- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Post-traumatic Seizures in Children with Abusive Head Trauma () - Sep 10, 2021 - Abstract #NCS2021NCS_439;
Although levetiracetam was most commonly used, monotherapy with the same was ineffective in >50%...While most PTS were clinical and occurred early, cEEG monitoring was essential in detection and treatment of subclinical seizures. Overall, PTS had a good survival rate and outcomes.
- |||||||||| levetiracetam / Generic mfg.
Evaluation of levetiracetam dosing for seizure prophylaxis in traumatic brain injury () - Sep 10, 2021 - Abstract #NCS2021NCS_403;
Although levetiracetam is frequently used for this indication, it is not currently recommended in the Brain Trauma Foundation guidelines over phenytoin due to insufficient evidence...Our study evaluated the incidence of seizure within seven days of TBI when utilizing low-dose levetiracetam (500 mg twice daily), compared to high-dose levetiracetam (greater than 500 mg twice daily)...Conclusions There were no statistically significant differences in seizure rates when comparing low-dose to high-dose levetiracetam. Levetiracetam 500 mg twice daily may be as effective as levetiracetam doses greater than 500 mg twice daily for early onset post-traumatic seizure prophylaxis.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
Thymoma Associated with Autoimmune Encephalitis and Subsequent Myasthenia Gravis. () - Sep 10, 2021 - Abstract #NCS2021NCS_286;
Conclusions Thymoma associated paraneoplastic syndromes of multifocal cortical encephalitis and subsequent myasthenia gravis may present in one person. Thymectomy and aggressive immunotherapy are required to achieve clinical improvement.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Rapid Brain Death Caused by Brain Abscess Associated with Over-the-Counter Sinus Irrigation () - Sep 10, 2021 - Abstract #NCS2021NCS_268;
After another witnessed seizure, he was intubated and loaded with Levetiracetam...Conclusions In the absence of other risk factors, it is possible that aggressive irrigation of colonized sinus mucosa might lead to spreading of infection. Further data is required to establish if neti pots are truly a risk factor for brain abscesses.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
[VIRTUAL] Insidious Presentation Of Brain Abscess: The Proof Is In The Pudding () - Sep 10, 2021 - Abstract #NCS2021NCS_250;
Repeated testing demonstrated a significant variation in infectious findings of CSF from alternate areas of sample. This emphasizes the significance of compromised CSF flow dynamics in the setting of brain abscess and ventriculitis.
- |||||||||| ketamine / Generic mfg.
Covid-19 Associated New-onset Refractory Status Epilepticus (NORSE): A Case Report () - Sep 10, 2021 - Abstract #NCS2021NCS_237;
Anti-epileptic drugs were escalated to lacosamide, phenytoin, midazolam infusion, propofol, and eventually ketamine and pentobarbital infusion...Patient was treated with 5 days of solumedrol and IVIG...Conclusions COVID-19 is thought to enter the central nervous system through the olfactory bulb, which may result in neurological manifestations including NORSE. Although our patient developed subarachnoid hemorrhage, possibly from anticoagulation, the refractory nature of his seizures appear to be out of proportion to the extent of subarachnoid hemorrhage demonstrated on neuroimaging, leading us to conclude that NORSE occurred due to COVID-19 infection.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
Giant Enigma: A Case Report of Post-infantile Giant Cell Hepatitis Presenting With Seizures (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_3011;
Once transferred, the vEEG revealed seizures, which were controlled with levetiracetam and phenytoin, and the patient was successfully extubated...High-dose methylprednisolone, mycophenolate mofetil, and lacosamide were started, leading to resolution of the patient’s transaminitis, seizures, and return to normal mental status...This presentation of seizures and altered mental status has been a rare complication of autoimmune hepatitis, but has not been documented in those with PIGCH. The resolution of symptoms and transaminitis once corticosteroids were introduced shows that higher dose steroids may be necessary for treatment.
