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39 Diseases |  |
5 Trials |
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5 Trials |  |
18506 News |  |
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- | morphine sulphate / Generic mfg.
Preclinical, Journal: Tempol Reverses the Negative Effects of Morphine on Arterial Blood-Gas Chemistry and Tissue Oxygen Saturation in Freely-Moving Rats. (Pubmed Central) - Oct 12, 2021
The injection of morphine caused a relatively minor fall in mean arterial blood pressure that was somewhat exacerbated by Tempol. These findings demonstrate that Tempol can reverse the negative effects of morphine on ABG chemistry in freely-moving rats paving the way of structure-activity and mechanisms of action studies with the host of Tempol analogues that are commercially available.
- ||| fentanyl citrate / Generic mfg.
Clinical: Simply awesome -- thank you both To amplify as this message is important for patients & GI docs: -emphasize hydration during/after prep -all preps ok w bf -fentanyl/versed/proposal ok w bf -as soon as awake enough to hold the baby, ok to bf (Twitter) - Oct 11, 2021
- | fentanyl citrate / Generic mfg.
Journal: Why are US military personnel prescribed transdermal fentanyl patches? (Pubmed Central) - Oct 10, 2021
While a substantial minority of transdermal fentanyl prescriptions to US military personnel did not meet FDA guidelines on appropriate use, the overall number of prescriptions fell dramatically over the study period. This suggests that automated profile review or additional targeted policies to limit transdermal fentanyl prescribing are unnecessary at this time.
- |||| fentanyl citrate / Generic mfg.
Clinical: Kills me is no one (except marketing intern) reads these. @CVSinAction @Cigna @UnitedHealthGrp @TheHartford @ShatterproofHQ @supportprop #Kolodny @BrandeisU are complicit lobbyists for illegal #fentanyl & pain/torture of many helpless pts, should b 2nd deg M for suicides #cpp (Twitter) - Oct 10, 2021
- | fentanyl citrate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Journal: Relative addictive potential of opioid analgesic agents. (Pubmed Central) - Oct 10, 2021
Fentanyl and hydromorphone are both very lipophilic allowing rapid penetration into the CNS, but are not rated as highly as other agents. Providers should consider the risk of addiction with the opioids they prescribe and give those with a lower addictive potential.
- || fentanyl citrate / Generic mfg., naltrexone / Generic mfg.
Clinical, Journal: Reversal of ingested fentanyl patch toxicity with oral naltrexone in remote Australia: case report. (Pubmed Central) - Oct 10, 2021
Providers should consider the risk of addiction with the opioids they prescribe and give those with a lower addictive potential. No abstract available
- | fentanyl citrate / Generic mfg.
Journal: Neuroform Atlas Stent for Treatment of Middle Cerebral Artery Aneurysms: 1-Year Outcomes From Neuroform Atlas Stent Pivotal Trial. (Pubmed Central) - Oct 10, 2021
Complete aneurysm occlusion rates have improved compared to historical data. Proper case selection can lead to acceptable endovascular results.
- || fentanyl citrate / Generic mfg.
Clinical, Journal, Epigenetic controller: An Exploratory Pilot Study of Changes in Global DNA Methylation in Patients Undergoing Major Breast Surgery Under Opioid-Based General Anesthesia. (Pubmed Central) - Oct 9, 2021
The alterations of global DNA methylation here observed seem to be in agreement with DNMTs gene expression changes. Furthermore, based on perioperative variations of IL6 and TNFα gene expression, we hypothesize that DNA hypomethylation may occur as a response to surgical stress rather than to opiate exposure.
- | fentanyl citrate / Generic mfg.
Journal: Activation of the μ-opioid receptor by alicyclic fentanyls: changes from high potency full agonists to low potency partial agonists with increasing alicyclic substructure. (Pubmed Central) - Oct 9, 2021
Cyclohexylfentanyl (EC50 = 3.1 μM, efficacy 48%) and TMCPF (EC50 = 1.5 μM, efficacy 65%) were partial agonists less potent than morphine (EC50 = 430 nM). Based on the results, cyclopropyl-, cyclobutyl- and cyclopentylfentanyl would be expected to induce intoxication or cause fatal poisonings at similar concentrations as fentanyl while toxic or fatal concentrations of cyclohexylfentanyl and TMCPF would be expected to be much higher.
