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5 Trials |
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- | ketamine / Generic mfg.
Journal: Sensitive determination of illicit drugs in wastewater using enrichment bag-based liquid-phase microextraction and liquid-chromatography tandem mass spectrometry. (Pubmed Central) - Jan 12, 2022
Finally, with standard addition method, EB-LPME-LC-MS/MS was successfully applied for the determination of the model drugs in a local hospital wastewater from Wuhan, China. This study clearly showed that EB-LPME displayed great potential as an efficient sample preparation method for isolation and enrichment of the drugs/pollutants from complex environmental samples for wastewater-based epidemiology in the near future.
- | fentanyl citrate / Generic mfg.
Journal: Analysis of 29 fentanyl analogs and their fragmentation mechanism by liquid chromatography-quadrupole time-of-flight mass spectrometry (Pubmed Central) - Jan 12, 2022
This method is rapid, simple, time-saving, highly sensitivity and stable, and it is applicable to a wide variety of samples. Hence, it is suitable for the identification, confirmation, and quantitative detection of the 29 fentanyl analogs in drugs, solids or powders containing sugar, beverages, drinking water, wine samples, etc.
- || ketamine / Generic mfg.
Clinical, Journal: Towards Evidence-Based Weaning: a Mechanism-Based Pharmacometric Model to Characterize Iatrogenic Withdrawal Syndrome in Critically Ill Children. (Pubmed Central) - Jan 11, 2022
The results yield hypotheses that could guide future clinical research on optimal weaning strategies. The mechanism-based PKPD modeling approach can be applied in other datasets to characterize the IWS dynamics of other drugs used in pediatric intensive care.
- | ketamine / Generic mfg.
Preclinical, Journal: Human histamine H receptors can initiate cardiac arrhythmias in a transgenic mouse. (Pubmed Central) - Jan 11, 2022
However, compounds reported to release histamine from cells and thereby leading to arrhythmias in humans, namely morphine, ketamine, and fentanyl, failed to induce a more pronounced positive inotropic effect in atrial preparations from H-TG compared to WT, arguing against an involvement of histamine release in their proarrhythmic side effects in patients...In summary, we noted that overexpression of human H-histamine receptors in a novel transgenic animal model can lead to arrhythmias. We suggest that this model might be useful to understand the mechanism(s) of histamine-induced cardiac arrhythmias in humans better in a molecular way and may be of value to screen novel antiarrhythmic drugs.
- || fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Clinical, Journal: Polysubstance Use Among Patients Treated With Buprenorphine From a National Urine Drug Test Database. (Pubmed Central) - Jan 11, 2022
While buprenorphine can curtail harmful opioid use, co-occurring use of nonprescribed substances, such as cocaine, methamphetamine, and other opioids, may negatively affect treatment outcomes...From 2013 to 2019, positivity rates increased for most substances (eg, fentanyl: from 131 of 21 412 [0.61%] to 1464 of 13 597 [10.77%])...In this cross-sectional study, patterns of nonprescribed substance positivity among patients prescribed buprenorphine varied widely. This study highlights the utility of UDT in public health surveillance efforts related to patients treated with buprenorphine for OUD.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Effects of fentanyl on acute locomotor activity, behavioral sensitization, and contextual reward in female and male rats. (Pubmed Central) - Jan 11, 2022
Fentanyl was more potent and/or effective to produce LMA and LMA sensitization in females but more potent to produce CPP in males. Furthermore, the role of sex in fentanyl responses varied across endpoints, and sex differences in LMA were not predictive of sex differences in CPP.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Characteristics of adults reporting illicitly manufactured fentanyl or heroin use or prescription opioid misuse in the United States, 2019. (Pubmed Central) - Jan 11, 2022
These findings provide new insights into this high-risk population and help identify strategies to address increasing overdose death rates involving IMF. Opportunities for intervention include expanding naloxone distribution and harm reduction programs and connecting individuals with nonfatal overdoses to SUD treatment.
