- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
Journal: A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration. (Pubmed Central) - Jun 22, 2021
Altogether, these assays demonstrated that the impact of BCRP on the delivery of zonisamide to the brain is lower after intranasal administration, probably due to direct nose-to-brain transport. Therefore, the intranasal administration of AEDs may be a relevant strategy to avoid the impact of efflux transporters at the BBB and the development of drug resistance.
- |||||||||| carbamazepine / Generic mfg.
Journal: HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring. (Pubmed Central) - Jun 22, 2021
Statistically significant correlations were observed (p < 0.05) for carbamazepine (r = 0.6887; r = 0.8299), carbamazepine-10,11-epoxide (r = 0.8633; r = 0.9291), S-licarbazepine (r = 0.5266; r = 0.7257) and levetiracetam (r = 0.7103; r = 0.8428). Our data support that this method can be used in TDM of AEDs using human saliva samples, constituting a new approach to establish individual therapeutic ranges and assess patient's adherence to treatment.
- |||||||||| Clinical, Review, Journal: Prescription patterns of antiseizure drugs in Tuberous sclerosis complex (TSC)-associated epilepsy: a multicenter cohort study from Germany and review of the literature. (Pubmed Central) - Jun 22, 2021
We evaluated the pattern of routine ASD use and everolimus prescriptions based on a 2019 multicenter survey of 268 individuals with TSC-associated epilepsy...In this German sample, the majority of patients were treated with polytherapy, and lamotrigine (34.7%), valproate (32.8%), oxcarbazepine (28.7%), vigabatrin (19.0%), and levetiracetam (17.9%) were identified as the most-commonly used ASDs...The selection of ASDs for patients with TSC-associated epilepsy follows well-evaluated recommendations, including the guidelines regarding vigabatrin use in children. Several characteristics, such as the comparatively high frequency of valproate use and polytherapy, reflect the severity of TSC-associated epilepsy.
- |||||||||| levetiracetam / Generic mfg.
Review, Journal: Treatment of epilepsy for people with Alzheimer's disease. (Pubmed Central) - Jun 22, 2021
Regarding efficacy and tolerability, no significant differences were found between levetiracetam, phenobarbital and lamotrigine. Large RCTs with a double-blind, parallel-group design are required to determine the efficacy and tolerability of treatment for epilepsy in people with Alzheimer's disease.
- |||||||||| levetiracetam / Generic mfg.
Observational data, PK/PD data, Journal: The Pharmacokinetics of Crushed Levetiracetam Tablets Administered to Neonates. (Pubmed Central) - Jun 22, 2021
No pharmacokinetic differences were observed between oral vs. naso-/orogastric administration. Crushed levetiracetam tablets can be considered for neonates in low-resource settings where intravenous and syrup access is limited.
- |||||||||| levetiracetam / Generic mfg.
Journal: Levetiracetam-associated irritability and potential role of vitamin B6 use in veterans with epilepsy. (Pubmed Central) - Jun 22, 2021
This project suggests that vitamin B6 supplementation may have a role in mitigating levetiracetam-associated irritability in a male Veteran population. These results support future prospective controlled studies to assess further the efficacy of this approach and characteristics associated with successful treatment in veterans.
- |||||||||| dexamethasone / Generic mfg., midazolam hydrochloride / Generic mfg.
An Awake Craniotomy At 4 P.m.! What A Way To End The Day! (Mezzanine 16AB) - Jun 20, 2021 - Abstract #ASA2021ASA_1630;
Remifentanil and propofol infusions are started at 0.03 mcg/kg/min and 50 mcg/kg/min respectively...Antibiotics and dexamethasone are administered prior to surgical incision...The patient reestablishes spontaneous ventilation, the Mayfield head clamp is removed, and the surgical incision dressed and wrapped. She is then transported to the neurosurgical intensive care unit without further incident.
- |||||||||| dexamethasone / Generic mfg., midazolam hydrochloride / Generic mfg.
An Awake Craniotomy At 4 P.m.! What A Way To End The Day! (Mezzanine 16AB) - Jun 20, 2021 - Abstract #ASA2021ASA_937;
Remifentanil and propofol infusions are started at 0.03 mcg/kg/min and 50 mcg/kg/min respectively...Antibiotics and dexamethasone are administered prior to surgical incision...The patient reestablishes spontaneous ventilation, the Mayfield head clamp is removed, and the surgical incision dressed and wrapped. She is then transported to the neurosurgical intensive care unit without further incident.
