| levetiracetam / Generic mfg. |
| Not yet recruiting | 4 | 20 | | | Prof. David C. Reutens, UCB Pharma | acute seizures | | | | |
ACTRN12606000102572: Neuropsychiatric, Neurocognitive And Quality Of Life Outcomes In Patients With Epilepsy Treated With Levetiracetam (Keppra) Verses Older AEDs As First Substitution Monotherapy. |
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| Recruiting | 4 | 200 | | | Associate Prof. Terence O'Brien and RMH Neurosciences Foundation, UCB Pharma Belgium | Epilepsy | | | | |
ACTRN12615000643572: EpiNet-First Trial 1: Comparison of efficacy of levetiracetam, lamotrigine and carbamazepine in people with previously untreated epilepsy who have focal seizures. |
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| Recruiting | 4 | 1467 | | | EpiNet Study Group, Health Research Council of New Zealand, Neurological Foundation of New Zealand, Julius Brendel Trust | Epilepsy | | | | |
ChiCTR-TRC-13003743: Anti-epilepsy drugs prophylaxis in cranioplasty for patients with skull defection: A prospective randomized controlled study |
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| Completed | 4 | 200 | | levetiracetam prophylaxis vs without levetiracetam prophylaxis | The First Affiliated Hospital of PLA General Hospital; Level of the institution：, Research funds | Epilepsy | | | | |
2012-001884-64: A study of Standard and New Antiepileptic Drugs – SANAD-II. |
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| Ongoing | 4 | 1510 | Europe | Sodium Valproate, Lamotrigine, Levetiracetam, Zonisamide, Tablet, Capsule, hard, Lamictal, Keppra, Zonegran | University of Liverpool, The Walton Centre NHS Foundation Trust, National Institute for Health Research (NIHR) Health Technology Assessment Program (HTA) | Epilepsy, Brain disorder, Diseases [C] - Nervous System Diseases [C10] | | | | |
ChiCTR-OCC-11001874: Evaluate the efficacy and safety of Levetiracetam for prophylaxis and treatment of febrile seizure in children |
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| Completed | 4 | 67 | | NA ;starting dose with LEV 30mg/kg | PLA General Hospital; PLA General Hospital, NA | febrile seizure | | | | |
2014-002188-13: Emergency treatment with levetiracetam or phenytoin in status epilepticus in children (EcLiPSE) - a randomsied unblinded controlled trial |
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| Ongoing | 4 | 308 | Europe | Levetiracetam, Phenytoin, Concentrate for solution for infusion, Keppra, Epanutin | University of Liverpool, Alder Hey Children's NHS Foundation Trust, National Institute Health Research Health Technology Assessment (NETSCC), ational Institute Health Research Health Technology Assessment (NETSCC) | Convulsive Status Epilepticus, A convulsive seizure which continues for a prolonged period (longer than five minutes), or when convulsive seizures occur one after the other with no recovery between., Diseases [C] - Nervous System Diseases [C10] | | | | |
2004-002114-11: A double blind, randomized, placebo-controlled, cross-over study to evaluate the effects of Levetiracetam on membrane excitability properties of afferent myelinated and unmyelinated fibers and change in neuropathic pain in patients with painful traumatic nerve injury. |
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| Ongoing | 4 | 20 | Europe | Levetiracetam, - Keppra 250mg, - Keppra 500mg, - Keppra 250mg, - Keppra 500mg | Infociencia Clinical Research | Neuropathic pain due to a traumatic nerve lesion | | | | |
2005-001516-41: Efficacy and safety of Levetiracetam treatment in patients suffering from Restless Legs SyndromeEficacia y seguridad de un tratamiento con levetiracetam en pacientes con síndrome idiopático de piernas inquietas |
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| Ongoing | 4 | 12 | Europe | Levetiracetam, Keppra 250, Keppra 500, Keppra 250, Keppra 500 | Clínica Plató Fundació Privada | Restless legs syndrome (RLS) | | | | |
2005-002042-19: Double-blind, placebo controlled cross-over study to assess the efficacy of Levetiracetam in paediatric and childhood non-epileptic myoclonusEstudio cruzado, aleatorizado, doble ciego controlado con placebo, para evaluar la eficacia del Levetiracetam en el tratamiento del mioclonus no epiléctico en pacientes pediátricos y adolescentes |
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| Ongoing | 4 | 20 | Europe | Levetiracetam, Keppra 250 mg, Keppra 500 mg, Keppra 250 mg, Keppra 500 mg | Hospital Sant Joan de Déu | Non-epileptic myoclonus | | | | |
2005-002041-40: Double-blind, placebo controlled cross-over study to assess efficacy of Levetiracetam in paediatric and childhood Tourette syndrome. Estudio cruzado, aleatorizado, doble ciego controlado con placebo, para evaluar la eficacia del Levetiracetam en el control de los tics de pacientes pediátricos y adolescentes con síndrome de Gilles de la Tourette |
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| Ongoing | 4 | 20 | Europe | Levetiracetam, Keppra 250 mg, Keppra 500 mg, Keppra 250 mg, Keppra 500 mg | Hospital Sant Joan de Déu | Tourette syndrome | | | | |
2005-002474-30: Influence of levetiracetam on gamma band activity in a group of epilepsy patientsEstudio sobre la influencia de levetiracetam en la actividad de las ondas gamma en pacientes con epilepsia |
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| Ongoing | 4 | 25 | Europe | Levetiracetam, Keppra 500mg, Keppra 1000mg, Keppra 500mg, Keppra 1000mg | Hospital Ruber Internacional | Epilepsy with partial and/or generalized seizures | | | | |
