Clavicle Fracture Surgery is Safe and Effective. (Pubmed Central) - Jul 30, 2021
Regional anesthesia using a combined brachial plexus and modified superficial cervical plexus block is a reliable, efficacious technique. The combined block appears to be a reasonable alternative to general anesthesia with an interscalene brachial plexus block, and it may have benefits regarding the anesthesia start time and total case time.
- || fentanyl citrate / Generic mfg., methadone / Generic mfg.
Clinical, Journal: Differences in Opioid Overdose Mortality Rates Among Middle-Aged Adults by Race/Ethnicity and Sex, 1999-2018. (Pubmed Central) - Jul 30, 2021
The combined block appears to be a reasonable alternative to general anesthesia with an interscalene brachial plexus block, and it may have benefits regarding the anesthesia start time and total case time. Policy making should consider unique subgroup risks and alternative trajectories of opioid use other than people being prescribed opioids, developing opioid use disorder, subsequently moving to heroin, and then to fentanyl.
- | fentanyl citrate / Generic mfg.
Journal: "I couldn't live with killing one of my friends or anybody": A rapid ethnographic study of drug sellers' use of drug checking. (Pubmed Central) - Jul 30, 2021
Our findings reposition drug sellers as embedded within their communities and demonstrate their potential role in alleviating the dangers of the volatile fentanyl market. Policies that target people who sell drugs, particularly murder or manslaughter charges, are likely to make the crisis worse, and serious consideration should be put into harm reduction approaches with drug sellers.
- | fentanyl citrate / Generic mfg.
Reimbursement, Journal, Medicare: Overdose deaths from nonprescribed prescription opioids, heroin, and other synthetic opioids in Medicare beneficiaries. (Pubmed Central) - Jul 30, 2021
There were substantial increases in patients' obtaining opioid analgesics from unlicensed sources and in overdose deaths from nonprescribed opioids during the study period (2012-2016). Increased access to pain management and opioid use disorder treatments is critical to reducing the opioid overdose deaths in the United States.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Competing risks of women and men who use fentanyl: "The number one thing I worry about would be my safety and number two would be overdose". (Pubmed Central) - Jul 30, 2021
Experiences with overdose and risk communication among people who use fentanyl-containing opioids varied by gender. The development of gender-responsive programs that address targeted concerns may be an avenue to enhance engagement with harm reduction and treatment services and create safe spaces for women not currently accessing available services.
- | fentanyl citrate / Generic mfg.
Journal: The discounting of death: Probability discounting of heroin use by fatal overdose likelihood and drug purity. (Pubmed Central) - Jul 30, 2021
Prior to completing the probability-discounting tasks, participants were randomized to read one of four prompts varying by the presence of information on heroin effects and active (e.g., fentanyl) or inert impurities...Expanded access to drug checking services, which inform impurity and overdose risk, can reduce fatal overdoses. Due to fear of legal sanctions for these services, legislation and judicial decisions should explicitly protect these services.
- fentanyl citrate / Generic mfg.
[VIRTUAL] Late Breaking Abstract - Less invasive surfactant administration (LISA) to preterm infants on high flow nasal cannula (nHFT). (Channel 3) - Jul 29, 2021 - Abstract #ERS2021ERS_4513;
nHFT-LISA was feasible and well tolerated without use of premedication. The use of premedication should be reserved for babies in whom procedural difficulties are expected, this will depend on baby’s tone, size or gestation.
- midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
[VIRTUAL] Monitored Anesthesia Care with Dexmedetomidine in Patients Undergoing Pleuroscopy: Effect on Oxygenation and Respiratory Function. A Prospective, Single-center Study. () - Jul 29, 2021 - Abstract #ERS2021ERS_3652;
This study demonstrated that dexmedetomidine use provides a lower decrease in FEV1 after pleuroscopy, reduces significantly the consumption of other sedatives and analgesics and accelerates postoperative awakening. Therefore dexmedetomidine can constitute a valuable alternative sedation agent in patients undergoing pleuroscopy, given its superior pharmacokinetic and pharmacodynamic profile.
