- |||||||||| levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
Trial completion, Trial completion date, HEOR: ESETT: Established Status Epilepticus Treatment Trial (clinicaltrials.gov) - Feb 28, 2020
P3, N=478, Completed,
Thus, the choice among newer and conventional AEDs should preferably focus on the experience of better efficacy in addition to safety data. Active, not recruiting --> Completed | Trial completion date: Oct 2019 --> May 2019
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Apnea events in neonatal age: A case report and literature review. (Pubmed Central) - Feb 25, 2020
Herein the authors suggest to consider the diagnosis of autonomic seizures in those neonates with apneic events associated with EEG suppression. Considering that apnea events are not only present in preterm infants but also in term neonates, it is mandatory to diagnose in this context neonatal seizures for a correct diagnosis and a proper therapeutic choice.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Preclinical, Journal, Combination therapy: Effect of gamma radiation on combination therapy of certain antiepileptic drugs in rats. (Pubmed Central) - Feb 25, 2020
The Results of the histopathological examination of liver, kidney, heart and brain tissues indicated coincidence with those recorded by the biochemical analysis. It seems promising to conclude that the exposure to υ-radiation intensified the deleterious and detrimental effect of dual treatment of LEV and OXC in rats.
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: EPICEINTE: Pharmacokinetic and Placental Transfer of Levetiracetam (clinicaltrials.gov) - Feb 25, 2020
P=N/A, N=50, Not yet recruiting,
It seems promising to conclude that the exposure to υ-radiation intensified the deleterious and detrimental effect of dual treatment of LEV and OXC in rats. Trial completion date: Mar 2022 --> Oct 2022 | Initiation date: Oct 2019 --> May 2020 | Trial primary completion date: Oct 2021 --> May 2022
- |||||||||| carbamazepine / Generic mfg.
Clinical, Journal: Psychosis in adults with epilepsy and its relationship to demographic, clinical and treatment variables. (Pubmed Central) - Feb 24, 2020
These findings emphasize the importance of optimizing patients' treatment and early recognition and management of IIP. Abbreviations: IIP: interictal psychosis; PIP: post-ictal psychosis; TLE: temporal lobe epilepsy; FLE: frontal lobe epilepsy; GTC: generalized tonic clonic; AEDs: antiepileptic drugs; CBZ: carbamazepine; VPA: valproate; LEV: levetiracetam; APDs: antipsychotic drugs.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: A case of dyskinesia after levetiracetam administration. (Pubmed Central) - Feb 23, 2020
Considering the temporal relationship and absence of ictal video-EEG findings, we suggest that development of choreoathetosis was closely associated with the undesirable effects of LEV. We propose that dopaminergic system dysregulation and genetic susceptibility might underlie this unusual phenomenon after LEV treatment.
- |||||||||| levetiracetam / Generic mfg.
Journal: Levetiracetam inhibits THP-1 monocyte chemotaxis and adhesion via the synaptic vesicle 2A. (Pubmed Central) - Feb 21, 2020
Furthermore, RT-PCR and western blot analysis demonstrated that LEV (300 μM) decreased the expression level of chemokine-related receptors (CX3CL1, CCR1, CCR2, and CCR5),and reduced levels of phosphorylated AKT (p-AKT) in THP-1 cells with SV2A expressing plasmids. Taken together, these findings indicated that LEV has an inhibitory effect on THP-1 monocyte adhesion and chemotaxis, suggesting that SV2A may serve as a novel therapeutic target to prevent AS.
- |||||||||| Vimpat (lacosamide) / UCB, levetiracetam / Generic mfg., levetiracetam low dose (AGB101) / AgeneBio
[VIRTUAL] Peri-ictal psychosis associated with neurocysticercosis: a case report. (All Screens in Poster Area) - Feb 20, 2020 - Abstract #EPA2020EPA_1330;
The diagnosis of psychotic states associated with epilepsy could be difficoult because of the very different clinical manifestations and. It is important to consider the high prevalence of psychiatric comorbility in patients with epilepsy to administer them a multidisciplinary treatment.
- |||||||||| levetiracetam / Generic mfg., hydrocortisone / Generic mfg.
