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- | fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
Journal: Safe Practice of Total Intravenous Anesthesia With Target-Controlled Infusion in Taiwan: A Recommendation. (Pubmed Central) - Jan 27, 2022
Due to a limited consensus among Taiwanese medical professionals, this document is intended to act as a safe practice reference for the use of TIVA with TCI. Additionally, two pithy formula codes, 4321 for propofol with fentanyl/alfentanil and 42222111 for propofol with remifentanil, are provided for the general population and one pithy formula code, 4321 for propofol with fentanyl, is provided for pediatric patients.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Emergency Department Drug Surveillance (EDDS) hospital's urinalysis results compared with expanded re-testing by an independent laboratory, a pilot study. (Pubmed Central) - Jan 27, 2022
The expanded testing also uncovered drugs that the hospital might consider adding to their routine screen. EDDS is a feasible system for monitoring and confirming recent substance use trends among ED patients.
- | Chirocaine (levobupivacaine) / Purdue, AbbVie
Journal: Progress of labor and obstetric outcome in parturients with combined spinal-epidural analgesia for labor: A comparative study. (Pubmed Central) - Jan 27, 2022
CSE analgesia did not affect the duration of labour, mode of delivery with minimal fetomaternal adverse effects and provides rapid onset of pain relief . CSE analgesia can be considered for safe and effective labour analgesia.
- || Instanyl (fentanyl) / Takeda
Clinical, Retrospective data, Journal: Intranasal Fentanyl and Midazolam Use in Children 3 Years of Age and Younger in the Emergency Department. (Pubmed Central) - Jan 27, 2022
Intranasal fentanyl and midazolam, alone and in combination, can provide analgesia and anxiolysis to children aged 3 years and younger in the ED setting. Further prospective studies are needed to better evaluate their safety and efficacy in this younger population.
- | fentanyl citrate / Generic mfg.
Observational data, Journal: Association between fentanyl treatment for acute pain in the emergency department and opioid use two weeks after discharge. (Pubmed Central) - Jan 27, 2022
Patients treated with fentanyl during ED stay did not consume more opioids after ED discharge, compared to those treated with other opioids. If fentanyl does cause more hyperalgesia compared to other opioids, it does not seem to have a significant impact on opioid consumption after ED discharge.
- || methadone / Generic mfg.
Clinical, Journal: Methadone initiation in a bridge clinic for opioid withdrawal and opioid treatment program linkage: a case report applying the 72-hour rule. (Pubmed Central) - Jan 27, 2022
While patients continue to face substantial access barriers, bridge clinics can play an important role in treating opioid withdrawal, building partnerships with OTPs to initiate methadone on demand, and preventing life-threatening delays to methadone treatment. Federal policy reform is urgently needed to make methadone more accessible to people with OUD.
- | Dynastat (parecoxib) / Pfizer
Journal: Comparison of Combination Between Ketamine and Parecoxib as Multimodal Preemptive Analgesia With Ketamine Alone for Elective Laparotomy. (Pubmed Central) - Jan 27, 2022
Federal policy reform is urgently needed to make methadone more accessible to people with OUD. Among laparotomy patients, multimodal preemptive analgesia by the use of a combination of low-dose IV ketamine and IV parecoxib was more effective than IV ketamine alone in reducing pain scores and postoperative analgesia requirement (e.g., PCA-administered morphine).
- | fentanyl citrate / Generic mfg.
Journal: Diverse psychotropic substances detected in drug and drug administration equipment samples submitted to drug checking services in Toronto, Ontario, Canada, October 2019-April 2020. (Pubmed Central) - Jan 27, 2022
Toronto's DCS identified a range of high-potency opioids with stimulants, benzodiazepine-type drugs, and a synthetic cannabinoid, AMB-FUBINACA. This information can inform a range of evidence-informed overdose prevention efforts.
- || fentanyl citrate / Generic mfg.
