levetiracetam / Generic mfg. 
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  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] Suicidality as a Side Effect of Phenytoin: Case Report and Review of Literature () -  May 2, 2021 - Abstract #APA2021APA_876;    
    Psychiatrists and Neurologists need to be abreast with the current literature on AED-induced PBSEs and remain vigilant in anticipating these side effects, especially for vulnerable patients. Further research is needed to understand the underlying mechanisms of AEDs causing PBSEs which may lead to more personalized selection for patients.
  • ||||||||||  lorazepam / Generic mfg., amantadine / Generic mfg.
    [VIRTUAL] When Ativan Isn’t Up to the Challenge: A Case Report of Concurrent Catatonia and Delirium () -  May 2, 2021 - Abstract #APA2021APA_572;    
    Her hospital course was complicated by bacteremia and bilateral pulmonary emboli treated with vancomycin and anticoagulation, respectively...These findings are based on the hypothesis that NMDA hyper-excitability in striato-cortical and cortico-cortical pathways and loss of GABA-A and dopamine in these regions may represent the pathophysiology of benzodiazepine resistant catatonia (Hervey, 2012). Several case series have been published on the use of amantadine in treating primary catatonia, however this is a unique case of amantadine’s utility in medical catatonia.
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] Diagnostic Overshadowing and Barriers to Care in a Patient With Hashimoto’s Encephalitis on the Psychiatry Unit () -  May 2, 2021 - Abstract #APA2021APA_514;    
    In this poster we will discuss the case of a 38 y/o woman with no known psychiatric history and a medical history of seizure disorder, well controlled on Keppra, who was brought to the hospital for one month of altered mental status, speaking gibberish, with delusions, and agitated behavior. Her initial classification as a psychiatric patient and subsequent admission to the inpatient psychiatric unit led to a delay in diagnosis and treatment of the cause of her alteration in mental status, Hashimoto’s encephalitis.
  • ||||||||||  sertraline / Generic mfg.
    [VIRTUAL] Seizing a Complex Case: Atypical Neuropsychiatric Manifestations of an Undiagnosed Seizure Disorder () -  May 2, 2021 - Abstract #APA2021APA_344;    
    K displayed no overt signs of psychosis while on olanzapine, yet reported a history of disorganized thought and auditory hallucinations...After initiation of the antiepileptic levetiracetam, Ms...K continued to require psychiatric treatment with sertraline monotherapy for generalized anxiety disorder and major depressive disorder, which are common comorbid conditions. In this presentation, we hope to review this intriguing case, discuss some of the countless ways in which seizure disorders may mimic psychiatric disturbances, and provide recommendations for when a neurological work-up may be merited for a patient with neuropsychiatric symptomatology.
  • ||||||||||  levetiracetam / Generic mfg.
    Biomarker, Preclinical, Journal:  Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice. (Pubmed Central) -  May 1, 2021   
    The aim of the presented study was the in vitro evaluation of potential neuroprotective properties of a new pyrrolidine-2,5-dione derivatives compound C11, as well as the in vivo assessment of the impact on the neurogenesis and cognitive functions of C11 and levetiracetam (LEV) after pilocarpine (PILO)-induced SE in mice...Moreover, this beneficial effect was reflected in the Morris Water Maze test evaluating the cognitive functions in mice. The in vitro confirmed protective effect of C11 on astrocytes, as well as the in vivo demonstrated beneficial impact on neurogenesis and cognitive functions, strongly indicate the need for further advanced molecular research on this compound to determine the exact neuroprotective mechanism of action of C11.
  • ||||||||||  levetiracetam / Generic mfg., topiramate / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  GENESIS: Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas (clinicaltrials.gov) -  Apr 29, 2021   
    P4,  N=56, Recruiting, 
    Persons with AD treated with antiepileptics should be carefully monitored due to their increased risk of falling and fractures. Not yet recruiting --> Recruiting | Trial completion date: Dec 2022 --> Dec 2024 | Trial primary completion date: Sep 2022 --> Sep 2024
  • ||||||||||  levetiracetam / Generic mfg.
