- |||||||||| Xeljanz (tofacitinib) / Pfizer, tofacitinib citrate topical gel (AC-1101) / Inmagene, TWi Pharma
Journal: Design of chondroitin sulphate coated proglycosomes for localized delivery of tofacitinib for the treatment of rheumatoid arthritis. (Pubmed Central) - Apr 25, 2023
The efficacy study revealed that CS-TOF-PG showed a significant (P < 0.001) reduction in inflammation in arthritic rat paws compared to the TOF oral and FD gel. The current study ensured that the CS-TOF-PG topical gel system would provide a safe and effective formulation for localization and site-specific delivery of TOF at the RA site and overcome the adverse effects associated with the TOF.
- |||||||||| tofacitinib citrate topical gel (AC-1101) / Inmagene, TWi Pharma
Trial completion date, Trial primary completion date: Study to Evaluate the Safety and Tolerability of AC-1101 Topical Gel in Patients With Granuloma Annulare (clinicaltrials.gov) - Mar 21, 2023
P1, N=15, Recruiting,
The current study ensured that the CS-TOF-PG topical gel system would provide a safe and effective formulation for localization and site-specific delivery of TOF at the RA site and overcome the adverse effects associated with the TOF. Trial completion date: May 2023 --> Oct 2023 | Trial primary completion date: May 2023 --> Oct 2023
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