- |||||||||| risperidone / Generic mfg., Egis, quetiapine / Generic mfg.
Clinical, Journal: Evaluation of the Clinical Features, Management, and Prognoses of Patients With Charles Bonnet Syndrome. (Pubmed Central) - Mar 13, 2020
The possible causes of CBS and what the patients perceived during their hallucinations were recorded. Antipsychotic agents, such as risperidone and quetiapine, and anticonvulsants, such as levetiracetam, may be effective in some cases.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Treatment of epilepsy in adults: Expert opinion in South Korea. (Pubmed Central) - Mar 13, 2020
Most of the survey results were in accordance with the US expert opinion survey published in 2016. This survey can assist clinicians in making clinical decisions when treating individual adult patients with epilepsy.
- |||||||||| tacrolimus / Generic mfg.
Clinical, Journal: Clinical Pharmacometrics for Rational Drug Treatment (Pubmed Central) - Mar 12, 2020
Pharmacokinetic and pharmacodynamic models were successfully built using electronic medical information to explain retrospective international normalized ratio values of prothrombin time before and after catheter ablation in warfarin-treated patients...A physiologically based pharmacokinetic model adapted to tacrolimus pharmacokinetic data in patients who underwent living-donor liver transplantation was constructed, and clarified that oral clearance of this drug was affected by CYP3A5 genotypes in both the liver and intestine to the same extent. In conclusion, pharmacometrics is a useful methodology for individualized and optimized drug therapy.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Cleidocranial dysplasia syndrome with epilepsy: a case report. (Pubmed Central) - Mar 10, 2020
In clinical practice, if a patient has unusual facies, typical clavicle defect, skull bone enlargement, and unclosed anterior fontanelle, we should consider the possibility of cleidocranial dysplasia, genetic detection are helpful to make a confirmed diagnosis. In such cases, early diagnosis and treatment is important to correct deformities and improve the quality of life of patients.
- |||||||||| carbamazepine / Generic mfg.
Journal: Seizure-recurrence risk in persons with epilepsy undergoing antiepileptic drug tapering. (Pubmed Central) - Mar 10, 2020
In such cases, early diagnosis and treatment is important to correct deformities and improve the quality of life of patients. There is a wide variation in AEDs tapering pattern and seizure recurrence risk can be minimized by considering the risk factors like history of smoking/alcoholic/tobacco, longer duration of epilepsy, frequency of seizures before control, and previously failed tapering.
- |||||||||| levetiracetam / Generic mfg.
Biomarker, Preclinical, Journal: Synthesis and in vivo evaluation of a novel PET radiotracer for imaging of synaptic vesicle glycoprotein 2A (SV2A) in non-human primates. (Pubmed Central) - Mar 9, 2020
Comparing to C-UCB-J, F-SDM-8 displayed the same attractive imaging properties: very high brain uptake, appropriate tissue kinetics, and high levels of specific binding. Given the longer half-life of F-18 and the feasibility for central production and multi-site distribution, F-SDM-8 holds promise as an excellent radiotracer for SV2A and as a biomarker for synaptic density measurement in neurodegenerative diseases and psychiatric disorders.
- |||||||||| prednisone / Generic mfg., levetiracetam / Generic mfg., cholestyramine / Generic mfg.
VALPROATE INDUCED DRESS SYNDROME CAUSING MIXED LIVER INJURY () - Mar 8, 2020 - Abstract #CDDW2020CDDW_169;
Her rash improved within 4 days and she was discharged on a slower steroid taper, with the addition of cholestyramine and insulin for steroid induced diabetes...Early recognition of DRESS syndrome as a mechanism of valproate induced liver injury in children is essential for earlier diagnosis and initiation of targeted therapy. Funding Agencies None
- |||||||||| mycophenolate mofetil / Generic mfg., carbamazepine / Generic mfg.
Clinical, Journal: Efficacy and tolerability of mycophenolate mofetil in a pediatric Rasmussen syndrome. (Pubmed Central) - Mar 7, 2020
Therefore, the patient was treated with mycophenolate mofetil (MMF), showing a good clinical response, with reduction of the seizures, and stability of the radiological findings. This case suggests the potential utility of MMF in the immune approach to RS.