Clinical, Observational data, Journal: Continuous Incisional Lidocaine in Pediatric Patients following Open Heart Surgery. (Pubmed Central) - Jan 27, 2022
Incisional analgesia was effective for the treatment of pain as it reduced the dose and duration of intravenous fentanyl (odds ratio (OR) 6.26, confidence interval (CI) 95%: 2.48-15.97, p = 0.001; OR 4.30, CI 95%: 2.09-8.84, p = 0.001, respectively)...This procedure reduced intravenous analgesic drug requirements in pediatric patients undergoing a median sternotomy incision. Although the incidence of secondary effects is low, monitoring of neurologic status and lidocaine blood levels are recommended in all patients.
- || fentanyl citrate / Generic mfg.
Only if you've got what it takes though. You'll have to have the conscience of a fentanyl dealer, the heart of human trafficker that is a pimp of underage girls, and the principles of a peddler of lies and disinformation to the public at large so as to sell your bullshit book. (Twitter) - Jan 26, 2022
- || Review, Journal: Opioids in COVID-19: Two Sides of a Coin. (Pubmed Central) - Jan 26, 2022
Out of the 5,273,598 opioid units used in this period all over the country, morphine, fentanyl, and remifentanil, accounted for, respectively, 559,270 (10.6%), 4,624,328 (87.6%), and 90,000 (1.8%) units...In the COVID-19 pandemic scenario, positive points related to opioids were mainly the occurrence of analgesia, to facilitate intubation and their use as coadjutants in the management of acute intensification of pain, whereas the negative points were indiscriminate use, the presence of human immunosuppressor response and increased adverse effects due to higher doses of the drug. The importance of rational and individualized use of analgesic hypnotics and sedative anesthetics should be considered at all times, especially in situations of high demand such as the COVID-19 pandemic.
- | fentanyl citrate / Generic mfg.
Journal: Correlation Between Anthropometric Measurements and Sensory Block Level of Spinal Anesthesia for Cesarean Section. (Pubmed Central) - Jan 26, 2022
Spinal anesthesia was induced by administering 8 mg of 0.5% hyperbaric bupivacaine and 20 μg of fentanyl at the L3-L4 interspace...When comparing the groups with and without hypotension, BMI, weight, and supine AC/height ratio were found to be significantly higher in the group with hypotension (P = 0.002, P = 0.004 and P = 0.006, respectively). We conclude that BMI and AC/height ratio correlate with the sensory block level of spinal anesthesia for cesarean section.
- || fentanyl citrate / Generic mfg.
Do you see reduced opioid use afterwards without prolonged withdrawal? I’m stuck on 1/3 my highest RX fentanyl (highly sensitive to withdrawal, v boring) but having Cholecystectomy soon, plan is to use perioperative ket & infusion for 2 days, told I might reduce total as result? (Twitter) - Jan 25, 2022
- || fentanyl citrate / Generic mfg.
No monoclonals, anti-viral pills, IM, but hey…plenty Fentanyl! 🙄🤦♀️ (Twitter) - Jan 23, 2022
- ||| fentanyl citrate / Generic mfg.
Impeach Biden for his lack of leadership; unfit due to dementia, sovereignty/boarder security-fentanyl abuse, C-19, foreign policy blunders; Ukraine/Russia, Afghanistan, inflation, ineptitude, “G.Floyd death greater than MLKs!, really? On MLK day. Divisive/Racist. IMPEACH 52-48🇺🇸 (Twitter) - Jan 23, 2022
- ||| fentanyl citrate / Generic mfg.
Fentanyl is the leading cause of death in Americans age 18-45. But let's keep talking about covid19. Fentanyl is also a communist chinese export. (Twitter) - Jan 22, 2022
- |||| fentanyl citrate / Generic mfg.
Clinical: And they continue to poison patients w/ RemDeathIsNear and never use cyproheptadin and use confounding fentanyl and blow out lungs on vents? All while reducing using sugar IV “nutrition “ that feeds Covid? Why is that ubiquitous? Why are so many families pleading for treatment? (Twitter) - Jan 21, 2022
- ||| fentanyl citrate / Generic mfg.
