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- | pethidine / Samaritan Pharma
Journal, Surgery: Inter-Semispinalis Plane Block Versus General Anesthesia for Postoperative Analgesia in Posterior Cervical Spine Surgery: A Randomized Controlled Trial. (Pubmed Central) - May 10, 2024
The study assessed intraoperative fentanyl use, postoperative VAS pain levels, the need for rescue analgesia, and complications...Additionally, the ISPB group required less postoperative pethidine (20% vs. 64%, P = 0.002) and had a longer delay before requesting pethidine (hazard ratio 0.215, P = 0.001)...The ISPB is an effective analgesic technique for posterior cervical spine surgery, reducing opioid consumption, providing better pain control, and enhancing surgeon satisfaction without increasing complications. This approach has the potential to improve postoperative care and patient outcomes in this surgical population.
- | fentanyl citrate / Generic mfg.
Journal: Comparison of Effectiveness and Safety of Oxycodone Hydrochloride and Fentanyl for Post-operative Pain Following Total Hip Arthroplasty: A Randomized Triple-Blind Trial. (Pubmed Central) - May 10, 2024
A bolus dose of 4 mg of oxycodone provided superior analgesic efficacy than 50 ug fentanyl as evidenced by significantly lower pain score, delayed onset to first request for analgesia, and the smaller amount of fentanyl consumption at 12, 24, and 48 h post-total hip arthroplasty compared to fentanyl. The incidence of adverse events was comparable between the 2 groups.
- | fentanyl citrate / Generic mfg.
Journal: Subcutaneous versus intravenous fentanyl for labor pain management: A multicenter randomized controlled trial. (Pubmed Central) - May 9, 2024
Maternal satisfaction with the childbirth experience was high regardless of the route of administration of fentanyl. No serious adverse effects of fentanyl were observed in either the mothers or the neonates.
- || fentanyl citrate / Generic mfg., isoflurane / Generic mfg.
Clinical, Observational data, Journal: Thoracotomy Patients Under General Anesthesia: A Comparison on Intra-Operative Anesthetic and Analgesic Requirements, When Combined with Either Epidural Analgesia or Continuous Unilateral Paravertebral Analgesia. (Pubmed Central) - May 9, 2024
GA with epidural analgesia resulted in significant reduction in the intraoperative consumption of isoflurane and fentanyl in comparison to GA with paravertebral analgesia. However, both the techniques were equally effective in the postoperative period.
- | methamphetamine / Generic mfg.
Journal: Characterising methamphetamine/amphetamine use among opioid agonist therapy-seeking adults with prescription-type opioid use disorder in Canada. (Pubmed Central) - May 9, 2024
P4
In this sample of people with POUD, methamphetamine/amphetamine use was associated with markers of complex and severe OUD, including overdose risk. This suggests the need for targeted interventions to optimise treatment outcomes and prevent future overdoses in this population.
- | fentanyl citrate / Generic mfg.
Journal: Detecting Substance Use Disorder Using Social Media Data and the Dark Web: Time- and Knowledge-Aware Study. (Pubmed Central) - May 8, 2024
The study crawled cryptomarket data and extracted posts for fentanyl, fentanyl analogs, and other novel synthetic opioids...The study's findings can be used to inform interventions and policies aimed at reducing substance misuse and addressing the opioid crisis. The study demonstrates the potential of deep learning models for analyzing social media data to gain insights into public health issues.
- | Journal: Structural insights into novel therapeutic deep eutectic systems with capric acid using 1D, 2D NMR and DSC techniques with superior gut permeability. (Pubmed Central) - May 8, 2024
Previously, THEDESs of risperidone, fentanyl and levofloxacin with capric acid (CA) were developed by our group...Herein, DESs of two drugs bearing cyclic tertiary amine nucleus, namely, droperidol and aripiprazole, in the presence of CA, were investigated as model drugs...Interestingly, the superior absorption and flux of the THEDES formulation of droperidol was demonstrated using the ERIS. Collectively, this work provides a green method to attain liquid formulations of APIs with enhanced pharmacokinetic features.
- | fentanyl citrate / Generic mfg., oxycodone/acetaminophen / Generic mfg.
