levetiracetam / Generic mfg. 
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 185 Diseases   81 Trials   81 Trials   6476 News 


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  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo
    Clinical, Journal:  Abdominal epilepsia partialis continua in a patient with astrocytoma treated with Lacosamide - value of repetitive EEG recordings. (Pubmed Central) -  Mar 24, 2022   
    The independent spikes in her frontal and parietal regions suggested the presence of a large epileptogenic zone generating independent epileptiform activities in the pre-central motor cortex and the post-central sensory cortex as the pathophysiologic phenomena in persistent abdominal EPC. To the best of our knowledge, this is the first report presenting a patient experiencing an abdominal EPC due to a cerebral mass resolved with lacosamide suggesting this drug is a promising treatment option in resistant EPC.
  • ||||||||||  pentylenetetrazole (BTD-001) / Balance Therap
    Preclinical, Journal:  Response to sertraline and antiepileptic drugs in pentylenetetrazole kindling in rats. (Pubmed Central) -  Mar 23, 2022   
    In case of glutathione (GSH), kindling had no significant effect. The use of sertraline for depression in persons with epilepsy on AEDs needs to be carefully evaluated and monitored due to likelihood of individual variation.
  • ||||||||||  dexamethasone / Generic mfg.
    AN INTERESTING CASE OF PULMONARY LYMPHOMATOSIS GRANULOMATOSIS ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_2164;    
    Based on biopsies, the leading diagnosis was non necrotizing granuloma sarcoid-like reaction from immunosuppression and he was placed on prednisone...He was started on prophylactic Dexamethasone and Keppra and underwent extensive infectious disease and autoimmune workup, all of which was unrevealing...Particularly when a patient does not respond appropriately to treatment, clinicians should consider alternative etiologies such as LYG. Maintaining a broad differential, especially when faced with treatment failure, can be life-saving as many disease processes such as LYG rely on prompt diagnosis.
  • ||||||||||  lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
    RAPIDLY PROGRESSIVE ANTI-NMDAR ENCEPHALITIS: MANAGEMENT CHALLENGE IN A PATIENT ADMITTED TO THE PICU ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_2082;    
    She developed hypoxemic respiratory failure, requiring mechanical ventilation, midazolam drip and IV antibiotic/acyclovir prophylaxis without improvement of movements...Once infection ruled out, Solu-medrol was started...This case is uncommon, our patient developed acute respiratory failure, AKI, and bullous lesions over the first 48hrs of admission. Prompt immunosuppressive therapy and high index of suspicion for paraneoplastic mass as etiology of her autoimmune encephalitis, helped control refractory focal movements, skin lesions and frail state in a timely manner.
  • ||||||||||  levetiracetam / Generic mfg.
    SEIZURE PROPHYLAXIS SELECTION AND OUTCOMES IN PATIENTS WITH INTRACRANIAL HEMORRHAGE ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1902;    
    All seizures occurred in patients receiving levetiracetam (LEV) for prophylaxis...Seizures occurred exclusively in patients receiving seizure prophylaxis, although no seizures were reported among patients initially receiving LCM. Prospective studies are warranted to further characterize the safety and efficacy of LCM as an alternative for seizure prophylaxis in intracranial hemorrhage.
  • ||||||||||  cefepime hydrochloride / Generic mfg., dexamethasone / Generic mfg., pregabalin / Generic mfg.
    INADVERTENT INTRATHECAL CEFEPIME ADMINISTRATION: A NEUROLOGIC EMERGENCY ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1900;    
    Patient was immediately intubated, given multiple benzodiazepine doses, dexamethasone, propofol, pentobarbital, and intermittent paralytic doses...Additional antiepileptic medications administered consisted of levetiracetam, valproate, and fosphenytoin...Patient was later discharged to inpatient rehabilitation on baclofen, levetiracetam, parampanel, phenobarbital wean, and pregabalin. Emergent intubation and seizure control with antiepileptics, particularly benzodiazepines and barbituates, and initiation of CVVHDF to decrease CSF cefepime levels were vital in the treatment of this first documented direct intrathecal cefepime toxicity.
  • ||||||||||  dexamethasone / Generic mfg., lorazepam / Generic mfg., tianeptine / Generic mfg.
    COMPLEX PARTIAL STATUS EPILEPTICUS PRECIPITATED BY SEROTONIN SYNDROME ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1790;    
    She was initiated on broad spectrum antibiotics, acyclovir and dexamethasone...She was treated with lorazepam and levetiracetam...After initiation of appropriate treatment, in the next 24 hours her mental status returned to baseline; on further questioning she admitted to taking tianeptine over-the-counter for insomnia, along with venlafaxine...Imbalance of glutamate excess and inadequate gamma aminobutyric acid as a result of SS provokes seizures. SS can be prevented by educating patients on potential drug interactions.
