- |||||||||| fentanyl citrate / Generic mfg.
Journal: Public health surveillance of new psychoactive substances: recent developments. (Pubmed Central) - Apr 8, 2024 Studies that combine self-report data with toxicology testing in particular are important for capturing unintentional or unknown exposure to NPS including fentanyls and drugs like xylazine. Given the limitations associated with individual indicators of drug use and associated harms, the harmonization of multiple data sources can help present a more complete picture of both trends involving NPS to better inform public health responses.
- |||||||||| fentanyl citrate / Generic mfg., naltrexone / Generic mfg.
Review, Journal: Nalmefene Hydrochloride: Potential Implications for Treating Alcohol and Opioid Use Disorder. (Pubmed Central) - Apr 8, 2024 The substantially longer half-life of nalmefene and 5-fold higher binding affinity to opioid receptors makes it a superior agent over naloxone in the reversal of high potency synthetic opioids like fentanyl and the emerging nitazenes. Nalmefene presents with a comparable side effect profile to other opioid antagonists and should be considered for further development as a maintenance treatment for opioid and other substance use disorders.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: Plasma drug screening using paper spray mass spectrometry with integrated solid phase extraction. (Pubmed Central) - Apr 8, 2024 The method was validated on authentic overdose samples collected from two emergency departments in Indianapolis, Indiana, from suspected or known overdoses. Commonly detected synthetic drugs included fentanyl related substances, designer benzodiazepines such as flubromazolam, and the synthetic cannabinoid 5F-PB-22.
- |||||||||| fentanyl citrate / Generic mfg.
PK/PD data, Journal: The pharmacokinetics and pharmacodynamics of fentanyl administered via transdermal patch in horses. (Pubmed Central) - Apr 4, 2024 There was a significant effect of time (p?=?0.003) on heart rate with overall heart rates being less than baseline at 64?h. Fentanyl administered via transdermal patch is well absorbed and well tolerated but does not result in an anti-nociceptive effect as measured by thermal and mechanical threshold at the doses studied.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Rapid detection of furanyl fentanyl in complex matrices using Leidenfrost desorption-assisted low-temperature arc plasma ionization mass spectrometry. (Pubmed Central) - Apr 3, 2024 Moreover, the characteristic ion peaks of furanyl fentanyl can be distinctly identified within complex matrices such as wine, beverages, urine, and lake water. This innovative drug detection technology offers several advantages, including a simple setup, cost-effectiveness, rapid detection, high sensitivity, and minimal sample pretreatment.
- |||||||||| fentanyl citrate / Generic mfg.
HCV reinfection among people who use drugs (PWUD) treated for HCV infection: a long-term view (Poster Area) - Apr 2, 2024 - Abstract #EASLILC2024EASL_ILC_740; Even within a very vulnerable group of individuals with a high risk of HCV reinfection, our program with systematic and comprehensive approaches to reduce the risk of reinfection are associated with rates below 5/100 py. As we treat increasing numbers of individuals who are more vulnerable, strategies such as the ones we have implemented will be important in maximizing the benefits of HCV therapy in these priority populations.
- |||||||||| Mavyret (glecaprevir/pibrentasvir) / AbbVie, Enanta Pharma
Long term outcome among HCV-infected people who use drugs (PWUD) successfully treated for HCV infection with Glecaprevir/Pibrentasvir (G/P) (Poster Area) - Apr 2, 2024 - Abstract #EASLILC2024EASL_ILC_737; Beyond our ability to successfully treat HCV infection in vulnerable inner-city populations, there is a need to maximize the benefit of therapy after a cure has been achieved, especially in the setting of the opioid crisis. Our data suggests that by maintaining these individuals in care post-SVR, our program leads to a reduction in overdose deaths, a systematic detection of reinfection events and prompt re-initiation of HCV therapy when it is required.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., dexamethasone injection / Generic mfg.
