- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Hypertonic Pseudohyponatremia with Seizures: A Treatment Dilemma () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_3744;
She received levetiracetam on the way to the hospital where she was unconscious and volume depleted...We propose that pOsm should guide the correction rate rather than pNa or pGL and only saline may be used initially to avoid rapid correction and OD. The mortality may be due to rapid correction.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Focal Segmental Glomerulosclerosis: A Rare Cause of Nephrotic Syndrome in Graft vs. Host Disease () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_2516;
Home medications were lisinopril 20mg daily, levetiracetam 500mg twice daily and prednisone 10mg daily...Partial remission of NS was achieved at 3 months of treatment with mycophenolate mofetil 500mg twice daily and prednisone 15mg twice daily...FSGS is an extremely rare complication of HCT and very few cases have been reported in the literature linking FSGS to HCT. Further documentation of this phenomenon is important to further characterize the clinical and pathological features of this complication.
- |||||||||| zonisamide / Generic mfg., levetiracetam / Generic mfg.
Clinical, P4 data, Journal, HEOR, Head-to-Head: The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. (Pubmed Central) - Oct 16, 2021
P4
These findings do not support the use of levetiracetam or zonisamide as first-line treatments for patients with focal epilepsy. Lamotrigine should remain a first-line treatment for patients with focal epilepsy and should be the standard treatment in future trials.
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg., oxcarbazepine / Generic mfg.
Clinical, Journal: Influence of Different Antiepileptic Drugs on Blood Ammonia and Homocysteine Levels in Children with Epilepsy. (Pubmed Central) - Oct 15, 2021
However, compared with sodium valproate, levetiracetam and oxcarbazepine have a lower incidence of adverse drug reactions and do not cause an increase in blood ammonia and Hcy levels, so they have higher safety of drug treatment. In addition, compared with sodium valproate, levetiracetam and oxcarbazepine have better recovery of cognitive function in children with epilepsy and so they have better application value.
- |||||||||| acetazolamide / Generic mfg., levetiracetam / Generic mfg., topiramate / Generic mfg.
Clinical, Journal: CACNA1A-associated epilepsy: Electroclinical findings and treatment response on seizures in 18 patients. (Pubmed Central) - Oct 14, 2021
Acetazolamide and calcium channel blockers were often effective when used...The first one, found in all 5 patients with GOF variants, is characterized by intractable seizures, early and recurrent SE and hemiplegic accesses. The second, less severe, found in 5 patients with LOF variants, is characterized by refractory early onset absence seizures.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo, Cytovene (ganciclovir) / Roche
[VIRTUAL] HYPERAMMONEMIA SYNDROME AFTER LUNG TRANSPLANTATION: A CALL FOR BROADENING OF THE PERI-OPERATIVE ANTIMICROBIAL COVERAGE () - Oct 13, 2021 - Abstract #CHEST2021CHEST_2457;
Furthermore, she developed generalized tonic clonic seizures on POD 17 requiring initiation of levetiracetam and lacosamide...Patient was transitioned to dual therapy treatment with azithromycin and levofloxacin given the severity of illness and risk of resistance... We, therefore, recommend including antibiotics with efficacy against atypical infections in the post-operative period among all LT patients.
- |||||||||| midazolam hydrochloride / Generic mfg.
[VIRTUAL] SPINAL MYOCLONUS LEADING TO ENDOTRACHEAL TUBE BITING AND CARDIAC ARREST () - Oct 13, 2021 - Abstract #CHEST2021CHEST_710;
Attempts to redirect patient were not successful, and he was given boluses of fentanyl and midazolam without resolution of biting...Post arrest, his mental status was poor and there was concern for status epilepticus, so propofol infusion was started and levetiracetam was given...Neurology diagnosed the patient with spinal segmental myoclonus, and he was initiated on clonazepam for treatment... In patients with a history of myoclonus, it may be prudent to prophylactically apply bite guard devices to prevent this rare complication of mechanical ventilation.
- |||||||||| ceftriaxone / Generic mfg.