Clinical: I hope so. Lack of social opprobrium is not the reason that people are dying from fentanyl overdoses. The longest U.S. war is not Afghanistan—it’s the War on Drugs. Could a strategy based on harm reduction succeed where law enforcement has failed? https://t.co/RtSP9rc5E7 (Twitter) - Jan 21, 2022
- | fentanyl citrate / Generic mfg.
Journal: Overdose from a patch (Pubmed Central) - Jan 21, 2022
Incorrect administration causes intoxication with the leading symptoms of loss of consciousness and respiratory depression. This case report extends the spectrum of symptoms to include skeletal muscle rigidity otherwise only described in connection with intravenous administration, especially in anaesthetic settings.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Review, Journal: Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, OPRM1: Insight into Complex Mu Opioid Actions. (Pubmed Central) - Jan 21, 2022
More importantly, the OPRM1 variants can be targeted for development of novel opioid analgesics that are potent against multiple types of pain, but devoid of many side-effects associated with traditional opiates. In this review, we provide an overview of OPRM1 alternative splicing and its functional relevance in opioid pharmacology.
- ||| fentanyl citrate / Generic mfg.
Interview: I recently spoke with @GDLA about the staggering number of fentanyl overdoses and what we can do to better prevent them. You can watch the full interview here: https://t.co/BswaESm9F3 (Twitter) - Jan 20, 2022
- | fentanyl citrate / Generic mfg.
Journal: Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated. (Pubmed Central) - Jan 20, 2022
A naloxone pretreatment (10 mg/kg) attenuated the hypoventilatory effects of all drugs. These results establish that the respiratory depressant effects of these fentanyl analogs are at least in part mediated by the MOR.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Enduring consequences of perinatal fentanyl exposure in mice. (Pubmed Central) - Jan 19, 2022
Finally, by adulthood (PD 55), they displayed impaired performance in a two-tone auditory discrimination task. Collectively, our findings suggest that perinatal fentanyl-exposed mice exhibit somatic withdrawal behavior and change into early adulthood reminiscent of humans born with NOWS.
- | fentanyl citrate / Generic mfg.
Journal: Determination of synthetic opioids in oral fluid samples using fabric phase sorptive extraction and gas chromatography-mass spectrometry. (Pubmed Central) - Jan 19, 2022
The absolute recovery values were in the range of 94.5%-109.1%. The validated method demonstrated its great potential to detect and quantify fentanyl analogs in possible forensic work and off-site analysis in road traffic cases.
- || midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
Retrospective data, Review, Journal: The anesthesia induction effect of dexmedetomidine in patients undergoing laryngeal mask intubation: a systematic review and meta-analysis of 7 RCTs. (Pubmed Central) - Jan 19, 2022
The validated method demonstrated its great potential to detect and quantify fentanyl analogs in possible forensic work and off-site analysis in road traffic cases. The application of dexmedetomidine in the anesthesia induction with LMI has a good sedative effect, improves the success rate of LMI, reduces adverse reactions.
- || fentanyl citrate / Generic mfg.
I real shout out to the amazing students who have gotten the University to agree to allow this, after much planning and negotiation. They changed university policy. Nicole Ticea, Max Moss, Jennifer Shah, others. 💪💪💪 #harmreduction works. Fentanyl test strips next. (Twitter) - Jan 18, 2022
- || Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Clinical, Journal: Tapentadol in Cancer Patients with Neuropathic Pain: A Comparison of Methadone, Oxycodone, Fentanyl, and Hydromorphone. (Pubmed Central) - Jan 18, 2022
However, the pain intensity was evaluated without pain assessment scales specific to NP. Thus, we think that it is desirable to validate our findings using assessment scales, such as the painDETECT questionnaire in future.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Pupil Light Reflex for the Assessment of Analgesia in Critically Ill Sedated Patients With Traumatic Brain Injury: A Preliminary Study. (Pubmed Central) - Jan 18, 2022
In our sample, percentages of variation in PLR and PD were found to be directly representative of TBI patients' fentanyl blood concentration. Considering information about blood drug concentration is generally not available at bedside, PLR could be used as a proxy to assess analgesia requirements before a nociceptive procedure in critically ill sedated TBI patients who are vulnerable to stress.
