- |||||||||| everolimus / Generic mfg.
Trial completion date, Trial primary completion date, Monotherapy: Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma (clinicaltrials.gov) - Feb 27, 2019 P2, N=4, Active, not recruiting, Trial completion date: Dec 2020 --> May 2022 | Trial primary completion date: May 2020 --> May 2022 Trial completion date: Feb 2020 --> Feb 2021 | Trial primary completion date: Feb 2019 --> Feb 2020
- |||||||||| Lenvima (lenvatinib) / Eisai, Merck (MSD)
Trial completion, Trial completion date, Combination therapy, Metastases: A Study of E7080 Alone, and in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Renal Cell Carcinoma Following One Prior Vascular Endothelial Growth Factor (VEGF)-Targeted Treatment (clinicaltrials.gov) - Feb 27, 2019 P1b/2, N=173, Completed, Trial completion date: Feb 2020 --> Feb 2021 | Trial primary completion date: Feb 2019 --> Feb 2020 Active, not recruiting --> Completed | Trial completion date: May 2017 --> Feb 2018
- |||||||||| carboplatin / Generic mfg., everolimus / Generic mfg., paclitaxel / Generic mfg.
Trial completion date, Trial primary completion date, Metastases: Gastric Cancer RAD001 Study (clinicaltrials.gov) - Feb 22, 2019 P1/2, N=35, Active, not recruiting, Active, not recruiting --> Completed | Trial completion date: Aug 2015 --> Jul 2017 Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Dec 2019
- |||||||||| Mekinist (trametinib) / Novartis, BeiGene
Enrollment change, Trial termination: GSK1120212 Rollover Study (clinicaltrials.gov) - Feb 19, 2019 P2, N=159, Terminated, Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Dec 2019 N=250 --> 159 | Completed --> Terminated; Company Decision
- |||||||||| itacitinib (INCB039110) / Incyte
Enrollment open, Combination therapy: Itacitinib + Everolimus in Hodgkin Lymphoma (clinicaltrials.gov) - Feb 8, 2019 P1/2, N=28, Recruiting, Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Dec 2019 Not yet recruiting --> Recruiting
- |||||||||| everolimus / Generic mfg.
Trial completion date, Trial primary completion date: RAD001 for Patients With Radioiodine Refractory Thyroid Cancer (clinicaltrials.gov) - Feb 7, 2019 P2, N=33, Active, not recruiting, Initiation date: Dec 2018 --> Mar 2019 Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2018 --> Dec 2019
- |||||||||| simvastatin / Generic mfg.
Trial completion date, Trial primary completion date: Safety of Simvastatin in LAM and TSC (clinicaltrials.gov) - Feb 6, 2019 P1/2, N=10, Active, not recruiting, Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2018 --> Dec 2019 Trial completion date: May 2019 --> Dec 2019 | Trial primary completion date: Jan 2018 --> Dec 2019
- |||||||||| Avastin (bevacizumab) / Roche
Trial completion, Enrollment change, Trial completion date, Trial primary completion date, Metastases: Sequential Therapy in Metastatic Renal Cell Carinoma (clinicaltrials.gov) - Feb 6, 2019 P2, N=22, Completed, Trial completion date: May 2019 --> Dec 2019 | Trial primary completion date: Jan 2018 --> Dec 2019 Active, not recruiting --> Completed | N=100 --> 22 | Trial completion date: May 2016 --> Sep 2016 | Trial primary completion date: May 2016 --> Sep 2016
- |||||||||| everolimus / Generic mfg.
Trial completion, Enrollment change, Trial completion date, Trial primary completion date, Combination therapy: Neoadj ph 2 AI Plus Everolimus in Postmenopausal Women w/ ER Pos/HER2 Neg, Low Risk Score (clinicaltrials.gov) - Feb 5, 2019 P2, N=17, Completed, Active, not recruiting --> Completed | N=100 --> 22 | Trial completion date: May 2016 --> Sep 2016 | Trial primary completion date: May 2016 --> Sep 2016 Active, not recruiting --> Completed | N=66 --> 17 | Trial completion date: Sep 2018 --> Dec 2018 | Trial primary completion date: Jan 2018 --> Jul 2017
- |||||||||| Enrollment change, Trial completion date, Trial primary completion date, Real-world evidence, Real-world, Metastases: Treat ER+ight: Treatment of Canadian Men and Pre/Peri/Post-menopausal Women With ER+ Advanced Breast Cancer in the Real-World Setting With Hormone Therapy (clinicaltrials.gov) - Feb 5, 2019
P=N/A, N=500, Recruiting, Active, not recruiting --> Completed | N=66 --> 17 | Trial completion date: Sep 2018 --> Dec 2018 | Trial primary completion date: Jan 2018 --> Jul 2017 N=320 --> 500 | Trial completion date: Dec 2019 --> Jan 2023 | Trial primary completion date: Dec 2019 --> Jan 2023
- |||||||||| cyclophosphamide / Generic mfg., everolimus / Generic mfg., mesna / Generic mfg.
