- |||||||||| Journal: Treatment of Refractory Convulsive Status Epilepticus: A Comprehensive Review by the American Epilepsy Society Treatments Committee. (Pubmed Central) - Aug 22, 2020
A structured literature search (MEDLINE, Embase, CENTRAL, CINAHL) was performed to identify original studies on the treatment of CRSE in children and adults using IV brivaracetam, ketamine, lacosamide, levetiracetam (LEV), midazolam (MDZ), pentobarbital (PTB; and thiopental), propofol (PRO), and valproic acid (VPA)...For the treatment of established convulsive SE (ie, not RSE), LEV, VPA, and fosphenytoin are likely equally effective, but whether this is also true for CRSE is unknown. Triple-masked, randomized controlled trials are needed to compare the effectiveness of parenteral anesthetizing and nonanesthetizing ASMs in the treatment of CRSE.
- |||||||||| levetiracetam / Generic mfg.
Enrollment open: Treating Hyperexcitability in AD With Levetiracetam (clinicaltrials.gov) - Aug 19, 2020
P2, N=85, Recruiting,
Triple-masked, randomized controlled trials are needed to compare the effectiveness of parenteral anesthetizing and nonanesthetizing ASMs in the treatment of CRSE. Active, not recruiting --> Recruiting
- |||||||||| Fycompa (perampanel) / Eisai, levetiracetam / Generic mfg.
Clinical, Retrospective data, Journal: Preliminary evidence about irritability in patients with epilepsy treated by perampanel as first add-on therapy compared to levetiracetam and valproic acid. (Pubmed Central) - Aug 19, 2020
This retrospective study described a stable and possibly lower degree of irritability in patients starting PER than LEV and VPA treatments, although we documented the comparable effectiveness of PER, LEV, and VPA as first add-on treatments in patients affected by uncontrolled epileptic seizures. However, the small sample of patients included in this study and the absence of I-EPI scores obtained at baseline visits in LEV and VPA groups require further investigations to confirm this preliminary evidence.
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: Antiepileptic drugs as prophylaxis for postcraniotomy seizures. (Pubmed Central) - Aug 15, 2020
The current evidence base is limited due to the different methodologies employed in the trials and inconsistencies in the reporting of outcomes including deaths and adverse events. Further evidence from good-quality, contemporary trials is required in order to assess the clinical effectiveness of prophylactic AED treatment compared to placebo or no treatment, or other AEDs in preventing postcraniotomy seizures in this select group of patients.
- |||||||||| Journal: An Insight into Gabapentin and Pregabalin in Scottish Prisoners. (Pubmed Central) - Aug 14, 2020
Other drugs found in positive AED samples were methadone (26%), cocaine (18%), buprenorphine (17%), amphetamines (4%), methamphetamines (4%) and barbiturates (4%). This study shows a high prevalence of AEDs within the Scottish prison system, primarily due to gabapentin and pregabalin, however due to the anonymity of the sample collection it is unknown if these are prescribed or illicit drug ingestions.
- |||||||||| levetiracetam / Generic mfg.
Journal: Administration of Levetiracetam in Traumatic Brain Injury: Is it Warranted? (Pubmed Central) - Aug 14, 2020
All six patients with non-severe TBI who experienced a seizure were receiving LEV. Conclusions Inappropriate use of LEV is common in patients admitted with non-severe TBI, with many patients continuing LEV post-discharge. With careful patient selection, patients with mild and moderate TBI likely do not need seizure prophylaxis with LEV. Education on appropriate indication and duration of LEV in patients with TBI is warranted.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Sodium valproate combined with levetiracetam in pediatric epilepsy and its influence on NSE, IL-6, hs-CRP and electroencephalogram improvement. (Pubmed Central) - Aug 13, 2020
Observation group had lowered content of NSE, GFAP, IL-6, hs-CRP and IL-2 (P<0.05), and α wave was markedly decreased, but θ and δ waves were notably increased in the observation group (P<0.05). In the treatment of pediatric epilepsy, sodium valproate combined with LEV produces better efficacy, fewer adverse reactions, significantly improves patients' QOL and notably lowers the content of NSE, IL-6 and hs-CRP with notable EEG improvement, so it is a safe and reliable treatment that is worth popularization.