- |||||||||| Acute Hepatitis B Infection Presenting as Hepatic Encephalopathy Induced Seizure (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_592;
Initial bloodwork revealed ALT 1040 U/L, AST 1005 U/L, ALP 172 U/L, total bilirubin 14.6 mg/dL, acetaminophen level < 7 ug/dL, and an ammonia level of 76 μmol/L in labs drawn prior to seizure event...Patient began tenofovir and levetiracetam with outpatient gastroenterology and neurology follow up...Once acute hepatitis B infection was found to be the cause of the neurological dysfunction, we were able to treat her appropriately with lactulose and subsequently tenofovir. In conclusion, hepatobiliary pathology must be considered in patients who present with altered mental status and seizure or the etiology may be missed, resulting in poor patient outcome.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Retrospective data, Review, Journal: A systematic review and meta-analysis of antiepileptic prophylaxis in spontaneous intracerebral hemorrhage. (Pubmed Central) - Sep 8, 2021
We searched key databases using combinations of the following terms: "levetiracetam," "prophylaxis," "ICH," "intracerebral hemorrhage," "intraparenchymal hemorrhage." Selected studies were reviewed for level of evidence and overall quality of data using Grading of Recommendations, Assessment, Development and Evaluations criteria...However, there are some important caveats including a possible confounding association between AED use and higher ICH score, as well as the overall poor quality of the available data. A randomized clinical trial may be helpful.
- |||||||||| levetiracetam / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: 1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients (clinicaltrials.gov) - Sep 2, 2021
P4, N=82, Completed,
Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022 Active, not recruiting --> Completed | Trial completion date: Mar 2022 --> Oct 2020 | Trial primary completion date: Mar 2022 --> Oct 2020
- |||||||||| gaboxadol (OV101) / Ovid Therapeutics, Angelini Group
Review, Journal: Epilepsy in Angelman syndrome: A scoping review. (Pubmed Central) - Sep 2, 2021
However, due to the unfavorable side effect profile of these AEDs, a recent treatment approach involves priority use of levetiracetam, clobazam, topiramate, lamotrigine, ethosuximide, VNS, and carbohydrate-restricted diets...Activation of the intact but silent paternal copy of UBE3A (antisense oligonucleotide therapy and artificial transcription factors); and 3. Downstream therapies (OV101/gaboxadol, ketone supplement, novel compounds/peptides, anti-inflammatory/regenerative therapy).
- |||||||||| levetiracetam / Generic mfg.
Clinical, Retrospective data, Journal: Callosal Diffusion-Restriction in Patients with Intracranial Hemorrhage. (Pubmed Central) - Sep 1, 2021
Although rare, diffusion restricting corpus callosum lesions can be seen in patients with ICH, especially in patients with IVH. The etiology and clinical significance of these lesions remains unknown and warrant further research.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Levetiracetam Therapeutic Drug Monitoring in a Large Cohort of Korean Epileptic Patients. (Pubmed Central) - Aug 29, 2021
In this large-scale clinical study, a large inter-individual difference in levetiracetam pharmacokinetics was observed, and levetiracetam concentrations were influenced by EIAEDs. For individual dose adjustments and monitoring compliance, routine levetiracetam TDM is needed in epilepsy patients.
- |||||||||| sodium valproate / Generic mfg., lorazepam / Generic mfg.
Retrospective data, Review, Journal: Intravenous Sodium Valproate in Status Epilepticus: Review and Meta-analysis. (Pubmed Central) - Aug 28, 2021
The combination of Lorazepam (LZP) with VPA and the combination of LZP with Levetiracetam presented no difference in efficacy [24h-efficacy: FE-OR =0.68, 95%CI=(0.37,1.24)]. Although, additional high-quality RCTs are warranted, according to our results, VPA can be considered a safe and effective option in the management of SE.
- |||||||||| levetiracetam / Generic mfg.
Clinical, PK/PD data, Journal: Levetiracetam pharmacokinetics in critically ill patients undergoing renal replacement therapy. (Pubmed Central) - Aug 25, 2021
Levetiracetam clearance was substantial with both modalities under the operating conditions reported. There is the potential for subtherapeutic concentrations with current recommended dosing strategies that account only for kidney function and not these extracorporeal routes of elimination.
- |||||||||| levetiracetam / Generic mfg.
Journal: L2HGDH Missense Variant in a Cat with L-2-Hydroxyglutaric Aciduria. (Pubmed Central) - Aug 25, 2021
The cat was treated with the anticonvulsants levetiracetam and phenobarbitone and has been seizure-free for 16 months...The identified homozygous variant, XM_023255678.1:c.1301A>G, is predicted to result in an amino acid change in the L2HGDH protein, XP_023111446.1:p.His434Arg. The available clinical and biochemical data together with current knowledge about L2HGDH variants and their functional impact in humans and dogs allow us to classify the p.His434Arg variant as a causative variant for the observed neurological signs in this cat.