- | midazolam hydrochloride / Generic mfg.
Retrospective data, Journal: Retrospective study on the factors influencing the severity of pressure injuries among intensive care unit patients. (Pubmed Central) - Jan 18, 2022
For critically ill patients on ventilators, it is recommended to devise a means of assessing each patient daily as well as systematically reduce their dosage of midazolam or fentanyl. Furthermore, regularly monitoring albumin and haemoglobin levels to understand their nutritional status is necessary.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Study on individualized analgesia guided by CYP3A4/5 polymorphisms in perioperative thoracoscopic surgery. (Pubmed Central) - Jan 18, 2022
Furthermore, regularly monitoring albumin and haemoglobin levels to understand their nutritional status is necessary. According to the genotype of CYP3A4/CYP3A5, an individualized application of fentanyl is feasible.
- |||| fentanyl citrate / Generic mfg.
Clinical: #PainPatientsAreNotAddicts How about making good on your statement that you support healthcare services for the disabled by addressing the medical abandonment of #ChronicPain patients, & @CDCgov's failure to distinguish between illicit fentanyl & legitimate Rx in OD stats? (Twitter) - Jan 17, 2022
- || fentanyl citrate / Generic mfg.
I survived! I was lucky to never run into fentanyl,though. 3 years opiate free. 508 days AF (Twitter) - Jan 17, 2022
- |||| fentanyl citrate / Generic mfg.
Clinical: Not in 2022. Nope. NADA. UH UH. No. Exactly No. Please stop adding to the “pain pills from doctors are everywhere and people are overdosing right & left on them” propaganda narrative. Illicit pressed fentanyl pills on the street? Absolutely Prescriptions? No @CDCDirector @DEAHQ (Twitter) - Jan 17, 2022
- || fentanyl citrate / Generic mfg.
13-Year-Old Dies After Fentanyl Overdose at School. Police found 40 small bags of powdered fentanyl in the gymnasium and several classrooms. @Cleavon_MD https://t.co/q7NdvpiV1l (Twitter) - Jan 16, 2022
- || fentanyl citrate / Generic mfg.
call me naive but I think one of the most concerning trends is the production of fentanyl containing pills. bag of heroin who knows that you get. but a pill used to be a measured dose of a drug. I've seen deaths related to this mistrust. tragically (Twitter) - Jan 15, 2022
- | ketamine / Generic mfg.
Journal: Prevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia. (Pubmed Central) - Jan 15, 2022
When there was pain, patients in the ketamine group gave a lower score to its intensity (p < 0.05). Ketamine could reduce the incidence of APP in breast cancer surgery, compared to opioids.
- || Instanyl (fentanyl) / Takeda
Clinical, PK/PD data, Journal: Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers. (Pubmed Central) - Jan 15, 2022
No serious AE occurred. Pharmacokinetic parameters and bioavailability of the investigated intranasal fentanyl indicated suitability for its intended use as an intranasal PCA option.
- ||| fentanyl citrate / Generic mfg.
Our kids and streets are RIDDLED w fentanyl. It’s absolutely horrible. I see so many wonderful people dying Fentanyl is SO powerful at stopping people from breathing, so they suffocate. Heartbreaking. (Twitter) - Jan 14, 2022
- ||| fentanyl citrate / Generic mfg.
Clinical: I don’t understand what you’re getting at here. Are you implying that fentanyl proximity leads to intoxication? 1st responders are increasingly reluctant to provide help to apneic pts due to unfounded fears. Yes, fentanyl is potent, but you still have to actually ingest it. (Twitter) - Jan 14, 2022
- ||| fentanyl citrate / Generic mfg.
Clinical: And they are mixing fentanyl into stimulant drugs like cocaine that people tend to consume as much as possible when they have it on-hand. Line after line, all night long until the synthetic opioid catches up to you… (Twitter) - Jan 14, 2022
- || fentanyl citrate / Generic mfg.
