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185 Diseases |  |
81 Trials |
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81 Trials |  |
6476 News |  |
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- || levetiracetam / Generic mfg., topiramate / Generic mfg.
Clinical, Journal: ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response. (Pubmed Central) - Jul 2, 2020
Even though Epilepsy is a significant clinical issue in ATP1A3 patients, only a minority of publications provide any information about patients' anti-epileptic treatment. The findings of treatment effectiveness in only 57% (or lower) of patients, and the non-existence of a clear first-line AED in ATP1A3 related epilepsy stresses the need for further research.
- || levetiracetam / Generic mfg.
Clinical, Journal: Levetiracetam mediates subtle pH-shifts in adult human neocortical pyramidal cells via an inhibition of the bicarbonate-driven neuronal pH-regulation - implications for excitability and plasticity modulation. (Pubmed Central) - Jun 29, 2020
Neurons with more acidic resting pHi-values showed a minimal alkalization upon LEV providing a mechanism for paradoxical proconvulsive LEV-effects rarely observed in epilepsy patients. The significance of these subtle pHi-shifts for cortical excitability and plasticity is discussed.
- || Fycompa (perampanel) / Eisai, levetiracetam / Generic mfg.
Clinical, Observational data, Journal: Accidental injuries in patients with generalized tonic-clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study). (Pubmed Central) - Jun 29, 2020
More than half of the patients had accidental injuries related with seizures. Symptomatic or with unknown etiology focal epilepsy and genetic generalized epilepsy, >1 seizure in the last year, and concomitant psychiatric disease are the risk factors associated with accidental injuries in patients with tonic-clonic seizures, with the consequent worsening of quality of life.
- || pregabalin / Generic mfg., Briviact (brivaracetam) / UCB, carbamazepine / Generic mfg.
PK/PD data, Retrospective data, Journal: Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: Pooled analysis of data from randomized clinical trials. (Pubmed Central) - Jun 28, 2020
P2, P3
In adults with focal seizures, adjunctive BRV treatment does not affect plasma concentrations of the evaluated AEDs but increases carbamazepine epoxide metabolite. Carbamazepine dose reduction should be considered if tolerability issues arise.
- | carbamazepine / Generic mfg.
Journal: Genotoxicity assessment of antiepileptic drugs (AEDs) in human embryonic stem cells. (Pubmed Central) - Jun 28, 2020
According to our results, all mentioned AEDs caused DNA damage, while Levetiracetam and topiramate caused more extensive DNA damages than the others. Noticeably, the addition of Folic acid to the treated cells decreased the DNA damages considerably.
- || levetiracetam / Generic mfg.
Clinical, Journal: Initial assessment of an interprofessional team-delivered telehealth program for patients with epilepsy. (Pubmed Central) - Jun 28, 2020
This pharmacist-delivered pilot program was effective in: reaching underserved patients with epilepsy, identifying and recommending resolutions to medication-related problems, and demonstrating the value of pharmacists in an interprofessional team. Further work is warranted to identify telehealth strategies to reduce medication associated problems.
- || clonazepam / Generic mfg., levetiracetam / Generic mfg., topiramate / Generic mfg.
Clinical, Journal: Congenital microcephaly with early onset epileptic encephalopathy caused by ASNS gene mutation: A case report. (Pubmed Central) - Jun 28, 2020
This is the first case of ASNSD in China. We identified 2 novel mutations (c.666_667delCT and c.1424C>T) in the ASNS gene, which expands the ASNS gene mutation profile and will be beneficial for genetic diagnosis.
- || levetiracetam / Generic mfg., clobazam / Generic mfg.
Clinical, Journal: A Proof-of-Principle, Case-Control Study to Compensate for Potential Carbohydrates in Liquid Antiseizure Drugs in Children on the Ketogenic Diet. (Pubmed Central) - Jun 26, 2020
This proof-of-principle study demonstrates feasibility of compensating for carbohydrates in liquid medications by increases in the daily ketogenic ratio. This ratio adjustment protocol may help ease an already complex adjustment to dietary therapy.
- || fluconazole / Generic mfg., carbamazepine / Generic mfg.
Clinical, PK/PD data, Journal: Development of a methodology to make individual estimates of the precision of liquid chromatography-tandem mass spectrometry drug assay results for use in population pharmacokinetic modeling and the optimization of dosage regimens. (Pubmed Central) - Jun 25, 2020
In the framework of precision pharmacotherapy, establishing the AEE of assayed drugs is the responsibility of the therapeutic drug monitoring service. This permits optimal dosages by providing the correct weighting factor of assay results in the development of population and individual pharmacokinetic models.
- | levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date, Monotherapy: PEACH: A Study of Levetiracetam as Monotherapy or Adjunctive Treatment of Partial Seizures in Pediatric Epileptic Subjects Ranging From 1 Month to Less Than 4 Years of Age (clinicaltrials.gov) - Jun 23, 2020
P3, N=48, Recruiting, Sponsor: UCB Japan Co. Ltd.
This permits optimal dosages by providing the correct weighting factor of assay results in the development of population and individual pharmacokinetic models. Trial completion date: Jan 2022 --> Aug 2023 | Trial primary completion date: Jan 2022 --> Aug 2023
- [VIRTUAL] Patient with Pseudohypoparathyroidism Type 1B, Graves Disease, and False Positive HIV Screen- a Rare Presentation () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_2156;
Although rare, thyrotoxicosis may present in patients with PHP1B. Additionally, it should be kept in mind that autoimmune diseases such as Graves disease can cause a false positive HIV ELISA, and follow-up Western blot testing should therefore be performed.
- methimazole / Generic mfg., levetiracetam / Generic mfg., Tirosint (levothyroxine) / IBSA Institute Biochemical SA
[VIRTUAL] Auto-Destruction of the Thyroid and Coexisting Glutamic Acid Decarboxylase Mediated Neurological Disease in an Adolescent: An Unusual Presentation of Autoimmunity () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_1553;
GAD-65 CNS autoimmunity is important to be considered in children with AT presenting with seizures or focal neurological signs. Continued vigilance and follow up for the development of other autoimmune conditions is warranted.
- lorazepam / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] A Neuro-Radiological Stroke Mimicker: Non-Ketotic Hyperglycemia Induced Occipital Lobe Hyperdensity Presenting with Seizures () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_1076;
The suggested pathophysiology for seizures is prolonged hyperglycemia leading to oxidative stress and cellular edema. Furthermore, this may contribute to the unique MRI findings and should not be confused for an acute stroke.
- levetiracetam / Generic mfg., acarbose / Generic mfg.
[VIRTUAL] Post-Bariatric Hypoglycemia: A Clinical Vignette on an Increasingly Recognized Disease () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_218;
By bypassing normal anatomy, gastric emptying is increased 2–3 x, which leads to a higher and more rapid appearance of glucose in the distal foregut. This subsequently leads to an amplified incretin response leading to a hyperinsulinemic response in patients who have had bariatric surgery; however, for unclear reasons some patients develop an even more amplified hyperinsulinemic response that leads to subsequent hypoglycemia.
- levetiracetam / Generic mfg.
Contraindications to Magnesium Sulfate and Alternative Seizure Prophylaxis for Severe Preeclampsia () - Jun 20, 2020 - Abstract #ACOG2020ACOG_827;
Levetiracetam, an alternative antiepileptic drug considered safe in pregnancy, has been suggested in such cases though its efficacy remains uncertain... The use of alternative anticonvulsant medications in preeclampsia, which may be less efficacious, must be reserved for true contraindications to magnesium sulfate.
- || levetiracetam / Generic mfg.
Clinical, Journal: Is There an Association Between Antiepileptic Drug Use and Dementia Risk? A Case-Control Study. (Pubmed Central) - Jun 19, 2020
Overall, AED use was not significantly associated with dementia risk in patients followed by general practitioners and neuropsychiatrists in Germany between 2013 and 2017. Nonetheless, the potential deleterious effects of levetiracetam generic brands on cognition deserve further investigation.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy. (Pubmed Central) - Jun 19, 2020
Levetiracetam (incident: focal, 267 [40.5%]; generalized, 271 [45.0%]; prevalent: focal, 794 [20.3%]; generalized, 871 [22.2%]), lamotrigine (incident: focal, 123 [18.6%]; generalized, 106 [17.6%]; prevalent: focal, 968 [24.8%]; generalized, 871 [22.2%]), and topiramate (incident: focal, 102 [15.5%]; generalized, 64 [10.6%]; prevalent: focal, 499 [12.8%]; generalized, 470 [12.0%]) were leading AEDs prescribed for both focal and generalized epilepsy...Many women appear to be treated with valproate and topiramate despite known teratogenicity risks. Comorbidities may affect selecting certain AEDs despite their teratogenicity risks.
- | Journal: Nonlesional late-onset epilepsy: Semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics. (Pubmed Central) - Jun 18, 2020
Oligoclonal bands were only detected in patients with NLLOE, indicating that careful exclusion of autoimmune encephalitis in this patient group is warranted. Our findings may help to more accurately identify and characterize patients with NLLOE to improve targeted diagnostics and adequate treatment in this challenging group of patients.
