levetiracetam / Generic mfg. 
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 185 Diseases   81 Trials   81 Trials   6476 News 


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  • ||||||||||  levetiracetam / Generic mfg.
    Effect of Time After Dose on Therapeutic Drug Monitoring During Pregnancy (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1111;    
    This leads to particularities for both convenience and trough sampling during TDM for pregnancy. Increased variability in convenience sampling without considering TAD can conceal concentration changes, while sampling at consistent times, such as trough sampling, cannot differentiate whether a concentration change is due to changes in clearance or volume of distribution.
  • ||||||||||  Different Cerebral Lesions with Generalized 3 Hz Spike-waves: Three Case Reports and Literature Review (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1080;    
    She received a diagnosis of epilepsy and was prescribed oxcarbazepine for treatment...Her medication was switched to levetiracetam. There may be clinical heterogeneity in the EEG pattern of generalized SW, and attention should be paid to whether there is a focal origin.The frontal and parietal lobe may be involved in the process of 3HZ SW formation
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Characterizing the SLC6A1 Phenotypic Spectrum Using a Digital Natural History Database (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1021;    
    The phenotypic spectrum consisted of generalized epilepsy, autism, developmental delay, intellectual disability and developmental regression, in concordance with previously described clinical features of this disorder. Our findings support the use of de-identified digital data registries for delineating phenotypic spectrum of rare diseases.
  • ||||||||||  deferiprone / Generic mfg., levetiracetam / Generic mfg.
    Biomarkers of Moderate/severe Traumatic Brain Injury in a Preclinical Model: Brain or Peripheral? (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_974;    
    We selected levetiracetam (LEV), used for prophylactic seizure control, and deferiprone (DEF), which is used in the management of hemorrhagic pathologies. Sprague-Dawley rats underwent craniotomy only (Sham, n=16) or left LFPI (n=60) at 3 sites (Einstein, Monash, UCLA); 11 na
  • ||||||||||  metformin / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  Metformin Efficacy and Safety in Epileptic Patients (clinicaltrials.gov) -  Nov 25, 2024   
    P3,  N=60, Completed, 
    Our patient's presentation mimicked autoimmune encephalitis, but rapid WES revealed a genetic syndrome. Recruiting --> Completed | Trial completion date: Oct 2023 --> Jun 2024 | Trial primary completion date: Oct 2023 --> Jun 2024
  • ||||||||||  Review, Journal:  Anti-epileptic Drugs Use and Increased Risk of Stroke: A Systematic Review. (Pubmed Central) -  Nov 17, 2024   
    We conclude significant stroke risk with AEDs (mainly enzyme inducers), and dose dependency need to be assessed. The risks and benefits of AEDs should be weighed among the patients, especially with vascular risk factors to limit the risk of ischemic stroke.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Beyond Seizures: the enigma of cardioinhibitory malignant vasovagal syncope in a complicated pregnancy journey. (Pubmed Central) -  Nov 14, 2024   
    4 years later, the patient remains asymptomatic. This case emphasises the importance of conducting a thorough differential diagnosis in patients with atypical seizure presentations, the multidisciplinary approach required to assure optimal outcomes in cardio-obstetric cases and the role of selective pacemaker placement in patients with documented prolonged ventricular asystole associated with CMVS.
  • ||||||||||  Review, Journal:  Advances in serum thyroid hormone levels and seizures. (Pubmed Central) -  Nov 13, 2024   
    However, the new ASMs, such as levetiracetam, have no effect on thyroid hormone levels...However, the precise mechanism underlying the interaction between serum thyroid hormone levels and seizures remains unclear. This review aims to explore the relationship between thyroid hormone levels and seizures, along with the underlying mechanisms.
  • ||||||||||  levetiracetam / Generic mfg.
    Review, Journal:  3D printed dosage forms, where are we headed? (Pubmed Central) -  Nov 13, 2024   
    Almost 8 years after the first USFDA approval of the 3D printed tablet Levetiracetam (Spritam), the interest in 3DP for drug products is high...3DP offers significant advantages in rapid prototyping for drug products, which could be beneficial for personalizing patient-based pharmaceutical dispensing. It seems inevitable that the coming decades will be marked by exponential growth in personalization, and 3DP could be a paradigm-shifting asset for pharmaceutical professionals.
  • ||||||||||  Rituxan (rituximab) / Roche
    Acute confusion, reduced conscious levels and stroke in systemic lupus erythematosus resulting from cerebral vasculitis () -  Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_34;    
    Within only a few weeks of starting treatment, the patient made a significant neurological recovery. Her cognitive function including both short and long-term memory was persevered and physically she has rehabilitated well in spite of extensive areas of infarction on cerebral imaging.Importantly this case underscores that in acute life or organ threatening presentations prompt definitive treatment is warranted when there is strong evidence of an underlying active inflammatory process even in the absence of conclusive diagnostic certainty of the underlying aetiology.Key learning points:
  • ||||||||||  carbamazepine / Generic mfg.