- || fentanyl citrate / Generic mfg.
Clinical, Journal, Real-world evidence: Wearable biosensors have the potential to monitor physiological changes associated with opioid overdose among people who use drugs: A proof-of-concept study in a real-world setting. (Pubmed Central) - Jan 11, 2022
Our preliminary findings suggest that using a wearable biosensor to monitor physiological changes associated with opioid use was feasible. However, more sensitive biosensors that facilitate triangulation of multiple physiological data points and larger studies of longer duration are needed.
- | fentanyl citrate / Generic mfg.
Journal: Catheter-mounted smart hydrogel ultrasound resonators for intravenous analyte monitoring. (Pubmed Central) - Jan 11, 2022
Selectivity to different drugs, e.g., fentanyl, can be accomplished by developing a corresponding smart hydrogel composition.Clinical Relevance- Many intravenous medications, especially anesthetics, show considerable pharmacokinetic inter-subject variability. Continuous monitoring of intravenous analyte concentrations would enable individualizing the administration of these drugs to the specific patient.
- | remifentanil / Generic mfg.
Journal: Effects of Remifentanil and Sufentanil Anesthesia on Cardiac Function and Serological Parameters in Congenital Heart Surgery. (Pubmed Central) - Jan 11, 2022
The incidence of bradycardia, nausea and vomiting, hypotension, muscle rigidity, and respiratory depression in the treatment group was 16.67% lower than that in the control group (P < 0.05). Remifentanil has less influence on hemodynamics and a better analgesic effect than fentanyl in inhibiting stress response in congenital heart surgery, which provides reference and basis for children congenital heart surgery.
- || Chirocaine (levobupivacaine) / Purdue, AbbVie
Clinical, Journal: A Comparison Between Dexmedetomidine and Clonidine as Adjuvants to Levobupivacaine in Labour Analgesia. (Pubmed Central) - Jan 11, 2022
Conclusion Both dexmedetomidine and clonidine provide hemodynamically stable labor with a fall in heart rate and maternal blood pressure in the initial hours. Dexmedetomidine has the advantage of faster onset of analgesia and time for maximum analgesia.
- || fentanyl citrate / Generic mfg., epinephrine / Generic mfg.
Clinical, Journal: The Impact of Documenting Patient Weight in Kilograms on Pediatric Medication Dosing Errors in Emergency Medical Services. (Pubmed Central) - Jan 11, 2022
Documenting a weight in kilograms appears particularly important for specific medications and patient age groups. Additional strategies (including age-based standardized dosing) may be needed to further reduce pediatric dosing errors by EMS.
- ||| fentanyl citrate / Generic mfg.
Interview: A recently chatted with @TheDonlonReport about why America’s fentanyl crisis isn’t going away anytime soon. You can watch the full interview here: https://t.co/6NcozDxwPc (Twitter) - Jan 10, 2022
- |||| fentanyl citrate / Generic mfg.
Clinical: Great opportunity to work at @VAPaloAlto on opioid safety interventions (they fund naloxone and fentanyl test strips don't you know) with the amazing Jodie Trafton and others at Program Evaluation and Resource Center (PERC) @dkowens @KeithNHumphreys https://t.co/HOZQAP83NQ (Twitter) - Jan 10, 2022
- |||| fentanyl citrate / Generic mfg.
Clinical: Apparently it's easier to shame individuals for structural failures. Or perhaps some medical doctors just see the lives of PWUD as so disposable, they're willing to ignore the higher rate of deaths from fentanyl and NSO poisoning compared to covid. #biopolitics #EndTheStigma (Twitter) - Jan 10, 2022
- ||| fentanyl citrate / Generic mfg.
Sadly, fentanyl poisoning killed ~2x as many 18-45 year olds as covid. Republicans are horrible, but you could easily check this data yourself. You're a doctor. Facts matter. https://t.co/pnGsEr4fGd (Twitter) - Jan 10, 2022
- ||| fentanyl citrate / Generic mfg., methadone / Generic mfg.