- ||| fentanyl citrate / Generic mfg.
Once had to do a PA for a fentanyl patch for a guy with a new dx of multiple myeloma who had multiple pathologic fractures. Lady on the phone asked me how to spell femur. Why am I having to justify my medical decisions to someone who doesn't even know what the bones are?? (Twitter) - Oct 8, 2021
- || fentanyl citrate / Generic mfg.
Low risk, high yield technique for c sections. Especially now that we’ve run out of diamorphine for our spinals (replaced with fentanyl). Some valuable top tips here! (Twitter) - Oct 7, 2021
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Developing Translational Vaccines against Heroin and Fentanyl through Investigation of Adjuvants and Stability. (Pubmed Central) - Oct 7, 2021
Finally, storing a freeze-dried opioid vaccine formulation maintained efficacy for up 1 year at room temperature. The results from our studies represent an advance toward a clinically feasible opioid vaccine.
- ||| fentanyl citrate / Generic mfg.
The US has never even tried to fight the illicit fentanyl poisoning crisis Choosing rather to use it as justification for no longer treating pain (Twitter) - Oct 6, 2021
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl inhibits acute myeloid leukemia differentiated cells and committed progenitors via opioid receptor-independent suppression of Ras and STAT5 pathways. (Pubmed Central) - Oct 6, 2021
Our findings demonstrate the anti-leukemia activity of fentanyl and synergistic effects between fentanyl and cytarabine in AML, via opioid receptor-independent suppression of Ras and STAT5 pathways. Our work is the first to suggest the beneficial effects of fentanyl in children with leukemia.
- | fentanyl citrate / Generic mfg., fentanyl buccal / Generic mfg.
Journal: A dose titration study of fentanyl buccal soluble film for breakthrough cancer pain in Taiwan. (Pubmed Central) - Oct 6, 2021
Individualized dose titration is recommended for BTP management for patients' benefit. Overall, FBSF was effective and well tolerated and was positively correlated with patients' background opioid dose for persistent pain management.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Efficacy of an Oxycodone-Propofol Combination versus a Fentanyl-Propofol Combination in Conscious Sedation during Therapeutic Endoscopic Retrograde Cholangiopancreatography in Elderly Patients. (Pubmed Central) - Oct 6, 2021
Overall, FBSF was effective and well tolerated and was positively correlated with patients' background opioid dose for persistent pain management. Oxycodone combined with propofol was effective in ERCP, with a low incidence of perioperative adverse events.
- || fentanyl citrate / Generic mfg.
Clinical, Journal, HEOR: Quality of life in patients with breakthrough cancer pain in radiation oncology departments in Spain: the CAVIDIOR study. (Pubmed Central) - Oct 6, 2021
P=N/A
Along with the QoL questionnaire, sleep quality and caregiver burden provide a more comprehensive assessment of overall health status in patients receiving radiation therapy in RODs. Clinical Trial Registration: NCT02836379 (ClinicalTrials.gov).
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Journal: Ultrasound-Guided Erector Spinae Plane Block In Patients Undergoing Laparoscopic Bariatric Surgery: A Prospective Randomized Controlled Trial. (Pubmed Central) - Oct 6, 2021
Clinical Trial Registration: NCT02836379 (ClinicalTrials.gov). Ultrasound-guided erector spinae plane block provided satisfactory postoperative analgesia following laparoscopic bariatric surgery with decreased analgesic consumption without significant difference in postoperative pulmonary functions compared to control group.
- | fentanyl citrate / Generic mfg.
Journal: Increasing presence of xylazine in heroin and/or fentanyl deaths, Philadelphia, Pennsylvania, 2010-2019. (Pubmed Central) - Oct 6, 2021
Xylazine's association with adverse outcomes in other locations indicates that potential health consequences should also be monitored in the USA. Whenever possible, jurisdictions should consistently test for xylazine.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Transcutaneous Electrical Nerve Stimulation for Pain Management of Aspiration Abortion up to 83 Days of Gestation: A Randomized Controlled Trial. (Pubmed Central) - Oct 6, 2021
P=N/A
Expanding pain management options can improve quality of and access to abortion. Transcutaneous electrical nerve stimulation could be a standalone or adjunct approach for abortion pain management for those without access to or are ineligible to receive IV sedation due to the lack of sedation practitioner, designated driver, or local restrictions.
- | fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal, Monotherapy: Old Is (Not) Gold: Midazolam Monotherapy versus Midazolam Plus Fentanyl for Sedation during Cardiac Catheterization. (Pubmed Central) - Oct 6, 2021
Among patients undergoing elective cardiac catheterization, no significant differences in pain scores were noted between sedation with midazolam alone compared to midazolam and fentanyl. Due to fentanyl's unfavorable interaction with P2Y12 agents, increased costs, and addiction potential, it is imperative that cardiologists revisit the role of effective procedural sedation with a single agent and avoid the use of fentanyl.
- | fentanyl citrate / Generic mfg.
Retrospective data, Journal: USG Guided Quadaratus Lumburoum Block and Low Dose Spinal Anesthesia in Abdominal Surgeries. (Pubmed Central) - Oct 5, 2021
Due to fentanyl's unfavorable interaction with P2Y12 agents, increased costs, and addiction potential, it is imperative that cardiologists revisit the role of effective procedural sedation with a single agent and avoid the use of fentanyl. For complex abdominal operations, a combination of ultrasound-guided QLB-TM and low dose spinal anesthesia achieves adequate analgesia and is a safe technique.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Enhanced Recovery Pathway as a Tool in Reducing Post-operative Hospital Stay After Caesarean Section, Compared to Conventional Care in COVID Era-A Pilot Study. (Pubmed Central) - Oct 5, 2021
Intravenous tramadol and fentanyl were given if needed apart from these analgesics...In ERAS pathway length of post-operative stay was significantly reduced as compared to conventional care. The online version contains supplementary material available at 10.1007/s13224-021-01461-6.
- || fentanyl citrate / Generic mfg.
Review, Journal: Illicitly Manufactured Fentanyl Entering the United States. (Pubmed Central) - Oct 5, 2021
Drug trafficking over the border also involves the tandem epidemic of money laundering as drugs enter the country and cash payments exit. While drug smuggling in and out of the US (and other nations) has been going on for decades, the patterns are changing. Highly potent and potentially lethal IMF is a dangerous new addition to the illicit drug landscape and one with disastrous consequences.
- fentanyl citrate / Generic mfg., quetiapine / Generic mfg.
[VIRTUAL] Tracheostomy Decreases Continuous Sedation Requirements (Channel 5) - Oct 5, 2021 - Abstract #ACSCLINCON2021ACS_CLINCON_2756;
Tracheostomy allows for a rapid and significant reduction in intravenous sedation and analgesia medication utilization. Post-tracheostomy sedation can transition to intermittent enteral medications, potentially contributing to observed improvements in postoperative mental status and agitation.
- || fentanyl citrate / Generic mfg.
Absolutely. True safe supply now is likely going to require prescription fentanyl. If it were low barrier I imagine many many people would be happy to gradually move down. But this is why existing safe supply fails. Must meet people at the tolerance they are at, so to speak. (Twitter) - Oct 4, 2021
- || fentanyl citrate / Generic mfg.
In another context, there are people smoking fentanyl and ODing outside our SCS. People who are making a 'safer' choice by smoking but we have way fewer supports for them because supervised consumption is conceived as a medical intervention with all the constraints that implies. (Twitter) - Oct 4, 2021
- | fentanyl citrate / Generic mfg.
Journal: Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples. (Pubmed Central) - Oct 3, 2021
Post-tracheostomy sedation can transition to intermittent enteral medications, potentially contributing to observed improvements in postoperative mental status and agitation. This fully validated method allowed to test for the first time 3-fluorofentanyl and norcarfentanil in hair among 15 other NSOs, and bring new data regarding 3-fluorofentanyl and methoxyacetylfentanyl hair concentrations.
- | alprazolam / Generic mfg.