- || carbamazepine / Generic mfg.
Clinical, Journal: Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria. (Pubmed Central) - Jun 17, 2020
Also, in patients placed on valproate therapy, pretreatment and follow-up monitoring of the hepatic effect was done in only 33.71% and 19.0% of the patients, respectively. The extent of monitoring of the hematologic effects of carbamazepine, as well as the hepatic effects of valproate in the cohort studied, is poor.
- | levetiracetam / Generic mfg.
Journal: Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions. (Pubmed Central) - Jun 17, 2020
Seizure incidence is increased in Alzheimer's disease (AD) patients and mouse models, and treatment with the antiseizure drug levetiracetam improves cognition...Our findings indicate that seizure-induced ΔFosB can bind genes in patterns that depend on seizure etiology, but can bind other genes regardless of seizure etiology. Understanding the factors that underlie these differences, such as chromatin accessibility and/or abundance of co-factors, could reveal novel insights into the control of gene expression in disorders with recurrent seizures.
- | levetiracetam / Generic mfg.
Journal: Levetiracetam-Through a Psychiatric Prism. (Pubmed Central) - Jun 14, 2020
Understanding the factors that underlie these differences, such as chromatin accessibility and/or abundance of co-factors, could reveal novel insights into the control of gene expression in disorders with recurrent seizures. No abstract available
- || Vimpat (lacosamide) / UCB, Daiichi Sankyo, levetiracetam / Generic mfg.
Clinical, Clinical data, Observational data, Journal: Clinical outcomes and treatments effectiveness in status epilepticus resolved by antiepileptic drugs: A five-year observational study. (Pubmed Central) - Jun 13, 2020
A high short-term mortality, stable over time, was observed in SE despite resolution of seizures, especially in SE with nonconvulsive semiology. Comparative AED efficacy showed no significant differences except for higher resolution rate for valproate versus levetiracetam in NCSE.
- | levetiracetam / Generic mfg.
Journal: Patterns of seizure prophylaxis after oncologic neurosurgery. (Pubmed Central) - Jun 11, 2020
Current practice patterns do not support a clear standard of care and may be driven in part by geographic variation, availability of post-discharge services, and electronic prescribing defaults rather than evidence. Given uncertainty regarding effectiveness, indications, and appropriate duration of AED prophylaxis, well-powered trials are needed.
- | levetiracetam / Generic mfg., topiramate / Generic mfg.
Trial completion, Monotherapy: A Study to Investigate the Safety of the Drugs Topiramate and Levetiracetam in Treating Children Recently Diagnosed With Epilepsy (clinicaltrials.gov) - Jun 11, 2020
P3, N=63, Completed, Sponsor: Janssen Research & Development, LLC
Given uncertainty regarding effectiveness, indications, and appropriate duration of AED prophylaxis, well-powered trials are needed. Active, not recruiting --> Completed
- | levetiracetam / Generic mfg.
New trial: Connectivity Alterations After Levetiracetam Application (clinicaltrials.gov) - Jun 11, 2020
P, N=30, Not yet recruiting, Sponsor: Beijing Neurosurgical Institute
- || levetiracetam / Generic mfg.
Clinical, Journal: Levetiracetam Pregnancy Registry: Final results and a review of the impact of registry methodology and definitions on the prevalence of major congenital malformations. (Pubmed Central) - Jun 10, 2020
P4
The LEV-Registry Expert Panel did not find evidence suggestive of teratogenic association with prenatal exposure to levetiracetam. The substantial differences in which physical findings were considered MCMs highlight the major impact of pregnancy registry methodology on MCM prevalence estimates.
- || levetiracetam / Generic mfg.
Clinical, Journal: Antiepileptic Drugs Usage in Pregnant Women with Epilepsy in Saudi Arabia. (Pubmed Central) - Jun 9, 2020
The only malformation detected was a ventricular septal defect in one child, whose mother was using polytherapy (valproic acid and levetiracetam)...In addition, specialized epilepsy clinics utilizing multidisciplinary care are highly recommended. A specific group of interest for such clinics are married women, who have epilepsy and are using antiepileptic drugs since planning of pregnancy is not part of the culture in Saudi Arabia.
- || levetiracetam / Generic mfg.
Clinical, Journal: Levetiracetam can decrease desmopressin requirement in children with diabetes insipidus. (Pubmed Central) - Jun 8, 2020
A specific group of interest for such clinics are married women, who have epilepsy and are using antiepileptic drugs since planning of pregnancy is not part of the culture in Saudi Arabia. No abstract available
- || levetiracetam / Generic mfg.