ASK HER HOW COVID IS RELATED TO FENTANYL AND WATCH HER TRY TO JUSTIFY METHADONE (Twitter) - Jan 9, 2022
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Analgesic efficacy and safety of erector spinae plane block in breast cancer surgery: a systematic review and meta-analysis. (Pubmed Central) - Jan 8, 2022
Additional strategies (including age-based standardized dosing) may be needed to further reduce pediatric dosing errors by EMS. Ultrasound-guided ESPB is an effective approach for reducing morphine consumption and pain intensity within the first 24 h after breast cancer surgery, compared with GA alone.
- | nafamostat / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Physical compatibility of nafamostat with analgesics, sedatives, and muscle relaxants for coronavirus disease treatment. (Pubmed Central) - Jan 8, 2022
Ultrasound-guided ESPB is an effective approach for reducing morphine consumption and pain intensity within the first 24 h after breast cancer surgery, compared with GA alone. Infusions combining nafamostat with the tested sedatives, analgesics, and muscle relaxants could be safely administered.
- || Chirocaine (levobupivacaine) / Purdue, AbbVie
Clinical, Journal: A Randomized Double-Blind Controlled Trial to Assess the Efficacy of Ultrasound-Guided Erector Spinae Plane Block in Cardiac Surgery. (Pubmed Central) - Jan 8, 2022
It decreased the first 24-hour postoperative analgesic consumption by 64.5% and risk of pain by five times in the authors' population. It also reduced the sedation and duration of mechanical ventilation in postcardiac surgery patients.
- | midazolam hydrochloride / Generic mfg.
Preclinical, Journal: Effects of opioids and benzodiazepines on bladder function of awake restrained mice. (Pubmed Central) - Jan 8, 2022
The presence of electrodes next to the EUS does not obstruct the bladder outlet. Opioids and benzodiazepines severely interfere with physiological bladder function: fentanyl and hydromorphine disrupted the voiding phase evidenced by the reduced coordination of EUS activity with detrusor contraction, while bladder emptying under midazolam was achieved by EUS relaxation only.
- |||| fentanyl citrate / Generic mfg.
Clinical: Did twice as many people overdose in Fentanyl last year then die of Covid? Doesnt CoVID have a 95% comorbidity death rate. People had terminal cancer with Covid. Doesn’t seem like this pandemic is the crisis you’re making it out to be. (Twitter) - Jan 8, 2022
- || fentanyl citrate / Generic mfg.
Clinical, PK/PD data, Journal: Analysis of Fentanyl Pharmacokinetics, and its Sedative Effects and Tolerance in Critically-Ill Children. (Pubmed Central) - Jan 7, 2022
Using SBS scores may guide the dosing titration of fentanyl that resulted in plasma concentrations within the therapeutic range of 1-3 ng/mL. For those who developed tolerance to fentanyl and/or a sedative, it was noted one day after goal sedation was achieved.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Impact of changes in opioid funding and clinical policies on rapid tapering of opioids in Ontario, Canada. (Pubmed Central) - Jan 7, 2022
The monthly prevalence of rapid tapering events was stable from January 2014 to September 2016 (average monthly prevalence: 1.4%) but increased from 1.4% in October 2016 to 1.8% in April 2017 (P = 0.001), coincident with Ontario's Fentanyl Patch-for-Patch Return Program implementation...Our sensitivity analysis examining longer-lasting rapid tapering found similar trends but lower prevalence, with no changes in complete discontinuation. These temporary increases in rapid tapering events highlight the need for improved communication and evidence-based resources for prescribers to minimize negative consequences of evolving policies and guidelines.
- || methadone / Generic mfg.
Review, Journal: Intraoperative Methadone Use in Cardiac Surgery: A Systematic Review. (Pubmed Central) - Jan 7, 2022
Intraoperative methadone use reduces acute postoperative pain and lowers opioid consumption in comparison with morphine and fentanyl. Initial results suggest that methadone may be an equivalent opioid to be administered during cardiothoracic procedures to reduce acute postsurgical pain, though further research is warranted.
