- |||||||||| levetiracetam / Generic mfg.
Journal: Creatine Kinase Surge: Levetiracetam-Induced Rhabdomyolysis. (Pubmed Central) - Sep 12, 2024
Our case displays the importance of considering levetiracetam as a cause of rhabdomyolysis, supporting this rare side effect of the antiseizure medication. Rhabdomyolysis is a potentially life-threatening condition that can lead to irreversible renal damage if not managed properly.
- |||||||||| lacosamide / Generic mfg., phenytoin / Generic mfg., levetiracetam / Generic mfg.
Review, Journal: Subacute encephalopathy with seizures in alcoholics (SESA) syndrome: Relevant questions. (Pubmed Central) - Sep 11, 2024
SESA syndrome represents a well-defined subtype of focal NCSE in patients with chronic alcoholism. Its prompt recognition can facilitate the initiation of early ASM therapy and help design appropriate video-EEG evaluation and a treatment strategy.
- |||||||||| piperacillin sodium/tazobactam sodium / Generic mfg., levetiracetam / Generic mfg.
MULTIFOCAL BRAIN ABSCESSES SECONDARY TO ESOPHAGEAL PERFORATION (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_7004;
Our case highlights the possibility of esophageal perforation serving as the origin of infection for brain abscesses. Clinicians should be aware of esophageal perforation
- |||||||||| tranexamic acid oral / Generic mfg.
STATUS EPILEPTICUS INDUCED BY TRANEXAMIC ACID IRRIGATION (Convention Center Exhibit Hall: Rapid Fire Area 2C) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6888;
TXA has been shown to cause hyperexcitability and convulsions when applied directly onto the central nervous system. This case is unique since TXA was used for hemostasis via irrigation topically in addition to an IV load.
- |||||||||| THE MYSTERIOUS VISITOR: A CHILLING ENCOUNTER WITH ELIZABETHKINGIA MIRICOLA (Convention Center Exhibit Hall: Rapid Fire Area 1B) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6435;
She received ampicillin-sulbactam for aspiration pneumonia, zoledronic acid for hypercalcemia, and promethazine/diphenhydramine for nausea...Levetiracetam was administered, and she was intubated for airway protection. Midazolam and propofol were started for analgosedation and she was transferred to our hospital for continuous electroencephalogram (EEG).Objective data at our facility: hypernatremia (146 mmol/L), normal anion gap acidosis (bicarbonate: 15 mmol/L, chloride: 120 mmol/L), severe hypocalcemia (6 mg/dL), normocytic anemia (hemoglobin: 8.9 g/dL), elevated lipase (239 U/L), and AKI (creatinine: 1.64 mg/dL)...leading to initiation of vancomycin, piperacillin-tazobactam and doxycycline...Susceptibility testing indicated resistance to piperacillin-tazobactam, tetracycline, cefepime, and sensitivity to ciprofloxacin, levofloxacin, and trimethoprim-sulfamethoxazole...Some research studies demonstrate resistance to beta lactam, monobactam, vancomycin, carbapenems, and aminoglycosides, with variable susceptibility to minocycline, trimethoprim-sulfmethoxazole, piperacillin-tazobactam and levofloxacin [10
- |||||||||| levetiracetam / Generic mfg.
KEPPRA-INDUCED RHABDODMYOLYSIS (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6379;
This report emphasizes the necessity of monitoring CPK levels during the initiation or reintroduction of levetiracetam for patients, as rhabdomyolysis remains a potential complication. Additionally, it underscores that even if patients have previously tolerated the medication, the occurrence of rhabdomyolysis cannot be ruled out, and it should be considered as one of the differentials in clinical evaluation.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg., clobazam / Generic mfg.
RECURRENT METABOLIC ENCEPHALOPATHY IN AN ADULT WITH ANGELMAN SYNDROME, LENNOX-GASTAUT SYNDROME, AND VLCAD DEFICIENCY: WHEN REMEDY FOR ONE MALADY IS THE CATALYST FOR ANOTHER (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6377;
Diagnosis is based on specific patterns of acylcarnitine elevation.(4) CASE PRESENTATION: The 38-year-old male, with Angelman syndrome related seizures treated with valproate, levetiracetam, levocarnitine, presented due to increased seizure frequency and myoclonic jerks...Clobazam and lacosamide reduced seizures initially, but lethargy developed post-discharge... Establishing the cause of metabolic encephalopathy in patients with complex syndromic pathology is essential to improve prognosis alongside empiric management.