Journal: Erector Spinae Plane Block Decreases Narcotic Requirements in Patients Undergoing Subcutaneous Implantable Cardioverter-defibrillator Placement Under Sedation. (Pubmed Central) - May 8, 2024
A significant reduction in intraoperative fentanyl use was observed [median ([interquartile range]) in the ESP block group (0 [0-50] ?g) compared to the wound infiltration block group (75 [50-100] ?g) (P = .001)...There was also a trend of decreased POD 0 oxycodone-acetaminophen use...These results indicate that ESP block is an innovative, safe, and effective technique that decreases intraoperative and postoperative opioid consumption and may be a useful adjunct pain-management technique in these high-risk patients. Larger studies are needed to further validate its use.
- || Instanyl (fentanyl) / Takeda
Retrospective data, Review, Journal: Efficacy and Safety of Intranasal Fentanyl in Pediatric Emergencies: A Systematic Review and Meta-analysis. (Pubmed Central) - May 7, 2024
Intranasal fentanyl also had a more favorable adverse event profile, with a lower risk of nausea and vomiting than other analgesics. However, no significant differences were observed in dizziness and hallucination between the groups.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Observational data, Retrospective data, Journal: Effectiveness of opioid switching for dyspnea and its predictors in cancer patients: a single-center retrospective observational study. (Pubmed Central) - May 7, 2024
This study indicates that opioid switching for dyspnea may have some effect. Furthermore, opioid switching for dyspnea may be more effective in older patients and less effective in terminally ill patients or in those with cachexia.
- | fentanyl citrate / Generic mfg.
Journal: A study of hemodynamic effects, postoperative recovery, and safety of esketamine (right handed) during flexible bronchoscopy under general anesthesia. (Pubmed Central) - May 7, 2024
The patients' QoR-40 total scores in the ES group were improved versus the control group at 1?day after surgery. Compared with fentanyl, the use of ES (right handed) in flexible bronchoscopy during general anesthesia produces more stable hemodynamics, faster onset and recovery time of anesthesia, longer duration of analgesia, lower incidence of adverse reactions, and improved early postoperative recovery quality in patients.
- | fentanyl citrate / Generic mfg., tramadol hydrochloride / Generic mfg., methadone / Generic mfg.
Journal: Fiber Laser-Generated Silver-109 Nanoparticles for Laser Desorption/Ionization Mass Spectrometry of Illicit Drugs. (Pubmed Central) - May 6, 2024
The results of the quantitative analysis of drugs using silver-109 PFL 2D GS LGN for LDI MS are presented. Laser-generated NPs are proven to be useful for the analysis of selected drugs, with exceptionally good results for fentanyl monitoring in a broad range of concentrations.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl test strip distribution acceptability and use among substance-related emergency department visits. (Pubmed Central) - May 6, 2024
Laser-generated NPs are proven to be useful for the analysis of selected drugs, with exceptionally good results for fentanyl monitoring in a broad range of concentrations. No abstract available
- | fentanyl citrate / Generic mfg., ropivacaine / Generic mfg., dexmedetomidine / Generic mfg.
Journal, Head-to-Head: Epidural dexmedetomidine or esketamine versus fentanyl to decrease ropivacaine use for labor analgesia: A randomized non-inferiority study. (Pubmed Central) - May 6, 2024
In setting of the conditions of this study, epidural dexmedetomidine was non-inferior compared with epidural fentanyl in combination with ropivacaine for PCEA during labor. Meanwhile, we failed to establish the non-inferiority of epidural esketamine compared with epidural fentanyl in combination with ropivacaine for labor analgesia.
- || Review, Journal: A narrative review of the literature relevant to obstetric anesthesiologists: the 2023 Gerard W. Ostheimer lecture. (Pubmed Central) - May 5, 2024
Meanwhile, we failed to establish the non-inferiority of epidural esketamine compared with epidural fentanyl in combination with ropivacaine for labor analgesia. Neonatal morbidity is reduced with antenatal maternal buprenorphine compared with methadone for treatment of opioid use disorder...The ED90 of 3% chloroprocaine (with IT fentanyl 10?
- | fentanyl citrate / Generic mfg.
Journal: Necrotic Upper-Extremity Infections in People Who Inject Drugs: A Case Series. (Pubmed Central) - May 4, 2024
The patients in this case series self-reported injection of tranquilizer-containing drugs, and xylazine has been reported to be present in 91% of heroin and fentanyl samples in our community. Although more studies are needed to confirm that xylazine is the definitive cause of the extensive tissue necrosis seen in these patients, we have found the severity of these infections to be noteworthy, given the likely expansion of xylazine to drug samples beyond our region.
