- |||||||||| Briviact (brivaracetam) / UCB
Clinical, Journal: Clinical experience with brivaracetam in a series of 46 children. (Pubmed Central) - Jan 21, 2021
Brivaracetam is effective in very diverse childhood epilepsies, including some that present with primarily generalized seizures. Given the characteristics of the population studied, we have not been able to confirm a better tolerability of BRV compared with levetiracetam (LEV).
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Clinical, Journal, Monotherapy: Polycystic-Ovarian-Syndrome in Nigerian women with epilepsy on carbamazepine/ levetiracetam Monotherapy. (Pubmed Central) - Jan 21, 2021
Given the characteristics of the population studied, we have not been able to confirm a better tolerability of BRV compared with levetiracetam (LEV). The increased frequency of PCOS and its subcomponent and the unsatisfactory effect of LEV compared to CBZ on reproductive endocrine function underscore the need for routine reproductive endocrine evaluation to improve overall quality of life.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Review, Journal: Stroke, Epilepsy, and Antiepileptic Drugs as the Etiology of Major Depressive Disorder: A Case Report and Review. (Pubmed Central) - Jan 16, 2021
The authors of this brief report describe the association of LPDs with acute catastrophic depression in a previously healthy patient who had a series of neurobiological insults caused by a stroke and its treatment that led to the development of significant psychopathology. Through this case of new and debilitating depression that followed a recent stroke, subsequent development of LPDs, and treatment with levetiracetam, the authors highlight the complex interplay of structural, electrophysiologic, and pharmacologic factors in the pathogenesis of poststroke depression and the crucial role of having a broad biopsychosocial assessment for optimal diagnosis and management.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg.
Journal: Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy. (Pubmed Central) - Jan 15, 2021
High throughput RNA-sequencing (RNA-seq) of the ipsilateral hippocampus of mice treated with the levetiracetam/topiramate combination showed that several genes that have been linked previously to epileptogenesis, were significantly differentially expressed, providing interesting entry points for future mechanistic studies. Overall, we have discovered a novel combination treatment with promise for prevention of epilepsy.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Review, Journal: Stiff-Person Syndrome: A Treatment Update and New Directions. (Pubmed Central) - Jan 14, 2021
We recommend adding levetiracetam or pregabalin if symptoms persist...We also suggest rituximab over tacrolimus...We conclude that intrathecal baclofen and IVIG are more effective than plasmapheresis in patients with refractory symptoms. Propofol may be used as a bridge - temporary therapy before initiating a permanent treatment.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg.
Clinical, Journal: Influence of age and co-medication on the concentration and efficacy of valproic acid in Chinese epilepsy children. (Pubmed Central) - Jan 9, 2021
Age could explain some of the inter-individual pharmacokinetic of VPA, however, gender was not related to the concentration or efficacy of VPA which suggested that concentration monitoring was indispensable to children. Low metabolism, especially in the combination of LEV and TPM, might associate with the resistance of VPA, which could be a new sight to explore the resistance of VPA.
- |||||||||| atorvastatin / Generic mfg., aspirin / Generic mfg., levetiracetam / Generic mfg.
Journal: Effects of atorvastatin and aspirin on post-stroke epilepsy and usage of levetiracetam. (Pubmed Central) - Jan 8, 2021
Conclusion Levetiracetam monotherapy was observed as effective and safe for children with epilepsy although side effects limit tolerance in a sizeable minority. Atorvastatin and aspirin co-treatment with levetiracetam can reduce epilepsy in PSE patients and reduce the dosage of levetiracetam required for effective control of PSE.
- |||||||||| busulfan / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] ORAL LEVETIRACETAM IS ASSOCIATED WITH DECREASED SYSTEMIC BUSULFAN EXPOSURE AFTER ORAL DOSING (Auditorium 5) - Jan 7, 2021 - Abstract #EBMT2021EBMT_988;
Atorvastatin and aspirin co-treatment with levetiracetam can reduce epilepsy in PSE patients and reduce the dosage of levetiracetam required for effective control of PSE. Our findings suggest that compared to phenytoin, oral levetiracetam reduces systemic exposure after oral Bu, most likely due to reduced bioavailability.
- |||||||||| levetiracetam / Generic mfg.
