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- fentanyl citrate / Generic mfg.
Correlation of pain perception and fentanyl consumption after major abdominal surgery with cgrp 4218t/c polymorphisms ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_968;
Genotype affects the pain perception and analgesic consumption.C/C genotype had highest fentanyl consumption implying that they had the highest pain perception,T/C genotype had least fentanyl consumption implying lower pain perception.Preoperative pharmacogenetics can be extrapolated for tailored effective postoperative analgesia.
- ketamine / Generic mfg.
Anaesthetic management of a patient with giant pulmonary bullae for video-assisted thoracoscopic surgery (VATS) bullectomy: a case report ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_957;
After resection, initiating two lung ventilation with low tidal volumes is crucial for slowly re-expand the collapsed lung. Learning points: Anaesthetic management of these patients is challenging and requires careful investigation and understanding of anatomical and pathophysiological variation of disease.
- | fentanyl citrate / Generic mfg.
Journal: Identifying counties at risk of high overdose mortality burden during the emerging fentanyl epidemic in the USA: a predictive statistical modelling study. (Pubmed Central) - Nov 25, 2021
Learning points: Anaesthetic management of these patients is challenging and requires careful investigation and understanding of anatomical and pathophysiological variation of disease. Our model shows that a regression approach can effectively predict county-level overdose death rates and serve as a risk assessment tool to identify future high mortality counties throughout an emerging drug use epidemic.
- || fentanyl citrate / Generic mfg.
Clinical, Review, Journal: Update on Management of the Oral and Maxillofacial Surgery Patient on Selective Serotonin Reuptake Inhibitors. (Pubmed Central) - Nov 25, 2021
Some of the effects can be severe. This chapter highlights use of SSRIs, the mechanism of action, medication dosages, common drug to drug interactions, and recommendations on management of the oral and maxillofacial surgery patient on SSRIs.
- || dexmedetomidine / Generic mfg.
Clinical, Journal: The effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial. (Pubmed Central) - Nov 24, 2021
There was no effect on early PONV, sore-throat or increase in incidence of adverse effects. Nebulized dexmedetomidine may represent a favorable alternative to the intravenous route in short duration surgeries.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Detecting risk level in individuals misusing fentanyl utilizing posts from an online community on Reddit. (Pubmed Central) - Nov 24, 2021
Moreover, our vocabulary of online terms for fentanyl and its analogues expands our understanding of online "street" nomenclature for opiates. Through an improved understanding of substance misuse risk factors, these findings allow for identification of risk concepts among those misusing fentanyl to inform outreach and intervention strategies tailored to this at-risk group.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Respiratory effects of low and high doses of fentanyl in control and β-arrestin 2 deficient mice. (Pubmed Central) - Nov 24, 2021
The ventilatory effects of fentanyl in b-arr2 deficient mice reported in the literature are primarily mediated by the "indirect" effects of sedation/hypometabolism on breathing control. There was an excess mortality at very high doses of fentanyl in the b-arr2 deficient mice, which mechanisms are still open to question, since the capacity of maintaining a rhythmic, although profoundly depressed, breathing activity remains similar in all of the surviving control and b-arr2 deficient mice.
- | fentanyl citrate / Generic mfg.
Journal: 'Nasal fentanyl and buccal midazolam carer administration 'as needed' for breakthrough symptom control in a specialist palliative care unit: a nested qualitative study'. (Pubmed Central) - Nov 24, 2021
Participation was acceptable to patients and lay carers, and beneficial for symptom relief. The findings will inform planning for a future community-based study.
- ||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Clinical, Journal, Adverse events: Disproportionality Analysis of Safety Signals for a Wide Variety of Opioid-Related Adverse Events in Elderly Patients Using the Japanese Adverse Drug Event Report (JADER) Database. (Pubmed Central) - Nov 24, 2021
These opioids were classified as early failure types using the Weibull distribution. Our results showed that elderly patients who are administered opioids should be closely monitored for AEs, such as respiratory depression, OIN and akathisia.
- || ketamine / Generic mfg.
Retrospective data, Review, Journal: Anesthesia for Patients Who Self-Report Cannabis (Marijuana) Use Before Esophagogastroduodenoscopy: A Retrospective Review. (Pubmed Central) - Nov 24, 2021
This study was specific to EGD procedures of short duration, and larger studies are needed to confirm results of no consequence in cannabis users undergoing anesthesia. Future studies should consider cannabis users who undergo anesthesia for diverse procedure types of various durations.
- | fentanyl citrate / Generic mfg., naltrexone / Generic mfg.
