- |||||||||| ciprofloxacin oral / Generic mfg., tizanidine / Generic mfg.
[VIRTUAL] A Dangerous Duo: Ciprofloxacin and Tizanidine Leading to Cardiogenic Shock () - Mar 14, 2021 - Abstract #ATS2021ATS_1954;
We suspect the prolonged vasopressor requirement for our patient was due to her underlying cirrhotic liver disease leading to poor clearance. Summative and synergistic medication interactions can lead to deleterious consequences, following stabilization and exclusion of immediately life-threatening causes of shock, a thorough medication history may point towards an underlying etiology and potentially prevent recurrence.
- |||||||||| Ubrelvy (ubrogepant) / AbbVie, Reyvow (lasmiditan) / Eli Lilly, Nurtec ODT (rimegepant ODT) / Portage
Journal: Non-interacting, Non-opioid, and Non-barbiturate Containing Acute Medication Combinations in Headache: A Pilot Combinatorics Approach Based on DrugBank Database. (Pubmed Central) - Mar 9, 2021
We updated a list of acute medications based on the widely used Jefferson Headache Manual with novel abortive medications including ubrogepant, lasmiditan, and rimegepant...Most common elements in these combinations are ubrogepant, prochlorperazine, followed by tizanidine...Only two of the four-drug combinations do not yield some form of drug-drug interactions. This list of headaches abortive medications without drug-drug interactions is a useful tool for clinicians seeking to more effectively manage refractory headaches by implementing a rational polypharmacy.
- |||||||||| gabapentin / Generic mfg.
Journal: Italian Consensus on treatment of spasticity in multiple sclerosis. (Pubmed Central) - Mar 3, 2021
The level of recommendation was weak for oral baclofen, tizanidine, gabapentin, benzodiazepimes and transcranial magnetic stimulation. There is a clear need for new larger multicenter well-designed clinical trials with a duration that allow to evaluate the persistence of the effects and the long term safety of the interventions.
- |||||||||| tizanidine / Generic mfg.
Journal: Incidence of muscle relaxant use in relation to diagnosis of Parkinson's disease. (Pubmed Central) - Feb 7, 2021
Conclusions The incidence of muscle relaxant use starts increasing years before the diagnosis of Parkinson's disease but declines after that. It is important to identify the causes of muscle symptoms to avoid unnecessary muscle relaxant use and consequent adverse effects and events.
- |||||||||| tizanidine / Generic mfg.
Journal: Optimization of Microemulgel for Tizanidine Hydrochloride. (Pubmed Central) - Jan 23, 2021
It is important to identify the causes of muscle symptoms to avoid unnecessary muscle relaxant use and consequent adverse effects and events. A stable, effective and elegant microemulgel formulation, exhibiting good in-vitro and ex-vivo drug release was formulated.
- |||||||||| Januvia (sitagliptin) / Merck (MSD)
Journal: Exploiting cheminformatic and machine learning to navigate the available chemical space of potential small molecule inhibitors of SARS-CoV-2. (Pubmed Central) - Jan 5, 2021
Fragment-based scaffold analysis and R-group decomposition uncovered pyrrolidine and the indole molecular scaffolds as the potent fragments for designing and synthesizing the novel drug-like molecules for targeting SARS-CoV-2. This comprehensive and systematic assessment of small-molecule viral therapeutics' entire chemical space realised critical insights to potentially privileged scaffolds that could aid in enrichment and rapid discovery of efficacious antiviral drugs for COVID-19.
- |||||||||| [VIRTUAL] Muscle Relaxers as Adjunctive Analgesics to Opioids () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3425;
The ideal muscle relaxer for reducing postoperative opioid consumption may be dependent upon the type of surgery, the chemical structure, and mechanism of the chosen drug. Further clinical trials are necessary to fully elucidate the most appropriate agent for the given procedure.
- |||||||||| tizanidine / Generic mfg.