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date: 1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients (clinicaltrials.gov) - Mar 6, 2020
P4, N=82, Recruiting,
This case suggests the potential utility of MMF in the immune approach to RS. Trial completion date: Sep 2020 --> Mar 2021 | Trial primary completion date: Mar 2020 --> Mar 2021
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Population-Based Study of Risk of Acute Kidney Injury with Levetiracetam. (Pubmed Central) - Mar 4, 2020
Variation was particularly notable for HIE patients without electrographic seizures, indicating that this population may be an appropriate target for QI processes to harmonize neuromonitoring and AED practices across centers. In this population-based study levetiracetam use was not associated with a higher risk of AKI.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Levetiracetam Improves Upper Limb Spasticity in a Patient With Unresponsive Wakefulness Syndrome: A Case Report. (Pubmed Central) - Mar 3, 2020
In these patients, abnormal postures may occur as an expression of severe brain damage. Here we present the case of a 52-year-old man in decorticate rigidity following a hypoxic-ischemic encephalopathy due to myocardial infarction who showed improvement of spasticity of upper limbs following intake of levetiracetam combined with the conventional neurorehabilitation program.
- |||||||||| levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
Trial completion, Trial completion date, HEOR: ESETT: Established Status Epilepticus Treatment Trial (clinicaltrials.gov) - Feb 28, 2020
P3, N=478, Completed,
Thus, the choice among newer and conventional AEDs should preferably focus on the experience of better efficacy in addition to safety data. Active, not recruiting --> Completed | Trial completion date: Oct 2019 --> May 2019
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Apnea events in neonatal age: A case report and literature review. (Pubmed Central) - Feb 25, 2020
Herein the authors suggest to consider the diagnosis of autonomic seizures in those neonates with apneic events associated with EEG suppression. Considering that apnea events are not only present in preterm infants but also in term neonates, it is mandatory to diagnose in this context neonatal seizures for a correct diagnosis and a proper therapeutic choice.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Preclinical, Journal, Combination therapy: Effect of gamma radiation on combination therapy of certain antiepileptic drugs in rats. (Pubmed Central) - Feb 25, 2020
The Results of the histopathological examination of liver, kidney, heart and brain tissues indicated coincidence with those recorded by the biochemical analysis. It seems promising to conclude that the exposure to υ-radiation intensified the deleterious and detrimental effect of dual treatment of LEV and OXC in rats.
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: EPICEINTE: Pharmacokinetic and Placental Transfer of Levetiracetam (clinicaltrials.gov) - Feb 25, 2020
P=N/A, N=50, Not yet recruiting,
It seems promising to conclude that the exposure to υ-radiation intensified the deleterious and detrimental effect of dual treatment of LEV and OXC in rats. Trial completion date: Mar 2022 --> Oct 2022 | Initiation date: Oct 2019 --> May 2020 | Trial primary completion date: Oct 2021 --> May 2022
- |||||||||| carbamazepine / Generic mfg.
Clinical, Journal: Psychosis in adults with epilepsy and its relationship to demographic, clinical and treatment variables. (Pubmed Central) - Feb 24, 2020
These findings emphasize the importance of optimizing patients' treatment and early recognition and management of IIP. Abbreviations: IIP: interictal psychosis; PIP: post-ictal psychosis; TLE: temporal lobe epilepsy; FLE: frontal lobe epilepsy; GTC: generalized tonic clonic; AEDs: antiepileptic drugs; CBZ: carbamazepine; VPA: valproate; LEV: levetiracetam; APDs: antipsychotic drugs.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: A case of dyskinesia after levetiracetam administration. (Pubmed Central) - Feb 23, 2020
Considering the temporal relationship and absence of ictal video-EEG findings, we suggest that development of choreoathetosis was closely associated with the undesirable effects of LEV. We propose that dopaminergic system dysregulation and genetic susceptibility might underlie this unusual phenomenon after LEV treatment.
- |||||||||| levetiracetam / Generic mfg.
Journal: Levetiracetam inhibits THP-1 monocyte chemotaxis and adhesion via the synaptic vesicle 2A. (Pubmed Central) - Feb 21, 2020
Furthermore, RT-PCR and western blot analysis demonstrated that LEV (300 μM) decreased the expression level of chemokine-related receptors (CX3CL1, CCR1, CCR2, and CCR5),and reduced levels of phosphorylated AKT (p-AKT) in THP-1 cells with SV2A expressing plasmids. Taken together, these findings indicated that LEV has an inhibitory effect on THP-1 monocyte adhesion and chemotaxis, suggesting that SV2A may serve as a novel therapeutic target to prevent AS.
