- |||||||||| carbamazepine / Generic mfg.
Clinical, Journal: Antiepileptic drugs and depression during pregnancy in women with epilepsy. (Pubmed Central) - Mar 2, 2021
By design it also shall collect information about therapy regimes and outcome aspects of this disease. Carbamazepine and topiramate both have established potentials for causing teratogenesis, and it is possible that replacement of carbamazepine with a less teratogenic AED, for example levetiracetam, might result in any subsequent depression that occurs in pregnancy being inappropriately attributed to the newly introduced agent.
- |||||||||| levetiracetam / Generic mfg.
Observational data, Journal: An open study of valproate in subfertile men with epilepsy. (Pubmed Central) - Mar 2, 2021
Carbamazepine and topiramate both have established potentials for causing teratogenesis, and it is possible that replacement of carbamazepine with a less teratogenic AED, for example levetiracetam, might result in any subsequent depression that occurs in pregnancy being inappropriately attributed to the newly introduced agent. Switching from valproic acid to levetiracetam or lamotrigine improved sperm counts and other sperm parameters in subfertile male patients and increased the chance of spontaneously conceiving in subfertile couples.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Review, Journal: Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention. (Pubmed Central) - Mar 2, 2021
The ASMs that yielded the most data (3 or more studies) were topiramate (TPM), followed by tiagabine (TGB), brivaracetam (BRV), and lamotrigine (LTG)...Promising results, but with data from only one or two studies, were seen with cenobamate (18-59% efficacy above placebo), lacosamide (45.1-78.7%), levetiracetam (40.1-60.3%), oxcarbazepine (58.5-81.5%), and gabapentin (50-53.8%)...This review was our attempt at filling a gap in the literature and calling for universal reporting of data specific to BTC seizure reduction in all future studies, preferably including specific reporting on nocturnal BTCS. This will help enable rational ASM selection to minimize BTC seizures and thereby decrease the risk of SUDEP.
- |||||||||| levetiracetam / Generic mfg.
Retrospective data, Review, Journal: Efficacy of levetiracetam for migraine prophylaxis: A systematic review and meta-analysis. (Pubmed Central) - Feb 26, 2021
Our study indicated that levetiracetam can significantly reduce headache frequency and severity in adults and children. Thus, oral levetiracetam can be a therapeutic option for migraine prophylaxis, especially concerning with the adverse effects or teratogenicity of other preventive treatments.
- |||||||||| humanised dinutuximab (Hu14.18K322A) / Essential Pharma
Trial completion date, Trial primary completion date, Metastases: Therapy for Children With Advanced Stage Neuroblastoma (clinicaltrials.gov) - Feb 24, 2021
P2, N=153, Active, not recruiting,
Thus, oral levetiracetam can be a therapeutic option for migraine prophylaxis, especially concerning with the adverse effects or teratogenicity of other preventive treatments. Trial completion date: Jul 2021 --> Dec 2023 | Trial primary completion date: Jan 2021 --> Dec 2021
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
[VIRTUAL] Recurrent hepatic encephalopathy: beyond infection and GI bleeding. () - Feb 23, 2021 - Abstract #BWG2021BWG_228;
During a subsequent admission for HE levetiracetam was started because of epileptic activity on EEG...In cases refractory to treatment, assessment of a portosystemic shunt is recommended. Around 60 % of patients remain free of hepatic encephalopathy three months after embolization, and 49-55 % after 1-2 years.
- |||||||||| Mekinist (trametinib) / Novartis
Clinical, Journal: Symptomatic neurocutaneous melanosis: mild clinical onset in a teenager. (Pubmed Central) - Feb 20, 2021
Along with the history of nevi, these imaging findings were concerning for NCM. The patient is being managed with levetiracetam and trametinib and shows no further neurological decline at 1-year follow-up, providing prognostic hope in this case of NCM.