- || fentanyl citrate / Generic mfg., ropivacaine / Generic mfg.
Clinical, Observational data, Journal: A prospective observational study on the feasibility of subumbilical laparoscopic procedures under epidural anesthesia in sedated spontaneously breathing infants with a natural airway. (Pubmed Central) - Jan 7, 2022
Initial results suggest that methadone may be an equivalent opioid to be administered during cardiothoracic procedures to reduce acute postsurgical pain, though further research is warranted. In experienced hands, given our success rate of 100%, epidural anesthesia performed in sedated spontaneously breathing infants with a natural airway can be an alternative strategy for subumbilical laparoscopic procedures.
- || fentanyl citrate / Generic mfg., ropivacaine / Generic mfg., dexmedetomidine / Generic mfg.
Clinical, Journal: The strong rationale for the use of dexmedetomidine instead of fentanyl as adjuvant to ropivacaine for epidural anaesthesia. (Pubmed Central) - Jan 7, 2022
In experienced hands, given our success rate of 100%, epidural anesthesia performed in sedated spontaneously breathing infants with a natural airway can be an alternative strategy for subumbilical laparoscopic procedures. No abstract available
- | fentanyl citrate / Generic mfg., ketamine / Generic mfg., dexmedetomidine / Generic mfg.
Preclinical, Journal: Safety and Efficacy of Ketamine-Fentanyl-Dexmedetomidine-Induced Anesthesia and Analgesia in Neonatal and Aged Rats. (Pubmed Central) - Jan 7, 2022
These results indicated that the administration of KFD combination offered safe and efficient anesthesia. Collectively, our results suggest the potential implication of the KFD combination in anesthesia management.
- || Clinical, Journal: Causality Evaluation of Drug-Induced Liver Injury in Newborns and Children in the Intensive Care Unit Using the Updated Roussel Uclaf Causality Assessment Method. (Pubmed Central) - Jan 7, 2022
In children, the commonly used drug combinations are fentanyl + midazolam (20.7%), ibuprofen + furosemide (18.4%), and diazepam + omeprazole (15.3%)...Also, attention should be paid to the effect on CYP enzymes when using multiple drugs at the same time. In future DILI cases, it is advisable to use the latest RUCAM for prospective study design so that complete case data and high RUCAM scores can be collected.
- || dexmedetomidine / Generic mfg.
Retrospective data, Review, Journal: Intravenous Dexmedetomidine as an Adjunct to Neuraxial Anesthesia in Cesarean Delivery: A Retrospective Chart Review. (Pubmed Central) - Jan 7, 2022
While the use of inotropic/vasopressor medications was common and similar in both groups, there was an increase in the incidence of bradycardia (Dexmed 15% vs. Standard 2%; p=0.042) but not hypotension (Dexmed 24% vs. Standard 24%; p=1.00) in the Dexmed group. In patients who required supplemental analgesia for cesarean delivery, those who received dexmedetomidine versus other medications had a similar rate of conversion to general anesthesia, a statistically significant increase in bradycardia, but no difference in the incidence of hypotension.
- | fentanyl citrate / Generic mfg.
Journal: Low Knowledge of HIV PrEP Within a Midwestern US Cohort of Persons who Inject Drugs. (Pubmed Central) - Jan 7, 2022
Knowledge of PrEP was poor. Patients felt that PrEP was for sexual intercourse rather than injection drug use, and PWID managed on medications for opioid use disorder felt that they had no need for PrEP.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Analgesic efficacy of ultrasound-guided transversus abdominis plane block for laparoscopic gynecological surgery: a randomized controlled trial. (Pubmed Central) - Jan 7, 2022
No significant difference was observed between the groups in need of rescue fentanyl or antiemetic and the nausea-vomiting scores. In patients undergoing laparoscopic gynecological surgery, ultrasound-guided TAP block provided greater postoperative analgesic benefits in terms of lower NRS and reduced analgesic requirements than port site LAI.