2005-003903-35: : The Role of Keppra in the Treatment of Tremor in Multiple Sclerosis |
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| Ongoing | 4 | 20 | Europe | Keppra ®, Keppra 250mg, Keppra 500mg | Newcastle-upon-Tyne Hospitals NHS Trust | Multiple Sclerosis | | | | |
2005-003411-75: Estudio sobre la utilización de levetiracetam en monoterapia en pacientes HIV-positivos con epilepsia |
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| Ongoing | 4 | 20 | Europe | levetiracetam, ucb-L059, Keppra 500 / 1000 mg comprimidos con cubierta pelicular, Keppra 500 / 1000 mg comprimidos con cubierta pelicular | Fundación para la Investigación Biomédica del Hospital Clínico de San Carlos | Pacientes HIV-positivos con epilepsia | | | | |
2008-000370-20: Evaluation of pharmacokinetic and pharmacodynamic interactions between escitalopram and drugs used for the treatment of bipolar disorders. |
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| Ongoing | 4 | 24 | Europe | Lamotrigine, Gabapentin, Carbamazepine, Oxcarbazepine, Levetiracetam, Valproic acid, CIPRALEX, LITIO CARBONATO, CIPRALEX, LITIO CARBONATO | AZIENDA OSPEDALIERA PISANA | bipolar disorders | | | | |
| Ongoing | 4 | 40 | Europe | carbamazepine, Levetiracetam, Lamotrigine, RVG 11401 (tabletten 100 mg), RVG 03899 (tabletten, RVG 29546, We won\'t be investigating a specific IMP but a group of antiepileptic drugs to be withdrawn earlier after epilepsy surgery. The earlier withdrawal is the research question. As discussed 3 IMPs wille be given; carbamazepine, Levetiracetam, Lamotrigine, We won\'t be investigating a specific IMP but a group of antiepileptic drugs to be withdrawn earlier after epilepsy surgery. The earlier withdrawal is the research question. As discussed 3 IMPs wille be given; carbamazepine, Levetiracetam, Lamotrigine | University Medical Center Utrecht, Dutch national epilepsy fund | We will investigate possible cognitive benifits of early antiepileptic drug withdrawal after pediatric epilepsy surgery. The concerning medical condition is refractory epilepsy | | | | |
2015-004827-30: Rapid versus slow withdrawal of antiepileptci monotherapy in two-year seizure free patients. Sospensione rapida contro sospensione lenta della monoterapia con un farmaco antiepilettico in pazienti senza crisi da almeno due anni |
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| Ongoing | 4 | 350 | Europe | Tablet, KEPPRA - 1000MG-COMPRESSA RIVESTITA CON FILM-USO ORALE BLISTER DIVISIBILE (ALLUMINIO/PVC)-100X1 (DOSE UNITARIA) | AZIENDA OSPEDALIERA "BIANCHI-MELACRINO-MORELLI", Ministero della Salute, REGIONE CALABRIA | Epilepsy Epilessia, Epilepsy Epilessia, Diseases [C] - Nervous System Diseases [C10] | | | | |
2018-000781-10: EFFICACY AND TOLERABILITY OF LOW versus STANDARD DAILY DOSES OF ANTIEPILEPTIC DRUGS IN NEWLY DIAGNOSED, PREVIOUSLY UNTREATED EPILEPSY Efficacia e tollerabilit¿ di basse dosi contro dosi standard dei farmaci antiepilettici in pazienti non trattati di nuova diagnosi. |
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| Not yet recruiting | 4 | 374 | Europe | CARBAMAZEPINA, OXCARBAZEPINA, LAMOTRIGINA, LEVETIRACETAM, TOPIRAMATO, ACIDO VALPROICO, GABAPENTIN, ZONISAMIDE, CARBAMAZEPINA BASSA DOSE, OXCARBAZEPINA BASSA DOSE, LAMOTRIGINA BASSA DOSE, LEVETIRACETAM BASSA DOSE, TOPIRAMATO BASSA DOSE, ACIDO VALPROICO BASSA DOSE, GABAPENTIN BASSA DOSE, ZONISAMIDE BASSA DOSE, CARBAMAZEPINA, OXCARBAZEPINA, LAMOTRIGINA, LEVETIRACETAM, TOPIRAMATO, ACIDO VALPROICO, GABAPENTIN, ZONISAMIDE, CARBAMAZEPINA BASSA DOSE, OXCARBAZEPINA BASSA DOSE, LAMOTRIGINA BASSA DOSE, LEVETIRACETAM BASSA DOSE, TOPIRAMATO BASSA DOSE, ACIDO VALPROICO BASSA DOSE, GABAPENTIN BASSA DOSE, ZONISAMIDE BASSA DOSE, Tablet, Capsule, hard, TEGRETOL - 200 MG COMPRESSE A RILASCIO MODIFICATO 30 COMPRESSE, TOLEP - 300 MG COMPRESSE 50 COMPRESSE DIVISIBILI, LAMOTRIGINA DOC - 100 MG COMPRESSE DISPERSIBILI 56 COMPRESSE IN BLISTER ACLAR/PVC/AL, LEVETIRACETAM DOC - 500 MG COMPRESSE RIVESTITE CON FILM 60 COMPRESSE, TOPIRAMATO DOC GENERICI - 100 MG COMPRESSE RIVESTITE CON FILM 60 COMPRESSE IN BLISTER AL/AL, ACIDO VALPROICO SANDOZ - 300 MG COMPRESSE A RILASCIO PROLUNGATO30 COMPRESSE, GABAPENTIN MYLAN GENERICS - 400 MG CAPSULE RIGIDE 500 (5X100) CAPSULE IN BLISTER PVC/ALU CONFEZIONE OSPEDALIERA, ZONEGRAN - 100 MG CAPSULA RIGIDA USO ORALE BLISTER (PVC/ALL) 196 CAPSULE | IRCCS- ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI, Ministero della Salute, Regione Lombardia | EPILEPSY EPILESSIA, EPILEPSY EPILESSIA, Diseases [C] - Nervous System Diseases [C10] | | | | |
ChiCTR-IPR-15007241: Intermittent oral levetiracetam preventing the recurrence of febrile seizure with epileptiform discharges under the monitoring of iThermonitor: a multicenter randomized controlled trail |
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| Not yet recruiting | 4 | 400 | | LEV 15-30mg/kg ;NA | Chinese PLA General Hospital; PLA General Hospital, NA | febrile seizure | | | | |
ACTRN12615000556549: EpiNet-First Trial 2: Comparison of efficacy of levetiracetam and sodium valproate in people with previously untreated epilepsy who have generalised seizures. |
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| Terminated | 4 | 506 | | | EpiNEt Study Group, Health Research Council of New Zealand;, Neurological Foundation of New Zealand, Julius Brendel Trust | Epilepsy | | | | |