    Review, Journal:  Carbamazepine-induced Stevens-Johnson Syndrome: A Case Report with Review of the Literature. (Pubmed Central) -  Nov 7, 2024   
    This report adds to the scientific literature by highlighting the potential dangers associated with anticonvulsant therapies and the necessity for personalized medicine approaches in preventing life-threatening conditions. The main takeaway is the pivotal role of genetic screening and vigilant monitoring in the management of patients requiring anticonvulsant medications to prevent serious adverse reactions.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma, Yescarta (axicabtagene ciloleucel) / Gilead
    Journal:  Tocilizumab Prophylaxis Following Axicabtagene Ciloleucel in Relapsed or Refractory Large B-cell Lymphoma. (Pubmed Central) -  Nov 6, 2024   
    We additionally provided expert guidance on their use in clinical situations. Based on these findings, prophylactic tocilizumab is not recommended to prevent CAR T-cell-related adverse events, and beneficial effects of prophylactic levetiracetam remain uncertain in patients with R/R LBCL.
  • ||||||||||  levetiracetam / Generic mfg., rocuronium / Generic mfg.
    Journal:  Delayed Rocuronium Onset in a Patient Taking Levetiracetam for Epilepsy: A Case Report. (Pubmed Central) -  Nov 6, 2024   
    However, it took more than 9 minutes to finally obtain a TOF count of 0. This case report highlights that patients with intractable epilepsy taking levetiracetam may have resistance to rocuronium and should be carefully monitored to avoid harm triggered by prematurely initiated intubation maneuvers.
  • ||||||||||  Standardization Protocol to Mitigate Progression of Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) in Elderly Patients Treated with CD28 Co-Stimulatory Anti-CD19 CAR-T Cells  (Halls G-H (San Diego Convention Center)) -  Nov 6, 2024 - Abstract #ASH2024ASH_3809;    
    Concomitant dexamethasone was added to tocilizumab when administered for CRS...Results Between 04/2023 and 06/2024, 32 patients treated were eligible (axicabtagene ciloleucel for LBCL, n=24; brexucabtagene autoleucel for MCL, n=7 and for B-ALL, n=1)...Mean cumulative steroid dose (by dexamethasone equivalent) was 368 (IQR 25-647) mg, and 28% required treatment with anakinra...Previously reported risk factors for neurotoxicity which are commonly considered when evaluating older patients as candidates for CAR-T, were not discriminatory. If reproduced in a larger cohort, these findings suggests that risk for ICANS in older adults can be ameliorated using an individualized assessment and treatment strategy.
  • ||||||||||  levetiracetam / Generic mfg.
    Utilization of Investigations for Neurotoxicity in CD19 and BCMA CART Recipients (Room 6B (San Diego Convention Center)) -  Nov 6, 2024 - Abstract #ASH2024ASH_1845;    
    All patients received levetiracetam for ICANS prophylaxis from Day 0-30...Brain MRI identified the highest yield of abnormal findings, with 9% exhibiting abnormalities, including alternate explanations for altered mental status. These results demonstrate a low utility of LP and EEG, which suggests that these tests may be reserved for higher grade or persistent ICANS
  • ||||||||||  levetiracetam / Generic mfg.
    Retrospective data, Journal:  Clinical characteristics and genetic analysis of mental retardation disorder with TRIO gene variant (Pubmed Central) -  Nov 5, 2024   
    The child with myoclonic seizures was treated with valproic acid and levetiracetam for seizure control, while the child with absence epilepsy was treated with valproic acid and lamotrigine for seizure control...R1078W may be a relative hotspot variant. The phenotype caused by the frameshift variant is relatively milder.
  • ||||||||||  levetiracetam / Generic mfg.
    Retrospective data, Journal:  Clinical characteristics of children with MT-TK gene m.8344A>G variation (Pubmed Central) -  Nov 5, 2024   
    Children with higher ratio of the m.8344A>G variant are more likely to present LS phenotype. Myoclonus, primarily focal, is a key feature, with levetiracetam as the first-line treatment and benzodiazepines recommended for refractory cases.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Recurrent Falls as the Only Clinical Sign of Cortical-Subcortical Myoclonus: A Case Report. (Pubmed Central) -  Nov 1, 2024   
    Antiseizure treatment with levetiracetam was started, with rapid clinical and electroencephalographic improvement...Furthermore, it highlights that lower limb myoclonus of cortical-subcortical origin may be an underestimate cause of gait disturbances and postural instability. Then, it may be reasonable to include the EEG in the diagnostic work-up of patients with recurrent falls.