- || aminophylline / Generic mfg.
Clinical, Journal: The effect of preoperative aminophylline on the recovery profile after major pelvic-abdominal surgeries: a randomized controlled double-blinded study. (Pubmed Central) - Jan 6, 2022
P1
In patients undergoing laparoscopic gynecological surgery, ultrasound-guided TAP block provided greater postoperative analgesic benefits in terms of lower NRS and reduced analgesic requirements than port site LAI. Premedication with aminophylline enhanced the recovery profile after pelvic-abdominal surgeries under general anaesthesia without cardiovascular complications.
- || dexmedetomidine / Generic mfg.
Clinical, Journal: Effects of lidocaine, dexmedetomidine, and their combination infusion on postoperative nausea and vomiting following laparoscopic hysterectomy: a randomized controlled trial. (Pubmed Central) - Jan 6, 2022
P=N/A
Lidocaine combined with dexmedetomidine infusion markedly decreased the occurrence of nausea and PONV at 0-2 h as well as the total 24 h PONV. However, it significantly increased the incidence of mouth dry, bradycardia, and over sedation during the PACU stay period after laparoscopic hysterectomy with general anesthesia.
- | midazolam hydrochloride / Generic mfg.
Journal: Choice of anesthesia and data analysis method strongly increases sensitivity of 18F-FDG PET imaging during experimental epileptogenesis. (Pubmed Central) - Jan 6, 2022
This study reveals evaluation of anesthesia protocols for preclinical 18F-FDG PET imaging as a critical step in the study design. Together with an appropriate data analysis workflow, the chosen anesthesia protocol may uncover otherwise concealed disease-associated regional glucometabolic changes.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Increased heroin intake and relapse vulnerability in intermittent relative to continuous self-administration: sex differences in rats. (Pubmed Central) - Jan 6, 2022
Intermittent heroin access in rats resembles critical features of heroin use disorder: a self-administration pattern characterized by repeated large doses of heroin and higher relapse vulnerability during early abstinence. This has significant implications for refining animal models of substance use disorder and for better understanding of the neuroadaptations responsible for this disorder.
- ||| midazolam hydrochloride / Generic mfg.
Clinical, Journal, Adverse events: Adverse events associated with electrical cardioversion in patients with acute atrial fibrillation and atrial flutter. (Pubmed Central) - Jan 5, 2022
Physicians should be aware that older age, coronary artery disease, and fentanyl are associated with a higher risk of important adverse events. This study provides more information for shared decision-making discussions with patients when choosing between drug-shock and shock-only cardioversion strategies.
- || fentanyl citrate / Generic mfg.
We have been maligned and neglected for years. My first forced tapering began in 2015. She did it 4 times before I found another provider. Then my care was abandoned, then forced tapered off 75 mcg of fentanyl in 5 days. Forced tapered this past August. Don't act like you care! (Twitter) - Jan 5, 2022
- |||| fentanyl citrate / Generic mfg., tramadol hydrochloride / Generic mfg.
Clinical: Well duh? Opioids containing cough and cold meds increased because we are in the middle of COVID pandemic. Original COVID and Delta variant the lungs were primary target. It's not Vet shopping. No one's paying;$250 vet bill for tramadol. Stop! Illicit fentanyl is killing people. (Twitter) - Jan 5, 2022
- |||| fentanyl citrate / Generic mfg.
Post 2 (SS). Lot of 5-HT-ergics (see list): MAOIs & SJW 2 wk washout; caffeine in excess dec flvx metab (stop caffeine or cut down as flvx inc its level in turn); ginseng, SAMe, ecstasy, cocaine,fentanyl- inc 5-HT. Avoid SSRI/SNRI. Grapefruit j to less ext blocks 1A2 (mainly 3A4) (Twitter) - Jan 5, 2022
- ||| fentanyl citrate / Generic mfg., dexmedetomidine / Generic mfg.