[VIRTUAL] Evidence of Drug-Drug Interactions between Tizanidine and CYP1A2 Inhibitors () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3293;
Toxic tizanidine accumulation from CYP1A2 inhibition leads to significant decrease in blood pressure and increased risk for patient harm. The data is focused on common CYP1A2 inhibitor, ciprofloxacin, but other CYP1A2 inhibitors demonstrate similar pharmacodynamic effects.
- |||||||||| tizanidine / Generic mfg.
Journal: Formulation development and optimization studies of mouth dissolving tablets of tizanidine HCl. (Pubmed Central) - Dec 17, 2020
Amongst the trial formulations F4 with concentration of croscarmellose sodium i.e. 5% was proved as best optimized due to satisfactory quality attributes such as least disintegration time and sufficient hardness. Hence, it was concluded that manufacturing of mouth dissolving tablets by addition of superdisintegrant is beneficial for treating patients with dysphagia.
- |||||||||| PK/PD data, Journal: A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug-Drug-Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine. (Pubmed Central) - Dec 12, 2020
Predicted concentration-time profiles accurately described a validation dataset, including data from patients with genetic polymorphisms, demonstrating that the models characterized the CYP2C19 and CYP1A2 network over the whole range of DDI studies investigated. The models are provided on GitHub (GitHub Inc., San Francisco, CA, USA), expanding the library of publicly available qualified whole-body PBPK models for DDI predictions, and they are thereby available to support potential recommendations for dose adaptations, support labeling, inform the design of clinical DDI trials, and potentially waive those.
- |||||||||| tizanidine / Generic mfg.
Journal: Microneedle-Mediated Transdermal Delivery of Tizanidine Hydrochloride. (Pubmed Central) - Nov 25, 2020
Microneedles are very short and sharp needles which do not cause pain. Thus, in the present investigation, preparation and evaluation of a transdermal delivery system for tizanidine hydrochloride based on microneedles are described.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] Reversible motor neuron syndrome in the setting of cancer () - Oct 24, 2020 - Abstract #SNO2020SNO_936;
When seen in clinic a month post discharge nearly all of her symptoms had resolved. Neurological exam showed subtle residual spasticity making this presentation most consistent with a reversible pure upper motor neuron syndrome.
- |||||||||| tizanidine / Generic mfg.
[VIRTUAL] SPINAL CORD STIMULATION IN DISSEMINATED ENDOMETRIOSIS WITH PELVIC NEUROPATHY AND LEGS PARAPARESIS () - Aug 30, 2020 - Abstract #WIP2020WIP_373;
First we tried with medication by codeine/paraceta- mol, tramadol, tapentadol and tizanidine hydrochloride at different times but no objective results were obtained but only side effects... In our experience, we can therefore state that this technique is recommended in those selected cases where the failure of other min invasive or pharmacological procedures is recorded.
- |||||||||| Review, Journal: New directions in the treatment of opioid withdrawal. (Pubmed Central) - Aug 27, 2020
Newer agents likewise exploit these pharmacological mechanisms, including tramadol (μ-opioid receptor agonism) and tizanidine (α2 agonism). Areas for future research include managing withdrawal in the context of stabilising patients with opioid use disorder to extended-release naltrexone, transitioning patients with opioid use disorder from methadone to buprenorphine, and tapering opioids in patients with chronic, non-cancer pain.
- |||||||||| tizanidine / Generic mfg., gabapentin / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date: Gabapentin and Tizanidine for Insomnia in Chronic Pain (clinicaltrials.gov) - Aug 7, 2020
P2, N=24, Enrolling by invitation,
Areas for future research include managing withdrawal in the context of stabilising patients with opioid use disorder to extended-release naltrexone, transitioning patients with opioid use disorder from methadone to buprenorphine, and tapering opioids in patients with chronic, non-cancer pain. Not yet recruiting --> Enrolling by invitation | Trial completion date: Jul 2021 --> Jul 2023 | Trial primary completion date: Jul 2021 --> Jul 2022
- |||||||||| Flagyl (metronidazole) / SLA, doxycycline / Generic mfg., Pierre Fabre, tizanidine / Generic mfg.