Journal: Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent. (Pubmed Central) - Nov 24, 2021
Methods have been developed that have utility to identify enhanced rescue agents for the treatment of OIRD. Analogue 29, possessing potent MOR antagonist activity in vitro and in vivo, provides a promising lead in our search for an enhanced synthetic opioid rescue agent.
- || fentanyl citrate / Generic mfg.
I can’t tell you how many times I have begged my HHS and the AGin my state to put out a PSA about illicit fentanyl in pills. They refuse. All they do are commercials having to do w opioids from a dr. Couldn’t care less about pill presses from dealers made to look like rx pills. (Twitter) - Nov 22, 2021
- |||| fentanyl citrate / Generic mfg.
Clinical: I just lost a relative to Fentanyl. My moms best friend died suddenly of a heart attack, and the uncle I lost to Fentanyl, his brother was totally healthy ready to get his PhD, dropped dead of a heart attack 2 days ago. Rough time these last 2 months. (Twitter) - Nov 22, 2021
- | fentanyl citrate / Generic mfg.
Journal: Is Opioid-free Anesthesia Possible by Using Erector Spinae Plane Block in Spinal Surgery? (Pubmed Central) - Nov 22, 2021
Analogue 29, possessing potent MOR antagonist activity in vitro and in vivo, provides a promising lead in our search for an enhanced synthetic opioid rescue agent. ESP block decreases opioid consumption and VAS score at postoperative one hour in patients, and also patients who receive ESP block do not require intraoperative opioid administration.
- ||| fentanyl citrate / Generic mfg., oxycodone/acetaminophen / Generic mfg.
I need a fucking hydrocodone. Sad ppl get addicted, my backs hurt since the “opioid epidemic” started. No Afghanistan=no poppy. Chinese fentanyl processed by Mexico into fake Percocet. And I need a real one. I’m sure I’m not alone. Sucks death or pain are the options since 2017. (Twitter) - Nov 22, 2021
- | fentanyl citrate / Generic mfg.
Journal: Effectiveness of Policies for Addressing the US Opioid Epidemic: A Model-Based Analysis from the Stanford-Lancet Commission on the North American Opioid Crisis. (Pubmed Central) - Nov 21, 2021
The U.S. opioid crisis has been exacerbated by COVID-19 and the spread of synthetic opioids (e.g., fentanyl)...Expanded health services for individuals with opioid use disorder combined with PMPs and reduced opioid prescribing would moderately lessen the severity of the opioid crisis over the next decade. Tragically, even with improved public policies, significant morbidity and mortality is inevitable.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Thirteen Cases of Valeryl Fentanyl in Michigan: A Call for Expanding Opioid Testing. (Pubmed Central) - Nov 21, 2021
Given the paucity of pharmacodynamic information, the prohibition of its use, the potential to buttress law enforcement efforts in monitoring drug trafficking trends, and to determine the efficacy of current regulations, laboratories should test for valeryl fentanyl. When testing for valeryl fentanyl, and likely other fentanyl analogs, the site of sample collection is important: central sources of blood are preferred to peripheral sources.
- | fentanyl citrate / Generic mfg.
Retrospective data, Journal: Structural modification of fentanyls for their retrospective identification by gas chromatographic analysis using chloroformate chemistry. (Pubmed Central) - Nov 21, 2021
The method's LLOD was determined to be 10 ng/mL while its LLOQ was found to be 20 ng/mL. This methodology represents the first application of chloroformates in the chemical modification of this class of synthetic opioids that are notoriously inert to common derivatization strategies available for GC-MS analysis.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Intravenous Infusion of Fentanyl Has No Effect on Blood Concentration of Tacrolimus In Patients Receiving Hematopoietic Stem Cell Transplantation. (Pubmed Central) - Nov 21, 2021
This methodology represents the first application of chloroformates in the chemical modification of this class of synthetic opioids that are notoriously inert to common derivatization strategies available for GC-MS analysis. Intravenous infusion of fentanyl does not affect the pharmacokinetics of TAC.
- || fentanyl citrate / Generic mfg.