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date: STING: Seizure Treatment in Glioma (clinicaltrials.gov) - Feb 18, 2021
P4, N=120, Recruiting,
Trial completion date: Aug 2020 --> Aug 2021 | Trial primary completion date: Aug 2020 --> Aug 2021 Trial completion date: Feb 2022 --> Jan 2027 | Trial primary completion date: Feb 2021 --> Jan 2025
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] DELAYED DIAGNOSIS OF CONVULSIVE SYNCOPE FROM PACEMAKER LEAD FRACTURE IN A PATIENT WITH HISTORY OF SEIZURE DISORDER (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_7560;
He also has a history of one prior seizure for which he was started on levetiracetam.Decision‐making: Initial telemetry tracing (figure 1) demonstrated normal sinus rhythm with atrial sensed and ventricular paced rhythm followed by asystole... Earlier diagnosis of lead fracture may have been achieved by more expedient interrogation, which would have shown episodes of elevated impedance readings.
- |||||||||| levetiracetam / Generic mfg., amiodarone / Generic mfg.
[VIRTUAL] THE HEART OF THE MATTER: TACHY-BRADYARRHYTHMIAS MASQUERADING AS SEIZURE DISORDER (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_6892;
Earlier diagnosis of lead fracture may have been achieved by more expedient interrogation, which would have shown episodes of elevated impedance readings. In an appropriate clinical context, tachy-bradyarrhythmias as a cause for AMS and seizures warrants consideration and evaluation.
- |||||||||| levetiracetam / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
[VIRTUAL] AUTOIMMUNE ENCEPHALITIS IN A PATIENT WITH CONCURRENT PERI-PARTUM CARDIOMYOPATHY (PPCM) (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_3601;
Further research into the potential association of anti-VGKC antibodies and development of cardiomyopathy may be warranted. Future studies clarifying treatment protocols for autoimmune encephalitis in the peripartum period would be valuable for providers.
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date: Levetiracetam (Keppra) to Improve Chronic Aphasia in Post-stroke Patients. (clinicaltrials.gov) - Feb 17, 2021
P1, N=50, Active, not recruiting,
Future studies clarifying treatment protocols for autoimmune encephalitis in the peripartum period would be valuable for providers. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
- |||||||||| Briviact (brivaracetam) / UCB
Journal: Intravenous brivaracetam for the management of refractory focal non-convulsive status epilepticus. (Pubmed Central) - Feb 17, 2021
However, limited data exist on brivaracetam's efficacy in SE. We describe a patient case with focal NCSE refractory to levetiracetam, fosphenytoin, lacosamide and valproate who demonstrated clinical and electrographic improvement on continuous electroencephalography monitoring after brivaracetam administration.
- |||||||||| levetiracetam / Generic mfg.
Journal: Operation Brain Trauma Therapy: An Exploratory Study of Levetiracetam Treatment Following Mild Traumatic Brain Injury in the Micro Pig. (Pubmed Central) - Feb 16, 2021
There were no differences in the numbers of APP+ axonal swellings within the pig thalamus with LEV treatment; however, significant alterations in the morphological properties of the APP+ axonal swellings, including reduced swelling area and increased swelling roundness, were observed. Additionally, expression of the neurite outgrowth marker, growth-associated protein 43, was reduced in axonal swellings following LEV treatment, suggesting potential effects on axonal outgrowth that warrant further investigation.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Retrospective data, Journal: Safety and Tolerability of Rapid Administration Undiluted Levetiracetam. (Pubmed Central) - Feb 9, 2021
Rapid administration of undiluted LEV doses ≤ 1000 mg were well tolerated with no concentration-related side effects. Further prospective research is needed to confirm this observation as well as the safety of higher doses.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Journal, Monotherapy: Evidence-based Anti-seizure Monotherapy in Newly Diagnosed Epilepsy: a New Approach. (Pubmed Central) - Feb 9, 2021
Lamotrigine and levetiracetam can be used as first choice for focal seizures and generalized epilepsy with GTC, suitable in all age-groups and for both men and women. Recommendations for GTC seizures have lower evidence than those for focal seizures.