Enrollment open: LITMMUS-MGH: Liver Transplantation With Tregs at MGH (clinicaltrials.gov) - Jan 25, 2019 P1/2, N=9, Recruiting, This finding may be applicable to other patient populations. Not yet recruiting --> Recruiting
- |||||||||| Lenvima (lenvatinib) / Eisai, Merck (MSD)
Enrollment closed, Enrollment change, Combination therapy, Metastases: A Trial to Evaluate Efficacy and Safety of Lenvatinib in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Non Clear Cell Renal Cell Carcinoma (nccRCC) Who Have Not Received Any Chemotherapy for Advanced Disease (clinicaltrials.gov) - Jan 23, 2019 P2, N=31, Active, not recruiting, Trial completion date: Dec 2018 --> Dec 2020 | Trial primary completion date: Dec 2018 --> Dec 2020 Recruiting --> Active, not recruiting | N=22 --> 31
- |||||||||| Sutent (sunitinib) / Pfizer
Enrollment closed, Enrollment change, Surgery, Metastases: Study of Mutation-Targeted Therapy With Sunitinib or Everolimus in People With Advanced Low- or Intermediate-Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgery (clinicaltrials.gov) - Jan 17, 2019 P2, N=16, Active, not recruiting, Although the MST in patients receiving everolimus was comparable to contemporary studies, it was inferior to the control in this randomized study. Recruiting --> Active, not recruiting | N=120 --> 16
- |||||||||| everolimus / Generic mfg., exemestane / Generic mfg.
Enrollment closed, Enrollment change, Combination therapy, Metastases: EVEREXES: Study in Post-menopausal Women With Hormone Receptor Positive, HER2-negative Advanced Breast Cancer (clinicaltrials.gov) - Jan 15, 2019 P3, N=236, Active, not recruiting, Recruiting --> Active, not recruiting | N=120 --> 16 Recruiting --> Active, not recruiting | N=400 --> 236
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin
Biomarker, Enrollment closed: TBHDT: TB Host Directed Therapy (clinicaltrials.gov) - Jan 10, 2019 P2, N=200, Active, not recruiting, This combination has limited clinical activity in heavily pretreated NHL. Recruiting --> Active, not recruiting
- |||||||||| everolimus / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Open-label Study on Treatment of Primary Aldosteronism With Everolimus (clinicaltrials.gov) - Jan 9, 2019 P2, N=12, Completed, Initiation date: Jun 2018 --> Jan 2019 Recruiting --> Completed | Trial completion date: Dec 2018 --> Jun 2018 | Trial primary completion date: Dec 2018 --> Jun 2018
- |||||||||| camizestrant (AZD9833) / AstraZeneca
Trial completion date, Trial primary completion date, Combination therapy, Metastases: SERENA-1: Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer. (clinicaltrials.gov) - Jan 9, 2019 P1, N=165, Recruiting, Recruiting --> Completed | Trial completion date: Dec 2018 --> Jun 2018 | Trial primary completion date: Dec 2018 --> Jun 2018 Trial completion date: Jun 2020 --> Nov 2021 | Trial primary completion date: Jun 2020 --> Nov 2021
- |||||||||| cyclophosphamide / Generic mfg., everolimus / Generic mfg., mesna / Generic mfg.
Trial completion date, Trial primary completion date: LITMMUS-UCSF: Liver Transplantation With Tregs at UCSF (clinicaltrials.gov) - Dec 28, 2018 P1/2, N=9, Not yet recruiting, Active, not recruiting --> Completed | Trial completion date: Dec 2019 --> Apr 2018 | Trial primary completion date: Dec 2018 --> Apr 2018 Trial completion date: Dec 2025 --> Feb 2025 | Trial primary completion date: Dec 2025 --> Feb 2025
- |||||||||| cyclophosphamide / Generic mfg., everolimus / Generic mfg., mesna / Generic mfg.
Trial completion date, Trial primary completion date: LITMMUS-MGH: Liver Transplantation With Tregs at MGH (clinicaltrials.gov) - Dec 28, 2018 P1/2, N=9, Not yet recruiting, Trial completion date: Dec 2025 --> Feb 2025 | Trial primary completion date: Dec 2025 --> Feb 2025 Trial completion date: Dec 2025 --> Feb 2025 | Trial primary completion date: Dec 2025 --> Feb 2025
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