- ||| fentanyl citrate / Generic mfg.
Journal, Adverse events: How side effects can improve treatment efficacy: a randomized trial. (Pubmed Central) - May 3, 2024
In this preregistered trial (DRKS00026648), 77 healthy participants were made to believe that they will receive fentanyl nasal sprays before receiving thermal pain in a controlled experimental setting...Using these mechanisms in clinical practice could provide an efficient way to optimize treatment outcome. In addition, our results indicate an important confound in clinical trials, where a treatment (with potential side effects) is compared to placebo.
- | fentanyl citrate / Generic mfg.
Journal: United States marijuana legalization and opioid mortality trends before and during the first year of the COVID-19 pandemic. (Pubmed Central) - May 3, 2024
An even greater increase in opioid mortality occurred in recreational-legalizing jurisdictions with the onset of the COVID-19 pandemic. Marijuana legalization is correlated with worsening of the US opioid epidemic.
- | fentanyl citrate / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Sedation for Colonoscopy Procedures Using Dexmedetomidine Versus Propofol-Fentanyl Infusions: A Prospective Randomized Controlled Trial. (Pubmed Central) - May 3, 2024
The administration of dexmetatomidine and propofol-fentanyl during colonoscopy was found to be safe. In addition, dexmetatomidine may present significant benefits in this context because of its lower occurrence of adverse respiratory events.
- Increase of synthetic opioid use: two evidence-based and low threshold interventions to prevent drug-related deaths (Poster board: 418) - May 2, 2024 - Abstract #AIDS2024AIDS_2479;
The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Tuesday, 23 July 2024, at 10:00 am Central European Summer Time (CEST). If an abstract is part of an official AIDS 2024 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.
- Risks and rewards of AI-generated HIV prevention and treatment information across four ai platforms (Poster board: 368) - May 2, 2024 - Abstract #AIDS2024AIDS_2297;
The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Tuesday, 23 July 2024, at 10:00 am Central European Summer Time (CEST). If an abstract is part of an official AIDS 2024 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.
- Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) / Gilead
Switch to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) among vulnerable people living with HIV: evidence for long-term efficacy (Poster board: 126) - May 2, 2024 - Abstract #AIDS2024AIDS_1482;
The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Tuesday, 23 July 2024, at 10:00 am Central European Summer Time (CEST). If an abstract is part of an official AIDS 2024 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.
- | fentanyl citrate / Generic mfg.
Biomarker, Journal, Metabolomic study: Combining fecal microbiome and metabolomics reveals diagnostic biomarkers for esophageal squamous cell carcinoma. (Pubmed Central) - May 2, 2024
Phenylethanolamine and despropionyl p-fluoro fentanyl could be used as reliable biomarkers to differentiate ESCC from healthy control...The results of this study provide favorable evidence for the early diagnosis of ESCC and subsequent individualized treatment and targeted interventions.IMPORTANCEWe describe for the first time the differences in fecal microbiome composition and metabolites between patients with esophageal squamous cell carcinoma (ESCC) and healthy controls by 16S rRNA gene sequencing and untargeted metabolomics. The results of this study provide a favorable basis for the early diagnosis of ESCC and subsequent targeted interventional therapy.
- | fentanyl citrate / Generic mfg.
Journal: Not Carfentanil-A Case of Unexpected Xylazine Detection. (Pubmed Central) - May 2, 2024
It has been more commonly added to illicit substances, most notably fentanyl, by drugmakers to enhance drug effect...Herein, we present the first documented case of xylazine identified via gas chromatography-tandem mass spectrometry at University of California Davis Health despite a peculiarly mild clinical presentation. We hope to increase awareness of this potentially fatal adulterant that is often missed in evaluation and engender further opportunities to study this ongoing issue.
- || Alfenta (alfentanil) / Abbott
PK/PD data, Journal: Prediction of Pediatric Pharmacokinetics for CYP3A4 Metabolized Drugs: Comparison of the Performance of Two Hepatic Ontogeny Within a Physiologically Based Pharmacokinetic Model. (Pubmed Central) - May 2, 2024
Identifying the optimal CYP3A4 ontogeny is important for regulatory use of PBPK especially given the number of drugs cleared by this enzyme. This study broadens the evidence from previous studies that Upreti is more favorable than Salem, but further work is needed especially in the neonatal and early infant age range.