[VIRTUAL] ULCERATIVE COLITIS FLARE PRESENTING AS STROKE AND THROMBOTIC STORM () - Oct 13, 2021 - Abstract #CHEST2021CHEST_707;
Our case of a patient with multiple thrombi, ischemic cerebrovascular accident, and severe anemia highlights the rare and potentially serious manifestations of untreated UC. Awareness is important to facilitate prompt treatment.
- |||||||||| lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
[VIRTUAL] COVID-19-ASSOCIATED LEUKOENCEPHALOPATHY PRESENTING AS NEW ONSET REFRACTORY STATUS EPILEPTICUS () - Oct 13, 2021 - Abstract #CHEST2021CHEST_705;
CASE PRESENTATION: A 50-year-old Caucasian woman with a past medical history significant for chronic lymphocytic leukemia (CLL) for which she was on umbralisib and venetoclax, was admitted with COVID-19 infection...After several courses of antibiotics, her septic shock was successfully treated with meropenem...Therapy with lorazepam, four doses of 4mg IV, propofol infusion, phosphenytoin and levetiracetam failed to abort the seizures...Lacosamide and midazolam infusion were then sequentially added and were successful in terminating the seizures... This case is unique in that this patient in addition to the depressed mental status typically seen in COVID-19-positive patients who develop leukoencephalopathy, developed new-onset refractory status epilepticus as well.
- |||||||||| [VIRTUAL] A CASE OF STATUS EPILEPTICUS SECONDARY TO BUPROPION OVERDOSE TREATED WITH IV LIPID EMULSION THERAPY () - Oct 13, 2021 - Abstract #CHEST2021CHEST_638;
Her roommate reported finding empty pill bottles of bupropion, gabapentin, and propranolol at her apartment...Salicylates, acetaminophen, and alcohol levels were undetectable...Despite being on lorazepam drip, her seizures continued and were also resistant to phenobarbital, levetiracetam, valproate, fentanyl, and propofol...Positive amphetamines on urine toxicology are expected with bupropion use as their metabolites have chemical structures similar to amphetamine... ILE therapy can be used as an antidote for severe bupropion toxicity.
- |||||||||| Herceptin (trastuzumab) / Roche
[VIRTUAL] PRES RELATED TO HYPERTENSION OR CHEMOTHERAPY? () - Oct 13, 2021 - Abstract #CHEST2021CHEST_590;
Chemotherapy-associated PRES is increasingly reported in the literature. The early diagnosis of PRES is crucial to prevent complications.
- |||||||||| dexamethasone / Generic mfg., amantadine / Generic mfg.
[VIRTUAL] POSTOPERATIVE SUPPLEMENTARY MOTOR AREA SYNDROME () - Oct 13, 2021 - Abstract #CHEST2021CHEST_583;
Acute stroke, seizure, pyramidal weakness should be ruled out before considering this diagnosis. Treatment is usually supportive and complete resolution occurs in one to several weeks.
- |||||||||| lorazepam / Generic mfg.
[VIRTUAL] ACUTE ACQUIRED MACROGLOSSIA IN REFRACTORY STATUS EPILEPTICUS PATIENT () - Oct 13, 2021 - Abstract #CHEST2021CHEST_545;
After admission, she had multiple seizure episodes responding to Lorazepam...She was started on Levetiracetam but was found to be in non-convulsive status epilepticus on continuous EEG monitoring...Lacosamide was added followed by sodium valproate and fosphenytoin without any improvement... In conclusion, in acute critically ill patients with acute acquired macroglossia, cessation of offending agents, with airway protection is cornerstone.
- |||||||||| Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) / Gilead
[VIRTUAL] AN UNSUSPECTING CASE OF ATYPICAL HIV ENCEPHALOPATHY () - Oct 13, 2021 - Abstract #CHEST2021CHEST_541;
It can present with radiographic imaging suggestive of cerebral atrophy and diffuse signal or density changes in the white matter. A clinician needs to have a high grade of suspicion to include HIV as a differential.
- |||||||||| lorazepam / Generic mfg.
