levetiracetam / Generic mfg. 
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  • ||||||||||  levetiracetam / Generic mfg.
    Reversible Vasoconstriction Syndrome associated with Vaping Cannabis Oil () -  Jan 21, 2020 - Abstract #AAN2020AAN_1300;    
    This report highlights one of the first cases illustrating the neurotoxic potential of vaped cannabis oils. Clearly, increased research and more evidence is needed to examine the potential neurological effects of widespread vaping as it becomes more easily accessible across the globe.
  • ||||||||||  Briviact (brivaracetam) / UCB, carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
    Real-world Study of Brivaracetam in the US: an Interim Analysis () -  Jan 21, 2020 - Abstract #AAN2020AAN_1230;    
    Determine whether BRV retention is associated with lifetime levetiracetam (LEV), lamotrigine (LTG), oxcarbazepine (OXC), or carbamazepine (CBZ) failure. This interim analysis indicates that BRV retention (a measure of effectiveness) at 3 and 6 months is similar between patients that previously failed LEV, LTG, OXC, and CBZ.
  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo, levetiracetam / Generic mfg.
    Infant presenting with Autoimmune NMDA Positive encephalitis secondary to Herpes Simplex Encephalitis: A Case Report () -  Jan 21, 2020 - Abstract #AAN2020AAN_1206;    
    Movement disorders in infants are difficult to diagnose, overlapping symptoms from seizures or cerebral palsy can make it further difficult. Relapsing symptoms post herpes simplex virus encephalitis should raise a high clinical suspicion of anti-NMDA receptor encephalitis and clinicians should be cautious as this condition can often be misdiagnosed in infants.
  • ||||||||||  carbamazepine / Generic mfg.
    The Twitching Trunk: Etiology and Treatment of Truncal Myoclonus () -  Jan 21, 2020 - Abstract #AAN2020AAN_1126;    
    It can be challenging to diagnose myoclonus in patients who have concurrent focal epilepsy from underlying stroke. It is most important to determine physiology since this dictates treatment: carbamazepine may worsen myoclonus; clonazepam is effective in all forms of myoclonus; valproic acid and levetiracetam are effective for cortical myoclonus, but not other forms.
  • ||||||||||  pregabalin / Generic mfg., clobazam / Generic mfg., Trileptal (oxcarbazepine) / Novartis
    Efficacy of clobazam as an add-on therapy in brain tumor-related epilepsy. () -  Jan 21, 2020 - Abstract #AAN2020AAN_889;    
    Our analysis shows clobazam to be an effective agent in BTRE. A comparative study between clobazam and other anti-epileptics in BTRE could be considered in the future.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Behavioral Complications from Levetiracetam in the Epilepsy Monitoring Unit () -  Jan 21, 2020 - Abstract #AAN2020AAN_887;    
    LEV was transitioned mostly commonly to lamotrigine (43.2%) in our population. We recommend counseling patients regarding behavioral side effects and prompt follow-up when side effects are noted.
  • ||||||||||  carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
    Journal:  Teratogenicity of antiepileptic drugs. (Pubmed Central) -  Jan 13, 2020   
    Although for MCMs the risk is primarily associated with the first trimester of gestation, influences on cognitive and behavioral development could extend throughout pregnancy. Available information now permits a more rational AED selection in women of childbearing potential, and evidence-based counseling on optimization of AED treatment before conception.
  • ||||||||||  levetiracetam / Generic mfg., topiramate / Generic mfg., lamotrigine liquid oral suspension / OWP Pharma
    Clinical, Journal:  Hormonal contraception in patients with epilepsy. (Pubmed Central) -  Jan 11, 2020   
    As interaction between OC and AEDs are common, nonhormonal, highly effective methods, such as IUDs, may be ideal for women with epilepsy. The results of the study indicate the need for closer cooperation between neurologist and gynecologist caring for women with epilepsy.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Total synthesis of levetiracetam. (Pubmed Central) -  Jan 10, 2020   
    Total synthesis of levetiracetam, an active ingredient of epilepsy treatment medications, is reported. The reported method is based on a one-pot dehydration/sigmatropic rearrangement of (R,E)-hept-4-en-3-ol carbamate to the corresponding allylamine derivative, an advanced precursor of levetiracetam.