Review, Journal: Caesarean Delivery: A Narrative Review on the Choice of Neuraxially Administered Opioid and Its Implications for the Multimodal Peripartum Pain Concept. (Pubmed Central) - Apr 1, 2024 Long-acting lipophobic opioids (diamorphine and morphine) have a significant analgesic advantage over short-acting lipophilic opioids (sufentanil and fentanyl)...The question remains as to whether a pain concept that is ideally adapted to a neuraxial short-acting opioid shows benefit to a pain concept that is optimally adapted to neuraxial morphine. If long-acting opioids are used, the timing of each additional component of the multimodal analgesia strategy could ideally be adjusted to this longer duration of action.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Evaluating the rate of reversal of fentanyl-induced respiratory depression using a novel long-acting naloxone nanoparticle, cNLX-NP. (Pubmed Central) - Mar 29, 2024 While cNLX-NP alone may not sufficiently reverse F/FA overdose in a timely manner, mixing free NLX with cNLX-NP can provide a mechanism to both rapidly reverse fentanyl-related effects and maintain extended protection against synthetic opioid toxicity. These data support further development of cNLX-NP as a fast-acting and long-lasting antidote to treat F/FA-induced respiratory depression and overdose, and potentially prevent renarcotization in humans.
- |||||||||| INI-4001 / Inimmune
Mechanistic insights into the cellular and molecular mechanisms of an anti-opioid vaccine formulated with a novel Toll-Like receptor (TLR) 7/8 agonist (Exhibit Hall F1; Poster Board Number: B575) - Mar 29, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_2069; We applied in vivo and in vitro flow cytometry-based assays to decipher innate immune response and B cell responses associated with adjuvanted fentanyl vaccine formulation. Kinetics of innate immune response post vaccination at the site of injection (muscle) and draining lymph nodes were tracked, as well as the maturation and the activation status of multiple dendritic cell (DC) subsets and other cells, to identify early molecular signatures of vaccine efficacy.
- |||||||||| fentanyl citrate / Generic mfg.
Optimization of an anti-fentanyl monoclonal antibody to improve stability (Exhibit Hall F1; Poster Board Number: B938) - Mar 29, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_1378; One specific mutation resulted in a 40-fold increase in affinity measured against a fentanyl hapten by BLI, and a 4-fold increase in affinity for free fentanyl by competitive ELISA. Future studies will seek to validate the improved mAb affinity in vivo relative to the parent mAb.
- |||||||||| fentanyl citrate / Generic mfg.
Optimization of an anti-fentanyl monoclonal antibody to improve stability (Exhibit Hall F1; Poster Board Number: B937) - Mar 29, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_1377; One specific mutation resulted in a 40-fold increase in affinity measured against a fentanyl hapten by BLI, and a 4-fold increase in affinity for free fentanyl by competitive ELISA. Future studies will seek to validate the improved mAb affinity in vivo relative to the parent mAb.
- |||||||||| fentanyl citrate / Generic mfg.
Journal, Video, Surgery: Postoperative pulmonary complications in awake video-assisted thoracoscopic surgery: Our 10-year experience. (Pubmed Central) - Mar 28, 2024 According to the ARISCAT scores, the patients with low and intermediate scores were included in Group L (n=173), while those with high scores (n=73) were included in Group H. Sedation protocol consisted of the combination of midazolam and fentanyl with propofol infusion, if necessary...The incidence of pulmonary complications was significantly higher in the pulmonary resection compared to non-pulmonary procedures (p=0.027). Awake video-assisted thoracoscopic surgery seems to be beneficial in reducing the incidence of postoperative pulmonary complications in high-risk patients as assessed with the ARISCAT.
- |||||||||| fentanyl citrate / Generic mfg.
Identification and Management of Illicit Substance Use (xylazine, fentanyl, kratom) (IB I, Virtual) - Mar 25, 2024 - Abstract #AAPP2024AAPP_82; Describe the pharmacologic profile and potency characteristics of xylazine, fentanyl, and kratom. Discuss the complications each substance may pose to traditional management of opioid overdose, withdrawal, and opioid use disorder treatment.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Child Protection System Interactions for Children With Positive Urine Screens for Illicit Drugs. (Pubmed Central) - Mar 25, 2024 Drug type, including amphetamines, barbiturates, benzodiazepines, cannabis, cocaine, fentanyl, opiates, and phencyclidine...In this cross-sectional study of emergency department and inpatient medical encounters, less than half of children with positive urine drug screens were reported to CPS; out-of-home placements were uncommon. With increased encounters for positive drug tests, it is unclear what services these children and families are receiving.
