fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Clinical, Journal:  Concomitant inpatient prescribing of strong opioids with sedatives: Associations with comorbid conditions. (Pubmed Central) -  Nov 16, 2021   
    Patients with comorbidities resulting in increased risk of respiratory depression/OIVI were more likely to have sedative co-prescription. Clinicians should be aware of the effects of high-risk medications and ensure that systems and monitoring are in place that help mitigate adverse outcomes.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Review, Journal:  Fentanyl, Acetylfentanyl, and Carfentanil in Impaired Driving Cases: A Review of 270 Cases. (Pubmed Central) -  Nov 16, 2021   
    Toxicology results show impaired drivers using multiple drugs with a wide range of observed behaviors. The inclusion of these drugs in routine impaired driver toxicology testing is extremely important when attempting to determine their overall prevalence.
  • ||||||||||  ketamine / Generic mfg.
    Preclinical, Journal:  A new anesthetic protocol to medullary nerve roots access in rats. (Pubmed Central) -  Nov 12, 2021   
    Based on requirement for rescue analgesia, postoperative analgesia was adequate in both groups. The new anesthetic protocol reduces the surgical time, allows better maintenance of the anesthetic plan, and brings more satisfactory postoperative recovery.
  • ||||||||||  fentanyl citrate / Generic mfg., phenytoin / Generic mfg., dexmedetomidine / Generic mfg.
    Clinical, Journal:  Intraoperative refractory status epilepticus caused by propofol. (Pubmed Central) -  Nov 11, 2021   
    The postoperative follow-up was uneventful. This article focuses on the management of intractable intraoperative seizure and highlights the need for the exploration of seizure characteristics caused by propofol.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Negotiating sex work and client interactions in the context of a fentanyl-related overdose epidemic. (Pubmed Central) -  Nov 11, 2021   
    Participants, comments regarding criminalisation and stigma surrounding drug use and sex work indicated a reticence to report overdoses, thereby potentially increasing the risks of overdose-related harms, including death. There is an urgent need for sex worker-led overdose prevention strategies that prioritise health and safety of sex workers and their clients with specific attention to how the criminalisation of particular drugs, practices and people contributes to overdose-related risks.
  • ||||||||||  paracetamol / Generic mfg.
    Clinical, Review, Journal:  Paracetamol as an adjuvant to opioids for cancer pain management (Pubmed Central) -  Nov 10, 2021   
    However, this technical report also describes that there is uncertainty about the impact of paracetamol as an adjuvant in patients with cancer pain who are already receiving strong opioids. This review aims to describe the current state of the art regarding the role of paracetamol as a coadjuvant in cancer pain patients.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Bacterial meningitis without pyrexia after spinal anesthasia for caesarean section: A case report. (Pubmed Central) -  Nov 10, 2021   
    The use of modern packaging is recommended. Despite absent of pyrexia empiric treatment must start earlier besides the application of national guideline developed by the Joint Commission of different associations including America society of regional anesthesia (ASRA) is recommended.
  • ||||||||||  midazolam hydrochloride / Generic mfg.
    [VIRTUAL] Improving safe sedation practices in bronchoscopy at a district general hospital () -  Nov 10, 2021 - Abstract #BTSWMI2021BTS_WM_I_393;    
    Results Maximum recommended dose of midazolam in ≥70yrs (3.5mg), was exceeded in 19% of EBUS cases and 5% of bronchoscopy cases pre-intervention...Maximum recommended dose of fentanyl (50mcg) was exceeded in 22% of EBUS and 4% of bronchoscopy cases pre-intervention...Implementation of a bronchoscopy suite poster, and specific recording fields for LA, has improved documentation practices. Methods introduced continue to be used in our trust’s bronchoscopy suite.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Clinical, Journal:  Analgesic efficacy of sufentanil in dressings after surgical treatment of burn wounds. (Pubmed Central) -  Nov 10, 2021   
    However, these effects are not severe, and we conclude that both agents are safe and effective to ensure sedation prior to painful burn-care procedures. Sufentanil in dressings after burn wound surgery provides effective and safe analgesia and the sufentanil concentration in dressings should be ≥0.10 μg/mL in a solution of octenidine and phenoxyethanol.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Improvements on a chemically contiguous hapten for a vaccine to address fentanyl-contaminated heroin. (Pubmed Central) -  Nov 10, 2021   
    This vaccine produced antibodies with nanomolar affinities and effectively blocked opioid analgesic effects elicited by adulterated heroin. These findings provide further insight into the development of chemically contiguous haptens for broad-spectrum immunopharmacotherapies against opioid use disorders.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Perceived occupational risk of fentanyl exposure among law enforcement. (Pubmed Central) -  Nov 10, 2021   
    These findings provide further insight into the development of chemically contiguous haptens for broad-spectrum immunopharmacotherapies against opioid use disorders. There is a substantial, pressing need for dissemination of research about the lack of overdose risk associated with dermal fentanyl exposure through channels that law enforcement trust, including through basic academy, in-service training, and law enforcement bulletins and newsletters.