  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo
    EVALUATION OF INPATIENT STAT ANTIEPILEPTIC DRUG ADMINISTRATION DELAYS ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1789;    
    This retrospective study evaluated patients who had one-time, “stat” or “now” orders for the following AEDs: fosphenytoin, lacosamide, levetiracetam, phenobarbital, and valproic acid from January 2019 to June 2021. Our findings add to the literature describing timeliness of AED administration in clinical practice and support the use of premix products whenever possible to avoid medication preparation delays.
  • ||||||||||  fentanyl citrate / Generic mfg., levetiracetam / Generic mfg., dexmedetomidine / Generic mfg.
    FACTORS ASSOCIATED WITH AGITATION AND USE OF PHYSICAL RESTRAINTS IN HOSPITALIZED CHILDREN ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1768;    
    Factors like judicious use of sedation medications and indwelling urinary catheter, as well as treating anemia were associated with decreased of use of restraints. Also use of medications like levetiracetam and methylprednisolone were associated with agitation and increased use of physical restraints among these patients.
  • ||||||||||  levetiracetam low dose (AGB101) / AgeneBio
    LOW-DOSE LEVETIRACETAM VERSUS PHENYTOIN FOR EARLY SEIZURE PROPHYLAXIS AFTER TRAUMATIC BRAIN INJURY ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1741;    
    Differences in ICU and hospital LOS were more likely attributable to the LEV cohort’s severity of injury, as measured by lower median GCS scores within the first 24 hours of admission in addition to an increased need for hyperosmolar and neurosurgical intervention. Larger, prospective studies involving more patients with penetrating TBIs would be necessary in order to validate observations made in this study.
  • ||||||||||  levetiracetam / Generic mfg.
    LEVETIRACETAM USE AFTER SPONTANEOUS INTRACEREBRAL HEMORRHAGE ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1718;    
    Most studies have primarily assessed phenytoin, which has fallen out of favor due to side effects and drug interactions. Though levetiracetam use following ICH is likely safe, it was not found to reduce the incidence of seizures and should not be routinely recommended as prophylaxis.
  • ||||||||||  levetiracetam / Generic mfg.
    LARGE VESSEL NEONATAL ARTERIAL ISCHEMIC STROKE IN EARLY-ONSET GROUP B STREPTOCOCCAL MENINGITIS ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1632;    
    She was treated with 21 days of antibiotics and discharged home on levetiracetam...Clinical presentation of NAIS is often subtle and non-specific, CT scan findings are inconclusive, and MRI and MRA are required to confirm the diagnosis of NAIS. We conclude that NAIS secondary to neonatal GBS meningitis may be more common than reported, can involve the large cerebral arteries and MRI and MRA should be undertaken in the acute phase to identify NAIS and modify treatment.
  • ||||||||||  lorazepam / Generic mfg.
    RARE POST-COVID-19 SEQUELAE: A CASE SERIES ON NEW-ONSET TEMPORAL LOBE SEIZURES IN HEALTHY ADULTS ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1132;    
    Underlying mechanisms for COVID-19 related seizures include neurotropism, entry of inflammatory cytokines into the nervous system & post-infectious immune mediated cerebritis. Hence long-term follow-up is needed to investigate the increased risk of developing epilepsy as a delayed manifestation of COVID-19.
  • ||||||||||  ceftriaxone / Generic mfg., lorazepam / Generic mfg., enoxaparin sodium / Generic mfg.
    POLYCYTHEMIC COVID-19 WITH CEREBRAL VENOUS THROMBOSIS AS INITIAL PRESENTATION: CAUSE OR COINCIDENCE? ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1109;    
    On hospital day 2, CT venogram confirmed extensive CVT and therapeutic enoxaparin was initiated...He was discharged on hospital day 8 on apixaban...Hypercoagulable states found with COVID-19 infections have been previously linked to CVT in young adults, however these are more often complicated by anemia. Our patient’s unique presentation of CVT underlined by polycythemia was found to be treatable with phlebotomy, leading to complete resolution of acute encephalopathy.
  • ||||||||||  Spikevax (elasomeran) / Moderna, Takeda
    ENCEPHALOPATHY AFTER COVID-19 INFECTION AND VACCINE IN A PATIENT WITH UNDERLYING AUTOIMMUNE DISEASE ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1095;    
    Despite broad workup without a definitive diagnosis, the striking association of symptom onset following both vaccine doses and the response to steroids suggest a potential inflammatory encephalopathy in response to mRNA-1273-SARS-CoV-2 vaccine in this patient with underlying autoimmune disease. This case describes the first documented response to immunosuppression in encephalopathy after COVID-19 vaccination and is the first such case of vaccine-related encephalopathy in a patient with prior infection.