- |||||||||| busulfan / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: Oral levetiracetam for prevention of busulfan-induced seizures in adult hematopoietic cell transplant. (Pubmed Central) - Feb 7, 2021
Levetiracetam was well tolerated and no serious adverse events were reported. Conclusions Our results suggest that giving levetiracetam at 1000 mg q12h p.o starting 12 h before the administration of i.v. busulfan until 48 h after the last dose, can be used as an alternative in the prevention of busulfan-induced seizures in adults.
- |||||||||| Journal: Changing Landscape of Dravet Syndrome Management: An Overview. (Pubmed Central) - Feb 7, 2021
Clobazam, valproate, levetiracetam, topiramate, zonisamide, ketogenic diet, and vagus nerve stimulation had been shown to be effective, but even with polytherapy, only 10% of patients get adequate seizure control...In recent years, the treatment paradigm of DS is changing with the approval of pharmaceutical-grade cannabidiol oil and stiripentol...Several agents targeted for DS are in the developmental stage: TAK935, lorcaserin, clemizole, huperzine analog, ataluren, selective sodium channel modulators and activators, antisense oligonucleotide therapy, and adenoviral vector therapy. As DS is associated with a high risk of sudden unexpected death in epilepsy, seizure detection devices can be used in this population for testing and clinical validation of these devices.
- |||||||||| Journal: Anti-Amyloid-β Protein agents for the treatment of Alzheimer's Disease: An update on emerging drugs. (Pubmed Central) - Feb 4, 2021
The actual results support the hypothesis that elevated Aβ represents an early stage in the AD continuum and demonstrate the feasibility of enrolling these high-risk participants in secondary prevention trials to slow cognitive decline during the AD preclinical stages. However, a series of clinical failures may question further development of Aβ-targeting drugs and the findings from current ongoing Phase III trials will hopefully give light to this critical issue.
- |||||||||| [VIRTUAL] Hyperthyroidism: A Rare Cause of Cerebral Venous Thrombosis (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1984;
Some proposed mechanisms include increased activity of pro coagulative plasma constituents including Von Willebrands Factor, Factor IX, X, antithrombin, and fibrinogen as well as an increased aPTT and a decrease in thrombolytic factors like t-PA. These changes result in an increased risk of thrombosis.
- |||||||||| desmopressin / Generic mfg., enoxaparin sodium / Generic mfg.
[VIRTUAL] Pulmonary Embolism in Adipsic DI: Can Desmopressin Be a Contributing Factor? (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1501;
All previously published cases of VTE in ADI have occurred in patients presenting with moderate to severe hypernatremia (sodium 157-181 mEq/L) and some degree of dehydration at the time of the event. Obesity and a recent hospitalization may have contributed to the development of VTE but desmopressin should also be taken into consideration due to its known effects on coagulation.
- |||||||||| lorazepam / Generic mfg.
[VIRTUAL] Unfortunate Case of Hypoglycemia Induced Seizures Resulting in Anoxic Encephalopathy (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1084;
She received Ativan and was intubated for airway protection...Patient received IV mannitol and IV dexamethasone for cerebral edema and Keppra for seizure prophylaxis, but was unable to be weaned from the ventilator and had to undergo tracheostomy and PEG tube placement, and was eventually discharged to inpatient rehabilitation...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- |||||||||| amphetamine / Generic mfg.
Preclinical, Journal: Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice. (Pubmed Central) - Jan 26, 2021
This suggests that LEV modulates the sensation of pain by controlling the expression of 5-HT and 5-HT in a tonic pain model, and that changes in the expression of 5-HT and 5-HT receptors are associated with the sensation of pain, furthermore its possibility to be used in clinical treatments for pain. Altogether, this study provides strain-related information to differentiate investigational agents from ASD standards-of-care in commonly employed preclinical discovery models and describes a novel kindled seizure model to further explore the mechanisms of drug-resistant epilepsy.
- |||||||||| carbamazepine / Generic mfg.
Journal: What has been the impact of new drug treatments on epilepsy? (Pubmed Central) - Jan 23, 2021
Although AED monotherapies require attention for SJS and TEN, some AED combinations require extra caution. Although the newer generation ASMs may not have improved the overall seizure control they have advantages in terms of drug-drug interactions and teratogenicity, and thus offer valuable individualized options in the treatment of epilepsy.
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