- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg.
Clinical, Journal: ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response. (Pubmed Central) - Jul 2, 2020 Even though Epilepsy is a significant clinical issue in ATP1A3 patients, only a minority of publications provide any information about patients' anti-epileptic treatment. The findings of treatment effectiveness in only 57% (or lower) of patients, and the non-existence of a clear first-line AED in ATP1A3 related epilepsy stresses the need for further research.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Initial assessment of an interprofessional team-delivered telehealth program for patients with epilepsy. (Pubmed Central) - Jun 28, 2020 This pharmacist-delivered pilot program was effective in: reaching underserved patients with epilepsy, identifying and recommending resolutions to medication-related problems, and demonstrating the value of pharmacists in an interprofessional team. Further work is warranted to identify telehealth strategies to reduce medication associated problems.
- |||||||||| levetiracetam / Generic mfg., acarbose / Generic mfg.
[VIRTUAL] Post-Bariatric Hypoglycemia: A Clinical Vignette on an Increasingly Recognized Disease () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_218; By bypassing normal anatomy, gastric emptying is increased 2–3 x, which leads to a higher and more rapid appearance of glucose in the distal foregut. This subsequently leads to an amplified incretin response leading to a hyperinsulinemic response in patients who have had bariatric surgery; however, for unclear reasons some patients develop an even more amplified hyperinsulinemic response that leads to subsequent hypoglycemia.
- |||||||||| levetiracetam / Generic mfg.
Contraindications to Magnesium Sulfate and Alternative Seizure Prophylaxis for Severe Preeclampsia () - Jun 20, 2020 - Abstract #ACOG2020ACOG_827; Levetiracetam, an alternative antiepileptic drug considered safe in pregnancy, has been suggested in such cases though its efficacy remains uncertain... The use of alternative anticonvulsant medications in preeclampsia, which may be less efficacious, must be reserved for true contraindications to magnesium sulfate.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Is There an Association Between Antiepileptic Drug Use and Dementia Risk? A Case-Control Study. (Pubmed Central) - Jun 19, 2020 Overall, AED use was not significantly associated with dementia risk in patients followed by general practitioners and neuropsychiatrists in Germany between 2013 and 2017. Nonetheless, the potential deleterious effects of levetiracetam generic brands on cognition deserve further investigation.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy. (Pubmed Central) - Jun 19, 2020 Levetiracetam (incident: focal, 267 [40.5%]; generalized, 271 [45.0%]; prevalent: focal, 794 [20.3%]; generalized, 871 [22.2%]), lamotrigine (incident: focal, 123 [18.6%]; generalized, 106 [17.6%]; prevalent: focal, 968 [24.8%]; generalized, 871 [22.2%]), and topiramate (incident: focal, 102 [15.5%]; generalized, 64 [10.6%]; prevalent: focal, 499 [12.8%]; generalized, 470 [12.0%]) were leading AEDs prescribed for both focal and generalized epilepsy...Many women appear to be treated with valproate and topiramate despite known teratogenicity risks. Comorbidities may affect selecting certain AEDs despite their teratogenicity risks.
- |||||||||| levetiracetam / Generic mfg.
Journal: Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions. (Pubmed Central) - Jun 17, 2020 Seizure incidence is increased in Alzheimer's disease (AD) patients and mouse models, and treatment with the antiseizure drug levetiracetam improves cognition...Our findings indicate that seizure-induced ΔFosB can bind genes in patterns that depend on seizure etiology, but can bind other genes regardless of seizure etiology. Understanding the factors that underlie these differences, such as chromatin accessibility and/or abundance of co-factors, could reveal novel insights into the control of gene expression in disorders with recurrent seizures.
- |||||||||| levetiracetam / Generic mfg.
Journal: Levetiracetam-Through a Psychiatric Prism. (Pubmed Central) - Jun 14, 2020 Understanding the factors that underlie these differences, such as chromatin accessibility and/or abundance of co-factors, could reveal novel insights into the control of gene expression in disorders with recurrent seizures. No abstract available
- |||||||||| levetiracetam / Generic mfg.