  • ||||||||||  carbamazepine / Generic mfg.
    [VIRTUAL] VALPROATE INDUCED PARKINSONISM AND COGNITIVE DECLINE IN EPILEPSY (EXHIBITION HALL) -  Jan 6, 2020 - Abstract #AATADPD2020AAT_ADPD_673;    
    Although rare in epilepsy it is more a side effects mainly from valproate. So VPA withdrawn and new generation AEDs introduction (LTG + LEV) in this case was a desirable option for this patient.
  • ||||||||||  rasagiline / Generic mfg.
    [VIRTUAL] ALZHEIMER’S DRUG DEVELOPMENT PIPELINE: NOVEL TARGETS AND INNOVATIVE APPROACHES (Hall E) -  Jan 6, 2020 - Abstract #AATADPD2020AAT_ADPD_54;    
    One novel combination approach consists of losartan, amlodipine, atorvastatin and exercise and rasagiline is an example of molecule with pleiotropic effects on dopamine and disease-biology pathways...Novel designs being integrated into AD drug development include basket trials, randomized withdrawal trials, serial parallel comparison designs, and platform trials. Conclusions Progress in development of agents with novel targets and novel approaches will accelerate drug development for AD, clarify the disease-biology, and contribute to the development of treatments and treatment combinations for different phases of AD.
  • ||||||||||  levetiracetam / Generic mfg., Cerebyx (fosphenytoin) / Pfizer, Nobelpharma
    Journal:  Status Epilepticus: The Slow and Agonizing Death of Phenytoin. (Pubmed Central) -  Jan 5, 2020   
    We believe that levetiracetam should become the preferred agent for seizures unresponsive to or recurring after treatment with a benzodiazepine as it is at least equally effective to PHT and has several important advantages. PHT has overstayed its welcome and it is simply time for it to exit the realm of acute seizure management as a first-line agent for benzodiazepine-refractory GCSE.
  • ||||||||||  levetiracetam / Generic mfg., divalproex sodium XR / Generic mfg.
    A case of gliomatosis cerebri () -  Jan 4, 2020 - Abstract #WSMRF2020WSMRF_489;    
    Surgical resection is generally not an option due to multilobar involvement, radiation and chemotherapy has no proven efficacy. Major obstacles toward establishing standardized treatments include rarity of the disease, lack of understanding of the tumor biology, variation across histopathologic grading and patient outcomes, and lack of response to therapies.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD), ceftriaxone / Generic mfg., fluconazole / Generic mfg.
    Pediatric coccidioidomycosis meningitis (Carmel Mission Inn – Carmelo Ballroom) -  Jan 4, 2020 - Abstract #WSMRF2020WSMRF_201;    
    Patient was admitted to the pediatric floor where he was given Dexamethasone, Acyclovir 200 mg, Ceftriaxone 2g and Vancomycin 320 mg...Very few cases of pediatric cocci meningitis have been reported. As a result, establishing a standard of care when encountering such cases is imperative.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD), Trileptal (oxcarbazepine) / Novartis
    Journal:  Abdominal epilepsia partialis continua in neurocysticercosis. (Pubmed Central) -  Jan 4, 2020   
    The involvement of the primary motor cortex during ictal propagation may account for this curious phenomenon. This is the first report of abdominal EPC in a patient with inflammatory granuloma as a result of neurocysticercosis.
  • ||||||||||  pregabalin / Generic mfg.
