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- lorazepam / Generic mfg.
Brugada Syndrome With Seizure History. How Would You Induce? (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4348;
Patient for observation. Discharged home next day with no further episodes or follow-up needed.
- fentanyl citrate / Generic mfg.
A Case Of Severe Serotonin Syndrome Triggered By Perioperative Administration Of Fentanyl (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4296;
Immediately after receiving fentanyl prior to induction, he developed hypertensive emergency, myoclonic twitching, inducible clonus, agitation, and confusion. Neuroimaging ruled out CVA, he was admitted to the ICU and recovered with supportive care and withholding offending medications.
- fentanyl citrate / Generic mfg.
A Case Of Intrathecal Fentanyl Pump Failure Leading To Hypercapnic, Hypoxic Respiratory Failure (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4275;
He was treated with a naloxone gtt and admitted to the ICU with bradycardia, hypercapnic/hypoxic respiratory failure and lactic acidosis. He was eventually weaned off naloxone and followed up outpatient for further pump evaluation.
- midazolam hydrochloride / Generic mfg.
Anesthetic Management Of A Pediatric Liver Transplant In A Patient With Family History Of Malignant Hyperthermia (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4217;
Anesthesia was maintained with infusions of fentanyl, midazolam and propofol. He tolerated the procedure well and extubated within the next 24 hours.
- fentanyl citrate / Generic mfg., remifentanil / Generic mfg., sevoflurane / Generic mfg.
Compromised Compliance: Chest Wall Rigidity And Glottic Closure After Opioid Administration (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4113;
25 mcg of fentanyl was administered for pain and apnea was noted, with steeply declining oxygen saturation thereafter. We discuss chest wall rigidity and glottic closure after the administration of opioid medications.
- fentanyl citrate / Generic mfg.
Inadvertent Total Spinal Anesthesia After An Epidural Injection In An Advanced Labor Patient (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4057;
Bolus dose of 100 mcg Fentanyl and 6ml of Chloroprocaine was injected...Pt was emergently taken to the OR and stat Cesarean section performed under General Anesthesia. Patient was extubated at end with no issues.
- midazolam hydrochloride / Generic mfg.
Management Of A Patient With Restless Leg Syndrome Who Underwent Foot Surgery After Receiving Peripheral Nerve Blocks (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4047;
Further evaluation revealed a history of restless leg syndrome (RLS). We suggest routinely asking patients about a history of RLS for those undergoing lower extremity surgery where peripheral nerve block will be used as surgical analgesia.
- Intraoperative Management Of A 19-year-old Male With Past History Of Double Outlet Right Ventricle With Transposition Of The Great Arteries Status-post Fontan Procedure With Tonsillar Hemorrhage (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_3569;
We performed a pre-induction arterial line, followed by a slow and controlled induction using etomidate, fentanyl, and rocuronium for intubation with indirect laryngoscopy. Further peripheral access was obtained, and he was maintained on sevoflurane, dexmedetomidine, and vasopressin boluses.
- fentanyl citrate / Generic mfg.
Consideration Of Patient Personal Well-being In Anesthesia Planning: Anesthesia Management For A Combined Scleral Buckle And Vitrectomy In A 40 Year-old, G5p0 Woman (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_3541;
Patient was sedated with a mixture of propofol, lidocaine, alfentanil and fentanyl...The fetus was normal post-surgery. She delivered a healthy baby 4 months later and has been updating the anesthesiologist yearly regarding her only child's well-being, who is seven now.
- ketamine / Generic mfg.
Management Of Intractable Abdominal Pain Secondary To Acute Gallstone Pancreatitis, Including The Use Of Ketamine (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_3486;
He was started on PCA in SICU. This case discusses management strategies of intractable pain secondary to acute gallstone pancreatitis, including the use of ketamine.
- fentanyl citrate / Generic mfg.
A Case Of Wooden Chest Syndrome (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_3483;
WCS involves rigidity of chest and abdominal wall making ventilation difficult. Our patient probably had WCS secondary to fentanyl administration but was not diagnosed due to her multiple comorbidities including lung disease
- fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
SAT09. Wasted Opportunity: Engaging Anesthesiologists in Optimizing the Use of Controlled Substance Intravenous Push Products (Upper 6F) - Sep 25, 2021 - Abstract #ASA2021ASA_3380;
A recent continuous observation workflow time study conservatively estimated total combined product and workforce waste per year for a subsect of patient care areas. Anesthesiologists are uniquely positioned to lead efforts to reduce unnecessary drug waste, adhere to best practices, and limit drug diversion opportunity.
- || fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
Clinical, Journal: Supine versus semi-Fowler's positions for tracheal extubation in abdominal surgery-a randomized clinical trial. (Pubmed Central) - Sep 25, 2021
Anesthesiologists are uniquely positioned to lead efforts to reduce unnecessary drug waste, adhere to best practices, and limit drug diversion opportunity. Tracheal extubation in the semi-Fowler's position is associated with less coughing, sputum suction, and pain, and more comfort, without specific adverse effects when compared to the conventional supine position.
- || dexmedetomidine / Generic mfg.
Clinical, Journal: The efficacy and safety of intrathecal dexmedetomidine for parturients undergoing cesarean section: a double-blind randomized controlled trial. (Pubmed Central) - Sep 25, 2021
Tracheal extubation in the semi-Fowler's position is associated with less coughing, sputum suction, and pain, and more comfort, without specific adverse effects when compared to the conventional supine position. DEX is a potential local anesthetic adjuvant that the intrathecal combination of 5 μg DEX can safely exhibit a facilitatory block effect and improve parturients' recovery quality.
- | fentanyl citrate / Generic mfg.
Journal: The dawn of a new synthetic opioid era: the need for innovative interventions. (Pubmed Central) - Sep 25, 2021
Novel interventions worth examining include supervising drug use, proactively deterring on-line distribution and new technologies aimed at improving transparency, such as point-of-use drug content testing. Continuing to approach this problem only with existing policies and available methods, such as naloxone, is unlikely to be enough and will result in many premature deaths.
- | fentanyl citrate / Generic mfg.
Journal: Carfentanil and the Rise and Fall of Overdose Deaths in the United States. (Pubmed Central) - Sep 25, 2021
The 2016-2017 acceleration and then 2018 decline in drug overdose deaths in the United States was associated with the sudden rise and then fall of carfentanil availability. Given the regional variation, carfentanil's decreased availability may have contributed to the reduction in overdose deaths in 2018.
- | fentanyl citrate / Generic mfg.
Journal: Age-based Preferences for Risk Communication in the Fentanyl Era: "A lot of people keep seeing other people die and that's not enough for them." (Pubmed Central) - Sep 25, 2021
Among people who engage in illicit fentanyl use, fentanyl-related risk communication experiences and preferences may vary by age, but some foundational elements including compassionate, trust-building approaches seem to be preferred across the age spectrum. Structural barriers in the clinical setting such as provider prescribing power and infrequent encounters may impede providers' ability to provide compassionate harm reduction communication.
- | dexmedetomidine / Generic mfg.
Retrospective data, Journal: Supplementation With Dexmedetomidine for Transsphenoidal Resection of Pituitary Adenoma: A Meta-Analysis of Randomized Controlled Trials. (Pubmed Central) - Sep 25, 2021
Structural barriers in the clinical setting such as provider prescribing power and infrequent encounters may impede providers' ability to provide compassionate harm reduction communication. Dexmedetomidine supplementation was effective in improving hemodynamic stability for transsphenoidal resection of pituitary adenoma.
- || fentanyl citrate / Generic mfg.
Another overdose death from illegal fentanyl heroin & cocaine. Rx opiods NOT involved. Rarely do Rx opiods cause accidental ODs @CR @RandPaul @CDCDirector @CDCgov @US_FDA @HHSGov @VanilaSingh @MarshaBlackburn @PattyMurray @MZHemingway @WSJhealth @NYTHealth https://t.co/R1guPyWsHR (Twitter) - Sep 24, 2021
- || fentanyl citrate / Generic mfg.
Clinical, Journal: First Polish case of fatal single-substance poisoning with cyclopropylfentanyl, a new synthetic opioid. (Pubmed Central) - Sep 24, 2021
The article presents the first Polish case of fatal single-substance poisoning with cyclopropylfentanyl, a representative of fentanyl derivatives, whose victim was a 37-year-old man...Blood and urine samples were analyzed using liquid chromatography with mass spectrometry. The concentration of cyclopropylfentanyl was 24 ng/mL in blood and 73 ng/mL in urine.
- || fentanyl citrate / Generic mfg.
I was so moved by The Wire many yrs ago. The complexity of characters who used drugs was revolutionary. Michael K. Williams' character especially resonated with me Fentanyl’s killing more ppl than ever. We must do everything possible to prevent OD deaths https://t.co/4mxIkYgi0n (Twitter) - Sep 24, 2021
- midazolam hydrochloride / Generic mfg.