  • ||||||||||  methionine enkephalin (IRT-101) / Immune Therap, Statera BioPharma
    Preclinical, Journal:  RGS-insensitive mice define roles of mu opioid receptor (MOR)-Gαo and Gαi subunit coupling in inhibition of presynaptic GABA release. (Pubmed Central) -  Nov 10, 2021   
    Fentanyl inhibited eIPSCs similarly in both WT and RGS-insensitive mice...Finally, baclofen-mediated inhibition of GABA release is unaffected in the RGS-insensitive mice and in the presence of Gαo and Gαi inhibitor peptides, suggesting that GABA receptor coupling to G proteins in vlPAG presynaptic terminals is different than MOR coupling...These data in RGS-insensitive mice provide evidence that MOR agonists differ in preference for Gαo versus Gαi and regulation by RGS proteins in presynaptic terminals, providing a mechanism for functional selectivity between agonists. The results further define important differences in MOR and GABA receptor coupling to G proteins that could be exploited for new pain therapies.
  • ||||||||||  midazolam hydrochloride / Generic mfg.
    Preclinical, Journal:  Application of alpha1-antitrypsin in a rat model of veno-arterial extracorporeal membrane oxygenation. (Pubmed Central) -  Nov 10, 2021   
    We suggest that α1-antitrypsin might have the potential to protect against both ECMO-induced systemic inflammation and immune paralysis. More studies are needed to corroborate our findings, to clarify the mechanisms by which α1-antitrypsin inhibits cytokine release in vivo and to explore the potential application of α1-antitrypsin in clinical ECMO.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Fentanyl epidemic hits the U.S. West Coast: Opioid-related deaths in San Francisco from 2009-2019. (Pubmed Central) -  Nov 10, 2021   
    These patterns appear to follow patterns seen in eastern states, albeit with an approximate 3-year delay, and may be indicative of other western populations. The described observations provide detailed demographic, chronological and toxicological information to public health and policy-making agencies for drug harm reduction measures.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Predictors of intentional fentanyl use: Market availability vs consumer demand. (Pubmed Central) -  Nov 10, 2021   
    The motivations underlying fentanyl use are multifactorial and vary across populations of PWUO, indicating a need for targeted interventions to counter the increasing spread and adverse consequences of fentanyl use. In order to counteract the increasing spread and adverse consequences of fentanyl use, these findings indicate a need for harm-reduction interventions, like drug testing or supervised injection sites, that address the differing motivations for fentanyl use among PWUO.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Acute high-intensity exercise and skeletal muscle mitochondrial respiratory function: The role of metabolic perturbation. (Pubmed Central) -  Nov 10, 2021   
    With the utilization of intrathecal fentanyl to attenuate afferent feedback from group III/IV muscle afferents, permitting increased muscle activation and greater intramuscular metabolic disturbance, this study aimed to better elucidate the role of metabolic perturbation on mitochondrial respiratory function...Somewhat surprisingly, despite this greater metabolic perturbation in FENT compared to CTRL, with the only exception of respiratory control ratio (RCR) (-3 and -36%) for which the impact of FENT was significantly greater, the degree of attenuated mitochondrial respiratory capacity post-exercise was not different between CTRL and FENT, respectively, as assessed by maximal respiratory flux through complex I (-15 and -33%), complex II (-36% and -23%), complex I+II (-31 and -20%), and state 3 control ratio (-24 and -39%). Although a basement effect cannot be ruled out, this failure of an augmented metabolic perturbation to extensively further attenuate mitochondrial function questions the direct role of high-intensity exercise-induced metabolite accumulation in this post exercise response.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  Preemptive light sedation in intensive care unit may reduce pulmonary complications in geriatrics receiving pancreaticoduodenectomy. (Pubmed Central) -  Nov 7, 2021   
    Although a basement effect cannot be ruled out, this failure of an augmented metabolic perturbation to extensively further attenuate mitochondrial function questions the direct role of high-intensity exercise-induced metabolite accumulation in this post exercise response. Postoperative preemptive light sedation in the ICU in geriatric patients following PD may not only reduce the rates of postoperative pulmonary complications and gastroparesis but also improve postoperative quality of life without prolonging the postoperative hospital LOS.