Clinical, Journal: Levetiracetam and non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation and epilepsy: a reasonable combination. (Pubmed Central) - Jun 8, 2020
No abstract available No abstract available
- || levetiracetam / Generic mfg.
Clinical, Journal: Optogenetically-Induced Population Discharge Threshold as a Sensitive Measure of Network Excitability. (Pubmed Central) - Jun 8, 2020
Epileptiform population discharges are network-wide events that represent a distinct transition from normal to abnormal functional modes. We developed a new method that uses light intensity-response curves to precisely determine the threshold for this transition as a surrogate measure of network excitability.
- | pentylenetetrazole (BTD-001) / Balance Therap, levetiracetam / Generic mfg.
Journal: An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy. (Pubmed Central) - Jun 8, 2020
There was a very minimal drug interaction between Ocimum and LEV. So, Ocimum as an adjuvant to LEV may be shelpful in enhancing the antiepileptic effect and also in minimizing the adverse effects.
- | levetiracetam / Generic mfg.
Journal: Drug-drug interaction between levetiracetam and non-vitamin K antagonist anticoagulants. (Pubmed Central) - Jun 5, 2020
So, Ocimum as an adjuvant to LEV may be shelpful in enhancing the antiepileptic effect and also in minimizing the adverse effects. No abstract available
- | Briviact (brivaracetam) / UCB
Preclinical, Journal: [EXPRESS] Brivaracetam attenuates pain behaviors in a murine model of neuropathic pain. (Pubmed Central) - Jun 4, 2020
SV2A may represent a novel target for neuropathic pain. BRV may warrant study in humans with neuropathic pain due to peripheral nerve injury.
- || levetiracetam / Generic mfg.
This is really helpful. Thanks. So many further studies needed! Will be interesting to see the Keppra paper when published (Twitter) - Jun 4, 2020
- |||| levetiracetam / Generic mfg.
Clinical: I dont even .... how to begin to interpret keppra as a chemosensitizer? https://t.co/oGpX4EsgYo 13m PFS and 29m OS in newly diagnosed-75 patients so its not a tiny cohort @AshleySumrallMD ? (Twitter) - Jun 3, 2020
- | levetiracetam / Generic mfg.
Journal: The impact of newer generation anticonvulsant prophylaxis on seizure incidence after spontaneous intracerebral hemorrhage. (Pubmed Central) - Jun 1, 2020
After adjustment for admission NIHSS and the presence of cortical involvement, the rate of new seizure events after ICH remained significantly lower in the patients who received prophylaxis (adjusted OR 0.28, 95%CI 0.11 - 0.71, p = 0.008). Administration of predominantly levetiracetam for anticonvulsant prophylaxis after ICH reduced the odds of new seizure events, independent of admission NIHSS score and the presence of cortical involvement.
- | levetiracetam / Generic mfg.
Biomarker, Preclinical, Journal: Quantification of [F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value. (Pubmed Central) - May 31, 2020
Due to its equivalence to the Vt, the SUV parameter can be considered in order to quantify [F]UCB-H uptake in the rat brain. This work, therefore, establishes a starting point for the simplification of SV2A in vivo quantification with [F]UCB-H, and represents a step forward to the clinical application of this PET radiotracer.
- | levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: Effects of valproate, carbamazepine and levetiracetam on Tp-e interval, Tp-e/QT and Tp-e/QTc ratio. (Pubmed Central) - May 29, 2020
Carbamazepine and levetiracetam groups were not statistically significant in terms of pre- and post-treatment values. It was concluded that an arrhythmogenic environment may be associated with the disease, and patients who received AED monotherapy may need to be followed up more closely for arrhythmia.
- || tacrolimus / Generic mfg.
Clinical, Journal: Acute symptomatic seizure due to tacrolimus-related encephalopathy after liver transplantation: two case reports. (Pubmed Central) - May 28, 2020
It was concluded that an arrhythmogenic environment may be associated with the disease, and patients who received AED monotherapy may need to be followed up more closely for arrhythmia. No abstract available
- | carbamazepine / Generic mfg.
Journal: Usage Pattern of Carbamazepine and Associated Severe Cutaneous Adverse Reactions in Singapore Following Implementation of HLA-B*15:02 Genotyping as Standard-of-Care. (Pubmed Central) - May 28, 2020
Additionally, the number of phenytoin-SJS/TEN cases also declined. Taken together, this represents a successful example of precision medicine through implementation of a genotyping program to reduce a rare but serious adverse drug reaction among at-risk individuals, while preserving the availability of an effective and low-cost medicine for the broader population.
