- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: Thyroid functions as a parameter in monitoring of antiepileptic drugs. (Pubmed Central) - Jul 1, 2022
A significant increase in TSH levels was found in epileptic patients on polytherapy. Our results give us the opportunity to highlight the potential unique or cumulative effect of antiepileptic drugs on thyroid hormone levels.
- |||||||||| Fycompa (perampanel) / Eisai
Review, Journal: Effects of antiepileptic drugs on sleep architecture parameters in adults. (Pubmed Central) - Jun 28, 2022
Studies found used different methodologies not always addressing the analysis on the same parameters. In spite of these, newer AEDs have less effects on sleep structure when compared with classic AEDs but furthermore robust evidence is needed.
- |||||||||| Fycompa (perampanel) / Eisai
The Efficacy of Anti-epileptic Drugs in the Animal Model of Autism Spectrum Disorder () - Jun 26, 2022 - Abstract #CINP2022CINP_261;
Hyperactivity of glutamatergic system represented by the up-regulation of NR2B and phosphorylation of ERK in the prefrontal cortex. The ameliorating effects of anti-epileptic drugs on the ASD-like behaviors suggested that modulation of glutamatergic nervous system is therapeutic target for ASD, which should be subjected for further investigation to verify the clinical relevance.
- |||||||||| Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
Journal: Characterization of Drug Release from Mesoporous SiO-Based Membranes with Variable Pore Structure and Geometry. (Pubmed Central) - Jun 25, 2022
Other relevant effectors include the occurrence of lateral diffusion within the carrier and drug-specific properties such as adsorption. The structure-property relationships derived from our data will allow further fine-tuning of the systems according to their desired properties as TDDS, thus guiding towards optimal systems for their use in transdermal drug applications.
- |||||||||| voriconazole / Generic mfg.
Biomarker, Journal: Pharmacogenetic Analysis of Voriconazole Treatment in Children. (Pubmed Central) - Jun 25, 2022
Voriconazole trough concentrations were influenced by polymorphisms within the metabolizing enzymes CYP2C19 and CYP3A4, and within the drug transporters ABCC2 and ABCG2, as well as by the co-medications ciprofloxacin, levetiracetam, and propranolol. In order to prescribe an optimal drug dosage, pre-emptive pharmacogenetic testing and careful consideration of co-medications in addition to therapeutic drug monitoring might improve voriconazole treatment outcome of children with invasive fungal infections.
- |||||||||| levetiracetam / Generic mfg.
ILiAD trial of levetiracetam (Ballroom 20A - San Diego Convention Center) - Jun 24, 2022 - Abstract #AAIC2022AAIC_3991;
- |||||||||| levetiracetam / Generic mfg.
New-onset movement disorders after COVID-19 () - Jun 24, 2022 - Abstract #MDSPAS2022MDS_PAS_53;
All patients were treated according the type of movement and time of symptoms onset, mainly with IV corticosteroids and levetiracetam. Despite the small sample, we think is useful to demonstrate a possible correlation between neurological symptoms onset with the underlying mechanism of COVID-19.
- |||||||||| levetiracetam / Generic mfg., amantadine / Generic mfg.
Myoclonus after Vaccination for SARS COVID19 () - Jun 24, 2022 - Abstract #MDSPAS2022MDS_PAS_41;
Both patients presented myoclonus one to four days after vaccination. In patient two, the initial interpretation of the involuntary movement as a tremor, led us to indicate a Fluorodopa PET to rule out dopamine deficient related movement disorder.Sputnik and Covishield share the same platform; they use non-replicating viral vectors also called recombinant virus vaccines.Based on the similar mechanism of action, we hypothesize that an immune-mediated mechanism, related to the faster occurrence of myoclonus in patient two (who had already been exposed to the vaccine) as compared to the delayed symptoms in patient one (who received his first dose), may underly the occurrence of symptoms.A detailed description and report on these findings can alert to the health organizations to contribute to a better understanding of the adverse effects profile associated with these different types of immunizations and to the level of evidence.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
Orthostatic Myoclonus: An Undiagnosed Cause of Instability in the Elderly () - Jun 24, 2022 - Abstract #MDSPAS2022MDS_PAS_40;
OM is maybe one of the most frequent cause of unsteadiness on standing in the elderly [2] unfortunately the delay for correct diagnosis could be up to ten years as it is often misdiagnosed as orthostatic tremor or even parkinsonism. EMG is extremely useful showing a characteristic pattern of spontaneous, irregular, asynchronous myoclonic bursts in lower limbs muscles lasting less than 100 ms and with a very variable frequency of 3–7.