  • ||||||||||  lidocaine topical / Generic mfg.
    Review, Journal:  A Substantive Narrative Review on the Usage of Lidocaine in Cataract Surgery. (Pubmed Central) -  Nov 7, 2021   
    Perhaps this standard could change over time as it is generally known that using intracameral injections in conjunction with topical anesthesia produces better patient outcomes. The authors find that although anesthetics and surgical treatment for cataracts are generally beneficial for patients, there are still many adjustments that could be implemented to enhance patient outcomes.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., levamisole / Generic mfg.
    Retrospective data, Journal:  Opioid Overdose Deaths with Buprenorphine Detected in Postmortem Toxicology: a Retrospective Analysis. (Pubmed Central) -  Nov 6, 2021   
    Although data are limited, buprenorphine may provide some risk mitigation against full agonist opioid overdose including fentanyl. Further work should explore the use of postmortem concentrations of buprenorphine, norbuprenorphine, and other opioid metabolites to determine the role of buprenorphine in fatal overdose pharmacology.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Observational data, Journal:  Painful procedures and pain management in newborns admitted to an intensive care unit. (Pubmed Central) -  Nov 6, 2021   
    Among 3 techniques, saddle block might be preferable in HoLEP because an adequate sensorial level was achieved with lower motor block and stable hemodynamics. Despite the high number of painful procedures, pain assessment records do not reflect procedural pain and the use of analgesic strategies was insufficient.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Implementation of a Physician Incentivized QI Strategy to Address Time to Parenteral Analgesia in Patients with Voe in the Pediatric Emergency Department (GWCC - Hall B5, Level 1) -  Nov 5, 2021 - Abstract #ASH2021ASH_4644;    
    This order set implemented the use of intranasal (IN) fentanyl as a first line analgesic for SCD patients who presents to the ED with VOE...Length of stay is also confounded by other factors during the hospitalization and acquisition of other diagnoses such as acute chest. Future research is needed to determine if the demonstrated trend of admission rates and hospital length of stay can be replicated in other pediatric EDs and whether earlier opioid administration affects the outcome of VOEs beyond the ED.
  • ||||||||||  Instanyl (fentanyl) / Takeda
    ASH Poster Walk on Healthcare Quality Improvement () -  Nov 5, 2021 - Abstract #ASH2021ASH_2448;    
    Quality improvement projects are also increasingly encouraged or required for hematology trainees; highlighting practice-changing work in the field can provide models for trainees and early-career hematologists to follow at their own institutions. The following abstracts will be featured in this session: A Resident-Led Quality Improvement Initiative to Optimize Care for Children and Young Adults with Sickle Cell Disease Vaso-Occlusive Pain with Intranasal Fentanyl in the Emergency Department , Wilson Vasconez Samaniego Implementation of a Physician Incentivized QI Strategy to Address Time to Parenteral Analgesia in Patients with Voe in the Pediatric Emergency Departmen t, Romy Shane Successful Quality Improvement Projects to Maximize Prescription Rates and Acceptance of Hydroxyurea Among Patients with Sickle Cell Anemia , Ofelia Alvarez Improving Value in Emergency Department Management of Deep Vein Thrombosis , Amar Kelkar Prospective Study to Reduce Clostridium Difficile Infection in Patients Receiving Autologous Stem Cell Transplantation , Samuel Maldonado Improving Feedback for Hematology and Oncology Fellows Via Virtual Workshops: Sustainability Analysis , Sarah Sewaralthahab
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Engagement in Harm Reduction Strategies After Suspected Fentanyl Contamination Among Opioid-Dependent Individuals. (Pubmed Central) -  Nov 4, 2021   
    In a multivariable analysis, participants who were white, low-income, polysubstance users, and had previously experienced an overdose or had previously administered naloxone were more likely to report a willingness to engage in harm reduction measures. These findings provide an evidence-based understanding of PWID's engagement in harm reduction behaviors after suspecting potential fentanyl exposure as well as a basis for tailoring intervention strategies in the context of fentanyl-adulterated markets.