ACTRN12615000641594: EpiNet-First Trial 5: Comparison of efficacy of levetiracetam and lamotrigine in people with previously untreated epilepsy who have unclassified seizures, and for whom sodium valporate is not deemed an acceptable anti-epileptic drug. |
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| Terminated | 4 | 664 | | | EpiNet Study Group, Health Research Council of New Zealand, Neurological Foundation of New Zealand, Julius Brendel Trust | Epilepsy | | | | |
ACTRN12615000640505: EpiNet-First Trial 4: Comparison of efficacy of levetiracetam, lamotrigine and sodium valproate in people with previously untreated epilepsy who have unclassified seizures. |
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| Terminated | 4 | 1176 | | | EpiNet Study Group, Health Research Council of New Zealand, Neurological Foundation of New Zealand, Julius Brendel Trust | Epilepsy | | | | |
ACTRN12615000639527: EpiNet-First Trial 3: Comparison of efficacy of levetiracetam and lamotrigine in people with previously untreated epilepsy who have generalised seizures, and for whom sodium valporate is not deemed an acceptable anti-epileptic drug. |
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| Terminated | 4 | 664 | | | EpiNet Study Group, Health Research Council of New Zealand, Neurological Foundation of New Zealand, Julius Brendel Trust | Epilepsy | | | | |
NCT04829838: Comparison of Efficacy of Phenytoin With Levetireacetam for the Management of Children With Status Epilepticus |
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| Recruiting | 4 | 244 | RoW | intravenous levetireacetam | ayesha tariq, King Edward Medical University | Status Epilepticus | 07/21 | 07/21 | | |
ChiCTR2200057041: Cost-effectiveness analysis of domestic and imported levetiracetam tablets in the treatment of children with focal epilepsy (real world study) |
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| Not yet recruiting | 4 | 80 | | Domestic levetiracetam treatment ;Imported levetiracetam treatment | Beijing Children's Hospital, Capital Medical University; Beijing Children's Hospital, Capital Medical University, none | Focal epilepsy in children | | | | |
ChiCTR2000030052: A single prospective randomized controlled clinical trial of antiepileptic drug regimen for glioma patients with non-preoperative epilepsy |
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| Not yet recruiting | 4 | 100 | | take levetiracetam for 1 week ;take levetiracetam for 4 weeks | Beijing Tiantan Hospital, Capital Medical University; Beijing Tiantan Hospital, Capital Medical University, Beijing Natural Science Foundation | Glioma related epilepsy | | | | |
ChiCTR2000030228: A single prospective randomized controlled clinical trial for antiepileptic drug regimen in the treatment of patients with glioma-related epilepsy |
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| Not yet recruiting | 4 | 100 | | levetiracetam for 6 months ;levetiracetam for 12 months | Beijing Tiantan Hospital, Capital Medical University; Beijing Tiantan Hospital, Capital Medical University, Beijing Natural Science Foundation | Glioma-related epilepsy | | | | |
NCT06403150: The Efficacy and Safety of Levetiracetam Versus Fosphenytoin in Convulsive Status Epilepticus |
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| Enrolling by invitation | 4 | 62 | RoW | Levetiracetam Injection, Iracet Injection, Neurocet Injection, Fosphenytoin Injection, Fosfen Injection | Dhaka Medical College | Status Epilepticus | 08/24 | 10/24 | | |
2020-004878-22: Pharmacokinetic and Placental Transfer of Levetiracetam Etude de la pharmacocinétique maternelle et du passage transplacentaire du Lévétiracétam |
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| Not yet recruiting | 4 | 50 | Europe | Film-coated tablet | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, DGOS | Epilepsy in pregnancy l'épilepsie pendant la grossesse, Epilepsy in pregnancy l'épilepsie pendant la grossesse, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Completed | 4 | 82 | US | Levetiracetam, Keppra | University of Michigan | Intracranial Aneurysms, Seizure | 10/23 | 10/23 | | |
GENESIS, NCT04759196: Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas |
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| Recruiting | 4 | 56 | Canada | Topamax, Topiramate, TPM, Levetiracetam, LEV, Keppra | Université de Sherbrooke | Chronic Subdural Hematoma, Epilepsy; Seizure, Cortical Depression; Cortical Depolarization, Nonepileptic, Stereotypical and Intermittent Symptoms, NESIS | 09/24 | 12/24 | | |
NCT06081283: Antiseizure Medication in Seizure Networks at Early Acute Brain Injury |
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| Active, not recruiting | 4 | 54 | US | Phenobarbital Sodium Injection, phenobarbital, Levetiracetam, Lacosamide Injectable Product, Valproate Sodium, Valproate, Phosphenytoin | University of North Carolina, Chapel Hill | Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia, Hypoxia-Ischemia, Brain, Heart Arrest, Stroke, Intracranial Hemorrhages, Coma, Persistent Vegetative State | 01/25 | 04/25 | | |
| Not yet recruiting | 4 | 600 | US | levetiracetam, Keppra, lacosamide, Vimpat | Wake Forest University Health Sciences | Traumatic Brain Injury | 04/26 | 04/26 | | |
NCT05969054: Improvement Effect of Lacosamide and Levetiracetam on Cognitive in Alzheimer's Disease Patients With Epilepsy |