Review, Journal: The opioid crisis and HIV in the USA: deadly synergies. (Pubmed Central) - Nov 21, 2021
Opioid overdose death rates have increased steadily for more than a decade and doubled in 2013-17, as the highly potent synthetic opioid fentanyl entered the drug supply...If the USA is serious about HIV prevention among this group, stigma must be eliminated, discriminatory policies must change, and comprehensive health care must be accessible to all. Finally, root causes of the opioid epidemic such as hopelessness need to be identified and addressed.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Review, Journal: Recent Advances in Peripheral Opioid Receptor Therapeutics. (Pubmed Central) - Nov 21, 2021
Recent innovations in peripheral opioid receptor therapeutics of pH-sensitive opioid ligands and limiting opioid permeability across the blood-brain barrier have had promising results in animal models. While this is grounds for optimism that some of these therapeutics will be efficacious in human subjects at a future date, each drug must undergo individualized testing for specific chronic pain syndromes to establish not only the nuances of each drug's therapeutic effect but also a comprehensive safety profile.
- || ketamine / Generic mfg.
Preclinical, Review, Journal: Anesthetic protocols for urodynamic studies of the lower urinary tract in small rodents-A systematic review. (Pubmed Central) - Nov 21, 2021
The lowest incidence of adverse effects was observed with the use of a combination of ketamine and xylazine. Although the variations in the reviewed study protocols represent a limitation, we believe that this summary will help in standardizing and optimizing future experiments.
- ||| midazolam hydrochloride / Generic mfg.
Journal, Adverse events: Risk of adverse events in gastrointestinal endoscopy: Zero-inflated Poisson regression mixture model for count data and multinomial logit model for the type of event. (Pubmed Central) - Nov 21, 2021
Although the variations in the reviewed study protocols represent a limitation, we believe that this summary will help in standardizing and optimizing future experiments. Age, BMI, ASA score, Mallampati score, in-hospital, procedure duration, other sedatives with propofol increase the risk for AEs during sedation for GI endoscopy.
- | fentanyl citrate / Generic mfg.
Retrospective data, Journal: Opioid-related deaths before and after COVID-19 stay-at-home orders in Los Angeles County. (Pubmed Central) - Nov 21, 2021
The increase in opioid-related overdose deaths following the onset of COVID-19 and related policies occurred most often among Non-Hispanic Caucasian individuals. Further research on this trend's underlying cause is needed to inform policy recommendations during these simultaneous public health crises.
- | fentanyl citrate / Generic mfg.
Journal: Less-Invasive Surfactant Administration for Neonatal Respiratory Distress Syndrome: A Consensus Guideline. (Pubmed Central) - Nov 21, 2021
Further research on this trend's underlying cause is needed to inform policy recommendations during these simultaneous public health crises. LISA has the potential to improve outcomes for preterm infants with RDS and can be introduced as a safe and effective part of UK-based neonatal care with appropriate training.
- | fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: Growing racial/ethnic disparities in overdose mortality before and during the COVID-19 pandemic in California. (Pubmed Central) - Nov 21, 2021
Growing racial disparities in overdose must be understood in the context of the unequal social and economic fallout from the COVID-19 pandemic, during which time Black communities have been subjected to the dual burden of disproportionate COVID-19 deaths and rising overdose mortality. Increased investments are required to ameliorate racial/ethnic disparities in substance use treatment, harm reduction, and the structural drivers of overdose, as part of the COVID-19 response and post-pandemic recovery efforts.
- || fentanyl citrate / Generic mfg.
@DrChinazo yes, no time to lose with fentanyl. https://t.co/zhZ6GHv2xn (Twitter) - Nov 20, 2021
- ||| fentanyl citrate / Generic mfg.
I came across the changing the narrative website and found it so useful. I will now use overdose epidemic vs opioid epidemic. My brother died of a fentanyl overdose, however, his death certificate also listed recent cocaine abuse. I use addict, though, when speaking about him. (Twitter) - Nov 20, 2021
- || fentanyl citrate / Generic mfg.
Antiquated language is one thing but it’s the antiquated thinking here that concerns me the most. No discussion of the rise of fentanyl as a *consequence* of prohibition. It’s remarkable after so many decades of a failed drug war that we can’t even see it failing. (Twitter) - Nov 20, 2021
- fentanyl citrate / Generic mfg.
[VIRTUAL] A Novel Role for the Hypothalamic Paraventricular Nucleus in Resuscitation From Opioid-Induced Respiratory Depression by Fentanyl in the Rat (ePosters) - Nov 20, 2021 - Abstract #AHA2021AHA_7825;
PVN opioid receptor antagonism and photoactivation of PVN oxytocin neurons are individually capable of reversing OIRD. Findings also indicate that PVN oxytocin neurons, previously unrecognized in reversal of OIRD, are a novel target for resuscitation agents.
- || fentanyl citrate / Generic mfg.