Journal: An unusual detection: tert-butyl-4-anilinopiperidine-1-carboxylate (4-Anilinopiperdine-t-BOC) found in seizures of falsified 'Xanax' tablets and also detected amongst items in a suspected heroin seizure submitted by Irish law enforcement. (Pubmed Central) - Oct 3, 2021
To the authors' best knowledge, information about the biological activity of 4-AP-t-BOC is not available. Removal of the t-BOC protecting group yields 4-anilinopiperidine (4-AP) which has been reported to be involved in the synthesis of fentanyl.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Treatment of Opioid Use Disorder Attributed to Fentanyl With High-Dose Buprenorphine: A Case Report. (Pubmed Central) - Oct 3, 2021
Removal of the t-BOC protecting group yields 4-anilinopiperidine (4-AP) which has been reported to be involved in the synthesis of fentanyl. No abstract available
- || midazolam hydrochloride / Generic mfg.
Clinical, Retrospective data, Journal: Impact of CytoSorb Hemoadsorption on Sedation Requirements in Patients With Severe COVID-19 on Venovenous Extracorporeal Membrane Oxygenation. (Pubmed Central) - Oct 3, 2021
CytoSorb therapy led to significant increases in analgesic requirements without impacting sedative requirements. Further research is needed to define the relevance of CytoSorb hemoadsorption on critical care pharmacotherapy.
- ||| fentanyl citrate / Generic mfg.
We'd like to give a shoutout to @AnnaMarina123 for setting up the first Drug Science Student Society at @QMULBartsTheLon At their stall they hosted two fantastic party games: 1. Pin the drug on the @ProfDavidNutt drug harms chart 2. Guess how much fentanyl can kill an elephant (Twitter) - Oct 2, 2021
- || fentanyl citrate / Generic mfg.
No worries, the comunautè made up in spades with the use of Fentanyl and other assorted goodies (Twitter) - Oct 2, 2021
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methadone / Generic mfg.
I've been an IV morphine/heroin/fentanyl user for a long time & tried bupe but it didn't work out for me hut I'm about to have 1 year on just methadone in 2 weeks (Twitter) - Oct 2, 2021
- || fentanyl citrate / Generic mfg., methamphetamine / Generic mfg., methadone / Generic mfg.
Biomarker, Clinical, Journal: "Waste Not, Want Not" - Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical Monitoring. (Pubmed Central) - Oct 2, 2021
In this manuscript, we describe the basic tenets and techniques of WBE, review its current application among drugs of abuse, and propose methods to scale and develop both monitoring and early warning systems with respect to measurement of illicit drugs and pharmaceuticals. We propose new frontiers in toxicological research with wastewater surveillance including assessment of medication assisted treatment of opioid use disorder (e.g., buprenorphine, methadone) in the context of other social burdens like COVID-19 disease.
- || fentanyl citrate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Clinical, Journal: Impact of expanded strong opioid availability on opioid prescription patterns in patients with cancer: A population-wide cohort study in Taiwan. (Pubmed Central) - Oct 1, 2021
Funding This study was supported by Ministry of Science and Technology, Taiwan (MOST-106-2314-B-002-213 and MOST-108-2314-B-002-072-MY3), Ministry of Health and Welfare, Taiwan (MOHW109-TDU-B-211-114002), National Taiwan University Hospital, Taipei, Taiwan (NTUH-103-002314 and NTUH. 105-S2954), and National Center of Excellence for Clinical Trial & Research, National Taiwan University Hospital, Taipei, Taiwan (NCTRC201208 and NCTRC201603).
- fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Rectus sheath catheters versus epidural analgesia for open midline incisions in major gynaecological- oncology surgery () - Oct 1, 2021 - Abstract #ESGO2021ESGO_672;
RSCs may have a place as a PMPOA in Gynae-Oncology patients requiring full-length midline incisions. Furthermore, if RSCs are implemented as a standard practice for PMPOA it may have a health-economic benefit.
- fentanyl citrate / Generic mfg.
Parkour and its consequences () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4681;
After starting on intravenous analgesia with fentanyl, an urgent consultation with on-call Traumatologist was made...However, back injuries, which can be serious and cause irreversible injury, are rare, and therefore may go undiagnosed by minimizing the mechanism of injury. It is important to know the same to avoid avoiding potentially severe injuries.
- fentanyl citrate / Generic mfg.