- |||||||||| fentanyl citrate / Generic mfg.
Review, Journal: Establishing a research agenda for the study and assessment of opioid withdrawal. (Pubmed Central) - Mar 23, 2024 The US Food and Drug Administration recently established a formal indication for opioid withdrawal that has invigorated interest in drug development for opioid withdrawal management. Action is now needed to support these interests and help industry identify new classes of medications so that real change can be achieved for people with opioid use disorder.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Pick your drugs carefully; cocaine may leave you with lifelong dialysis () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_676; Urine drug screen (UDS) was positive for methamphetamine (MA), fentanyl, and benzodiazepines. Additional studies on patients with severe cocaine DIR and timing of HD are needed to assess the impact on renal recovery.
- |||||||||| Bridion (sugammadex) / Merck (MSD)
Idiopathic Fanconi Syndrome after a Vascular Surgery () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_589; The abrupt postoperative onset of these finding, suggest an acquired cause of FS, possibly due to a medication. A proposed cause was Vancomycin, since it was a new medication and it has been linked in the literature to nephrotoxicity, including proximal tubule dysfunction.
- |||||||||| fentanyl citrate / Generic mfg.
A Rare Case of Alcoholic hepatitis/ Fentanyl-induced Renal TMA () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_574; INTRODUCTION: Thrombotic Microangiopathy (TMA) represents a pathologic diagnosis in which abnormalities in the microvasculature lead to thrombosis that can affect multiple organs including the kidneys. It is important to recognize these substances, including opioid derived or synthetic formulations, as possible triggers for TMA.
- |||||||||| fentanyl citrate / Generic mfg.
Optimization of an anti-fentanyl monoclonal antibody to improve stability (Room W178) - Mar 22, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_583; One specific mutation resulted in a 40-fold increase in affinity measured against a fentanyl hapten by BLI, and a 4-fold increase in affinity for free fentanyl by competitive ELISA. Future studies will seek to validate the improved mAb affinity in vivo relative to the parent mAb.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Performance of Fentanyl Immunoassays in an ED Patient Population. (Pubmed Central) - Mar 22, 2024 A sizable portion of drug-positive samples from our ED were positive for fentanyl, with a subset of patients testing positive for fentanyl alone. Implementation of fentanyl testing into routine toxicology panels can elucidate polysubstance abuse paradigms and capture ED patients that would go undetected in standard panels.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: A confirmed case of xylazine-induced skin ulcers in a person who injects drugs in Miami, Florida, USA. (Pubmed Central) - Mar 20, 2024 Many PWUD at highest risk for acute and chronic health consequences of xylazine-adulterated fentanyl do not have access to healthcare outside of low barrier clinics and SSPs due to lack of insurance or mistrust of the traditional healthcare system due to stigma. There is an urgent need for access to XTS for PWUD and clinical practice guidelines for the treatment of xylazine-related wounds in outpatient clinics.
- |||||||||| fentanyl citrate / Generic mfg.
Journal, Heterogeneity: Beyond a spec: assessing heterogeneity in the unregulated opioid supply. (Pubmed Central) - Mar 20, 2024 On a practical level, this provides data to help guide communication of limitations of drug checking services, supporting the aim of trust and transparency between services and people who use drugs. However, if drug checking services continue to be restricted from fully engaging with the reality of manufacturing, buying, selling, mixing and dosing practices, the accuracy, usefulness, and impact will always be limited.
- |||||||||| fentanyl citrate / Generic mfg.
Review, Journal: Xylazine: A Drug Adulterant of Clinical Concern. (Pubmed Central) - Mar 20, 2024 Specifically, introducing fentanyl as a drug adulterant has been shown to impact overdose rates drastically...Related to widespread use in veterinary medicine and increasing circulation in illicit drug markets, there is a critical need for public awareness and additional clinical-based studies to further increase understanding of mediated or modulated pharmacological effects of xylazine in humans. Further research is urgently needed to more clearly understand the implications of unregulated xylazine in the illicit drug market, to formulate public health interventions, and to implement harm reduction strategies.
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