@CDCgov @CDCDirector @DrNancyM_CDC @CDC_eHealth @cdc DEA & @CDCgov has taken over our healthcare by telling our drs that it’s ok for us die but protect addicts at all cost, well your not protecting addicts over 100 thousand deaths this from illicit fentanyl coming across (2) (Twitter) - Nov 18, 2021
- ||| fentanyl citrate / Generic mfg.
It is so important to distinguish between those who use illegal drugs with fentanyl, and those who use prescription meds responsibly to control chronic pain conditions. No one seems to make that distinction, and it is killing those of us who need those meds. (Twitter) - Nov 18, 2021
- || fentanyl citrate / Generic mfg.
They are putting Fentanyl in everything now..its not just heroin ... (Twitter) - Nov 18, 2021
- || Chirocaine (levobupivacaine) / Purdue, AbbVie
Clinical, Journal: Comparison of block characteristics of intrathecal isobaric levobupivacaine versus isobaric ropivacaine for infra-umbilical surgeries in school-age children: A prospective randomised double-blind study. (Pubmed Central) - Nov 17, 2021
Intrathecal isobaric levobupivacaine and ropivacaine with fentanyl produces effective surgical anaesthesia and postoperative analgesia without any adverse effects. Early regression of sensorimotor blockade makes ropivacaine better in comparison to levobupivacaine for short infra-umbilical surgeries in children.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Journal: Effect of Ultrasound-Guided Thoracolumbar Interfascial Plane Block on the Analgesic Requirements in Patients Undergoing Lumbar Spine Surgery Under General Anesthesia: A Randomized Controlled Trial. (Pubmed Central) - Nov 17, 2021
The intraoperative fentanyl consumption was lower in the TLIP group (15±35.11 mcgs) versus the control group (105±62.08 mcgs)...Patients in the TLIP group had lower perioperative hemodynamic responses to surgical stimulation in comparison to the control group. Combined TLIP block with general anesthesia in patients undergoing spinal surgery reduced both postoperative and intraoperative analgesic needs, reduced intra-operative hemodynamic response to surgery, and achieved good postoperative pain control.
- || fentanyl citrate / Generic mfg.
Watch & Share #DeadOnArrival #FentanylDocumentary #Trailer #Film #20Min To Help #SaveALife💜 @ToEndAddiction @j_addictions @JAM_ASAM https://t.co/5X8fM5Fzd0 @ASAMorg @EVargasTV @GayleKing @KatyTurNBC @Wdekanter @RepKatiePorter @NSBAPublicEd @usedgov @NYMayors @NatlGovsAssoc (Twitter) - Nov 17, 2021
- || fentanyl citrate / Generic mfg.
We really need to wake up to this. More treatment access will not fix this much. There is way too much unsafe supply of meth and fentanyl. Fixing this is essential. 100,000 Americans died of drug overdoses in 12 months during the pandemic https://t.co/RWrpoUwRNt (Twitter) - Nov 17, 2021
- ||| fentanyl citrate / Generic mfg.
100,000 Americans died of drug overdoses in one year. Officials think it was fueled by the #COVID19 pandemic which made it hard to get treatment and support as well as a growing prevalence of deadly #fentanyl. https://t.co/AoVGmeAX6k (Twitter) - Nov 17, 2021
- | fentanyl citrate / Generic mfg.
Journal: Is Europe Facing an Emerging Opioid Crisis Comparable to the U.S.? (Pubmed Central) - Nov 17, 2021
In the U.S., an opioid overdose crisis has emerged, attributable to over-prescription of opioid analgesics, driven by aggressive marketing by pharmaceutical companies, followed by surging heroin overdose deaths, and more recently, by the high mortality rates predominately because of illicitly manufactured fentanyl and analogs of fentanyl...Considering that the use of prescription opioids has been declining rather than increasing in Europe, an opioid crisis is not anticipated there yet. Authorities should, however, remain vigilant.
- || fentanyl citrate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Clinical, Journal: Conversion From Continuous Infusion Fentanyl to Continuous Infusion Hydromorphone in the Pediatric Intensive Care Unit. (Pubmed Central) - Nov 17, 2021
A median 14% fentanyl dose reduction was noted when transitioning to hydromorphone. Further exploration is needed to determine if opioid rotations with hydromorphone can reduce opioid/sedative exposure.
- | morphine sulphate / Generic mfg.