- || dexmedetomidine / Generic mfg.
Clinical, Review, Journal: Dexmedetomidine for analgesia and sedation in newborn infants receiving mechanical ventilation. (Pubmed Central) - May 2, 2024
Furthermore, data on dexmedetomidine safety are scarce, and there are no data available on its long-term effects. Future studies should address the efficacy, safety, and long-term effects of dexmedetomidine as a single drug therapy for sedation and analgesia in newborn infants.
- | fentanyl citrate / Generic mfg.
Journal: Effectiveness of implementing a standardized perioperative pain management protocol in children undergoing tonsillectomy: A quality improvement project. (Pubmed Central) - May 2, 2024
The quality improvement project highlighted notable improvements in the intervention group for whom a standardized perioperative pain management protocol was used, including reduced opioid medication administration, lower incidence of respiratory interventions, and high adherence to the pain management protocol. These findings underscore the effectiveness and feasibility of standardized protocols in enhancing patient outcomes.
- | Naldebain (dinalbuphine) / Lumosa Therap
Retrospective data, Journal, Video: Analgesic Effectiveness of Dinalbuphine Sebacate in Video-Assisted Thoracoscopic Wedge Resection and Its Effect on Reducing Postoperative Pulmonary Complications: A Retrospective Cohort Study. (Pubmed Central) - May 2, 2024
A single preoperative injection of DS reduced the frequency of salvage analgesic administration and total consumption of certain postoperative analgesics, suggesting the effective pain relief of DS, and it did not increase the incidence of PPCs. Additionally, it reduced the need for postoperative oxygen therapy, which may suggest a better prognosis and smoother postoperative pulmonary recovery for patients.
- || fentanyl citrate / Generic mfg., tramadol hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
Clinical, Journal, Surgery: Comparison of Ultrasound-Guided Anterior, Posterior and Combination of Quadratus Lumborum Block in Laparoscopic Abdominal Surgeries: A Pilot Study. (Pubmed Central) - May 2, 2024
Further studies can be planned to evaluate the best approach for QLB in terms of perioperative analgesia, which remains a dilemma in this pilot study. The anterior, posterior, and combined anterior-posterior QLB approaches appear equally efficacious as a component of multimodal analgesia in laparoscopic abdominal surgeries.
- || dexmedetomidine / Generic mfg.
Clinical, Journal: Perioperative analgesic effects of the erector spinae plane block with bupivacaine or bupivacaine-dexmedetomidine in dogs undergoing hemilaminectomy: A randomized controlled trial. (Pubmed Central) - May 2, 2024
Postoperative methadone (mg/kg) required during the first 12 h was 0.5 (0 to 1.4) in Group B (P = 0.003) and 0 (0 to 0) in BD (P < 0.001), compared to C (P = 0.003 and P < 0.001, respectively). An ESP block with bupivacaine, with or without dexmedetomidine, was associated with a reduction in perioperative opioid consumption and provided effective acute pain control.
- | fentanyl citrate / Generic mfg.
Journal: Drug use and COVID-19 testing, vaccination, and infection among underserved, minority communities in Miami, Florida. (Pubmed Central) - Apr 30, 2024
Users of cannabis, cocaine/crack, heroin/fentanyl, methamphetamines, hallucinogens, and/or prescription drug misuse in the previous 12 months were considered PWUD...PWUD presented with greater difficulties accessing COVID-19 testing, greater vaccine hesitancy, and lower odds of vaccination. Testing and immunization plans that are tailored to the needs of PWUD and consider access, trust-building campaigns, and education may be needed.
- || fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
Clinical, Journal: Clinical usefulness of nebulized dexmedetomidine for conscious sedation in daycare flexible bronchoscopy in Southern India. (Pubmed Central) - Apr 30, 2024
It blunts the pressure response during bronchoscopy and could be a safer and cost-effective agent in its nebulized form for conscious sedation in bronchoscopy. The study is approved by the institutional ethics committee (IEC KMC MLR 10-2021-310).
- | fentanyl citrate / Generic mfg.
Journal: Case 324: CHANTER Syndrome. (Pubmed Central) - Apr 30, 2024
Urine drug screening was positive for cocaine, marijuana, fentanyl, and benzodiazepines...Multisequence MRI of the brain with administration of intravenous contrast material was ordered for further assessment. CT of the abdomen and pelvis was unremarkable (images not shown).