- |||||||||| phenytoin / Generic mfg., levetiracetam / Generic mfg.
Review, Journal: A Comparison of Seizure Prophylaxis: Phenytoin Versus Levetiracetam. (Pubmed Central) - Jun 16, 2021
After analysis of past research, the more advantageous AED still remains unclear. Future research must be conducted that involve large patient populations, stratifying age populations, and studies analyzing cost-effectiveness to clearly determine if there is indeed a more advantageous AED between levetiracetam and phenytoin.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] ICTAL APHASIA VERSUS EPILEPTIC APHASIA () - Jun 14, 2021 - Abstract #CSCTRMWAFMR2021CSCTR-MWAFMR_86;
Seizures were controlled with levetiracetam until she presented with aphasia...Autoimmune encephalitis resulted in epileptic aphasia in Patient-2. This is interesting since LandauKleffner syndrome, a well-known epileptic aphasia syndrome in childhood, appears to be a form of autoimmune encephalitis.
- |||||||||| levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
Clinical, Review, Journal: Pharmacotherapy for Pediatric Convulsive Status Epilepticus. (Pubmed Central) - Jun 10, 2021
Ultimately, etiological workup and related treatment of CSE, including broad spectrum immunotherapies as clinically indicated, is crucial. A potential therapeutic approach for future studies may entail consideration of interventions that may accelerate diagnosis and treatment of SE, as well as rational and early polytherapy based on synergism between ASMs by utilizing medications targeting different mechanisms of epileptogenesis and epileptogenicity.
- |||||||||| Fycompa (perampanel) / Eisai, Briviact (brivaracetam) / UCB, lamotrigine liquid oral suspension / OWP Pharma
Clinical, Review, Journal: Pharmacological Management of the Genetic Generalised Epilepsies in Adolescents and Adults. (Pubmed Central) - Jun 10, 2021
The mechanisms underlying genetic generalised epilepsies, including genetic abnormalities, are unclear at present. As the pathophysiology is unravelled, this may lead to the development of novel therapies and improved outcomes for patients with these syndromes.
- |||||||||| levetiracetam / Generic mfg., oxcarbazepine / Generic mfg.
Journal: Different experiences of two PRRT2-associated self-limited familial infantile epilepsy. (Pubmed Central) - Jun 9, 2021
Oxcarbazepine, which plays the mechanism of the sodium channel blockers, has a more significant effect than levetiracetam, which has no mechanism of the sodium channel blockers in self-limited familial infantile epilepsy. The PRRT2 gene of infantile epileptic patients with a family history of infantile convulsions or paroxysmal kinesigenic dyskinesia(PKD) could be detected by sanger sequencing and a biomarker to select antiepileptic drugs which play the mechanism of the sodium channel blockers could be utilized.
- |||||||||| Nexavar (sorafenib) / Bayer, Amgen
Journal, Adverse events: Adverse Events in Twitter-Development of a Benchmark Reference Dataset: Results from IMI WEB-RADR. (Pubmed Central) - Jun 8, 2021
The PRRT2 gene of infantile epileptic patients with a family history of infantile convulsions or paroxysmal kinesigenic dyskinesia(PKD) could be detected by sanger sequencing and a biomarker to select antiepileptic drugs which play the mechanism of the sodium channel blockers could be utilized. A manually curated benchmark reference dataset based on Twitter data has been created and is made available to the research community to evaluate the performance of automated methods and systems for adverse event recognition in unstructured free-text information.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Review, Journal: Levetiracetam and Suicidality: A Case Report and Literature Review. (Pubmed Central) - Jun 8, 2021
The risk of suicidality should be balanced with the risk of uncontrolled seizures. Specifically, in the case of levetiracetam, it is important to be aware of the subgroup of individuals with prior severe psychiatric illness, a history of traumatic brain injury, or a history of substance use disorder who might be at an increased risk of developing suicide-related behavior and suicidal ideations once levetiracetam is started.