    Clinical, Journal:  Use of antiepileptic drugs in women of fertile age. (Pubmed Central) -  Jan 4, 2020   
    The overall use of AEDs in women of fertile age and pregnant women has increased in the past 16 years, especially due to an increased use of lamotrigine. However, valproate use in pregnant women and in younger women of fertile age has become less frequent.
  • ||||||||||  lacosamide / Generic mfg., levetiracetam / Generic mfg., Cerebyx (fosphenytoin) / Pfizer, Nobelpharma
    Retrospective data, Journal, HEOR:  Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus. (Pubmed Central) -  Jan 1, 2020   
    VPA and PB were more effective than PHT for SE. There is substantial overlap in the cost-effectiveness of non-BZD AEDs for SE, but available evidence does not support the preeminence of PHT, neither in terms of effectiveness nor in terms of cost-effectiveness.
  • ||||||||||  levetiracetam / Generic mfg.
    Trial completion date, Trial primary completion date:  Levetiracetam (Keppra) to Improve Chronic Aphasia in Post-stroke Patients. (clinicaltrials.gov) -  Dec 23, 2019   
    P1,  N=50, Active, not recruiting, 
    Therefore, AEDs should be considered as add-on treatment, and similar to treatment of other encephalitis symptoms, immunotherapy is crucial. Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2019 --> Dec 2020
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] NEUROCARDIOGENIC SYNCOPE MASQUERADING AS REFRACTORY SEIZURES (eAbstract Virtual Hall) -  Dec 22, 2019 - Abstract #ACC2020ACC_7133;    
    While TTT is the initial test of choice for NCS, prolonged cardiac monitoring should be considered in the evaluation of recurrent seizures or syncope of uncertain origin in the absence of high risk syncope criteria. Pacemakers are effective in patients with NCS with predominant cardio-inhibitory component.
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] BRADYARRHYTHMIA SECONDARY TO VAGUS NERVE STIMULATOR AFTER 7 YEARS OF PLACEMENT: A CASE REPORT (eAbstract Virtual Hall) -  Dec 22, 2019 - Abstract #ACC2020ACC_7123;    
    Therefore, providers caring for patients with vagus nerve stimulators should be aware of and remain vigilant for the complications associated with this therapeutic alternative. This notion even applies to patients who have tolerated their vagus nerve stimulators and remained asymptomatic for many years.
  • ||||||||||  Cardilor (amiodarone) / Generic mfg.
    [VIRTUAL] LEVETIRACETAM FOR THE TREATMENT OF MYOCLONIC NEUROTOXICITY INDUCED BY AMIODARONE (eAbstract Virtual Hall) -  Dec 22, 2019 - Abstract #ACC2020ACC_7114;    
    This notion even applies to patients who have tolerated their vagus nerve stimulators and remained asymptomatic for many years. This case demonstrates a novel potential use for levetiracetam in the rare setting of amiodarone-induced neurotoxic side effects that may otherwise linger in spite of its discontinuation.
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] ICTAL ATRIAL FIBRILLATION TRIGGERED BY ATRIAL TACHYCARDIA IN A PEDIATRIC PATIENT (FIT Clinical Decision Making Moderated Poster Theater 1_eAbstract Virtual Hall) -  Dec 22, 2019 - Abstract #ACC2020ACC_3458;    
    We report the first case of pediatric ictal AF likely triggered by atrial tachycardia with successful RF ablation and no arrhythmic recurrence. A high index of suspicion for additional arrhythmic substrates is necessary in non-obese pediatric AF patients and EPS is warranted in unusual cases.
  • ||||||||||  pregabalin / Generic mfg., Trileptal (oxcarbazepine) / Novartis
    Journal:  Update on Antiepileptic Drugs 2019. (Pubmed Central) -  Dec 20, 2019   
    A high index of suspicion for additional arrhythmic substrates is necessary in non-obese pediatric AF patients and EPS is warranted in unusual cases. Knowledge of AED pharmacokinetics, efficacy, and tolerability profiles facilitates the choice of appropriate AED therapy for patients with epilepsy.