- | fentanyl citrate / Generic mfg., oxycodone controlled release / Generic mfg.
Journal: The effect of opioid use on traffic fatalities. (Pubmed Central) - Apr 29, 2024
The effect is mainly concentrated in fatal crashes with drug involvement of drivers ages between 25 and 44. Our results highlight additional long-term detrimental consequences of the introduction and marketing of OxyContin.
- || fentanyl citrate / Generic mfg.
Review, Journal: Caring for Hospitalized Adults With Opioid Use Disorder in the Era of Fentanyl: A Review. (Pubmed Central) - Apr 29, 2024
The findings of this review indicate that fentanyl creates increased urgency and new challenges for hospital OUD care. Hospital clinicians and systems have a central role in addressing the current drug crisis.
- | fentanyl citrate / Generic mfg.
Journal: Exploring Novel Fentanyl Analogues Using a Graph-Based Transformer Model. (Pubmed Central) - Apr 29, 2024
We compared the generated molecules from transformer model and data augmentation method based on substructure replacement with those generated by the other two molecular generation models based on deep learning, and found that the model in this paper can generate more novel potential fentanyl analogues. Finally, the findings of the paper indicate that transformer model based on molecular graph helps us explore the structure of potential fentanyl molecules as well as understand distribution of original molecules of fentanyl.
- | fentanyl citrate / Generic mfg.
Journal, Surgery: Regional analgesia using ultrasound-guided intermediate cervical plexus block versus cervical erector spinae block for anterior cervical spine surgery: a randomized trial. (Pubmed Central) - Apr 29, 2024
P=N/A
For patients undergoing anterior cervical spine surgery, the intermediate cervical plexus block does not provide better postoperative regional analgesia compared to the cervical erector spinae block. Performance time and onset time were shorter in the IC group, whereas nalbuphine consumption was lower in the ES group.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: The role of morphine- and fentanyl-induced impairment of intestinal epithelial antibacterial activity in dysbiosis and its impact on the microbiota-gut-brain axis. (Pubmed Central) - Apr 29, 2024
Improved epithelial barrier function with FMT or butyrate prevented the enrichment of the mucin-degrading A. muciniphila in morphine-dependent mice. These data implicate impairment of the antimicrobial activity of the intestinal epithelium as a mechanism by which opioids disrupt the microbiota-gut-brain axis.
- | fentanyl citrate / Generic mfg.
Journal: A Dynamic Model of Opioid Overdose Deaths in Canada during the Co-Occurring Opioid Overdose Crisis and COVID-19 Pandemic. (Pubmed Central) - Apr 27, 2024
The increasing presence of fentanyl and its analogues in the illegal drugs supply has been an important driver of the crisis...The simulated scenarios provided decision makers with insight into possible trajectories of the opioid crisis in Canada during the COVID-19 pandemic, highlighting the potential of the crisis to take a turn for the worse under certain assumptions, and thus, informing planning during a period when surveillance data were not yet available. This model provides a starting point for future models, and through its development, we have identified important data and evidence gaps that need to be filled in order to inform future action.
- | fentanyl citrate / Generic mfg.
Journal: Ventricular bigeminy associated with myocardial ischemia in a dog with a colonic torsion: a case report. (Pubmed Central) - Apr 27, 2024
This is the first documented case of ventricular bigeminy in the canine patient with a colonic torsion. Assessment of patient volume status and appropriate fluid resuscitation along with continuous electrocardiogram (ECG) monitoring are vital to patient stability under general anesthesia.
- | fentanyl citrate / Generic mfg.
Observational data, Journal: Evaluating preferences for medication formulation and treatment model among people who use opioids non-medically: A web-based cross-sectional study. (Pubmed Central) - Apr 27, 2024
Likewise, the majority preferred non-integrated treatment in specialty substance use settings. Reasons for these preferences provide insight on developing effective educational tools for patients and suggesting targets for intervention to develop a more acceptable treatment system.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Clinical, Journal: The effect of ultrasound-guided rectus sheath block on postoperative analgesia in robot assisted prostatectomy: A randomized controlled trial. (Pubmed Central) - Apr 26, 2024
Reasons for these preferences provide insight on developing effective educational tools for patients and suggesting targets for intervention to develop a more acceptable treatment system. RSB exhibits effective analgesia by significantly reducing postoperative opioid consumption in robotic prostatectomy operations.
