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- STK-009/SYNCAR-001 / Synthekine
Orthogonal IL-2/IL-2R? signaling selectively enhances and sustains a synthetic effector state via a novel mechanism and outperforms constitutive armoring approaches (Section 40) - Mar 5, 2024 - Abstract #AACR2024AACR_7710;
P1
This analysis also identified a novel mechanism by which STK-009/oR? signaling induces a superior synthetic effector state via transcriptional repression of the stress response/proteosome.These findings support the advantages of an orthogonal platform that selectively drives and sustains potent T cell effector function without safety concerns associated with constitutively expressed armored approaches.