fentanyl citrate / Generic mfg. 
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  • ||||||||||  ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Acacia Pharma
    Clinical, Journal:  Anesthetic management of super-elderly patients with remimazolam: a report of two cases. (Pubmed Central) -  Sep 18, 2021   
    Remimazolam could be useful in general anesthesia, particularly for super-elderly patients. However, the appropriate dose for induction and maintenance of anesthesia should be carefully considered based on BIS or vital signs.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Evidence for the emergence of an opioid-resistant respiratory rhythm following fentanyl overdose. (Pubmed Central) -  Sep 17, 2021   
    When a similar injection was performed 30 minutes after the first injection, in a separate group of rats, an apnea and breathing depression was produced in 30% of the animals, while in the other rats, ventilation was unaffected. We conclude that the depressed regular respiratory activity emerging during and following fentanyl overdose is uniquely resistant to fentanyl.
  • ||||||||||  fentanyl citrate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Analysing wastewater to estimate fentanyl and tramadol use in major Chinese cities. (Pubmed Central) -  Sep 17, 2021   
    Temporally, there is a significant decrease in tramadol use in major cities of China from 2016 to 2019. The results of our study suggested that tramadol use in China was predominantly from pharmaceutical prescription and not as prevalent as in other countries.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Quantification of fentanyl analogs in oral fluid using LC-QTOF-MS. (Pubmed Central) -  Sep 17, 2021   
    The validated method was used to quantify fentanyl analogs in authentic oral fluid samples (n=17) from probationers/parolees. Fentanyl and 4-ANPP concentrations were 1.0-104.5 ng/mL and 1.2-5.7 ng/mL, respectively.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Clinical, Journal:  The association between initial opioid type and long-term opioid use after hip fracture surgery in elderly opioid-naïve patients. (Pubmed Central) -  Sep 16, 2021   
    The findings suggest that some elderly, opioid-naïve patients appear to be presented with untreated pain conditions when seen in the hospital for a hip fracture surgery. Decisions regarding the opioid type prescribed after hospitalization for hip fracture surgery may be linked to different indication for pain treatment, emphasizing the likelihood of careful and conscientious opioid prescribing behavior.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Preclinical, Journal:  In silico prediction, LC-HRMS/MS analysis, and targeted/untargeted data-mining workflow for the profiling of phenylfentanyl in vitro metabolites. (Pubmed Central) -  Sep 15, 2021   
    Illicit fentanyl and analogues have been involved in many fatalities and cases of intoxication across the United States over the last decade, and are becoming a health concern in Europe...Phase II transformations were infrequent, and the hydrolysis of the biological samples is not required to increase the detection capability of non-conjugated metabolites. The overall workflow is easily adaptable for the metabolite profiling of other novel psychoactive substances.
  • ||||||||||  fentanyl citrate / Generic mfg.
    PHM-08 - Will the Real Fentanyl Please Stand Up? (Gracia 1 / L3) -  Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_185;    
    Finally, we will detail the difficulty in reversing these types of overdoses, including the need for high-dose naloxone products. Learning Objectives: Recognize the multitude of factors responsible for the opioid overdose death rates across the United States, emphasizing the role of fentanyl analogues Delineate between various pharmaceutical and illicitly manufactured fentanyl compounds by physiochemical, pharmacodynamic, and pharmacokinetic characteristics that helps debunk common myths and mischaracterizations about this crisis Identify clinical situations in which higher dose naloxone products may be needed in the reversing overdoses involving fentanyl analogues
  • ||||||||||  fentanyl citrate / Generic mfg.
    The Association between Opioid Use Disorder and Childhood Adverse Experiences () -  Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_86;    
    ACEs are strongly associated with OUD, but there is little recognition of this link in the public or among those outside of the field of addiction medicine or psychology. Greater awareness of ACEs by health care professionals and efforts to reduce them may be an important and effective way to reduce OUD, as well as other potentially life-threatening substance use disorders.
  • ||||||||||  baclofen / Generic mfg.
    Retrospective comparison of the effectiveness of buprenorphine versus baclofen for acute opiate withdrawal () -  Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_78;    
    Greater awareness of ACEs by health care professionals and efforts to reduce them may be an important and effective way to reduce OUD, as well as other potentially life-threatening substance use disorders. Common ancillary medications administered included baclofen (95.8%), clonidine (83.3%) and clonazepam (37.5%)...Important to note, a greater number of patients in the buprenorphine arm presented with a positive fentanyl screening which could impact clinical outcomes...Further research is warranted to determine its comparable efficacy.
  • ||||||||||  oxycodone/acetaminophen / Generic mfg.
    Opioid Prescribing Patterns in an Emergency Department at a Veterans Affairs Hospital () -  Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_54;    
    Literature review suggests our ED opioid prescribing rates may be lower than other healthcare facilities, although there exists continued opportunities to reduce the rate of long-acting and injectable opioid use within the ED. Further conclusions will be made as data regarding trends continues to be analyzed.
  • ||||||||||  Anjeso (meloxicam IV) / Baudax Bio
    Meloxicam IV for the Management of Pain Following Radiofrequency Ablation (RFA) of the Spine: A Case Study () -  Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_47;    
    [3]In this case study, three of the 12 subjects treated with meloxicam IV had a reduction from baseline in pain intensity during the post procedural recovery period before discharge, and six subjects reported no pain compared to baseline. At the 24-hour post procedure assessment, five subjects had reductions in pain intensity from baseline, and one subject continued to be pain free.