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| Recruiting | 4 | 140 | RoW | Lacosamide 100 mg, Levetiracetam 250mg | Xiangya Hospital of Central South University | Alzheimer Disease 3, Epilepsy | 12/25 | 12/25 | | |
| Recruiting | 4 | 120 | Europe | Levetiracetam, Keppra, Valproic Acid, Depakine | Leiden University Medical Center, Medical Center Haaglanden, Erasmus Medical Center, Amsterdam UMC, location VUmc | Glioma | 07/26 | 07/28 | | |
NCT05737511: Efficacy of Hydroxyzine for Patients With Panic Disorder |
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| Not yet recruiting | 4 | 80 | NA | Hydroxyzine, Atarax, Vistaril, Escitalopram Oxalate, citalopram, fluoxetine, fluvoxamine, paroxetine, paroxetine CR, sertraline, venlafaxine XR,, Alprazolam, clomipramine, clonazepam, diazepam, imipramine, lorazepam, mirtazapine, reboxetine, Bupropion SR, divalproex, duloxetine, gabapentin, levetiracetam, milnacipran, moclobemide, olanzapine, phenelzine, quetiapine, risperidone, tranylcypromine | Sultan Qaboos University | Panic Disorder | 12/26 | 12/26 | | |
2005-001776-13: Efficacy of Levetiracetam in the treatment of spasticity in MS: a ranomized double blind cross over study |
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| Ongoing | 3 | 24 | Europe | Levetiracetam, | Organisation name was not entered | Multiple Sclerosis | | | | |
2007-005414-40: Efficacy and activity of levetiracetam on Multiple Sclerosis cerebellar symptoms: a multicenters double blind, randomized, placebo-controlled, cross over study |
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| Ongoing | 3 | 60 | Europe | KEPPRA, KEPPRA | AZIENDA SANITARIA N. 3 GENOVESE | Patients with an established and stable Multiple Sclerosis (according to Poser criteria). | | | | |
2018-001312-30: Investigating the use of levetiracetam to prevent seizures after brain surgery. |
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| Not yet recruiting | 3 | 804 | Europe | Keppra, ucb 22059, Tablet, Keppra | Common Services Agency | Seizures in patients with suspected cerebral glioma, Seizures in patients with suspected primary brain tumour, Diseases [C] - Cancer [C04] | | | | |
PEACH, NCT03340064 / 2021-003372-13: A Study of Levetiracetam as Monotherapy or Adjunctive Treatment of Partial Seizures in Pediatric Epileptic Subjects Ranging From 1 Month to Less Than 4 Years of Age |
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| Completed | 3 | 38 | Japan | Levetiracetam, Keppra, E-Keppra, LEV | UCB Japan Co. Ltd., UCB Japan Co. Ltd. | Partial Seizures | 06/21 | 07/23 | | |
2021-003392-34: Aggressive or less aggressive treatment of persistent epileptic seizures |
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| Ongoing | 3 | 140 | Europe | Briviracetam, e.g. Keppra, e.g. Topimax, e.g. orfiril, Vimpat, n.a. many producers, different producers, Concentrate and solvent for solution for infusion, Infusion, Tablet, Briviract, Levetiracetam, Fosfenytoin, Topriamate, Orfiril/valproic acid, Vimpat, Propofol, Midazolam | Odense Universitetshospital, In-house funding Odense University Hospital | Verfied non convulsive status epilepticus refractory to standard treatment with benzodiazepines and at least one first line drug, Persistent epileptic seizures that do not respond to standard treatment, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT05722951: Metformin Efficacy and Safety in Epileptic Patients |
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| Completed | 3 | 60 | RoW | Levetiracetam &/or sodium valproate, Levetiracetam &/or valproic acid, Metformin | Tanta University | Epilepsy | 06/24 | 06/24 | | |
2021-003372-13: A Study of Levetiracetam as Monotherapy or Adjunctive Treatment of Partial Seizures in Pediatric Epileptic Subjects Ranging from 1 Month to Less Than 4 Years of Age |
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| Not yet recruiting | 3 | 48 | Japan | Solution for infusion, Powder for syrup, E Keppra® for I.V. infusion 500 mg, E Keppra® Dry Syrup 50% | UCB Japan Co. Ltd., UCB Japan Co. Ltd. | Partial Seizures, A partial seizure is a seizure which occurs in just one area of the brain., Diseases [C] - Nervous System Diseases [C10] | | | | |
| Not yet recruiting | 3 | 70 | NA | Levetiracetam, Placebo | Hamilton Health Sciences Corporation, McMaster University | Seizures, Brain Tumor | 03/26 | 03/26 | | |
| Recruiting | 3 | 604 | RoW | Levetiracetam | Tata Memorial Centre | Seizures, Brain Tumors, Antiepileptics, Levetiracetam | 06/31 | 06/31 | | |
KISS, NCT06851078: Evaluation of Early Administration of Levetiracetam in the Prevention and Treatment Encephalopathy in Septic Shock: Randomized, Double-blind, Placebo-controlled Trial |
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| Not yet recruiting | 3 | 280 | NA | Levetiracetam IV, Placebo control | Assistance Publique - Hôpitaux de Paris | Septic Shock | 06/27 | 06/27 | | |
EAST, NCT06773364: Early Initiated Ambulance-delivered Levetiracetam and Headposition in Hyper-acute Stroke Trial |
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| Not yet recruiting | 3 | 2423 | NA | Levetiracetam, Guide-recommended management, The lying flat (0°) head position, The sitting-up (≥30°) head position | Shanghai East Hospital | Suspected Stroke | 12/28 | 12/29 | | |
| Not yet recruiting | 3 | 1649 | NA | Phenytoin Sodium, Levetiracetam, Keppra | Cambridge University Hospitals NHS Foundation Trust, University of Cambridge | Traumatic Brain Injury, Post Traumatic Seizures | 03/26 | 03/28 | | |