    Trial completion date, Trial primary completion date:  ILiAD: An Investigation of Levetiracetam in Alzheimer's Disease (clinicaltrials.gov) -  Apr 28, 2021   
    P2,  N=30, Active, not recruiting, 
    Levetiracetam may be an effective alternative to fosphenytoin in management of BRSE in children but multicentric trials with large sample size are needed to substantiate this observation. Trial completion date: Sep 2021 --> Dec 2022 | Trial primary completion date: Sep 2021 --> Dec 2022
  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo
    Clinical, PK/PD data, Journal:  Lacosamide Pharmacokinetics in a Critically Ill Patient During Continuous Renal Replacement Therapy. (Pubmed Central) -  Apr 27, 2021   
    Yet, we demonstrated that measuring serum lacosamide concentrations in the critically ill population during continuous renal replacement therapy may be useful to individualize dosing programs. Further pharmacokinetic studies of lacosamide may be necessary to generate widespread dosing recommendations.
  • ||||||||||  clozapine / Generic mfg.
    [VIRTUAL] The Usage of Clozapine in a Patient with Schizophrenia and Epilepsy: a Case Report (e-Poster Gallery) -  Apr 26, 2021 - Abstract #EPA2021EPA_2577;    
    Since then, the patient was treated with levetiracetam and the dosage of clozapine was lowered to 275mg/d. The seizures did not re-occur and clinical response to the psychiatric treatment was positive.  Conclusions This case report highlights how clozapine can be used safely and effectively for patients with TRS and epilepsy and how the epileptogenic effects can be moderated by using antiepileptics in the overall treatment scheme.
  • ||||||||||  Fycompa (perampanel) / Eisai, Catalyst Pharma
    New trial:  Post-stroke Epilepsy: Primary Prophylaxis Study (clinicaltrials.gov) -  Apr 25, 2021   
    P=N/A,  N=180, Recruiting, 
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] Phantosmiaassociated withAnti-Phospholipid Antibody Syndrome () -  Apr 25, 2021 - Abstract #AAN2021AAN_3449;    
    Treatment with anti-seizure medication (levetiracetam) resolved the olfactory aura spells. APS should be considered in the differentials for patients presenting with adult-onset seizures in the setting of SLE.
  • ||||||||||  levetiracetam / Generic mfg., isoflurane / Generic mfg.
    Biomarker, Preclinical, Review, Journal:  The holy grail of epilepsy prevention: preclinical approaches to antiepileptogenic treatments. (Pubmed Central) -  Apr 24, 2021   
    Promising agents include TrkB inhibitors, losartan, statins, isoflurane, anti-inflammatory and anti-oxidative drugs, the SV2A modulator levetiracetam, and epigenetic interventions. Research on translational target validity and on prognostic biomarkers that can be used to stratify patients (or experimental animals) at high risk of developing epilepsy will hopefully soon lead to proof-of-concept clinical trials with the most promising drugs, which will be essential to make prevention of epilepsy a reality.
  • ||||||||||  Trileptal (oxcarbazepine) / Novartis
    Review, Journal:  Epileptogenesis and oncogenesis: An antineoplastic role for antiepileptic drugs in brain tumours? (Pubmed Central) -  Apr 23, 2021   
    Therefore, a special focus will be provided on the anticancer effects of commonly prescribed AEDs (including levetiracetam, valproic acid, oxcarbazepine and others), with an overview of both preclinical and clinical data. Potential clinical applications of this finding are discussed.
  • ||||||||||  levetiracetam / Generic mfg.
    Trial completion date, Trial primary completion date:  EPICEINTE: Pharmacokinetic and Placental Transfer of Levetiracetam (clinicaltrials.gov) -  Apr 22, 2021   
    P=N/A,  N=50, Not yet recruiting, 
    Potential clinical applications of this finding are discussed. Trial completion date: Oct 2022 --> Sep 2023 | Trial primary completion date: May 2022 --> Apr 2023
  • ||||||||||  levetiracetam / Generic mfg.