- |||||||||| levetiracetam / Generic mfg.
Enrollment closed: LEV-AD: Levetiracetam for Alzheimer's Disease-Associated Network Hyperexcitability (clinicaltrials.gov) - Aug 13, 2020
P2a, N=36, Active, not recruiting,
In the treatment of pediatric epilepsy, sodium valproate combined with LEV produces better efficacy, fewer adverse reactions, significantly improves patients' QOL and notably lowers the content of NSE, IL-6 and hs-CRP with notable EEG improvement, so it is a safe and reliable treatment that is worth popularization. Recruiting --> Active, not recruiting
- |||||||||| levetiracetam / Generic mfg.
Trial completion, Enrollment change: Levetiracetam Versus Valproate in Idiopathic Generalized Tonic-clonic Seizures (clinicaltrials.gov) - Aug 12, 2020
P4, N=103, Completed,
Not yet recruiting --> Recruiting | Trial completion date: Jan 2020 --> Dec 2020 | Trial primary completion date: Sep 2019 --> Dec 2020 Active, not recruiting --> Completed | N=148 --> 103
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Critical Care Management of Status Epilepticus at a Tertiary Care University Hospital. (Pubmed Central) - Aug 5, 2020
Following BDZs, PHT and levetiracetam were the most commonly initiated AEDs as first- and second-line agents and were deemed effective in 30/44 and 5/11 patients, respectively...Further studies of the predictors of PHT effectiveness, specifically obesity, are necessary to help individualize care. Finally, we suggest that PHT should be loaded according to the guidelines as 20 mg/kg followed by an MD of at least 400 mg/day or >5 mg/kg per day.
- |||||||||| levetiracetam / Generic mfg., levetiracetam low dose (AGB101) / AgeneBio
Clinical, Clinical data, PK/PD data, Journal: Pharmacokinetic and Pharmacodynamic modeling of levetiracetam: investigation of factors affecting the clinical outcome. (Pubmed Central) - Aug 5, 2020
Using discrete time Markov chains, it was shown that the transition probability from focal seizures to focal to bilateral tonic-clonic is significantly altered in relation to patient's CrCL.Simulations showed that dose should be adjusted in relation to CrCL, while low doses of levetiracetam are more efficient for seizure control. Modeling and simulation in every-day clinical practice, may provide significant information for the optimization of seizure control using well-known agents.
- |||||||||| zonisamide / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: Evaluation of fecal Lactobacillus populations in dogs with idiopathic epilepsy: a pilot study. (Pubmed Central) - Aug 5, 2020
Further studies are warranted to evaluate the role of the gut microbiome in disease progression and treatment response in dogs with epilepsy. Lactobacilli in culture were not killed or inhibited from growing when exposed to phenobarbital, potassium bromide, zonisamide or levetiracetam, suggesting that antiepileptic drug administration is less likely to be a confounding factor in future studies evaluating the role of Lactobacillus in epilepsy.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] VUS or non VUS in ACTA2? (E-Poster Area) - Aug 4, 2020 - Abstract #ESHG2020ESHG_1959;
A CT scan demonstrated a type A aortic dissection (AD) not involving coronary arteries, surgically corrected without complications.During the follow up, occasional seizures were observed, successfully treated with Levetiracetam...The c.1004C>T (p.Pro335Leu) in the ACTA2 gene is predicted to be "pathogenic" by several bioinformatics tools, but to date its clinical significance is still uncertain.This case suggests the importance to consider clinical history in VUS evaluation for specific conditions. Further studies are required to clarify the role of ACTA2 missense variants in type A aortic dissections.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Treatment of severe traumatic brain injury in German pediatric intensive care units-a survey of current practice. (Pubmed Central) - Aug 2, 2020
Levetiracetam monotherapy causes no significant function or morphological change in ocular tissues in pediatric epilepsies. This survey provides an overview of the current PICU practices of isolated severe TBI management in Germany and demonstrates a wide instrumental and therapeutical range, revealing an unmet need for the revised national guideline and further (international) clinical trials for the treatment of severe TBI in pediatrics.