Preclinical, Journal: Validation and noninvasive kinetic modeling of [C]UCB-J PET imaging in mice. (Pubmed Central) - Jan 6, 2021
V values estimated with one- and two-tissue compartmental models (1TCM and 2TCM) were highly comparable (r=0.999, p < 0.0001), with 1TCM performing better than 2TCM for K. A scan duration of 60 min was sufficient for reliable V and K estimations. In vivo metabolism of [C]UCB-J was relatively rapid, with a parent fraction of 22.5 ± 4.2% at 15 min p.i. In conclusion, our findings show that [C]UCB-J selectively binds to SV2A with optimal kinetics in the mouse representing a promising tool to noninvasively quantify synaptic density in comparative or therapeutic studies in neuropsychiatric and neurodegenerative disorder models.
- |||||||||| levetiracetam / Generic mfg., clobazam / Generic mfg.
[VIRTUAL] Prospective study of epilepsy in NGLY1 deficiency (Room 1) - Jan 6, 2021 - Abstract #WSMRF2021WSMRF_3;
Commonly used medications in various combinations include valproate and clobazam, indicating hepatic tolerance of these medications. Providers should educate caregivers about varied seizure types to ensure prompt detection and treatment of epilepsy.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo, pentylenetetrazole (BTD-001) / Balance Therap
Preclinical, Journal: Evaluation of the impact of compound C11 a new anticonvulsant candidate on cognitive functions and hippocampal neurogenesis in mouse brain. (Pubmed Central) - Jan 6, 2021
C11 revealed high efficacy in acute animal seizure models such as the maximal electroshock model (MES), the pentylenetetrazole model (PTZ) and the 6 Hz (6 Hz, 32 mA) seizure model, as well as in the kindling model of epilepsy induced by repeated injection of PTZ in mice...The following drugs were used: C11, levetiracetam (LEV), ethosuximide (ETS) and lacosamide (LCM)...A new hybrid compound C11 in contrast to LCM has no negative impact on the process of neurogenesis and neurodegeneration in the mouse hippocampus. Furthermore, chronic treatment with C11 turned out to have no negative impact on cognitive functions of treated mice, which, is certainly of great importance for further more advanced preclinical and especially clinical trials.
- |||||||||| carbamazepine / Generic mfg.
Journal: Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition. (Pubmed Central) - Jan 6, 2021
Loss of normal PSEN2 function may be an underexplored molecular contributor to seizures. The use of validated models of chronic seizures in aged rodents may uncover age-related changes in susceptibility to epileptogenesis and/or ASD efficacy in mice with AD-associated genotypes, which may benefit the management of seizures in AD.
- |||||||||| Review, Journal: Anti-Epileptogenic Effects of Antiepileptic Drugs. (Pubmed Central) - Jan 6, 2021
The available experimental data indicate that diazepam (at low and high doses), gabapentin, pregabalin, topiramate and valproate exhibited potent or moderate neuroprotective effects in diverse models of SE in rats...One of such combinations, levetiracetam + topiramate proved highly synergistic in two models of seizures and this particular combination significantly inhibited epileptogenesis in rats following status SE...It may be strikingly concluded that there is no correlation between neuroprotection and antiepileptogenesis. Probably, preclinically verified combinations of AEDs may be considered for an anti-epileptogenic therapy.
- |||||||||| levetiracetam / Generic mfg.
Journal: Is the anticonvulsant activity of levetiracetam dose-dependent? (Pubmed Central) - Jan 5, 2021
Probably, preclinically verified combinations of AEDs may be considered for an anti-epileptogenic therapy. Contrary to our long-term clinical impression, LEV dose increments were reasonable and improved the seizure situation in PWE, usually without additional safety hazards.
- |||||||||| Xcopri (cenobamate) / SK Biopharmaceuticals, Arvelle Therap
Journal: Cenobamate (Xcopri) for focal seizures. (Pubmed Central) - Dec 30, 2020
Communicated by Ramaswamy H. Sarma. No abstract available
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
[VIRTUAL] Safety and Efficiency of Intravenous Push versus Intravenous Piggyback with Levetiracetam and Lacosamide () - Dec 26, 2020 - Abstract #ASHP2020ASHP_5036;
Lacosamide safety outcomes were evaluated for hypotension (SBP less than 90mmHg), bradycardia (HR less than 60 BPM), and infusion-related reactions within two hours of administration. Levetiracetam safety outcomes were assessed for injection site pain and discomfort, erythema, extravasation, and intravenous line replacement leading to IV levetiracetam discontinuation.