- |||||||||| levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg.
CENTRAL LINE MANIPULATION-INDUCED AIR EMBOLISM IN A PATIENT POSTAUTOLOGOUS STEM CELL TRANSPLANT (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6360;
This case underscores the importance of vigilance during any procedures involving central line access. Adherence to best practices during catheter manipulation and awareness of potential complications are essential in preventing and effectively managing this potentially catastrophic complication.
- |||||||||| Cubicin (daptomycin) / Merck (MSD)
TROUBLE DOWN THE ROAD: STERNAL MSSA OSTEOMYELITIS AND RETROSTERNAL ABSCESS FORMATION SECONDARY TO MOTOR VEHICLE ACCIDENT (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6338;
He had been found after he had driven off the road multiple times and was started on Keppra due to concern for eplipsey...Escalation to daptomycin or linezolid in cases of vancomycin-resistant Staphylococcus aureus (VRSA) infection may also be required... Clinicians should remain cognizant of those at risk for osteomyelitis, and initiate both workup and appropriate care urgently to avoid an increased risk of complication or mortality.
- |||||||||| EROSIVE SINUSITIS: UNCOMMON COMPLICATIONS OF COMMON CONDITIONS (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_5930;
The patient was started on ceftriaxone and vancomycin along with Keppra and Midazolam for seizure prophylaxis. Prompt diagnosis and management of erosive sinusitis can reduce the risk of life-threatening and disabling complications.
- |||||||||| levetiracetam / Generic mfg., brivaracetam / Generic mfg.
Journal: Ru-Catalyzed Asymmetric Hydrogenation of ?,?-Unsaturated ?-Lactams. (Pubmed Central) - Sep 2, 2024
Mechanistic studies based on detailed control experiments and computational investigation revealed that the cationic Ru-complex acts as the active catalytic species; the protonation process of the oxa-?-allyl-Ru complex, which is formed by the migratory insertion of the C=C double bond to the Ru-H bond (the stereocontrolling step) followed by an isomerization process, is the rate-determining step, and the existence of PPh3 is crucial for the highly efficient catalytic behavior. The protocol provides a straightforward and practical pathway for the synthesis of key intermediates for several chiral drugs and bioactive compounds, particularly for the 150 kg-scale industrial production of Brivaracetam, an antiepileptic drug that shows 13-fold more potent binding to the synaptic vesicle protein 2A compared with the well-known Levetiracetam.
- |||||||||| levetiracetam / Generic mfg.
Journal: The Role of Levetiracetam and Prednisolone in the Treatment of Sydenham's Chorea. (Pubmed Central) - Sep 1, 2024
The protocol provides a straightforward and practical pathway for the synthesis of key intermediates for several chiral drugs and bioactive compounds, particularly for the 150 kg-scale industrial production of Brivaracetam, an antiepileptic drug that shows 13-fold more potent binding to the synaptic vesicle protein 2A compared with the well-known Levetiracetam. No abstract available
- |||||||||| levetiracetam / Generic mfg.
Retrospective data, Journal: An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: Protocol. (Pubmed Central) - Sep 1, 2024
These will be scanned for individuals aged 16-54 years with epilepsy and on valproate who either continued, switched to lamotrigine or levetiracetam, or discontinued valproate between 2014-2024, creating four groups...A causal prediction model will be developed from these data to aid in predicting the safest alternative antiseizure medications. Together, these findings will optimise informed decision-making about valproate withdrawal and alternative treatment selection, providing immediate and vital information for patients, clinicians and regulators.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Dravet-like syndrome with PCDH19 mutations in Taiwan - A multicenter study. (Pubmed Central) - Aug 27, 2024
Patients are usually treated with a wide array of standard antiseizure medications, with no preferred antiseizure medication class. No strong correlations between phenotype and location of variant mutations were found in our patients.
- |||||||||| levetiracetam / Generic mfg.
P1 data, Journal: A Phase I trial of Non-invasive (Pubmed Central) - Aug 26, 2024
This is a Phase I trial largely designed to test the feasibility, tolerability and safety of using non-invasive ventilatory support and LVT prophylaxis in cerebral malaria. ISRCTN76942974 (5.02.2019); PACTR202112749708968 (20.12.2021).