- |||||||||| levetiracetam / Generic mfg.
Retrospective data, Journal: Risk factors predisposing to psychotic symptoms during levetiracetam therapy: A retrospective study. (Pubmed Central) - Aug 2, 2020
Our retrospective study found that psychotic symptoms during LEV therapy were significantly associated with status epilepticus, a history of psychotic symptoms, a history of psychiatric illness other than psychosis, and concomitant PHT usage, whereas concomitant LTG usage was protective. Psychotic symptoms specifically as an adverse drug reaction to LEV were significantly associated with female gender, intellectual disability, status epilepticus, and a history of psychotic symptoms.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Review, Journal: Sexual dysfunction in people with epilepsy. (Pubmed Central) - Aug 2, 2020
Every effort should be made to identify and treat reversible causes including changing to nonenzyme-inducing ASDs and to provide symptomatic relief. Large, prospective studies are required to improve our understanding on prevalence and mechanisms of sexual dysfunction in PWE.
- |||||||||| levetiracetam / Generic mfg., levetiracetam low dose (AGB101) / AgeneBio
[VIRTUAL] A randomized controlled trial measuring changes in cerebral blood flow after Levetiracetam in patients with Alzheimers disease () - Aug 2, 2020 - Abstract #AAIC2020AAIC_3362;
One possible explanation could be that in mild AD, epileptic activity in the hippocampus leads to an excessive inhibition, and so relieving the inhibition with levetiracetam leads to an increased blood flow. These findings provide evidence of a potential beneficial effect of levetiracetam in patients with Alzheimers disease, but larger studies are needed, particularly with longer dosage schedules to determine whether there are any clinical improvements.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Effects of Levetiracetam treatment on cognitive and non-cognitive impairments in a mouse model of tauopathy. () - Aug 2, 2020 - Abstract #AAIC2020AAIC_2206;
Interestingly, Leviteracetam diet resulted in a decrease in body weight together with improvement in rotarod in non-transgenic littermates when compared to chow diet, whereas no effects were observed in Tg4510 mice treated with leviteracetam. Biochemical and histochemical analysis will be performed in brain tissue to know if treatment with Levetiracetam had an effect on tau pathology.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Pharmacological suppression of seizure-like activity in the PS2APP model of amyloidosis () - Aug 2, 2020 - Abstract #AAIC2020AAIC_1671;
Our Levetiracetam studies confirm that pharmacological intervention can normalize seizure-like activity in PS2APP mice. Medications with different mechanism of action need to be tested for their ability to reduce spike activity and improve cognition in this animal model.Ultimately, it will be important to see if such pharmacological effects translate to humans and if reductions in seizure activity are linked to functional improvements.
- |||||||||| levetiracetam / Generic mfg., Cerebyx (fosphenytoin) / Pfizer, Nobelpharma
Journal: Lessons from the Established Status Epilepticus Treatment Trial. (Pubmed Central) - Jul 29, 2020
We consider that the ESETT is already informing both clinical practice and future trial design. This article is part of the Special Issue "Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures".
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Levetiracetam in genetic generalized epilepsy: A prospective unblinded active-controlled trial. (Pubmed Central) - Jul 25, 2020
There were differences in AED selection by epilepsy etiology; levetiracetam is the most commonly prescribed drug for both cohorts. LEV has similar efficacy and acceptable safety in comparison to VPA in short-term treatment of patients with genetic GTCS and JME, and it could be considered as an alternative to VPA particularly in women of reproductive age.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Review, Journal: Levetiracetam efficacy in PCDH19 Girls Clustering Epilepsy. (Pubmed Central) - Jul 24, 2020
Levetiracetam was effective in two cohorts of females with PCDH19-GCE where 42% and 76% of females became seizure free for >12 months, respectively. Levetiracetam is an effective therapy for females with PCDH19-GCE and should be considered early in the management of the highly refractory clusters of seizures that characterise this genetic disease.
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