2008-001098-13`ACTRN12617001195347: Simultaneous administration of lorazepam and levetiracetam in non-convulsive status epilepticus, followed by IV valproate: a prospective, randomized, placebo-controled, double-blind pilot trial. |
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| Ongoing | 2 | 80 | Europe | LEVETIRACETAM, L059, KEPPRA®, KEPPRA® | UZ Leuven, Department of Health, Western Australia | Peanut allergy | | | | |
2020-003698-24: A study to investigate JNJ-40411813 in combination with levetiracetam in epilepsy |
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| Ongoing | 2 | 112 | Europe | JNJ-40411813, JNJ-40411813, Tablet | Janssen-Cilag International NV, Janssen Research and Development LLC, US | Focal Onset Seizures, Seizures, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT01857934: Therapy for Children With Advanced Stage Neuroblastoma |
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| Active, not recruiting | 2 | 153 | US | cyclophosphamide, Cytoxan(R), topotecan, Hycamtin(R), hu14.18K322A, humanized anti-GD2 antibody, monoclonal antibody, dinutuximab, peripheral blood stem cell harvest, PBSCH, surgical resection, cisplatin, Platinol-AQ(R), etoposide, VP16, Vepesid(R), Etopophos(R), doxorubicin, Adriamycin(R), vincristine, Oncovin(R), busulfan, Busulfex(R), melphalan, L-phenylalanine mustard, Phenylalanine mustard, L-PAM, L-sarcolysin, Alkeran(R), peripheral blood stem cell transplantation, PBSCT, natural killer cell infusion, NK cell infusion, radiation therapy, GM-CSF, sargramostim, Leukine(R), granulocyte macrophage colony stimulating factor, G-CSF, Granulocyte colony stimulating factor, Neupogen(R), Filgrastim, mesna, Mesnex(R), levetiracetam, Keppra, interleukin-2, IL-2, aldesleukin, Proleukin(R), Isotretinoin, 13-cis retinoic acid, CliniMACS, Cell Selection System | St. Jude Children's Research Hospital, Cookies for Kids' Cancer, CURE Childhood Cancer, Inc. | Neuroblastoma | 10/21 | 12/25 | | |
| Completed | 2 | 18 | Europe | Intravenous Levetiracetam | University Hospital, Tours, Assistance Publique - Hôpitaux de Paris, Rennes University Hospital, Amiens University Hospital | Neonatal Seizures | 02/22 | 02/22 | | |
| Completed | 2 | 8 | Europe | Levetiracetam, Placebo Oral Tablet | University of Oxford, Oxford University Hospitals NHS Trust, Oxford Health NHS Foundation Trust, Northumberland, Tyne and Wear NHS Foundation Trust, UCB Pharma | Alzheimer Disease, Epilepsy | 03/22 | 03/22 | | |
TRIP, NCT04643327: Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease |
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| Recruiting | 2 | 28 | RoW | Levetiracetam, Placebo | The University of Queensland, Queensland University of Technology, Johns Hopkins University, Cleveland Clinic Lou Ruvo Center for Brain Health, Royal Brisbane and Women's Hospital | Parkinson Disease, Mild Cognitive Impairment, Memory Impairment | 01/25 | 12/25 | | |
NCT03875638: Treating Hyperexcitability in AD With Levetiracetam |
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| Recruiting | 2 | 85 | US | Levetiracetam, Placebo oral capsule | Beth Israel Deaconess Medical Center | Alzheimer Dementia, Alzheimer Disease, Dementia of Alzheimer Type, Mild Cognitive Impairment | 10/25 | 11/25 | | |
| Recruiting | 2 | 84 | US | Levetiracetam Pill, Keppra, Placebo | NYU Langone Health | Early Psychosis | 01/25 | 01/25 | | |
| Completed | 2 | 110 | Europe, US, RoW | JNJ-40411813, Placebo | Janssen Research & Development, LLC, Janssen Research and Development LLC, US | Focal Onset Seizures | 02/24 | 02/24 | | |
NCT06345495: High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly |
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| Recruiting | 2 | 30 | US | Ruxolitinib, Jakafi, INCB018424, INC424, Allogeneic Stem Cell Transplantation, Autologous stem cell transplant, Cord Blood, Levetiracetam, Eltrombopag, Promacta®, Busulfan, Busulfex™, Myleran®, Romiplostim, AMG 531, Nplate, Fludarabine phosphate, Fludarabine, Fludara®, Cyclophosphamide, Cytoxan®, Neosar®, Mesna, Mesnex™, Tacrolimus, Prograf® | M.D. Anderson Cancer Center, Incyte Corporation | Splenomegaly, Myelofibrosis | 01/27 | 01/29 | | |
LAPSE, NCT04004702: Levetiracetam for Alzheimer's Disease Neuropsychiatric Symptoms Related to Epilepsy Trial |
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| Not yet recruiting | 2 | 65 | US | Levetiracetam, Keppra | Walter Reed National Military Medical Center | Alzheimer Disease | 12/24 | 06/25 | | |
NCT04559529: Pharmacological Modulation of Hippocampal Activity in Psychosis 2 |
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| Completed | 2 | 62 | US | Levetiracetam (LEV) 500 mg, Keppra, Placebo | Vanderbilt University Medical Center | Schizophrenia; Psychosis | 12/23 | 12/23 | | |
| Recruiting | 2 | 133 | US, RoW | Levetiracetam Injection, Phenobarbital Sodium Injection | University of California, San Diego, University of Minnesota, Rady Children's Hospital, San Diego, Auckland City Hospital, University of Auckland, New Zealand, Middlemore Hospital, New Zealand | Neonatal Seizure, Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Seizure Newborn | 07/27 | 12/27 | | |
NCT05735717: MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies |
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| Recruiting | 2 | 150 | US | Fludarabine, Busulfan, Melphalan, Rituximab, Levetiracetam, Keppra | Masonic Cancer Center, University of Minnesota | Hematologic Malignancy, Acute Leukemia, Remission, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, AML, TP53, Intrachromosomal Amplification of Chromosome 21, Cytogenetic Abnormality, CNS Leukemia, Minimal Residual Disease, Myelodysplasia, Juvenile Myelomonocytic Leukemia, Somatic Mutation, PTPN11 Gene Mutation, N-RAS Gene Amplification, Neurofibromatosis 1, NF1 Mutation, CBL Gene Mutation, Monosomy 7, Chromosome Abnormality, Fetal Hemoglobin | 11/27 | 11/30 | | |
| Ongoing | 1/2 | 10 | Europe | Keppra, Keppra | ErasmusMedical Center-Sophia | epileptic seizures in neonates admitted to the intensive care unit | | | | |
| Not yet recruiting | 1/2 | 100 | RoW | Oral levetiracetam, Keppra, Intravenous phenobarbital, phenobarbitone | The People's Hospital of Dehong Autonomous Prefecture, Children's Hospital of Fudan University, Xiamen Children's Hospital, Fujian of China, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangzhou Women and Children's Medical Center, Second Affiliated Hospital of Wenzhou Medical University, Maternal and Child Health Hospital of Hubei Province | Neonatal Seizures | 12/18 | 12/18 | | |
| Completed | 1/2 | 307 | Europe, Canada, US, RoW | Axicabtagene Ciloleucel, Yescarta®, Fludarabine, Cyclophosphamide, Levetiracetam, Tocilizumab, Dexamethasone, High-dose methylprednisolone, Bendamustine, Rituximab, Doxorubicin, Prednisone, Vincristine, Ifosfamide, Carboplatin, Etoposide, Gemcitabine, Oxaliplatin, Cisplatin, Methylprednisolone | Kite, A Gilead Company | Refractory Diffuse Large B Cell Lymphoma (DLBCL), Relapsed Diffuse Large B-Cell Lymphoma, Transformed Follicular Lymphoma (TFL), Primary Mediastinal B-cell Lymphoma (PMBCL), High Grade B-cell Lymphoma (HGBCL) | 07/23 | 07/23 | | |
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NCT04497142: Effect of Perampanel on Peritumoral Hyperexcitability in HGG |
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| Completed | 1/2 | 12 | US | Perampanel, E2007, Fycompa, Standard of Care, Standard treatment (typically the anti-seizure medication levetiracetam) | Dana-Farber Cancer Institute, National Cancer Institute (NCI), Eisai Inc. | Glioma, Malignant, Surgery, Seizures | 05/23 | 05/23 | | |
CAN-GT, NCT04833907: rAAV-Olig001-ASPA Gene Therapy for Treatment of Children With Typical Canavan Disease |
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| Recruiting | 1/2 | 24 | US | rAAV-Olig001-ASPA, MYR-101, Levetiracetam, Keppra, Prednisone | Myrtelle Inc. | Canavan Disease | 08/26 | 08/27 | | |
NCT03034356: Reducing Hippocampal Hyperactivity and Improving Cognition in Schizophrenia |
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| Completed | 1/2 | 67 | US | Levetiracetam, Keppra, Placebo | VA Office of Research and Development | Schizophrenia | 06/24 | 06/24 | | |
| Terminated | 1/2 | 60 | RoW | Oral levetiracetam, Keppra, Intravenous phenobarbital, phenobarbitone | Children's Hospital of Fudan University, Xiamen Children's Hospital, Fujian of China, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangzhou Women and Children's Medical Center, Second Affiliated Hospital of Wenzhou Medical University, Maternal and Child Health Hospital of Hubei Province, The Maternal & Children Health Hospital of Dehong, Yunnan of China | Neonatal Seizures | 01/17 | 01/17 | | |
| Completed | 1 | 24 | | levetiracetam injection versus levetiracetam tablet | Peking University First Hospital; Sichuan Dingnuo Taichen Technology Co., Ltd., Sichuan Dingnuo Taichen Technology Co., Ltd. | epilepsy | | | | |
NCT00227461: Levetiracetam (Keppra) to Improve Chronic Aphasia in Post-stroke Patients. |
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| Active, not recruiting | 1 | 50 | US | Wait first, then levetiracetam, Keppra, Levetiracetam first, then wait | Kessler Foundation, UCB Pharma | Aphasia, Stroke | 12/21 | 12/21 | | |
ACTRN12624001326583: Efficacy of levetiracetam versus phenytoin in children with convulsive status epilepticus, Single blinded Randomized controlled trial |
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| Not yet recruiting | N/A | 134 | | | Dr Hina Parvaiz- Medical Teaching Institute Lady Reading Hospital Peshawar | Status epilepticus | | | | |
ACTRN12623001032640: The ALLEVIATE study. A prospective observational comparative plasma and cerebrospinal fluid pharmacokinetics study of levetiracetam in aneurysmal subarachnoid haemorrhage and traumatic brain injury. |
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| Recruiting | N/A | 40 | | | The University of Queensland, Royal Brisbane and Women's Hospital & RBWH Foundation Project Grant | traumatic brain injury, aneurysmal subarachnoid haemorrhage | | | | |
ChiCTR1800015004: Bioequivalence study of Levetiracetam Tablets in Healthy Chinese Volunteers |
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| Recruiting | N/A | 48 | | RT in fasted states ;TR in fasted states ;RT in fed states ;TR in fed states | First Affiliated Hospita, College of Medicine, Zhejiang University; ZHEJIANG JINGXIN PHARMACEUTICAL CO., LTD., ZHEJIANG JINGXIN PHARMACEUTICAL CO.,LTD. | Healthy Volunteers | | | | |
ChiCTR2000031542: The effects of selective dorsal root rhizotomy in children with spastic cerebral palsy |