Journal: Patterns of seizure prophylaxis after oncologic neurosurgery. (Pubmed Central) - Jun 11, 2020 Current practice patterns do not support a clear standard of care and may be driven in part by geographic variation, availability of post-discharge services, and electronic prescribing defaults rather than evidence. Given uncertainty regarding effectiveness, indications, and appropriate duration of AED prophylaxis, well-powered trials are needed.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg.
Trial completion, Monotherapy: A Study to Investigate the Safety of the Drugs Topiramate and Levetiracetam in Treating Children Recently Diagnosed With Epilepsy (clinicaltrials.gov) - Jun 11, 2020 P3, N=63, Completed, Given uncertainty regarding effectiveness, indications, and appropriate duration of AED prophylaxis, well-powered trials are needed. Active, not recruiting --> Completed
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Antiepileptic Drugs Usage in Pregnant Women with Epilepsy in Saudi Arabia. (Pubmed Central) - Jun 9, 2020 The only malformation detected was a ventricular septal defect in one child, whose mother was using polytherapy (valproic acid and levetiracetam)...In addition, specialized epilepsy clinics utilizing multidisciplinary care are highly recommended. A specific group of interest for such clinics are married women, who have epilepsy and are using antiepileptic drugs since planning of pregnancy is not part of the culture in Saudi Arabia.
- |||||||||| levetiracetam / Generic mfg.
Journal: The impact of newer generation anticonvulsant prophylaxis on seizure incidence after spontaneous intracerebral hemorrhage. (Pubmed Central) - Jun 1, 2020 After adjustment for admission NIHSS and the presence of cortical involvement, the rate of new seizure events after ICH remained significantly lower in the patients who received prophylaxis (adjusted OR 0.28, 95%CI 0.11 - 0.71, p = 0.008). Administration of predominantly levetiracetam for anticonvulsant prophylaxis after ICH reduced the odds of new seizure events, independent of admission NIHSS score and the presence of cortical involvement.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: Effects of valproate, carbamazepine and levetiracetam on Tp-e interval, Tp-e/QT and Tp-e/QTc ratio. (Pubmed Central) - May 29, 2020 Carbamazepine and levetiracetam groups were not statistically significant in terms of pre- and post-treatment values. It was concluded that an arrhythmogenic environment may be associated with the disease, and patients who received AED monotherapy may need to be followed up more closely for arrhythmia.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal, Monotherapy: Effect of levetiracetam monotherapy on lipid profiles and thyroid hormones in children with epilepsy: A prospective study. (Pubmed Central) - May 27, 2020 In conclusion, long-term LEV monotherapy does not cause adverse alterations on thyroid hormones and serum lipids in children with epilepsy. More studies are needed to clarify whether LEV monotherapy have a favourable effect on serum lipids and whether LEV may be considered as a safer alternative drug for the prevention of antiepileptic drug-induced cardiovascular complications in adult life.
- |||||||||| Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo, Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: New-Onset Refractory Status Epilepticus with Underlying Autoimmune Etiology: a Case Report. (Pubmed Central) - May 22, 2020 Remarkably, the patient was subsequently discharged to a rehabilitation facility with complete neurologic recovery. We discuss treatment strategies for new-onset refractory status epilepticus and highlight the role of rapid initiation of burst suppression with high-dose IV anesthetics to ensure neuroprotection while the underlying etiology is addressed with immune-modulating therapy.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Cerebrovascular Accident in a Pediatric Patient Presenting With Influenza. (Pubmed Central) - May 21, 2020 The patient was transferred for specialty evaluation and was discharged 2 weeks later on levetiracetam...A high level of suspicion is needed so as not to miss the diagnosis of pediatric AIS in the emergency department. A thorough neurologic assessment is warranted, and subtle abnormalities should be investigated further.
|