- |||||||||| Avastin (bevacizumab) / Roche
Journal: Glioblastoma (Pubmed Central) - Jun 8, 2021
In this chapter, I describe the overview of the multidisciplinary treatments of glioblastoma. I also describe the future perspectives.
- |||||||||| levetiracetam / Generic mfg.
Journal: Event-related potential (P300): the effects of levetiracetam in cognitive performance. (Pubmed Central) - Jun 1, 2021
Our study observed the ERP component-P300-through the variation of its amplitude and latency to evaluate a supposed higher CNS efficiency when participants were under the LEV effect. Our findings sustain this premise, mainly due to reducing in P300 latency for the LEV condition, supporting the neural efficiency hypothesis.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
[VIRTUAL] Ictal visual hallucinations as a manifestation of hyperglycaemia (Room Istanbul) - May 30, 2021 - Abstract #EAN2021EAN_2168;
Hiperglycaemic states are sufficient conditions for development of acute symptomatic occipital seizures and typical MRI changes. During the period of uncontrolled glycaemia, visual phenomena can change over time, be refractory to antiepileptic drugs, and revert with correction of the metabolic insult.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
[VIRTUAL] Paroxysmal dystonia: a vascular event or epileptic seizure (Raum2) - May 30, 2021 - Abstract #EAN2021EAN_2103;
We present a case of posterior circulation stroke in combination with arm dystonia and cephalic rotation, an interesting phenomenology with a challenging aetiological diagnosis. Despite the potential of thalamic hypoperfusion causing dystonia, both semiology and MRI changes suggest that it was probably a result of an acute symptomatic seizure originated in the hippocampus, in the context of an ischaemic stroke.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Cerebral venous thrombosis due to overdrainage in a patient with normal pressure hydrocephalus (Room Berlin) - May 30, 2021 - Abstract #EAN2021EAN_1908;
CT cerebral venography revealed middle and posterior third superior sagittal sinus, torcula, right transverse sinus and right sigmoid thrombosis and he was started on low molecular weight heparin and levetiracetam... The temporal association between pressure adjustment and symptoms onset and the evidence of progressive subdural effusions suggest that the decrease of CSF volume by overdrainage leaded to an increase in cerebral blood volume and dilatation of venous sinus, which precipitated thrombus formation.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Generalized epilepsy in a patient with GBJ1 X-linked Charcot-Marie-Tooth disease (Room Seville) - May 30, 2021 - Abstract #EAN2021EAN_1554;
This report describes a now 31-year-old male with X-Linked Charcot Marie Tooth disease associated with generalized seizures. Genetic studies reported for the first time in our knowledge, a GJB1 mutation in a patient with this unusual association, confirming the diagnosis.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Religious prayers as a manifestation of Temporal Lobe Epilepsy – a case report (Room Seville) - May 30, 2021 - Abstract #EAN2021EAN_1552;
Admitting a possible focal status epilepticus, the patient was treated with a levetiracetam perfusion, reversing speech deficits... We describe a rare presentation of temporal lobe epilepsy, characterized by brain imaging and electroencephalographic findings on the left cerebral hemisphere, contrasting to the previously reported cases in the literature, where the right temporal and frontal lobes emerge as the centers for religiosity.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Usher syndrome type II and epilepsy, coincidence? (Room Seville) - May 30, 2021 - Abstract #EAN2021EAN_1549;
Usher syndrome is a rare disease without a clear known association with epilepsy. Despite the likely coincidence, this case aims to alert to the possible association, based on the fact that the causal gene for Usher syndrome type IIC is also found in patients with familial febrile seizures.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg., oxcarbazepine / Generic mfg.
[VIRTUAL] Differential diagnosis of seizures in Klinefelter’s syndrome (Room Seville) - May 30, 2021 - Abstract #EAN2021EAN_1541;
In our case, Kariotype and VEEG allowed successful diagnosis and treatment. We should be aware that focal signs of onset as well as MRI images, could induce misdiagnose and pharmacoresistance in GE.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg.
[VIRTUAL] The effectiveness of monotherapy in juvenile myoclonic epilepsy (Room Seville) - May 30, 2021 - Abstract #EAN2021EAN_1534;
Valproates are more effective in JME treatment than topiramate or levetiracetam. The prognosis for JME in the presence of three types of seizures (myoclonus, GTCS, absences) is worse than in the presence of one or two types.
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