Suprasellar Atypical Teratoid Rhabdoid Tumor (ATRT) with Endocrinopathy () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1626;
Effectively learning the common endocrine dysfunctions and areas of the brain involved will assist the physiatrist in effectively managing these patients. Understanding the medications and interventions needed, as well as warning signs of potential decline will help better treat these patients.
- |||||||||| Flagyl (metronidazole) / SLA, ceftriaxone / Generic mfg.
Subdural empyema in a teenage female () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1612;
Conclusions : In the setting of sinusitis a possible complication that one must readily recognize is subdural empyema. Early recognition and treatment is key in order to avoid further complications including seizures, neurological impairments such as hemiparesis and altered mental status, and even death.
- |||||||||| duloxetine delayed release / Generic mfg.
Smoking Cessation and Duloxetine Toxicity: A Case Report () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1573;
Patient was stabilized and continued his home medications including amiodarone, digoxin, carvedilol, spironolactone, sacubitril/valsartan, aspirin, clopidogrel, warfarin, tiotropium, budesonide, finasteride, and duloxetine...After LVAD placement, he continued to have myoclonus despite increased levetiracetam and clonazepam...Although computerized surveillance systems alert clinicians of interactions when an offending drug is introduced, they do not alert when a drug is discontinued. It is crucial to remember to not rely solely on these systems, as the lack of proper medication reconciliation can lead to devastating outcomes.
- |||||||||| primidone / Generic mfg., levetiracetam / Generic mfg., divalproex sodium XR / Generic mfg.
Rehabilitation of Persistent Posthypoxic Myoclonus (Lance-Adams Syndrome [LAS]): A Case Report () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1481;
A combination of pharmacotherapy with coordinated multidisciplinary rehabilitation may optimize functional improvement. Further study is warranted, especially in cases with severe LAS that persist despite pharmacologic interventions.
- |||||||||| leucovorin calcium / Generic mfg.
Mitochondrial Polymerase Gamma Gene Mutation Presenting as Status Epilepticus and Liver Failure () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1210;
His POLG mutation was managed with an IV mitochondrial cocktail consisting of N-Acetylcysteine, carnitine, riboflavin, thiamine, and folinic acid...There is a lack of research regarding management of POLG mutations in the post-acute setting.Conclusions : Early diagnosis of POLG mutations can have a significant difference on the management and goals of rehabilitation therapy. More research needs to be conducted on the post acute management of POLG mutation.
- |||||||||| mirtazapine / Generic mfg.
Mirtazapine-induced hyponatremia in the acute rehabilitation setting () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1208;
Conclusions : Mirtazapine-induced hyponatremia in acute inpatient rehabilitation poses a significant barrier to meaningful goal-oriented therapies and can lead to serious morbidity. When patients especially above age 65 and with cardiac co-morbidities are started on mirtazapine, sodium levels should be monitored closely.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
Lance Adams Syndrome after Anoxic Brain injury () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1141;
Given it's frequent misdiagnosis and potential for significant morbidity, it is an important syndrome for clinicians to be aware of. Rehabilitation considerations include not only medication management, but also educating patients about stress management, therapists on adaptations to assistive devices (ie weights on walkers), which can improve quality of life for patients with Lance Adams Syndrome.
- |||||||||| valacyclovir / Generic mfg., levetiracetam / Generic mfg., acyclovir / Generic mfg.
From Cold Sore to Encephalitis: A Case Report () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_972;
Conclusions : The clinical course of HSV1 encephalitis secondary to a recent “cold sore” in an otherwise healthy patient has a sudden onset and usually a poor prognosis. However, with the correct treatment followed by aggressive rehabilitation; the prognosis is very favorable.
- |||||||||| levetiracetam / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
DRESS, a Serious Reaction from Levetiracetam Seizure Prophylaxis in TBI () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_776;
This patient demonstrates that serious complications, such as DRESS syndrome may occur with levetiracetam within 8 weeks of initiation. Conclusions : Physiatrists should be aware of DRESS syndrome as a severe drug induced reaction of levetiracetam and be mindful in using antiepileptics to prevent early posttraumatic seizures.
- |||||||||| desipramine / Generic mfg.
Desipramine withdrawal syndrome complicating recovery from hypoxic-ischemic brain injury: Acase study () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_730;
Conclusions : To our knowledge, this is the first reported case of desipramine exacerbating post-hypoxic myoclonus, likely through the effects of one or both of serotonin or norepinephrine. In this complex case, where rehabilitation treatments for cognitive, motor, and mood symptoms were both overlapping and conflicting, identifying and addressing desipramine withdrawal paved the way for a better functional outcome.