    Trial completion date, Trial primary completion date:  1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients (clinicaltrials.gov) -  Apr 22, 2021   
    P4,  N=82, Active, not recruiting, 
    Trial completion date: Oct 2022 --> Sep 2023 | Trial primary completion date: May 2022 --> Apr 2023 Trial completion date: Mar 2021 --> Mar 2022 | Trial primary completion date: Mar 2021 --> Mar 2022
  • ||||||||||  levetiracetam / Generic mfg.
    Clinical, Retrospective data, Journal, Monotherapy:  Levetiracetam monotherapy in children with epilepsy: Experience from a tertiary pediatric neurology center. (Pubmed Central) -  Apr 21, 2021   
    Additional studies are necessary to determine if the association is causal or due to unmeasured confounders and/or selection bias. The present study suggests that the high retention rates, high percentage of seizure reduction, the low discontinuation rate due to adverse events and inefficacy, and the relatively benign and transient profile of adverse events make LEV preferable as monotherapy in the pediatric population.
  • ||||||||||  Fycompa (perampanel) / Eisai
    Journal:  Levetiracetam, perampanel, and the issue of aggression: A self-report study. (Pubmed Central) -  Apr 21, 2021   
    Comparing features of the behavioral negative side effects of LEV and PER revealed that LEV appears to have a negative impact on a much broader range of behaviors than PER, which specifically seems to induce aggression and irritability and no other psychiatric side effects. Further research should aim at different expression and different mechanisms of aggression and irritability underlying the superficially similar effects of the two drugs.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Delayed Recognition of Levetiracetam-induced Pancytopenia. (Pubmed Central) -  Apr 21, 2021   
    Levetiracetam was not identified as the culprit until other causes like platelet consumption, heparin-induced thrombocytopenia, idiopathic immune thrombocytopenic purpura, and bone marrow involvement by metastatic disease were ruled out. Levetiracetam can cause both acute and delayed-onset pancytopenia through bone marrow suppression.The phenomenon is normally reversible and blood counts improve with drug cessation.Clinicians should consider checking a complete blood profile within a month of drug initiation, particularly in high-risk patients.
  • ||||||||||  Briviact (brivaracetam) / UCB
    Clinical, Review, Journal:  Potential role of brivaracetam in paediatric epilepsy. (Pubmed Central) -  Apr 20, 2021   
    However, a positive response was also achieved in patients affected by encephalopathic epilepsies (e.g Jeavons' epilepsy, Dravet syndrome, Lennox Gastaut syndrome and juvenile myoclonic epilepsy), and ongoing studies are now testing BRV in order to widen its application to other forms of epilepsy and to test its effectivness when used in monotherapy. This review aims to provide a comprehensive analysis of the literature surrounding the efficacy and tolerability of BRV for paediatric patients.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Factors correlated with intracranial interictal epileptiform discharges in refractory epilepsy. (Pubmed Central) -  Apr 20, 2021   
    Identifying ways to diminish negative outcomes and worries in connection with a switch is an important future field of research in order to ensure high quality, cost-effective health care for the most vulnerable people in our societies. The current study ranks the relative influence that subject-specific factors have on IED rates and highlights the importance of considering certain factors, such as SOZ location and ASM status, when analyzing IEDs for clinical or research purposes.
  • ||||||||||  cyclophosphamide / Generic mfg., busulfan / Generic mfg.
    Enrollment change:  Busulfan and Cyclophosphamide Followed By ALLO BMT (clinicaltrials.gov) -  Apr 13, 2021   
    P=N/A,  N=5, Terminated, 
    Valproate altered bone turnover in adult patients with epilepsy, while LTG and LEV did not exert harmful effects on bone health in adult patients. N=30 --> 5
  • ||||||||||  lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
    Journal:  Treatment of Status Epilepticus: What Are the Guidelines and Are We Following Them? (Pubmed Central) -  Apr 7, 2021   
    This retrospective review demonstrates how guidelines and recommendations for SE are not consistently followed. Under dosing of AEDs and aggressive weaning of anesthetic agents may result in higher morbidity and mortality.