- | methadone / Generic mfg.
Journal: Single-Dose Intraoperative Methadone for Pain Management in Pediatric Tonsillectomy: A Randomized Double Blind Clinical Trial. (Pubmed Central) - Apr 26, 2024
RSB exhibits effective analgesia by significantly reducing postoperative opioid consumption in robotic prostatectomy operations. This small initial study in children undergoing tonsillectomy found that single-dose intraoperative methadone at 0.15 mg/kg age ideal body weight was opioid-sparing compared with intermittent fentanyl.
- | fentanyl citrate / Generic mfg.
Journal, Video, Surgery: The efficacy of rhomboid intercostal block for pain management after video-assisted thoracoscopic surgery: a prospective, randomized-controlled trial. (Pubmed Central) - Apr 26, 2024
This small initial study in children undergoing tonsillectomy found that single-dose intraoperative methadone at 0.15 mg/kg age ideal body weight was opioid-sparing compared with intermittent fentanyl. US-guided RIB provides effective post-VATS analgesia.
- | citalopram / Generic mfg., fentanyl citrate / Generic mfg., venlafaxine / Generic mfg.
Journal: Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths. (Pubmed Central) - Apr 26, 2024
This complex phenomenon can have a significant impact on the analysis, interpretation of genotypes, and accurate conclusions in forensic toxicology. Nevertheless, more research with more cases in the future is needed to confirm these results.
- || naloxone injection / Generic mfg., fentanyl citrate / Generic mfg.
Clinical, PK/PD data, Review, Journal: Clinical Pharmacokinetics and Pharmacodynamics of Naloxone. (Pubmed Central) - Apr 26, 2024
Nasal uptake [mean time to maximum concentration (Tmax) 15-30 min] is likely slower than intramuscular, as reversal of respiration lag behind intramuscular naloxone in overdose victims...Fentanyl overdoses likely require higher doses of naloxone...Modeling studies provide valuable insight in pharmacotherapy but cannot replace clinical trials. Laypeople should always have access to at least two dose kits for their interim intervention.
- | Journal: Adulteration and substitution of drugs purchased in Australia from cryptomarkets: An analysis of Test4Pay. (Pubmed Central) - Apr 26, 2024
Cryptomarkets are not immune to this problem, despite review systems, which should, in theory, make vendors more accountable for the quality of their stock. These findings demonstrate a need for expansion of local drug checking services in Australia.
- | fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Opioid-induced hypogonadism in opioid use disorder, its role in negative reinforcement, and implications for treatment and retention. (Pubmed Central) - Apr 26, 2024
We then review evidence from chronic pain patients that testosterone replacement provides clinically significant benefits to men with OIH. Finally, using this framework, we compare extant OUD therapeutics and discuss critical gaps in the clinical literature-including the relative dearth of data regarding hypothalamic-pituitary-gonadal function in females who use opioids-where future study should be focused.
- | fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
Preclinical, Journal: In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs. (Pubmed Central) - Apr 26, 2024
Further studies are indicated for this topic, which may use more complex cell culture models and global pharmacovigilance reports, addressing the limitation of the used cell model: HepG2/C3A cells have a lower metabolic capacity due to their low levels of CYP enzymes compared to primary hepatocytes. However, while the test model is suitable for parental substances, it is not for toxicity testing of metabolites.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal, Surgery: Safety and Efficacy of Ultrasound-Guided Combined Segmental Thoracic Spinal Epidural Anesthesia in Abdominal Surgeries and Laparoscopic Procedures: A Prospective Randomized Clinical Study. (Pubmed Central) - Apr 26, 2024
A combination of 10 mg of hyperbaric bupivacaine 0.5% and 25 ?g of fentanyl was injected through the spinal needle...Postoperatively, pain in both groups was treated with intravenous (IV) morphine by patient controlled analgesia (PCA), PCA settings were 1 mg morphine/mL, no background infusion, bolus dose 2 mL and lockout interval 15 min...Also, the time of the first analgesia request and patient satisfaction were substantially greater in group 2 than in group 1. Combined thoracic spinal/epidural block results in stable hemodynamics, longer postoperative analgesia with fewer side effects, and greater surgeon and patient satisfaction in patients undergoing abdominal operations and laparoscopic procedures.