Journal: Evidence-based guidance for use of intrathecal morphine as an alternative to diamorphine for Caesarean delivery analgesia. (Pubmed Central) - Nov 17, 2021
Evidence suggests minimal differences in clinical efficacy and side-effects between intrathecal morphine and diamorphine. Recommended intrathecal morphine doses for Caesarean delivery analgesia are 100-150 ug.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Retrospective data, Journal: Intravenous patient-controlled analgesia does not increase the risk of postoperative delirium compared to patient-controlled epidural analgesia: a propensity score-matched retrospective cohort study. (Pubmed Central) - Nov 17, 2021
There was no difference in the incidence of POD between morphine IVPCA and fentanyl PCEA when the patient characteristics were matched using propensity score matching. POD occurs regardless of the route and dose of opioid administration.
- | fentanyl citrate / Generic mfg.
Journal: Simultaneous Quantification of 25 Fentanyl Derivatives and Metabolites in Oral Fluid by Means of Microextraction on Packed Sorbent and LC-HRMS/MS Analysis. (Pubmed Central) - Nov 17, 2021
Good results were obtained in terms of recoveries, matrix effect and sensitivity, showing that this method could represent a useful tool in forensic toxicology. The presented method was successfully applied to the analysis of proficiency test samples.
- fentanyl citrate / Generic mfg.
Awake cranial surgery with intraoperative language mapping for brain tumors. A single-center experience () - Nov 16, 2021 - Abstract #SNO2021SNO_1242;
Conscious sedation was the anesthetic technique (propofol, fentanyl, and NSAIDs)...CONCLUSION Tumor resection in awake patients showed to be a safe procedure, and well tolerated by the patients. Preoperative planning of anatomical and functional aspects and intraoperative neurophysiological assessment are the cornerstones for pursuing maximal safe resection.
- || fentanyl citrate / Generic mfg.
$NTRB $NTRBW Nutriband Inc. Initiates Commercial Development of Lead Product AVERSA(TM) Fentanyl https://t.co/C9T8MAmQqR (Twitter) - Nov 16, 2021
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Fentanyl versus nalbuphine for intubating conditions during awake fiberoptic bronchoscopy: A randomized double-blind comparative study. (Pubmed Central) - Nov 16, 2021
Hemodynamic responses and propofol and lignocaine requirements were also comparable. Both fentanyl and nalbuphine provide comparable intubating conditions when used before awake fiberoptic intubation with minimal adverse effects on hemodynamic profile.
- || ibuprofen / Generic mfg., dexmedetomidine / Generic mfg.
Clinical, Journal: Comparison between caudal epidural and ultrasound-guided ilioinguinal-iliohypogastric block with bupivacaine and dexmedetomidine for postoperative analgesia following pediatric inguinal hernia surgeries: A prospective randomized, double-blind study. (Pubmed Central) - Nov 16, 2021
The time taken for the performance of block was significantly higher for caudal compared to IL/IH (547 ± 93 vs. 317 ± 179 s; P < 0.001). Both caudal epidural and USG-IL/IH block with dexmedetomidine as additive provide the comparable duration of postoperative analgesia with no significant side effects.
- | fentanyl citrate / Generic mfg.
Retrospective data, Journal: A retrospective study comparing analgesic efficacy of ultrasound-guided serratus anterior plane block versus intravenous fentanyl infusion in patients with multiple rib fractures. (Pubmed Central) - Nov 16, 2021
US guided SAPB is an opioid sparing, effective interfascial plane block which is safe and should be considered early in all patients who sustain MRFs. Continuous SAPB by placing a catheter can provide pain relief for longer duration, facilitate early mobilization, physiotherapy and early ICU discharge.
- || fentanyl citrate / Generic mfg.
Clinical, Observational data, Journal: Influence of gender on postoperative pain in percutaneous nephrolithotomy: A prospective observational study. (Pubmed Central) - Nov 16, 2021
The mean pain score values (VAS P = 0.361; DVAS P = 0.332) and postoperative fentanyl (P = 0.703) did not show a statistically significant difference in males and females...No significant difference was observed in postoperative pain among males and females in patients undergoing PCNL surgery. The analgesic requirement, however, was found to be more in females than in males.
- | fentanyl citrate / Generic mfg.
Journal: Quantification of Classic, Prescription, and Synthetic Opioids in Hair by LC-MS-MS. (Pubmed Central) - Nov 16, 2021
The linearity range was 1-500 pg/mg for fentanyl and synthetic opioids and 10-500 pg/mg for prescription and classic opioids...This method was applied to 64 authentic cases, identifying 13 compounds from our panel. A sensitive and specific method was developed for the identification and quantification of 27 classic, prescription and synthetic opioids in hair by LC-MS-MS.