- pethidine / Samaritan
[VIRTUAL] Non intubated surgery in empyema thoracis () - Jul 29, 2021 - Abstract #ERS2021ERS_2947;
2. The procedure is not only technically feasible and cost-effective, but may be also a safe and less invasive alternative.
- midazolam hydrochloride / Generic mfg.
[VIRTUAL] Sedative medications in COVID-19 positive ARDS patients undergoing tracheostomy () - Jul 29, 2021 - Abstract #ERS2021ERS_1935;
Fentanyl was used in 38 (69.1%), dexmedetomidine in 28 (50.9%), midazolam in 13 (23.6%), hydromorphone in 13 (23.6%), and propofol in 12 (21.8%) patients. In a small cohort of 55 COVID-19 ARDS patients, we were able to describe significantly decreased SAM administritation, improved sedation parameters, and improved physical functioning.
- || paracetamol / Generic mfg.
Clinical, Journal, Monotherapy: Comparison of Monotherapy Versus Combination of Intravenous Ibuprofen and Propacetamol (Acetaminophen) for Reduction of Postoperative Opioid Administration in Children Undergoing Laparoscopic Hernia Repair: A Double-Blind Randomized Controlled Trial. (Pubmed Central) - Jul 29, 2021
In a small cohort of 55 COVID-19 ARDS patients, we were able to describe significantly decreased SAM administritation, improved sedation parameters, and improved physical functioning. The use of ibuprofen plus propacetamol immediately following laparoscopic hernia repair surgery in children resulted in the reduced use of an opioid drug compared with the use of propacetamol alone.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Pediatric opioid fatalities: What can we learn for prevention? (Pubmed Central) - Jul 29, 2021
These pediatric ingestions have closely mirrored the opioid epidemic in adults transitioning from prescription medications to illicit drugs including fentanyl and fentanyl analogues...Accidental pediatric poisonings are preventable. Risk reduction through improving awareness and education of the dangers of opioids is a key factor in mitigating these tragedies.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl-related substance scheduling as an effective drug control strategy. (Pubmed Central) - Jul 29, 2021
Opposition to permanent class-wide was lodged due to concerns over law enforcement overreach, inadequate Health and Human Services input, and hindrance of research. This paper reaffirms the importance of a class-based scheduling strategy while also arguing for increased research of schedule I controlled substances.
- ||| fentanyl citrate / Generic mfg.
Opiod Hysteria leads 2 denial of safe Rx opiates 4 pain relief after surgery. Illegal fentanyl heroin cocaine meth are the killers. @RandPaul @CDCDirector @CDCgov @ (Twitter) - Jul 29, 2021
- ||| fentanyl citrate / Generic mfg.
Opiod Hysteria leads 2 denial of safe Rx opiates 4 pain relief after surgery. Illegal fentanyl heroin cocaine meth are the killers. @RandPaul @CDCDirector @CDCgov @ThomasKlineMD @DanLairdMD @rlamartini @DrNickels @VanilaSingh @MZHemingway @PattyMurray @DineshDSouza @CR @WSJhealth (Twitter) - Jul 29, 2021
- ||| fentanyl citrate / Generic mfg.
Usually very well with the distracting pain and using a fair amount of lidocaine infiltration. I try to avoid versed in the elderly but sometimes use fentanyl. (Twitter) - Jul 28, 2021
- || nafamostat / Generic mfg.
Clinical, P2 data, Journal: Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial. (Pubmed Central) - Jul 28, 2021
CRAI with NM did not inhibit the development of pancreatic necrosis although early analgesic effect of CRAI was superior to that of IV. Less-invasive IV therapy can be considered a viable alternative to CRAI therapy.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Electromyographic Comparison of the Efficacy of Ultrasound-guided Suprainguinal and Infrainguinal Fascia Iliaca Compartment Block for Blockade of the Obturator Nerve in Total Knee Arthroplasty: A Prospective Randomized Controlled Trial. (Pubmed Central) - Jul 28, 2021
Less-invasive IV therapy can be considered a viable alternative to CRAI therapy. Suprainguinal FICB significantly increased the incidence of successful obturator nerve block and significantly decreased fentanyl consumption 24 hours after TKA compared to infrainguinal FICB.