- |||||||||| risperidone / Generic mfg., Egis, cyclophosphamide intravenous / Generic mfg., Rituxan (rituximab) / Roche, Biogen
Anti-NMDAR Encephalitis in a 9-year-old boy () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_486;
Patient was diagnosed with Anti-NMDA receptor encephalitis (ANRE) and treated with a regimen of high-dose pulse solumedrol followed by steroid taper, IVIG, rituximab, and cytoxan...He had a lengthy rehabilitation course which was complicated by severe agitation requiring risperidone and ativan...Early recognition of this condition is important to prevent treatment delay and to improve prognosis. Prompt treatment and proper agitation management allows for improved rehabilitation progress and clinical outcomes.Conclusions : Early recognition of ANRE allows for prompt treatment and improved patient recovery, rehabilitation, and clinical outcomes.
- |||||||||| levetiracetam / Generic mfg.
Phase classification: Reducing Hippocampal Hyperactivity and Improving Cognition in Schizophrenia (clinicaltrials.gov) - Feb 10, 2020
P1/2, N=50, Recruiting,
This case study aims to describe myoclonus as a sequela of hypoxic brain injury, to suggest potential pharmacologic treatment of post-hypoxic myoclonus, and to spread awareness of this uncommon, yet clinically significant syndrome in the inpatient rehabilitation setting. Phase classification: P=N/A --> P1/2
- |||||||||| levetiracetam / Generic mfg.
Review, Journal: Epilepsy in brain metastasis: an emerging entity. (Pubmed Central) - Feb 10, 2020
New preclinical and clinical studies should define the risk of brain metastasis in light of the new treatment options in the different tumor types. New clinical trials should be designed in patients with brain metastases in terms of treatment or prophylaxis of seizures.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg., lamotrigine liquid oral suspension / OWP Pharma
Journal: Management of epilepsy in brain tumors. (Pubmed Central) - Feb 8, 2020
Management of seizures in patients with BTE should be multidisciplinary. The panel evidenced conflicting or lacking data regarding the role of EEG, the choice of therapeutic strategy, and timing to withdraw AEDs and recommended high-quality long-term studies to standardize BTE care.
- |||||||||| levetiracetam / Generic mfg.
Journal, Adverse events: Rhabdomyolysis: a rare adverse effect of levetiracetam. (Pubmed Central) - Feb 8, 2020
Within 12 hours of withdrawal of levetiracetam, there was a downward trend in the CPK levels, with a 10-fold decrease in CPK levels over the next 4 days. This is only the ninth case reported in literature regarding this rare and potentially serious adverse effect of levetiracetam.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: A Rare Case of Prolonged Ictal Aphasia. (Pubmed Central) - Feb 7, 2020
In this case, aphasia was determined to be an ictal semiology, as patient had complete resolution of his symptoms supported by a normal EEG after receiving seizure medications. We suggest keeping high suspicion for an ictal process in patients with sudden-onset aphasia supported by EEG findings of LPDs.
- |||||||||| methylprednisolone oral / Generic mfg.
Journal: Syncope and Twitching at the Emergency Department. (Pubmed Central) - Feb 7, 2020
Sinus arrest may occur because of a direct pathophysiological dysfunction of the structures involved in autonomic cardiac rhythm control or as an ictal or postictal phenomenon. Early diagnosis and initiation of immunosuppressive therapy are both of utmost importance for favorable clinical outcome.
- |||||||||| levetiracetam / Generic mfg., acarbose / Generic mfg.
Post-Bariatric Hypoglycemia: A Clinical Vignette on an Increasingly Recognized Disease (ENDOExpo) - Feb 7, 2020 - Abstract #ENDO2020ENDO_3222;
By bypassing normal anatomy, gastric emptying is increased 2-3 x, which leads to a higher and more rapid appearance of glucose in the distal foregut. This subsequently leads to an amplified incretin response leading to a hyperinsulinemic response in patients who have had bariatric surgery; however, for unclear reasons some patients develop an even more amplified hyperinsulinemic response that leads to subsequent hypoglycemia.
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