- |||||||||| levetiracetam low dose (AGB101) / AgeneBio
[VIRTUAL] Low-dose levetiracetam versus phenytoin for early seizure prophylaxis after traumatic brain injury () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4903;
Demographic data to be collected include: age, sex, weight, Glasgow-Coma Score (GCS) on admission, best and worst GCS within 24 hours of TBI, if penetrating versus blunt TBI, and interventions performed on patients (e.g. intracranial pressure monitoring or neurosurgical intervention). Categorical data will be analyzed via Fisher’s exact test and continuous data will be analyzed via student’s t-test or Mann-Whitney U test.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Levetiracetam use after spontaneous intracerebral hemorrhage () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4899;
The primary outcome will be defined as any of the following occurring 7 days or greater after day 0 of ICH symptoms: documented clinical symptoms consistent with seizure or documented electroencephalogram (EEG) results consistent with seizure. Secondary outcomes include occurrence of adverse drug events, intensive care unit (ICU) length of stay (LOS), hospital LOS, mortality, and discharge disposition.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Evaluation of levetiracetam in patients with neurologic injury () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3912;
Secondary outcomes include duration of levetiracetam therapy, medication dosage form, development of seizures, and adverse effects associated with the use of levetiracetam. Descriptive statistics will be used in this study to analyze primary and secondary endpoints.
- |||||||||| milrinone / Generic mfg.
[VIRTUAL] Milrinone for cerebral vasospasm following aneurysmal subarachnoid hemorrhage () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3418;
A combination of intra-arterial verapamil and intravenous milrinone was started to manage CVS and maintain cardiac output...Per AHA/ASA 2012 guidelines, he was started on oral nimodipine and underwent emergent endovascular repair with aneurysmal coiling...After a 32 day length of stay, the patient was discharged to a rehabilitation facility on aspirin and simvastatin, as well as levetiracetam and lacosamide for seizure prevention...Based off of limited data, milrinone appears to be a safe intervention for CVS in patients with aSAH. Further studies are needed to establish the efficacy and safety of milrinone treatment for CVS.
- |||||||||| capecitabine / Generic mfg., cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] Capecitabine-induced leukoencephalopathy in a patient with triple-negative breast cancer () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3111;
Further neoadjuvant treatment consisted of enrollment in a clinical research study with Docetaxel 75mg/m2 once every 21 days plus study drug, NG-monomethyl-l-arginine (LNMMA) 20 mg/kg from days 1 - 5 every 21 days cycle regimen for 4 cycles...Levetiracetam (Keppra) 500 mg by mouth twice daily was initiated and the patient’s clinical condition normalized...The second mechanism involves the thymidylate synthase gene (TYMS) polymorphisms which have been associated with reversible neurotoxicity following capecitabine withdrawal. Overall, there is limited information in regards to capecitabine induced leukoencephalopathy and further studies are needed to address its mechanism and also patients at increased risk.
- |||||||||| Flagyl (metronidazole) / SLA
[VIRTUAL] Refractory seizures secondary to neurocysticercosis () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2914;
In ED, she had two more GTCS which required lorazepam for the first episode and repeat of lorazepam with an increase in propofol for the second episode...She was started on ceftriaxone and metronidazole for empiric treatment of post-partum endometritis...The patient was started on albendazole and dexamethasone...This case represents a rare status epilepticus refractory to neurocysticercosis with a patient that was in remission for ten years. It is important to consider neurocysticercosis on the differential in any patient presenting with status epilepticus.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Evaluating the impact of intravenous push levetiracetam in a community hospital emergency department () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2625;
It is important to consider neurocysticercosis on the differential in any patient presenting with status epilepticus. Conversion to an IV push strategy for levetiracetam resulted in decreased time to administration, decreased pharmacy and nursing time due to missing doses, and decreased pharmacy costs without an increase in documented adverse events.
- |||||||||| ciprofloxacin oral / Generic mfg., ceftazidime / Generic mfg.
[VIRTUAL] Ciprofloxacin-Induced Seizure () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2531;
He received ceftazidime initially for one week...Drugs that lower seizure threshold include bupropion, clozapine, varenicline, carbapenems (particularly, imipenem), lithium, meperidine, penicillin, and tramadol may interact with ciprofloxacin and increase the likelihood of seizure...Levetiracetam (Keppra) was chosen as the antiepileptic drug of choice for the patient because it has few drug interactions, fast oral absorption, and quick onset of action. This case report demonstrates that ciprofloxacin may have been a potential cause of seizure in a patient at risk who received high dose, extended duration of antibiotic treatment.
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