[VIRTUAL] Results of a Randomized Study to Understand the Patient Experience of Pain and Satisfaction During Cardiac Catheterization Using an Interval of Time (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_6429;
However, the findings suggest that longer intervals may reduce reported pain among patients undergoing PCI. Further investigation of sedation timing during PCI is needed to potentially improve the patient experience.
- || fentanyl citrate / Generic mfg., methadone / Generic mfg.
Clinical, Journal: Remotely delivered incentives to promote buprenorphine treatment engagement in out-of-treatment adults with opioid use disorder. (Pubmed Central) - Sep 24, 2021
Further investigation of sedation timing during PCI is needed to potentially improve the patient experience. Remotely delivered incentives can connect out-of-treatment adults with opioid use disorder to treatment, but additional supports are needed to promote buprenorphine adherence.
- | fentanyl citrate / Generic mfg.
Journal: "Etazene, safer than heroin and fentanyl": Non-fentanyl novel synthetic opioid listings on one darknet market. (Pubmed Central) - Sep 24, 2021
This increased heterogeneity of available novel synthetic opioids could reduce the efficiency of existing overdose prevention strategies. Identification of new opioids underpins the value of cryptomarket data for early warning systems of emerging substance use trends.
- || alprazolam / Generic mfg.
Clinical, Journal: Opioid deaths involving concurrent benzodiazepine use: Assessing risk factors through the analysis of prescription drug monitoring data and postmortem toxicology. (Pubmed Central) - Sep 24, 2021
MAPS scores did not adequately predict risk of opioid-related death. Contrary to expectations, prescription opioid use was not correlated with opioid-related death, whereas concurrent use of opioids and benzodiazepines represented a highly significant risk factor.
- || fentanyl citrate / Generic mfg.
Reimbursement: Prior Auth Pergatory. Insurance company won't cover Fentanyl 37.5. Ask for 2 scripts - one for 25 and another for 12. Require a Prior Auth for each script. Chaching Chaching wasted time and money. #LimitPriorAuths @AmerMedicalAssn (Twitter) - Sep 23, 2021
- midazolam hydrochloride / Generic mfg.
PROLONGED QT DURING ANAESTHESIA FOR PEDIATRIC CADAVERIC LIVER TRANSPLANTATION: A CASE REPORT () - Sep 23, 2021 - Abstract #ESOT2021ESOT_1864;
The anesthesia was induced with propofol 3 mg/kg, fentanyl 2 mcg/kg and rocuronium 1 mg/kg...Sevoflurane administration was stopped, and midazolam iv infusion (0.2 mg/kg/h) was started...The LQT is associated with liver dysfunction and hyperdynamic circulatory syndrome typical of cirrhotic patients 4 . Therefore, it is necessary to prevent severe ventricular arrhythmias during LT by optimizing electrolyte balance and avoiding drugs that can prolong QT through accurate hourly analysis of ECG and kalemia during LT.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Pseudo-addiction in cancer patients and rapid-release fentanyl for breakthrough pain: An increasingly common concern. (Pubmed Central) - Sep 23, 2021
Therefore, it is necessary to prevent severe ventricular arrhythmias during LT by optimizing electrolyte balance and avoiding drugs that can prolong QT through accurate hourly analysis of ECG and kalemia during LT. No abstract available
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Correlates of injection-related wounds and skin infections amongst persons who inject drugs and use a syringe service programme: A single center study. (Pubmed Central) - Sep 23, 2021
Risk factors associated with wounds and skin infections amongst persons who inject drugs may have changed in the era of fentanyl and now stimulant coinjection...Given the high prevalence of wounds in syringe services programme clients, wound care clinicians can make a significant difference and improve outcomes. We also shed light on correlates of wounds and skin infections in persons who inject drugs in order to spur further research to devise efficacious interventions for this underserved group.
- || fentanyl citrate / Generic mfg.
I know!!! That's one of the many things that drove me crazy because it's simply nuts & shows zero understanding of how drug markets actually work. Fentanyl did not appear on market due to demand, it was cheaper to supply. (Twitter) - Sep 22, 2021
- | fentanyl citrate / Generic mfg.