  • ||||||||||  A Needle in a Haystack: OTC Analgesics in Our Opioid Crisis () -  Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_4;    
    Even though these medications are available without a prescription, or in other words, without any mandated healthcare professional guidance or recommendations, each year there continues to be approximately 50,000 acetaminophen-related emergency room (ER) visits annually in the United States. Considering that this study also involved other OTC pain medications known as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) including ibuprofen and naproxen, one can easily understand the need for more education, or perhaps even novel OTC pain medications with lower risk profiles.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Evaluation of fentanyl test strip distribution in two Mid-Atlantic syringe services programs. (Pubmed Central) -  Sep 15, 2021   
    There are no obvious reasons why these trends will not spread to other continents. Our findings demonstrate that FTS programs could be helpful in promoting fentanyl awareness and risk reduction among PWUD and in monitoring the evolving drug supply in areas where comprehensive community-based drug checking programs have not been established.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Kratom Use Within the Context of the Evolving Opioid Crisis and the COVID-19 Pandemic in the United States. (Pubmed Central) -  Sep 14, 2021   
    Since 2015, efforts to restrict access to prescription opioids have resulted in a marked increase in the use of "street" opioids such as heroin and illicit fentanyl...The lack of access to care for patients with chronic pain and opioid use disorder has been magnified by the emergence of the COVID-19 pandemic. In this report, we highlight how these converging factors have led to a surge in interest in kratom as a potential harm reduction agent in the treatment of pain and opioid use disorder.
  • ||||||||||  midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  Dexmedetomidine combined with midazolam infusion guided by bispectral index during bronchoscopy. (Pubmed Central) -  Sep 12, 2021   
    The conscious sedation regimen of dexmedetomidine combined with midazolam monitored by BIS is considered to be safe and effective during bronchoscopy. The occurrence of hypoxia and tachycardia was less, and the fluctuation of blood pressure and heart rate was mild, but the proportion of bradycardia in dexmedetomidine group was higher than that in fentanyl combined with midazolam group.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Treating Fentanyl Withdrawal. (Pubmed Central) -  Sep 11, 2021   
    Fentanyl withdrawal is common, but pharmacological management has largely mirrored traditional approaches to opioid withdrawal. Observations in a large urban center suggest alternative approaches, including the need for dose modification, should be considered.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  The opioid overdose crisis as a global health challenge. (Pubmed Central) -  Sep 11, 2021   
    Furthermore, outside of North America, more countries like Estonia, Lithuania, Sweden, Finland, and Norway show very concerning numbers. Without a consistent system response, effects will be devastating.
  • ||||||||||  ticagrelor / Generic mfg., oxycodone/acetaminophen / Generic mfg.
    [VIRTUAL] Opiates can Lower Ticagrelor P2Y12 Activity in Neuroendovascular ICU Patients () -  Sep 10, 2021 - Abstract #NCS2021NCS_263;    
    Therefore, digital subtraction angiogram performed confirming intra-stent thrombosis of right MCA with successful thrombectomy and intra-arterial tirofiban followed by aspirin and ticagrelor load...During hospitalization, the patient received boluses of fentanyl for pain averaging at 175 mcg per day...The patient takes oxycodone- acetaminophen for chronic pain management as an outpatient...Lower drug concentration and reduced platelet activity of ticagrelor was noted from co- administration with opiates. This case describes clinical consequences of such drug-drug interactions and possible avoidance of co-administration of these agents.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Trends in substances involved in polysubstance overdose fatalities in Maryland, USA 2003-2019. (Pubmed Central) -  Sep 10, 2021   
    Most individual substances became less common over time, while cocaine and fentanyl involvement increased. Unintentional fentanyl consumption through contaminated cocaine may be an increasingly important driver of deaths in Maryland, indicating the importance of implementing widespread harm reduction programs, especially drug checking.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    PREHOSPTIAL PAIN MANAGEMENT IS EFFECTIVE AND SAFE BUT UNDERUTILIZED IN TRAUMA PATIENTS () -  Sep 9, 2021 - Abstract #AAST2021AAST_207;    
    The use of opioids in the prehospital setting significantly reduced pain among injured patients with few adverse events. Despite its efficacy and safety, the majority of patients with major injuries and severe pain do not receive opioid analgesia in the prehospital setting.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Syringe Coverage Among People Who Inject Drugs in West Virginia, USA. (Pubmed Central) -  Sep 9, 2021   
    Having exclusively acquired syringes from a syringe services program was associated with increased odds of adequate syringe coverage. Rural PWID may benefit from tailored interventions designed to increase sterile syringe access.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Decontamination options for indoor surfaces contaminated with realistic fentanyl preparations. (Pubmed Central) -  Sep 9, 2021   
    In nearly all cases, the spray application of peracetic acid or acetified bleach oxidants resulted in statistically significant degradation of fentanyl (>95% reduction), with noticeably lower efficacy for other oxidants (e.g., pH neutral bleach and OxiClean™). The decontamination efficacy was significantly reduced upon the addition of cutting agents that competed for oxidant demand.
  • ||||||||||  lorazepam / Generic mfg.
    A Life-Saving Abdominal CT Revealing a Spontaneous Esophageal Rupture (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_2696;    
    Urine toxicology was positive for fentanyl...Afterwards, he developed two tonic-clonic seizure episodes, aborted with lorazepam...This case highlights that Boerhaave's syndrome should be suspected in patients with intractable vomiting and seizure disorder, as prompt clinical recognition is fundamental to prevent life-threatening consequences.Figure: Figure 1- Panel A: CT scan of the abdomen showing a small foci of air adjacent to the esophagus within the mediastinum. Panel B, C: CT scan of the chest showing chest pneumomediastinum extending into the cervical soft tissues.