Clinical: 3/ This patient on 100% O2 and high-dose propofol & fentanyl did not need both agents. When able, we try to avoid prop & benzos. We stopped Prop, continued Fentanyl & added dexmedetomidine because it’s shorter acting & won’t build up so much in her brain. This is the #A2Fbundle. (Twitter) - Jan 4, 2022
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Same-day opioid administration in opiate naïve patients is not associated with opioid-induced esophageal dysfunction (OIED). (Pubmed Central) - Jan 4, 2022
EGDs were performed exclusively with versed and fentanyl...Same-day acute opioid administration did not affect HRM findings in opioid naïve patients. Studies assessing the pathophysiology of and duration-dependent relationship with opioids in OIED are needed.
- || fentanyl citrate / Generic mfg., ketamine / Generic mfg.
Clinical, Journal: Investigation Of The Effects Of Propofol/Ketamine Versus Propofol/Fentanyl On Nausea-Vomiting Administered For Sedation In Children Undergoing Magnetic Resonance Imaging: A Prospective Randomized Double-Blinded Study. (Pubmed Central) - Jan 4, 2022
Studies assessing the pathophysiology of and duration-dependent relationship with opioids in OIED are needed. In our study, we showed that the vomiting rate was higher in the 1st hour in Group K compared to Group F.
- | fentanyl citrate / Generic mfg., paclitaxel / Generic mfg.
Journal: Cannabinoid CB Receptor Activation Attenuates Fentanyl-Induced Respiratory Depression. (Pubmed Central) - Jan 4, 2022
Moreover, the CB agonist, administered alone, did not alter respiration. Our findings suggest that the CB cannabinoid agonist LY2828360 may provide CB-mediated protection against fentanyl-induced respiratory depression, a detrimental and unwanted side effect of opioid use and abuse.
- | lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Assessment of 2-Year Neurodevelopmental Outcomes in Extremely Preterm Infants Receiving Opioids and Benzodiazepines. (Pubmed Central) - Jan 4, 2022
In contrast, BSID-III scores for infants with short exposure to both opioids and benzodiazepines were not different than those of infants without exposure. In this study, prolonged combined use of opioids and benzodiazepines was associated with a risk of poorer neurodevelopmental outcomes as measured by BSID-III at 2 years' corrected age.
- | dexmedetomidine / Generic mfg.
Retrospective data, Journal: Effect of continuous infusion of dexmedetomidine on blood loss in orthognathic surgery: a retrospective study. (Pubmed Central) - Jan 4, 2022
In this study, prolonged combined use of opioids and benzodiazepines was associated with a risk of poorer neurodevelopmental outcomes as measured by BSID-III at 2 years' corrected age. Continuous infusion of dexmedetomidine can decrease blood loss in orthognathic surgery.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Review, Journal: Opioids in patients with COPD and refractory dyspnea: literature review and design of a multicenter double blind study of low dosed morphine and fentanyl (MoreFoRCOPD). (Pubmed Central) - Jan 4, 2022
P4
We believe our study design to investigate both sustained-release morphine and transdermal fentanyl for refractory dyspnea will provide valuable information for better treatment of refractory dyspnea in COPD. Trial registration NCT03834363 (ClinicalTrials.gov), registred at 7 Feb 2019, https://clinicaltrials.gov/ct2/show/NCT03834363 .
- |||| fentanyl citrate / Generic mfg., tramadol hydrochloride / Generic mfg.
Clinical: Paying hundreds of dollars for a chihuahua sized dose of tramadol crumbs for a dog surgery makes so much sense compared to the ubiquitous availability of illegal cartel-dealt fentanyl in every town in U.S. Pets are suffering agony just like our elderly, hospice, cancer patients. (Twitter) - Jan 4, 2022
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Journal: Effects of Morphine and Fentanyl on Patients with COVID-19. (Pubmed Central) - Jan 4, 2022
This may be due to the use of these drugs in the viral phase of the disease. The use of morphine and fentanyl in the viral phase of COVID 19 disease do not show significant benefits.