Clinical, Journal: Correlates of experiencing and witnessing non-fatal opioid overdoses among individuals accessing harm reduction services in Philadelphia, Pennsylvania. (Pubmed Central) - Sep 22, 2021
Factors associated with witnessing an overdose were unstable housing (aOR: 5.14; 95% CI: 2.57-10.28), recent incarceration (aOR: 2.88; 95% CI: 1.24-6.74), and a history of being trained to use naloxone (aOR: 3.39; 95% CI: 1.63-7.04). Findings presented here show characteristics of those most likely to witness an overdose or experience a non-fatal overdose who could be served by expansion of OEND programs.
- | fentanyl citrate / Generic mfg.
Journal: Temporal changes in non-fatal opioid overdose patterns among people who use drugs in a Canadian setting. (Pubmed Central) - Sep 22, 2021
Background and Aims: Little is known about how the expansion of opioid agonist therapy (OAT) and emergence of fentanyl in the illicit drug supply in North America has influenced non-fatal opioid overdose (NFOD) risk...Notably, there was a sudden increase in reports of overdose following exposure to unknown substances since 2015, the majority of whom reported no recent addiction treatment engagement. Further study into patterns of substance use and strategies to improve addiction treatment engagement is needed to improve and focus overdose prevention efforts.
- || fentanyl citrate / Generic mfg.
Clinical, PK/PD data, Journal: The influence of cardiac output on propofol and fentanyl pharmacokinetics and pharmacodynamics in patients undergoing abdominal aortic surgery. (Pubmed Central) - Sep 22, 2021
The model predicted (not observed) CO values correlated best with measured responses. Patients' age was identified as a covariate affecting the rate of CO changes during the anesthesia leading to age-related difference in individual patient's responses to both drugs.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Unusually High Concentration of Fentanyl in a Driver: A Case Report. (Pubmed Central) - Sep 22, 2021
Data presented on fentanyl in ante-mortem cases over time from several regions of North America show geographic differences on whether fentanyl concentrations are increasing. This case is an example of a blood concentration that could have been assumed to be fatal if presented on its own; a reminder that concentrations, especially those of opioids, must be interpreted with care.
- | fentanyl citrate / Generic mfg.
Journal: Long-Term Stability of 13 Fentanyl Analogs in Blood. (Pubmed Central) - Sep 22, 2021
Samples suspected to contain fentanyl analogs are recommended to be stored refrigerated or frozen with limited freeze/thaw cycles. Due to instability, in the event of an acrylfentanyl overdose, samples should be analyzed immediately or stored frozen with analysis within 1 month.
- | fentanyl citrate / Generic mfg.
Journal: Circumstances, Postmortem Findings, Blood Concentrations and Metabolism in a Series of Methoxyacetylfentanyl Related Deaths. (Pubmed Central) - Sep 22, 2021
Due to instability, in the event of an acrylfentanyl overdose, samples should be analyzed immediately or stored frozen with analysis within 1 month. Methoxyacetylfentanyl is one of many fentanyl analogs available as new psychoactive substances...No abstract available
- | fentanyl citrate / Generic mfg.
Journal: Acute Intoxications Involving Valerylfentanyl Identified at the New York City Office of Chief Medical Examiner. (Pubmed Central) - Sep 22, 2021
Valerylfentanyl is a relatively unknown fentanyl analog with limited information in the scientific literature. This study presents the first publication detailing a series of postmortem cases involving valerylfentanyl in acute intoxications and includes key demographic information and femoral blood concentrations for improved interpretation and analysis.
- || dexamethasone / Generic mfg.
Retrospective data, Review, Journal: The Facilitatory Effects of Adjuvant Pharmaceutics to Prolong the Duration of Local Anesthetic for Peripheral Nerve Block: A Systematic Review and Network Meta-analysis. (Pubmed Central) - Sep 22, 2021
These findings provide evidence for the consideration of dexmedetomidine, dexamethasone, and clonidine as adjuvants to prolong the duration of PNB. The addition of dexamethasone to ropivacaine has a longer time of FAR compared with clonidine or dexmedetomidine.
- | cebranopadol (GRT6005) / Assertio, Grunenthal
Journal: Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates. (Pubmed Central) - Sep 22, 2021
Similar to nociceptin/μ receptor partial agonists, cebranopadol displayed reduced side effects, such as a lack of respiratory depression and pruritus. Although cebranopadol showed reduced reinforcing strength, its detectable reinforcing effects and strength warrant caution, which is critical for the development and clinical use of cebranopadol.
- | Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Journal: Atypical opioids and their effect on respiratory drive. (Pubmed Central) - Sep 22, 2021
In addition, experimental hypercapnic stress in healthy volunteers demonstrated no respiratory depression following the administration of a single dose of the buccal film formulation of buprenorphine when compared with placebo. Overall, the data suggest that atypical opioids may be a safer option than conventional opioids for the treatment of pain.
- | fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Which illicit drugs are injected in Oslo? A study based on analysis of drug residues in used injection equipment and self-reported information. (Pubmed Central) - Sep 21, 2021
Overall, the data suggest that atypical opioids may be a safer option than conventional opioids for the treatment of pain. Analysis of the injection equipment proved useful as a non-invasive, rapid and accurate means to obtain detailed information on injected drugs in Oslo and supplement traditional PWID survey information.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Effectiveness of Sublingual Buprenorphine and Fentanyl Pump in Controlling Pain After Open Cholecystectomy. (Pubmed Central) - Sep 21, 2021
In the early hours after surgery (2 and 6 hours), nausea and vomiting were lower in the buprenorphine group than in the fentanyl group even though the difference was not significant. This study suggests buprenorphine as an effective drug for patients to reduce postoperative pain because of its limited complications, inexpensiveness, and more convenient administration method.
- lansoprazole / Generic mfg., amitriptyline / Generic mfg.
[VIRTUAL] Untangling the Gut: A Phenome-Wide Association Study of Drugs and Diseases with Gastrointestinal Dysfunction in Systemic Sclerosis () - Sep 21, 2021 - Abstract #ACRCONVERGENCE2021ACR_CONVERGENCE_2090;
Using the diagnosis and drug dictionaries, we identified 673 diagnoses (including ANAs) and 634 drugs. Top drugs (prevalence): omeprazole 56%, losartan 49%, lansoprazole 42%, and mycophenolate mofetil (MMF) 40%; top diagnoses: limited SSc 65%, Raynaud’s 50%, interstitial lung disease (ILD) 36%, and overlap 27%.
- ||||| fentanyl citrate / Generic mfg.
Clinical: Real-word user case of oral fentanyl in the management of prehospital trauma pain and its implication for civilian mass casualty response. An experience from @LDNairamb https://t.co/4uqZYBwXK4 @gareth_grier @Amcdonald_1 @IofPHC @BJAJournals @HughHemmings (Twitter) - Sep 21, 2021
- | fentanyl citrate / Generic mfg.
* illicit fentanyl. ... My bad. (Twitter) - Sep 21, 2021
- || fentanyl citrate / Generic mfg.
Raise you one: serotonin syndrome from fentanyl + linezolid from @MayoClinicINFD @omarabusaleh15 et al https://t.co/e98yjI3cnp (Twitter) - Sep 20, 2021
- |||| fentanyl citrate / Generic mfg.
Clinical: Stop trying 2 make a name for yourself off the agony of people in real pain. If U want 2 help this situation. Realize the people that need help are the ones dying from ILLICIT FENTANYL POISONING in the black market that was created when meds were taken from innocent pts (Twitter) - Sep 20, 2021
- | fentanyl citrate / Generic mfg.
Journal: French trends in the misuse of Fentanyl: From 2010 to 2015 (Pubmed Central) - Sep 19, 2021
Our results report significant and worrying misuse of transmucosal fentanyl formulations with wide off-label use and also primary dependence on fentanyl, regardless of galenic formulation, in patients treated for chronic non cancer pain. Given the significant risks of fentanyl, it is necessary to continue the monitoring of misuse, in particular, thanks to the activities of the French Addictovigilance network allowing a multisource approach and who provides information concerning cases of abuse, misuse and dependence.
- | labetalol / Generic mfg.
Retrospective data, Journal: Pharmacological strategies to prevent haemodynamic changes after intubation in parturient women with hypertensive disorders of pregnancy: A network meta-analysis. (Pubmed Central) - Sep 19, 2021
The maximal heart rate was lowest for labetalol (99.9%) followed by high dose of remifentanil (81.2%) and fentanyl (61.6%). High-dose remifentanil produces minimum blood pressure changes, while labetalol is most effective in maintaining normal heart rate in parturient women with hypertensive disorders of pregnancy during caesarean section under general anaesthesia.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: The synthetic opioid fentanyl enhances viral replication in vitro. (Pubmed Central) - Sep 19, 2021
Collectively, these data suggest that synthetic opioids promote viral replication but may have distinct effects depending on the drug dose and the viral target. As higher viral loads are associated with pathogenesis and virus transmission, additional research is essential to an enhanced understanding of opioid-virus pathogenesis and for the development of new and optimized treatment strategies.