[VIRTUAL] Acute Lung Injury Secondary to Tizanidine Inhalation (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5298;
Following the procedure the patient was started on antibiotic therapy with IV Flagyl, Doxycycline, Cefepime and Vancomycin...IV Solumedrol was transitioned to oral Prednisone taper...The inflammatory response to such irritation can lead to further lung damage. Long term effects may lead to disease of the airways and cause difficulty breathing and related systemic problems.
- |||||||||| tizanidine / Generic mfg.
Journal: Proton Transfer Can Govern Regioselectivity Assisted by Iron Catalysis. (Pubmed Central) - Jun 16, 2020
The application potential of this Fe-catalyzed method is demonstrated by the convenient synthesis of three alkaloids and tizanidine. This report raises the possibility that proton transfer could serve as the basis of developing new selective C-H functionalization reactions.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, Allergan
Journal: Consensus of the Brazilian Headache Society on the treatment of chronic migraine. (Pubmed Central) - Apr 22, 2020
Oral topiramate and onabotulinum toxin A injections are the only treatments granted Class A recommendation, while valproate, gabapentin, and tizanidine received Class B recommendation, along with acupuncture, biofeedback, and mindfulness. The anti-CGRP or anti-CGRPr monoclonal antibodies, still unavailable in Brazil, are promising new drugs already approved elsewhere for migraine prophylactic treatment, the efficacy of which in chronic migraine is still to be definitively proven.
- |||||||||| tizanidine / Generic mfg.
[VIRTUAL] Sleep disorder symptoms improvement after the 12-week mindfulness therapy sessions in myofascial facial pain syndrome patients (Room: Screen A3) - Apr 9, 2020 - Abstract #EAN2020EAN_2202;
All patients received venlafaxitine 75mg/day and tizanidine 4mg/day during 12 and 4 weeks respectively.The study group was additionally educated with mindfulness meditation techniques (weekly 2-hour group sessions with following daily outside preparation during 12 weeks and individual session for every participant).Treatment effectiveness was evaluated at admission, 6 and 12 weeks after treatment by measuring pain intensity using a subjective visual analogue scale (VAS) and sleep disorders characteristics–total wake time (TWT) and Insomnia Severity Index(ISI)... Mindfulness therapy can significantly improve sleep disorders in MFPS patients.
- |||||||||| ciprofloxacin / Generic mfg.
Journal: The IOU Consensus Recommendations for Empirical Therapy of Cystitis in Nursing Home Residents. (Pubmed Central) - Mar 20, 2020
An expert panel of clinical pharmacists was able to reach consensus on a set of recommendations for the empirical treatment of cystitis with oral anti-infective medications in older nursing home residents. The recommendations were incorporated into a treatment algorithm for uncomplicated cystitis in noncatheterized nursing home residents and used in educational materials for health professionals in an ongoing controlled intervention study.
- |||||||||| tizanidine / Generic mfg., ibuprofen / Generic mfg.
Clinical, Journal: A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain. (Pubmed Central) - Mar 18, 2020
The recommendations were incorporated into a treatment algorithm for uncomplicated cystitis in noncatheterized nursing home residents and used in educational materials for health professionals in an ongoing controlled intervention study. Adding baclofen, metaxalone, or tizanidine to ibuprofen does not appear to improve functioning or pain any more than placebo plus ibuprofen by 1 week after an ED visit for acute low back pain.
- |||||||||| Flagyl (metronidazole) / SLA, doxycycline / Generic mfg., tizanidine / Generic mfg.
Acute Lung Injury Secondary to Tizanidine Inhalation (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_7864;
Following the procedure the patient was started on antibiotic therapy with IV Flagyl, Doxycycline, Cefepime and Vancomycin...IV Solumedrol was transitioned to oral Prednisone taper...The inflammatory response to such irritation can lead to further lung damage. Long term effects may lead to disease of the airways and cause difficulty breathing and related systemic problems.
- |||||||||| Primary Sacroiliac Mass: A Rare Cause of Sacral Radiculopathy () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1390;
Conclusions : This case presentation presents a primary sacral tumor, an uncommon cause of back pain. It is important to identify and manage this patient's diagnosis in a timely manner to prevent subsequent functional decline and poor quality of life.
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