Maybe if @CDCgov / @DEAHQ had correctly reported ODs as being from illicit fentanyl rather than prescription drugs these last 10 years, their message would actually get some traction. When you lie about the etiology of a problem, it is impossible to solve. (Twitter) - Jan 14, 2022
- ||| fentanyl citrate / Generic mfg.
Clinical: School campus locked down after 13-year-old's apparent fentanyl overdose. "Ask every parent you know to talk their children, and make sure they know how serious and how dangerous any drug can be." https://t.co/rK2QhGOLye (Twitter) - Jan 13, 2022
- || fentanyl citrate / Generic mfg.
Great piece by @MorganGodvin and @kristen_mph. Not the usual narrative, important to read. Thanks for sending @KyleHarrisonMD. It’s about #fentanyl don’t you know. Learning the Blues: West Coast Grapples With Shifting Drug Supply https://t.co/q1JFs7xqkP via @Filtermag_org (Twitter) - Jan 13, 2022
- ||||| fentanyl citrate / Generic mfg.
Clinical: A fatal does of fentanyl is only this many specks👇. Prison yards & streets are full of it. 👎 Not detected on many drug screens. My last several pts who died of respiratory arrest & anoxic brain injury were in their 20s. So sad. Teach our kids the dangers of street drugs. (Twitter) - Jan 13, 2022
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Effect of surgical pleth index-guided analgesia versus conventional analgesia techniques on fentanyl consumption under multimodal analgesia in laparoscopic cholecystectomy: a prospective, randomized and controlled study. (Pubmed Central) - Jan 13, 2022
Pharmacokinetic parameters and bioavailability of the investigated intranasal fentanyl indicated suitability for its intended use as an intranasal PCA option. Lower doses of fentanyl are required intraoperatively with shorter extubation times when SPI is used to guide intraoperative analgesia compared to conventional analgesia techniques under multimodal analgesia in laparoscopic cholecystectomy.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Efficacy of Preemptive Analgesia on Postoperative Pain Control in Children Who Underwent Full-Mouth Dental Rehabilitation Under General Anesthesia: A Randomized Controlled Clinical Trial. (Pubmed Central) - Jan 13, 2022
Preemptive use of intravenous paracetamol reduces postoperative pain scores and postoperative opioid consumption. However, there is a need to evaluate pain levels in children who receive comprehensive dental treatment under general anesthesia after hospital discharge for effective postoperative pain control.
- || ondansetron / Generic mfg.
Clinical, Journal: Medication Errors in Pediatric Patients After Implementation of a Field Guide with Volume-Based Dosing. (Pubmed Central) - Jan 13, 2022
After implementation of a precalculated mL dose system by patient age for EMS providers, most pediatric medications were reportedly administered within the appropriate dose range. A field guide with precalculated doses (in mL) may be an effective tool for reducing pediatric medication dosing errors by EMS providers.
- || dextromethorphan / Generic mfg.
Review, Journal: Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity. (Pubmed Central) - Jan 12, 2022
Opioids may provoke serotonin toxicity especially if administered in conjunction with other serotonergic medications. The increasing use of opioid analgesics and widespread prescribing of antidepressants and psychiatric medicines, indicates the likelihood of an increased incidence of serotonin toxicity in opioid-treated patients.
- | fentanyl citrate / Generic mfg.
Journal: Severe poisoning after smoking a mixture of 4-fluoroisobutyryl fentanyl (4-FiBF) and alpha-pyrolidinoisohexaphenone (α-PiHP). (Pubmed Central) - Jan 12, 2022
Unique combination of clinical symptoms was a result of a simultaneous 4-FiBF and α-PiHP intoxication. To our knowledge, this is the first case of ingestion such unusual mixture of new psychoactive substances with a full description of medical treatment.
- ||| fentanyl citrate / Generic mfg.
..food intake of the obese? They don’t handle the fentanyl issue. (Twitter) - Jan 12, 2022