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| Completed | N/A | 90 | | selective dorsal root rhizotomy and levetiracetam ;routine rehabilitation and levetiracetam ;levetiracetam | The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital; China National Nuclear Corporation 416 Hospital Ethics Committee, the health planning committee of Sichuan Foundation Project | children with spastic cerebral palsy | | | | |
ChiCTR1900028636: Effect of pregabalin monotherapy on sleep in patients with epilepsy |
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| Completed | N/A | 60 | | pregabalin; levetiracetam | The First Hospital of Shanxi Medical University; The First Hospital of Shanxi Medical University, Funding support for Shanxi Province key R & D plan (international cooperation) project | epilepsy | | | | |
ChiCTR1900028463: Study for comparison of levetiracetam and oxcarbazepine/Sodium valproate monotherapy among infants with newly diagnosed focal epilepsy |
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| Recruiting | N/A | 300 | | oxcarbazepine ;levetiracetam ;Sodium valproate | Children's Hospital, Chongqing Medical University; Children's Hospital, Chongqing Medical University, self-financing | focal epilepsy in infants | | | | |
NCT02866877: Effects of Augmented Renal Clearance on Pharmacokinetic and Pharmacodynamic Properties of Levetiracetam in Subarachnoid Hemorrhage |
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| Completed | N/A | 15 | US | Pharmacokinetic modeling | University of Colorado, Denver | Subarachnoid Hemorrhage | 06/19 | 03/21 | | |
ChiCTR2100050276: Pilot study to evaluate the bioequivalence of levetiracetam extended-release tablets in healthy subjects |
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| Recruiting | N/A | 32 | | the reference preparation was given on an empty stomach in large size ;the test preparation was given on an empty stomach in large size ;the reference preparation was given on an empty stomach in small size ;the test preparation was given on an empty stomach in small size ;the reference preparation was given after meals in large size ;the test preparation was given after meals in large size ;the reference preparation was given after meals in small size ;the test preparation was given after meals in small size | Dongyang Hengdian Hospital; Dongyang Hengdian Hospital, Hangzhou Bio-Sincerity Pharma-Tech Co., Ltd. | Pharmacokinetic study | | | | |
| Completed | N/A | 169 | RoW | Levetiracetam, Sodium valproate | Mazandaran University of Medical Sciences | Treatment of Idiopathic Generalized Epilepsy | 03/24 | 03/24 | | |
levcbz, NCT06138847: Does Levetiracetam and Carbamazepine Impact the Autonomic Activity of Children With Self-limiting Focal Epilepsy? |
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| Active, not recruiting | N/A | 119 | RoW | electroencephalogram | İpek Dokurel | Epilepsy; Syndrome, Seizures of Localized Onset | 08/23 | 12/23 | | |
NCT06067412: Efficacy of Phenytoin vs Levetiracetam in Status Epilepticus at Institute of Child Health,Faisalabad |
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| Completed | N/A | 70 | RoW | Levetiracetam, Phenytoin | Shaheed Zulfiqar Ali Bhutto Medical University | Status Epilepticus | 01/23 | 01/23 | | |
| Recruiting | N/A | 50 | Europe | biological collection | Assistance Publique - Hôpitaux de Paris | Epilepsy in Pregnancy | 06/23 | 09/23 | | |
NCT04939675: Modification of Epilepsy Screen Questionnaire and Treatment Feasibility Evaluation |
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| Not yet recruiting | N/A | 40 | NA | Zonisamide 100mg, Zonegran 100mg, Levetiracetam 500mg, Keppra 500mg, LamoTRIgine 50mg, Lamictal 50mg | National Taiwan University Hospital | Epilepsy | 06/23 | 06/25 | | |
ChiCTR1800016975: Short-course prevention of febrile seizures in children: A Prospective, Multi-Center, and Real-World study |
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| Recruiting | N/A | 6000 | | without intervention ;Oral diazepam at the early stage of fever to prevent febrile seizure, 0.3mg/kg (Max≤10 mg), q8h (≤3 times in 24h) ;oral Levetiracetam after the first episode, 15-30mg/(kg.d), bid, for 3-5 days | The Second Affiliated Hospital of Shantou University Medical College (Department of Pediatrics); The Second Affiliated Hospital of Shantou University Medical College, Patients own expense on necessary medical care | febrile seizures(FS) | | | | |
NCT04858841: Post-stroke Epilepsy: Primary Prophylaxis Study |
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| Recruiting | N/A | 180 | RoW | Levetiracetam Oral Product, keppra, Perampanel Oral Product, fycompa, Placebo | National Cheng Kung University, Ministry of Science and Technology, Taiwan, National Cheng-Kung University Hospital | Middle Cerebral Artery Stroke | 07/23 | 07/23 | | |
| Recruiting | N/A | 80 | Europe | Ketamine, Perampanel, Any anti-epileptic and anesthetic therapy, excluding Ketamine and Perampanel, Levetiracetam, Valproate, Phenytoin, Lacosamide, Topiramate, Propofol, Midazolam, Thiopental | University of Milano Bicocca, Azienda Ospedaliera San Gerardo di Monza, Azienda Ospedaliero-Universitaria di Modena, Azienda Ospedaliera Universitaria Integrata Verona, Ospedale Centrale Bolzano, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Azienda Ospedaliero-Universitaria Careggi, Azienda Ospedaliero-Universitaria di Parma, Santa Chiara Hospital, Ospedale M. Bufalini Cesena, Azienda Ospedaliera Brotzu, Istituto Di Ricerche Farmacologiche Mario Negri | Status Epilepticus, Cardiac Arrest | 03/25 | 03/25 | | |