[VIRTUAL] BIZARRE BEHAVIORS: AUTOIMMUNE ENCEPHALITIS MASQUERADING AS A PSYCHIATRIC SYNDROME () - Oct 13, 2021 - Abstract #CHEST2021CHEST_526;
He received Lorazepam and Levetiracetam...Not being controlled with lorazepam and haloperidol, a Dexmedotomide drip was started.Laboratory data including urine drug screen was unremarkable except elevated CK (3127 U/L)... The differential of NMDA receptor antibody encephalitis must be considered in young patients with neuropsychiatric symptoms as they are often misdiagnosed with psychiatric disorders, which impedes early treatment.The removal of the tumor and immunotherapy generally carry a good prognosis with complete recovery.
- |||||||||| Tekturna (aliskiren) / PDL
Preclinical, Journal: Effect of aliskiren on the anticonvulsant activity of antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice. (Pubmed Central) - Oct 13, 2021
The obtained results confirm earlier findings from other seizure tests (maximal electroshock and pentylenetetrazole-induced seizure test) that aliskiren has a neutral or positive effect on the anticonvulsant efficacy of AEDs, which suggest its safe use for the treatment of high blood pressure in patients with epilepsy. The beneficial anticonvulsant effect of the concomitant treatment with aliskiren and valproate is worthy of recommendation to further both preclinical and clinical studies.
- |||||||||| pregabalin / Generic mfg.
Retrospective data, Journal: Network meta-analysis of antiepileptic drugs in focal drug-resistant epilepsy. (Pubmed Central) - Oct 13, 2021
The beneficial anticonvulsant effect of the concomitant treatment with aliskiren and valproate is worthy of recommendation to further both preclinical and clinical studies. The results indicate that, based on seizure-free rate and all-cause discontinuation rate, brivaracetam is the most efficacious and acceptable AED, with mild adverse events and acknowledgement of potential publication bias.
- |||||||||| gabapentin / Generic mfg., carbamazepine / Generic mfg.
Journal: Inhibitory effect of anti-seizure medications on ionotropic glutamate receptors: special focus on AMPA receptor subunits. (Pubmed Central) - Oct 13, 2021
Only a few ASMs evaluated in this study showed direct interaction with ionotropic glutamate receptors. Perampanel is the only ASM that had a potent inhibitory effect on all AMPA receptor subtypes, but did not inhibit NMDA or kainate receptor subunits; while phenobarbital inhibited GluA2(R), and carbamazepine and lamotrigine inhibited the NMDA receptor at high concentration ranges.
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg., oxcarbazepine / Generic mfg.
Clinical, Journal: Trends of anti-seizure medication use in pediatric patients in six cities in China from 2013 to 2018. (Pubmed Central) - Oct 13, 2021
Levetiracetam has replaced sodium valproate as the most frequently prescribed ASM in pediatric patients. Newer ASMs with fewer side effects and drug interactions are increasingly utilized, which is consistent with evolving recommendations by the medical community.
- |||||||||| pentylenetetrazole (BTD-001) / Balance Therap
Preclinical, Journal: Digoxin enhances the effect of antiepileptic drugs with different mechanism of action in the pentylenetetrazole-induced seizures in mice. (Pubmed Central) - Oct 13, 2021
Experimental data demonstrates that cardiac glycoside digoxin enhances the anticonvulsant activity of sodium valproate, topiramate, levetiracetam, phenobarbital and clonazepam in the model of pentylenetetrazole-induced seizures, providing a clear protective effect of their sub-effective doses. Digoxin may be a valuable component of adjuvant pharmacotherapy for epilepsy, as it reduces the doses of the classic AEDs without compromising the effectiveness of treatment.
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: Analysis of the Clinical Effects of Sodium Valproate and Levetiracetam in the Treatment of Women with Epilepsy during Pregnancy. (Pubmed Central) - Oct 12, 2021
After treatment, the levels of NSE, MBP, TNF-α, and IL-6 in the two groups decreased, and the levels of BDNF increased, and the LEV group changed significantly compared with the VPA group (P < 0.05). Compared with sodium valproate monotherapy, levetiracetam is more effective in controlling seizures and improving maternal and infant outcomes in women with epilepsy during pregnancy and can effectively regulate their neurological and cognitive functions and reduce the serum inflammation factor level.