- |||||||||| carbamazepine / Generic mfg.
Clinical, Journal: Patterns of antiepileptic drug use among elderly patients with epilepsy: 2004-2015. (Pubmed Central) - Aug 20, 2021
However, potentially harmful AEDs (e.g. phenytoin, carbamazepine, phenobarbital, primidone and valproate) were still being prescribed to 42.9 % of all patients between 2013-2015. Increased work to educate providers regarding the use of more appropriate AEDs in this population is needed.
- |||||||||| Briviact (brivaracetam) / UCB
Clinical, Journal: An update on brivaracetam for the treatment of pediatric partial epilepsy. (Pubmed Central) - Aug 19, 2021
However, a positive response was also achieved in patients affected by some encephalopathic epilepsies. Comparative efficacy studies between BRV and other ASMs, in addition to well-designed RCTs that include larger pediatric populations are needed to better define the role and potentiality of this ASM.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma
Trial completion date, Trial primary completion date: Effect of Perampanel on Peritumoral Hyperexcitability in HGG (clinicaltrials.gov) - Aug 18, 2021
P1/2, N=20, Recruiting,
Comparative efficacy studies between BRV and other ASMs, in addition to well-designed RCTs that include larger pediatric populations are needed to better define the role and potentiality of this ASM. Trial completion date: Jul 2022 --> Mar 2023 | Trial primary completion date: Aug 2021 --> Mar 2023
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date: R33: Levetiracetam in Early Psychosis (clinicaltrials.gov) - Aug 18, 2021
P2, N=84, Recruiting,
Trial completion date: Jul 2022 --> Mar 2023 | Trial primary completion date: Aug 2021 --> Mar 2023 Trial completion date: Sep 2022 --> Jan 2023 | Trial primary completion date: Sep 2022 --> Jan 2023
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date: Levetiracetam in Early Psychosis (clinicaltrials.gov) - Aug 18, 2021
P2, N=32, Recruiting,
Trial completion date: Sep 2022 --> Jan 2023 | Trial primary completion date: Sep 2022 --> Jan 2023 Trial completion date: Dec 2020 --> Mar 2022 | Trial primary completion date: Dec 2020 --> Mar 2022
- |||||||||| Journal: Provision of Sedation and Treatment of Seizures During Neonatal Therapeutic Hypothermia. (Pubmed Central) - Aug 18, 2021
Dexmedetomidine represents an interesting alternative, with preclinical data suggesting direct efficacy against shivering during induced hypothermia and neuroprotection in the setting of HIE...Traditional therapies, including phenobarbital, fosphenytoin, and benzodiazepines, control seizures in the vast majority of neonates...Unfortunately, levetiracetam is inferior to phenobarbital as first-line therapy for neonatal seizures. Considering both the benefits and risks of traditional anticonvulsant agents, treatment should be limited to the shortest duration indicated, with maintenance therapy reserved for neonates at high risk for recurrent seizures.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal, HEOR: Quality of Life and Stigma among Women with Epilepsy during Their Reproductive Years. (Pubmed Central) - Aug 17, 2021
Being uneducated, married, unemployed, having children, having generalized tonic-clonic seizures, duration of illness (>10 years), and consuming levetiracetam, anti-epileptic drug (AED), were the significant contributing factors for low quality of life among women with epilepsy during the reproductive age group...The study assessed the relationship between the quality of life and the Stigma scale of epilepsy and demonstrated the impact of stigma and quality of life on socio-demographic and clinical variables of women with epilepsy under the reproductive age group. To enhance the quality of life and reduce the stigma levels among women with epilepsy, some of the modifiable parameters can be considered by the multidisciplinary health care professionals from the findings of the current research.
- |||||||||| trazodone ER / Generic mfg., lorazepam / Generic mfg.
Clinical, Journal: Benzodiazepine Withdrawal Catatonia, Delirium, and Seizures in a Patient With Schizoaffective Disorder. (Pubmed Central) - Aug 15, 2021
He was taking olanzapine, venlafaxine, and trazodone for schizoaffective disorder...Seizures stopped with levetiracetam, lacosamide, and propofol on day 4...As with prior observations, the patient's catatonia was more sensitive to benzodiazepine withdrawal and treatment than his seizures. The efficacy of benzodiazepines in aborting catatonia, seizures, and mixed delirium-catatonia syndromes suggests a key pathogenetic role of abnormal GABA neurotransmission in these brain disorders.
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