LEVET, NCT06498362: The "New" Place of IRACETAM in the Management of Status Epilepticus in Children |
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| Recruiting | N/A | 151 | Europe | | University Hospital, Strasbourg, France | Epilepsy in Children | 05/25 | 05/25 | | |
NCT02647437: Effects of Low-dose Levetiracetam on Clinical Symptoms, Cognition and Hippocampal Hyperactivity in Schizophrenia |
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| Recruiting | N/A | 30 | US | Levetiracetam, Keppra, Placebo | University of Colorado, Denver | Schizophrenia | 06/24 | 06/24 | | |
NCT05543122: Drug Concentrations in Breast Milk and Prediction of Blood Levels of the Breastfed Infants |
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| Completed | N/A | 39 | Canada | either of Atenolol, Bupropion, Brivaracetam, Escitalopram, Fluconazole, Lacosamide, Lamotrigine, Levetiracetam, Methotrexate or Ezetimibe, Typical brand names include, but not limited to: Tenoretic, Wellbutrin, Zyban, Briviact, Cipralex, Lexapro, Diflucan, Vimpat, Lamictal, Keppra, Trexall, Xatmep, Ezetrol, Nexlizet | The Hospital for Sick Children, St. Justine's Hospital, University of Waterloo | Breast Feeding | 12/23 | 03/24 | | |
NCT06181383: Phenobarbital Versus Levetiracetam Neonatal Convulsion |
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| Not yet recruiting | N/A | 42 | NA | | Assiut University | Neonatal Convulsion | 11/24 | 05/25 | | |
ChiCTR2100041861: Clinical application of nocturnal high-dose levetiracetam in the treatment of BECT |
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| Recruiting | N/A | 90 | | 2 hours before going to bed at night, 3 doses for 2 stroke and 3 doses for 1 stroke in the morning. ;The total dose should be taken at a time of 2 hours before going to bed at night. ;The total dose was divided into two parts, one hour before bedtime and one dose in the morning, with an interval of 12 hours. | West China Second University Hospital, Sichuan University; West China Second University Hospital, Sichuan University, Clinical Research Foundation of West China Second Hospital of Sichuan University-KL072 | Benign childhood epilepsy with centro-temporal spikes, BECT | | | | |
ChiCTR2000041512: Clinical application of nocturnal high-dose antiepileptic drugs in the treatment of BECT |
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| Recruiting | N/A | 240 | | levetiracetam ;oxcarbazepine ;levetiracetam ;oxcarbazepine | West China Second Hospital of Sichuan University; West China Second Hospital of Sichuan University, KL072 | Benign childhood epilepsy with centro-temporal spikes, BECT | | | | |
NCT05860153: Intermittent Levetricetam in Treatment of Febrile Convulsions |
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| Not yet recruiting | N/A | 100 | NA | Levetiracetam, Tiratam, Diazepam, Valinil | Assiut University | Febrile Convulsion | 01/24 | 08/24 | | |
NCT01666080: Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC) |
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| Recruiting | N/A | 30 | US | Busulfan, Busulfex, Fludarabine, Fludara, Total body irradiation, Stem cell transplant, Keppra, Levetiracetam | Masonic Cancer Center, University of Minnesota | Hematologic Disorders, Hemoglobinopathies, Immunodeficiencies | 06/25 | 06/25 | | |
LEVHIPPRO, NCT06224530: Investigating the Effect of a Single-dose of Levetiracetam on Brain Function, Chemistry and Cognitive Performance in Psychosis Risk |
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| Recruiting | N/A | 69 | Europe | Levetiracetam, Keppra, Placebo | King's College London | Psychosis | 02/26 | 02/26 | | |
ChiCTR2200059080: A randomized, controlled, multicenter clinical study evaluating the efficacy and safety of perampanel versus levetiracetam monotherapy in newly diagnosed focal epilepsy greater than or equal to 12 years of age |
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| Not yet recruiting | N/A | 200 | | Oral perampanel ;Oral Levetiracetam | The Seventh Affiliated Hospital, Sun Yat-Sen University; The Seventh Affiliated Hospital, Sun Yat-Sen University, China Association Against Epilepsy | Epilepsy | | | | |
NCT03511118: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants |
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| Recruiting | N/A | 1600 | Canada, US | Tranexamic acid (TXA), labetalol, metformin, nifedipine, clindamycin, oxycodone, azithromycin, escitalopram, sertraline, ondansetron, Ciprofloxacin, Doxycycline, Levofloxacin, Methylphenidate, Sumatriptan, Citalopram, Cyclobenzaprine, Furosemide, Gabapentin, Hydrochlorothiazide, Hydroxyurea, Rosuvastatin, Topiramate, Trazodone, Valganciclovir, Venlafaxine, Verapamil, Remdesivir, Anakinra, Tocilizumab, Fluvoxamine, Amoxicillin, Bupropion, Duloxetine, Hydrocodone, Levetiracetam, Paroxetine, Buprenorphine | Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI | 07/26 | 07/27 | | |
NCT06491303: Effects of Levetiracetam Monotherapy on Various Hematological Parameters in Adult Patients Suffering of Epilepsy |
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| Not yet recruiting | N/A | 45 | NA | | Assiut University | Neutropenia, Thrombocytopenia, Aplastic Anemia, Anemia, Epilepsy | 11/25 | 12/25 | | |
| Recruiting | N/A | 550 | Europe | Levetiracetam, [11C]-UCB-J PET-MR scan, Levetiracetam Tablets, Lamotrigine tablet, Lamotrigine | Gitte Moos Knudsen | Epilepsy | 12/26 | 12/31 | | |