Parkour and its consequences () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4680;
After starting on intravenous analgesia with fentanyl, an urgent consultation with on-call Traumatologist was made...However, back injuries, which can be serious and cause irreversible injury, are rare, and therefore may go undiagnosed by minimizing the mechanism of injury. It is important to know the same to avoid avoiding potentially severe injuries.
- fentanyl citrate / Generic mfg.
Parkour and its consequences () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4679;
After starting on intravenous analgesia with fentanyl, an urgent consultation with on-call Traumatologist was made...However, back injuries, which can be serious and cause irreversible injury, are rare, and therefore may go undiagnosed by minimizing the mechanism of injury. It is important to know the same to avoid avoiding potentially severe injuries.
- fentanyl citrate / Generic mfg.
Parkour and its consequences () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4678;
After starting on intravenous analgesia with fentanyl, an urgent consultation with on-call Traumatologist was made...However, back injuries, which can be serious and cause irreversible injury, are rare, and therefore may go undiagnosed by minimizing the mechanism of injury. It is important to know the same to avoid avoiding potentially severe injuries.
- fentanyl citrate / Generic mfg.
The buried man () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4665;
We treated the patient with fluid therapy, fentanyl 100 mcg and oxygen therapy with oxygen mask with reservoir...In our case, the patient underwent a surgery for treating the pelvic fracture. The symtoms related with traumatic asphyxia recovered completely without any further treatment.
- fentanyl citrate / Generic mfg.
The buried man () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4664;
We treated the patient with fluid therapy, fentanyl 100 mcg and oxygen therapy with oxygen mask with reservoir...In our case, the patient underwent a surgery for treating the pelvic fracture. The symtoms related with traumatic asphyxia recovered completely without any further treatment.
- fentanyl citrate / Generic mfg.
The buried man () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4663;
We treated the patient with fluid therapy, fentanyl 100 mcg and oxygen therapy with oxygen mask with reservoir...In our case, the patient underwent a surgery for treating the pelvic fracture. The symtoms related with traumatic asphyxia recovered completely without any further treatment.
- fentanyl citrate / Generic mfg.
The buried man () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4662;
We treated the patient with fluid therapy, fentanyl 100 mcg and oxygen therapy with oxygen mask with reservoir...In our case, the patient underwent a surgery for treating the pelvic fracture. The symtoms related with traumatic asphyxia recovered completely without any further treatment.
- fentanyl citrate / Generic mfg., tranexamic acid oral / Generic mfg.
Optimization of out-of-hospital management of a patient with aortic dissection () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4033;
In accelerations the opposite would occur. The measures that we will adopt to alleviate the adverse effects of speed are: carry out regular and prudent driving, correctly immobilize the patient, firmly hold the patient to the stretcher, use of seat belts, fix materials in the ambulance.
- fentanyl citrate / Generic mfg., tranexamic acid oral / Generic mfg.
Optimization of out-of-hospital management of a patient with aortic dissection () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4032;
In accelerations the opposite would occur. The measures that we will adopt to alleviate the adverse effects of speed are: carry out regular and prudent driving, correctly immobilize the patient, firmly hold the patient to the stretcher, use of seat belts, fix materials in the ambulance.
- fentanyl citrate / Generic mfg., tranexamic acid oral / Generic mfg.
Optimization of out-of-hospital management of a patient with aortic dissection () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4031;
In accelerations the opposite would occur. The measures that we will adopt to alleviate the adverse effects of speed are: carry out regular and prudent driving, correctly immobilize the patient, firmly hold the patient to the stretcher, use of seat belts, fix materials in the ambulance.
- fentanyl citrate / Generic mfg., tranexamic acid oral / Generic mfg.
Optimization of out-of-hospital management of a patient with aortic dissection () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4030;
In accelerations the opposite would occur. The measures that we will adopt to alleviate the adverse effects of speed are: carry out regular and prudent driving, correctly immobilize the patient, firmly hold the patient to the stretcher, use of seat belts, fix materials in the ambulance.
- Penthrox (methoxyflurane) / Medical Developments International
Effectiveness of Penthrox in managing Fracture and Dislocation in Emergency Department () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_3765;
From the data, the use of Penthrox prevented the need for sedation in majority of the patients, especially in the higher-risk group. We need more data to further strengthen our point.