- || levetiracetam / Generic mfg.
Clinical, Journal: Long-term follow-up with therapeutic drug monitoring of antiepileptic drugs in patients with juvenile myoclonic epilepsy. (Pubmed Central) - May 27, 2020
There was extensive pharmacokinetic variability of AEDs in and between patients with JME. A long-term TDM approach may contribute to closer monitoring of patients with JME and be used as a practical tool during clinical consultations.
- || levetiracetam / Generic mfg.
Clinical, Journal, Monotherapy: Effect of levetiracetam monotherapy on lipid profiles and thyroid hormones in children with epilepsy: A prospective study. (Pubmed Central) - May 27, 2020
In conclusion, long-term LEV monotherapy does not cause adverse alterations on thyroid hormones and serum lipids in children with epilepsy. More studies are needed to clarify whether LEV monotherapy have a favourable effect on serum lipids and whether LEV may be considered as a safer alternative drug for the prevention of antiepileptic drug-induced cardiovascular complications in adult life.
- | levetiracetam / Generic mfg.
Journal: Intravenous Levetiracetam for Treatment of Seizures in Term and Preterm Neonates. (Pubmed Central) - May 22, 2020
No severe adverse effects were observed. Our data suggest that levetiracetam may be a safe and effective treatment for neonatal seizures, which are unresponsive to phenobarbital.
- || Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo, Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: New-Onset Refractory Status Epilepticus with Underlying Autoimmune Etiology: a Case Report. (Pubmed Central) - May 22, 2020
Remarkably, the patient was subsequently discharged to a rehabilitation facility with complete neurologic recovery. We discuss treatment strategies for new-onset refractory status epilepticus and highlight the role of rapid initiation of burst suppression with high-dose IV anesthetics to ensure neuroprotection while the underlying etiology is addressed with immune-modulating therapy.
- || levetiracetam / Generic mfg.
"Le keppra pourrait limiter le viral budding en pertubant les voies de l'exocytose...." (Twitter) - May 22, 2020
- || levetiracetam / Generic mfg.
Clinical, Journal: Cerebrovascular Accident in a Pediatric Patient Presenting With Influenza. (Pubmed Central) - May 21, 2020
The patient was transferred for specialty evaluation and was discharged 2 weeks later on levetiracetam...A high level of suspicion is needed so as not to miss the diagnosis of pediatric AIS in the emergency department. A thorough neurologic assessment is warranted, and subtle abnormalities should be investigated further.
- | carbamazepine / Generic mfg.
Retrospective data, Journal: Etiology of neonatal seizures and maintenance therapy use: a 10-year retrospective study at Toulouse Children's hospital. (Pubmed Central) - May 19, 2020
In our cohort, valproic acid was the most frequently prescribed maintenance antiepileptic therapy. However, the arrival on the market of new antiepileptic drugs and a better understanding of the physiopathology of genetic encephalopathies is changing our practice.
- [VIRTUAL] REFRACTORY SEVERE ICANS IN A PATIENT TREATED WITH AXICABTAGENE CILOLEUCEL SUBSEQUENTLY FOUND TO HAVE SUSPECTED CNS DISEASE. () - May 16, 2020 - Abstract #EHA2020EHA_1196;
Despite this she remained in status epilepticus necessitating intubation and 2 doses of Siltuximab...Conclusion This case demonstrates a case of protracted refractory severe ICANS despite optimal therapy (as per global guidance) with significant CAR-T cell presence in the CSF in the context of suspected previously unknown CNS lymphoma. The subsequent clinical course and management of these patients remains an important unsolved challenge.
- | levetiracetam / Generic mfg.
Journal: Exploration and preparation of a dose-flexible regulation system for levetiracetam tablets via novel semisolid extrusion (SSE) 3D printing. (Pubmed Central) - May 15, 2020
Faster release behavior for levetiracetam can be achieved from the small sized tablets due to their larger surface area/mass ratio. All the results demonstrated the potential and capability of SSE 3D printing as a novel pharmaceutical manufacturing technique to provide a dynamic and highly accurate controllable system for preparing patient-tailored medicines.
- [VIRTUAL] Direct Oral Anticoagulants and Antiepileptic Drugs: Is There Room for Concurrent Treatment? (Virtual Meeting Room 6) - May 14, 2020 - Abstract #ISTH2020ISTH_2328;
In our experience, concurrent treatment with AED and DOAC usually did not lead to a reduction in drug concentration. In a clinical follow-up, in both AF and VTE patients, no adverse events due to reduced DOACs effect have been registered at present.