- |||||||||| Vimpat (lacosamide) / UCB, levetiracetam / Generic mfg., levetiracetam low dose (AGB101) / AgeneBio
[VIRTUAL] Peri-ictal psychosis associated with neurocysticercosis: a case report. (All Screens in Poster Area) - Feb 20, 2020 - Abstract #EPA2020EPA_1330;
The diagnosis of psychotic states associated with epilepsy could be difficoult because of the very different clinical manifestations and. It is important to consider the high prevalence of psychiatric comorbility in patients with epilepsy to administer them a multidisciplinary treatment.
- |||||||||| levetiracetam / Generic mfg., hydrocortisone / Generic mfg.
Suprasellar Atypical Teratoid Rhabdoid Tumor (ATRT) with Endocrinopathy () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1626;
Effectively learning the common endocrine dysfunctions and areas of the brain involved will assist the physiatrist in effectively managing these patients. Understanding the medications and interventions needed, as well as warning signs of potential decline will help better treat these patients.
- |||||||||| Flagyl (metronidazole) / SLA, ceftriaxone / Generic mfg.
Subdural empyema in a teenage female () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1612;
Conclusions : In the setting of sinusitis a possible complication that one must readily recognize is subdural empyema. Early recognition and treatment is key in order to avoid further complications including seizures, neurological impairments such as hemiparesis and altered mental status, and even death.
- |||||||||| duloxetine delayed release / Generic mfg.
Smoking Cessation and Duloxetine Toxicity: A Case Report () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1573;
Patient was stabilized and continued his home medications including amiodarone, digoxin, carvedilol, spironolactone, sacubitril/valsartan, aspirin, clopidogrel, warfarin, tiotropium, budesonide, finasteride, and duloxetine...After LVAD placement, he continued to have myoclonus despite increased levetiracetam and clonazepam...Although computerized surveillance systems alert clinicians of interactions when an offending drug is introduced, they do not alert when a drug is discontinued. It is crucial to remember to not rely solely on these systems, as the lack of proper medication reconciliation can lead to devastating outcomes.
- |||||||||| primidone / Generic mfg., levetiracetam / Generic mfg., divalproex sodium XR / Generic mfg.
Rehabilitation of Persistent Posthypoxic Myoclonus (Lance-Adams Syndrome [LAS]): A Case Report () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1481;
A combination of pharmacotherapy with coordinated multidisciplinary rehabilitation may optimize functional improvement. Further study is warranted, especially in cases with severe LAS that persist despite pharmacologic interventions.
- |||||||||| leucovorin calcium / Generic mfg.
Mitochondrial Polymerase Gamma Gene Mutation Presenting as Status Epilepticus and Liver Failure () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1210;
His POLG mutation was managed with an IV mitochondrial cocktail consisting of N-Acetylcysteine, carnitine, riboflavin, thiamine, and folinic acid...There is a lack of research regarding management of POLG mutations in the post-acute setting.Conclusions : Early diagnosis of POLG mutations can have a significant difference on the management and goals of rehabilitation therapy. More research needs to be conducted on the post acute management of POLG mutation.
- |||||||||| mirtazapine / Generic mfg.
Mirtazapine-induced hyponatremia in the acute rehabilitation setting () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1208;
Conclusions : Mirtazapine-induced hyponatremia in acute inpatient rehabilitation poses a significant barrier to meaningful goal-oriented therapies and can lead to serious morbidity. When patients especially above age 65 and with cardiac co-morbidities are started on mirtazapine, sodium levels should be monitored closely.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
Lance Adams Syndrome after Anoxic Brain injury () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1141;
Given it's frequent misdiagnosis and potential for significant morbidity, it is an important syndrome for clinicians to be aware of. Rehabilitation considerations include not only medication management, but also educating patients about stress management, therapists on adaptations to assistive devices (ie weights on walkers), which can improve quality of life for patients with Lance Adams Syndrome.
- |||||||||| valacyclovir / Generic mfg., levetiracetam / Generic mfg., acyclovir / Generic mfg.
From Cold Sore to Encephalitis: A Case Report () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_972;
Conclusions : The clinical course of HSV1 encephalitis secondary to a recent “cold sore” in an otherwise healthy patient has a sudden onset and usually a poor prognosis. However, with the correct treatment followed by aggressive rehabilitation; the prognosis is very favorable.
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