  • ||||||||||  ifosfamide / Generic mfg., temozolomide / Generic mfg., carbamazepine / Generic mfg.
    Clinical data, Preclinical, Review, Journal:  Relevant pharmacological interactions between alkylating agents and antiepileptic drugs: preclinical and clinical data. (Pubmed Central) -  Mar 19, 2022   
    On the other side, valproic acid, acting as histone deacetylase inhibitor, showed synergistic effects with temozolomide when tested in glioblastoma...Firstly, clinicians should avoid the use of enzyme-inducing AEDs in combination with alkylating agents and prefer the use of AEDs, such as levetiracetam, that have a low or no impact on hepatic metabolism. Secondly, a careful therapeutic drug monitoring of both alkylating agents and AEDs (and their active metabolites) is necessary to maintain therapeutic ranges and to avoid serious adverse reactions.
  • ||||||||||  levetiracetam / Generic mfg., hydrocodone/paracetamol / Generic mfg.
    Clinical, Journal:  Polypharmacy composition and patient- and provider-related variation in patients with epilepsy. (Pubmed Central) -  Mar 19, 2022   
    Variation in medication fills was substantially more related to provider-to-provider rather than patient-to-patient variation. The better understanding of drivers of high-prescribing practices may reduce avoidable medication-related harms.
  • ||||||||||  Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
    Clinical, Review, Journal:  Indirect treatment comparison of cenobamate to other ASMs for the treatment of uncontrolled focal seizures. (Pubmed Central) -  Mar 19, 2022   
    The better understanding of drivers of high-prescribing practices may reduce avoidable medication-related harms. Patients receiving FDA-RDMD of cenobamate were more likely to have ≥50% seizure reduction compared with FDA-RDMD of the seven assessed ASMs and branded ASMs, without an increase in treatment discontinuation due to TEAEs.
  • ||||||||||  Fycompa (perampanel) / Eisai
    Clinical, Journal, Adverse events:  Differences in aggression as psychiatric side effect of levetiracetam and perampanel in patients with epilepsy. (Pubmed Central) -  Mar 19, 2022   
    Healthcare utilization and related costs showed significant difference between ASM groups. Our results indicate that while easily visible outward-directed aggression tends to be dominant in patients given PER, aggression provoked by LEV may be felt more subjectively or in an inward-directed manner, which can lead to more diverse expression and misrecognition.
  • ||||||||||  levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
    Review, Journal:  Management of seizures in neonates with neonatal encephalopathy treated with hypothermia. (Pubmed Central) -  Mar 18, 2022   
    Phenobarbital remains the mainstay of treatment, as it is more effective than levetiracetam and easier to administer than fosphenytoin. Emerging evidence suggests that, for many neonates, it is safe to discontinue the phenobarbital after acute seizures resolve and prior to hospital discharge.
  • ||||||||||  levetiracetam / Generic mfg.
    Enrollment open:  Pharmacological Modulation of Hippocampal Activity in Psychosis 2 (clinicaltrials.gov) -  Mar 16, 2022   
    P2,  N=60, Recruiting, 
    The use of levetiracetam during CCRT in patients with newly diagnosed glioblastoma may result in improved outcomes, but further investigations are warranted. Active, not recruiting --> Recruiting
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Effect of antiepileptic drug levetiracetam on cochlear function. (Pubmed Central) -  Mar 15, 2022   
    The delayed cochlear neural response may be partially related to the prevention of audiogenic seizure. However, neuropharmacological changes in the central nervous system must play a major role in the treatment of audiogenic seizure, as it does in the treatment of focal epilepsy.
  • ||||||||||  zonisamide / Generic mfg., vigabatrin / Generic mfg., levetiracetam / Generic mfg.
    Clinical, Journal:  Variability of the clinical expression of KCNB1 encephalopathy (Pubmed Central) -  Mar 11, 2022   
    KCNB1 encephalopathy has a heterogeneous natural history, mainly with respect to epilepsy, ranging from patients with refractory epilepsy to patients without any epileptic seizures. All had neurodevelopmental disorders, such as intellectual disability or autism spectrum disorder, independent of epilepsy.
  • ||||||||||  XEN1101 / Xenon
    Biomarker, Journal:  Spontaneous and TMS-related EEG changes as new biomarkers to measure anti-epileptic drug effects. (Pubmed Central) -  Mar 11, 2022   
    Spontaneous and TMS-related cortical oscillations represent a powerful tool to characterize the effect of AEDs on in vivo brain activity. Spectral fingerprints of specific AEDs should be further investigated to provide robust and objective biomarkers of biological effect in human clinical trials.