- |||||||||| bintrafusp alfa (M7824) / EMD Serono, SX-682 / Syntrix, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic
New P1/2 trial, Combination therapy, Metastases: Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With BinTrafusp Alfa (M7824 or TGF-beta "Trap"/PD-L1) With CV301 TRICOM in Advanced Solid Tumors (STAT) (clinicaltrials.gov) - Oct 4, 2020 P1/2, N=105, Not yet recruiting,
- |||||||||| bintrafusp alfa (M7824) / EMD Serono, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic, ProstVac (rilimogene galvacirepvec) / Bavarian Nordic
Trial completion date, Trial primary completion date: Combination Immunotherapy in Biochemically Recurrent Prostate Cancer (clinicaltrials.gov) - Oct 3, 2019 P2, N=34, Recruiting, Trial primary completion date: Oct 2019 --> Jan 2020 Trial completion date: Dec 2020 --> Dec 2023 | Trial primary completion date: Dec 2019 --> Dec 2023
- |||||||||| Panvac-VF (falimarev/inalimarev) / Bavarian Nordic
Journal: When cancer vaccines go viral. (Pubmed Central) - Aug 27, 2019 Heterologous viral prime/boost immunization with the BN-CV301 vaccine promotes activation of immune responses that provide a clinical benefit to cancer patients. This viral platform may be used to harbor different antigens and prime tumor immunity potentially useful for combinatorial strategies.
- |||||||||| Leukine (sargramostim) / Partner Therap, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic
Phase classification, Combination therapy, Metastases: PANVAC-V and PANVAC-F Vaccines Plus Sargramostim to Treat Advanced Cancer (clinicaltrials.gov) - Apr 20, 2019 P1/2, N=51, Completed, Trial primary completion date: Jun 2019 --> Oct 2019 Phase classification: P2 --> P1/2
- |||||||||| Panvac-VF (falimarev/inalimarev) / Bavarian Nordic
Enrollment closed, Phase classification, Enrollment change, Trial primary completion date, Combination therapy: A Trial of CV301 in Combination With Anti-PD-1 Therapy in Subjects With Non-Small Cell Lung Cancer (clinicaltrials.gov) - Dec 16, 2018 P1, N=24, Active, not recruiting, Trial completion date: Feb 2019 --> Feb 2020 Recruiting --> Active, not recruiting | Phase classification: P1/2 --> P1 | N=200 --> 24 | Trial primary completion date: Dec 2020 --> Jan 2020
- |||||||||| bintrafusp alfa (M7824) / EMD Serono, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic, ProstVac (rilimogene galvacirepvec) / Bavarian Nordic
Trial completion date, Trial primary completion date: Combination Immunotherapy in Biochemically Recurrent Prostate Cancer (clinicaltrials.gov) - Sep 25, 2018 P2, N=34, Recruiting, Not yet recruiting --> Recruiting Trial completion date: Jun 2020 --> Dec 2020 | Trial primary completion date: Jun 2019 --> Dec 2019
- |||||||||| Leukine (sargramostim) / Partner Therap, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic
Trial completion, Trial completion date, Combination therapy, Metastases: PANVAC-V and PANVAC-F Vaccines Plus Sargramostim to Treat Advanced Cancer (clinicaltrials.gov) - Jun 4, 2018 P2, N=51, Completed, Trial primary completion date: Nov 2013 --> Dec 2018 Active, not recruiting --> Completed | Trial completion date: Apr 2019 --> May 2018
- |||||||||| Leukine (sargramostim) / Partner Therap, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic
Trial completion date, Combination therapy, Metastases: PANVAC-V and PANVAC-F Vaccines Plus Sargramostim to Treat Advanced Cancer (clinicaltrials.gov) - Jun 2, 2018 P2, N=51, Active, not recruiting, Active, not recruiting --> Completed | Trial completion date: Apr 2019 --> May 2018 Trial completion date: Apr 2018 --> Apr 2019
- |||||||||| bintrafusp alfa (M7824) / EMD Serono, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic, ProstVac (rilimogene galvacirepvec) / Bavarian Nordic
Enrollment open: Combination Immunotherapy in Biochemically Recurrent Prostate Cancer (clinicaltrials.gov) - Mar 20, 2018 P2, N=34, Recruiting, N=19 --> 30 Not yet recruiting --> Recruiting
- |||||||||| bintrafusp alfa (M7824) / EMD Serono, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic, ProstVac (rilimogene galvacirepvec) / Bavarian Nordic
Trial initiation date: Combination Immunotherapy in Biochemically Recurrent Prostate Cancer (clinicaltrials.gov) - Mar 3, 2018 P2, N=34, Not yet recruiting, Not yet recruiting --> Recruiting Initiation date: Mar 2018 --> Mar 2018
- |||||||||| Leukine (sargramostim) / Partner Therap, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic
Phase classification, Combination therapy, Metastases: PANVAC-V and PANVAC-F Vaccines Plus Sargramostim to Treat Advanced Cancer (clinicaltrials.gov) - Jan 31, 2018 P2, N=51, Active, not recruiting, Initiation date: Mar 2018 --> Mar 2018 Phase classification: P1 --> P2
- |||||||||| Leukine (sargramostim) / Partner Therap, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic
Trial primary completion date, Combination therapy, Metastases: PANVAC-V and PANVAC-F Vaccines Plus Sargramostim to Treat Advanced Cancer (clinicaltrials.gov) - Jan 25, 2018 P1, N=51, Active, not recruiting, Phase classification: P1 --> P2 Trial primary completion date: Jan 2019 --> Apr 2018
- |||||||||| Leukine (sargramostim) / Partner Therap, Panvac-VF (falimarev/inalimarev) / Bavarian Nordic
Trial primary completion date, Combination therapy, Metastases: PANVAC-V and PANVAC-F Vaccines Plus Sargramostim to Treat Advanced Cancer (clinicaltrials.gov) - Jan 5, 2018 P1, N=51, Active, not recruiting, Trial primary completion date: Jan 2018 --> Sep 2018 Trial primary completion date: Jan 2018 --> Jan 2019
- |||||||||| Panvac-VF (falimarev/inalimarev) / Bavarian Nordic, ProstVac (rilimogene galvacirepvec) / BMS
Journal: Analyses of Pre-therapy Peripheral Immunoscore and Response to Vaccine Therapy. (Pubmed Central) - Nov 30, 2017 In another trial, prostate cancer patients with metastatic bone lesions were randomly assigned to receive a bone-seeking radionuclide ± PROSTVAC vaccine...Larger randomized studies will be required to validate these findings. These studies, however, provide the rationale for the evaluation of refined immune cell subsets to help determine which patients may benefit most from immunotherapy.
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