- |||||||||| levetiracetam / Generic mfg.
Journal: Trait impulsivity in Juvenile Myoclonic Epilepsy. (Pubmed Central) - Oct 10, 2021
These findings warrant consideration of impulsivity as a distinct target of intervention, and as a stratifying factor for AED treatment in JME, and perhaps other types of epilepsy. The role of impulsivity in treatment adherence and psychosocial outcome requires further investigation.
- |||||||||| pregabalin / Generic mfg., gabapentin / Generic mfg., carbamazepine / Generic mfg.
Clinical, Journal: Antiepileptic medicines in men and women with stroke in Sweden, a registry-based study. (Pubmed Central) - Oct 9, 2021
This study suggests that AED is mainly used for neuropathic/poststroke pain and the study shows gabapentin and pregabalin to be the most used AEDs. For epilepsy, carbamazepine and levetiracetam were the most used AEDs in patients with previous stroke.
- |||||||||| Fintepla (low-dose fenfluramine) / Zogenix
Journal: Fenfluramine (Fintepla) for Dravet syndrome. (Pubmed Central) - Oct 7, 2021
Our findings suggest that LEV may enhance rat embryonic neurogenesis mainly through an NMDA receptor-mediated mechanism. No abstract available
- |||||||||| levetiracetam / Generic mfg.
Journal: Hair as a matrix in monitoring drug epilepsy therapy. (Pubmed Central) - Oct 6, 2021
A smaller standard deviation between the results was obtained in the case of pulverized hair. The results indicate that pulverization gives a more reliable result of drug concentration in hair than cutting and that drug concentration in hair can reflect the scheme of levetiracetam administration.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Clinical, PK/PD data, Review: Population Pharmacokinetics of Levetiracetam: A Systematic Review. (Pubmed Central) - Oct 6, 2021
Levetiracetam dose regimen is dependent on the body size and renal function of patients. Further studies are needed to evaluate levetiracetam pharmacokinetics in neonates and pregnant women.
- |||||||||| ketamine / Generic mfg.
Clinical, Review, Journal: S2k guidelines: status epilepticus in adulthood : Guidelines of the German Society for Neurology (Pubmed Central) - Oct 6, 2021
As the increasing evidence supports the relevance of inflammatory comorbidities (e.g. pneumonia) related clinical chemistry should be obtained and repeated over the course of a SE treatment, and antibiotic therapy initiated if indicated.Treatment is applied on four levels: 1. Initial SE: An adequate dose of benzodiazepine is given i.v., i.m., or i.n.; 2. Benzodiazepine-refractory SE: I.v. drugs of 1st choice are levetiracetam or valproate; 3. Refractory SE (RSE) or 4. Super-refractory SE (SRSE): I.v. propofol or midazolam alone or in combination or thiopental in anaesthetic doses are given...ketamine or inhalative isoflorane can be considered...I.v. allopregnanolone or systemic hypothermia should not be used.
- |||||||||| carbamazepine / Generic mfg.
Clinical, Journal: The effect of weight reduction surgery on the efficacy and tolerability of epilepsy pharmacotherapy. (Pubmed Central) - Oct 3, 2021
However, a significant minority of patients may experience medication side effects or an increase in seizure tendency due to the impact of bariatric surgery on ASD drug absorption and metabolism leading. Pre- and post-surgical serum concentrations should be measured in patients with seizures or epilepsy receiving ASDs.
- |||||||||| levetiracetam / Generic mfg.
Journal: Tongue Tremor After Levetiracetam Administration. (Pubmed Central) - Oct 2, 2021
Familial and sporadic IGE patients do not differ in terms of clinical phenotype and treatment response. No abstract available
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: Antiepileptic drugs for acute encephalitic patients presented with seizure. (Pubmed Central) - Oct 2, 2021
The first three months after acute phase was the peak time for relapse and AEDs may should be used during this period. Both sodium valproate and levetiracetam could be selected.
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