- |||||||||| CR4056 / Rottapharm Biotech
Imidazoline receptor targeting as a novel method of seizure control during nerve agent induced status epilepticus in a rat model. (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_12354;
Second line antiseizure drugs like levetiracetam, fosphenytoin, and valproate are only effective in approximately half of cases, which underscores a need to develop novel treatments that terminate SE when other options fail...Twenty minutes after onset of SE, rats received midazolam and a test treatment (CR4056, 2-BFI, agmatine) or control (saline)...Post-treatment mortality rates for CR4056 and 2-BFI were 2/13 and 3/12 respectively. Future work will include targeted blocking and reversal experiments to determine if imidazoline receptor antagonists can prevent or reverse the ability of dexmedetomidine to control SE.
- |||||||||| levetiracetam / Generic mfg., ethosuximide / Generic mfg.
Neurobiological Effects of Antiepileptic Drugs in Rats with Age-related Spatial Memory Deficits (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_9489;
Pharmacological approaches to reducing excessive hippocampal activity, and thus restoring cognitive function in aged rats, has included administration of the antiepileptic drug levetiracetam (LEV)...Next, we carried out a within-subject pharmacological approach, testing the efficacy of LEV at reducing SWD activity among aged AI rats, in comparison to another antiepileptic drug, ethosuximide (ETX), which unlike LEV, appears not to hold cognitive therapeutic potential...While LEV did not significantly reduce the number (p>0.05) or duration (p>0.05) of SWDs, ETX significantly reduced both the number (p<0.0001) or duration (p<0.0001) of SWDs. Given that these doses of LEV are within the range shown to be effective at improving cognition in AI rats, but were ineffective at reducing SWDs, further indicates that SWDs are not coupled to cognitive capacity among aged LE rats.
- |||||||||| levetiracetam / Generic mfg.
Synaptic Vesicle 2A-Microglia Interactions in Early Life Adversity-Induced Binge Eating (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_6554;
In the third week, Paired and Isolated groups received Levetiracetam (LEV, 10 mg/kg) or Vehicle...Finally, ?PET showed stark increases in 18F-SDM-8-SV2A radioligand measurements in the hippocampus of adolescent SI females compared to age-matched males. This study marks progress in identifying maladaptive BE mechanisms and developing predictive behavioral biomarkers for disordered eating.
- |||||||||| levetiracetam / Generic mfg.
Sv2a deletion in human ipsc-derived neurons leads to reduced synapse numbers and impaired synaptic transmission (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_434;
Mutations in the human SV2A gene also lead to epilepsy and SV2A is the molecular target of frequently prescribed anti-epileptic drugs (levetiracetam/Keppra)...In mass cultures, SV2A-/- neurons showed reduced network frequency and calcium spike prominence during calcium imaging. Together, our study shows that SV2A modulates synapse formation/stabilization and controls release pool replenishment in human glutamatergic neurons resulting in lower network activity and evoked release amplitudes.
- |||||||||| levetiracetam / Generic mfg., diazepam / Generic mfg.
Effective screening of anticonvulsants in chronically epileptic mice using on-demand seizures (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_198;
Finally, we use this model to compare ASM efficacy between evoked seizures in freely-moving, chronically epileptic animals and to acute seizures induced in naive animals .Our results indicate that the on-demand seizure model is capable of accelerating efficacy and kinetic evaluations of pharmacologics in chronically epileptic animals. We envision that this approach could reduce the time needed for drug discovery and therapeutic evaluation, and may identify promising ASM candidates not identified by current screening methods .
- |||||||||| pentylenetetrazole (BTD-001) / Balance Therap
Bioinformatics guided rotenone adjuvant kindling in mice as a new animal model of drug resistant epilepsy. (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_197;
In conclusion, rotenone kindling model is more advantageous than earlier described lamotrigine and corneal kindling models which respond to drug combinations. As a result, pre-clinical drug screening through rotenone kindling may uncover broad spectrum drugs with novel antiseizure mechanisms which is a pressing issue to deal with drug-resistant epilepsy.
- |||||||||| levetiracetam / Generic mfg.
Utilizing rat kindling models (amygdala and hippocampal) for anti-epileptic drugs (AEDs) screening (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_141;
Simultaneity, after discharge (AD) of EEG and deep brain LFP were collected for offline analysis. In this current study, we have used three reference compounds including Levetiracetam showing robust anti-seizure effect in chronic and rapid kindling procedures in both rat hippocampus and amygdala were used for the study.
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