- |||||||||| prednisone / Generic mfg., levetiracetam / Generic mfg.
Enrollment status: CAN-GT: rAAV-Olig001-ASPA Gene Therapy for Treatment of Children With Typical Canavan Disease (clinicaltrials.gov) - Jun 24, 2022
P1/2, N=24, Enrolling by invitation,
EMG is extremely useful showing a characteristic pattern of spontaneous, irregular, asynchronous myoclonic bursts in lower limbs muscles lasting less than 100 ms and with a very variable frequency of 3–7. Recruiting --> Enrolling by invitation
- |||||||||| levetiracetam / Generic mfg., digoxin / Generic mfg., topiramate / Generic mfg.
Journal: Digoxin at sub-cardiotonic dose modulates the anticonvulsive potential of valproate, levetiracetam and topiramate in experimental primary generalized seizures. (Pubmed Central) - Jun 23, 2022
It was found that under the conditions of primary generalized seizures induced by picrotoxin, thiosemicarbazide, strychnine, and camphor, digoxin not only shows its own strong anticonvulsant activity but also significantly enhances the anticonvulsant potential of classical AEDs sodium valproate, levetiracetam, and topiramate. The obtained results substantiate the expediency of further in-depth study of digoxin as an anticonvulsant drug, in particular, the in-depth study of neurochemical mechanisms of its action.
- |||||||||| Journal: Individualizing doses of antiepileptic drugs. (Pubmed Central) - Jun 22, 2022
We used Pubmed, Google Scholar and EMBASE database's to support our article. To ensure that the patient with seizure receives the best treatment in relation to their comorbidities, careful clinical-laboratory monitoring is necessary to maximize effectiveness while maintaining safety, especially in the case of polytherapy.
- |||||||||| Review, Journal: Impact of Antiseizure Medications on Appetite and Weight in Children. (Pubmed Central) - Jun 22, 2022
The ASM most robustly associated with increased appetite and/or weight gain is valproic acid; however, both pregabalin and perampanel may also lead to modest weight gain or increased appetite in children. Certain ASMs may impact both appetite and weight, which may lead to increased morbidity of the underlying disease and impaired adherence to the treatment regimen.
- |||||||||| levetiracetam / Generic mfg.
Journal, Monotherapy: Relationship between bone density and levetiracetam monotherapy in epilepsy patients. (Pubmed Central) - Jun 22, 2022
Furthermore, no deleterious impact on bone metabolism was observed in long-term treatment. LEV seems as a rational drug for treatment of epilepsy patients, particularly for those with osteoporosis, since the comparative results of one year and longer than 5-years usage data did not show any statistically significant difference.
- |||||||||| Review, Journal: Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide. (Pubmed Central) - Jun 22, 2022
Data on teratogenic risks are also favorable for oxcarbazepine, whereas topiramate tends to have an unfavorable profile...During pregnancy most ASMs (e.g. lamotrigine, oxcarbazepine, and levetiracetam) need to be increased to compensate for the decline in serum levels; exceptions are valproate and carbamazepine...Many ASMs in monotherapy are (moderately) safe for breastfeeding and women should be encouraged to do so. This review provides a practically oriented overview of the complex management of WWE before, during, and after pregnancy.
- |||||||||| Contrast-induced encephalopathy following cerebral angiography: a case report (Virtual Platform - Poster section) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_554;
This case report evidences the rare potential for development of contrast-induced encephalopathy (CIE) following administration of iodinated contrastand bolsters awareness of its management.83-year-old female, 65kg, ASA III, with hypertension which underwent carotid cavernousfistula and unruptured aneurysm embolization.ASA standardmonitoring was established, GA was induced (fentanyl 0.1mg, propofol 120mg, rocuronium 80mg, dexamethasone 8mg) and the procedure performed using iohexol 120mL, without complications.Upon admission on ICU, patient was somnolent and poorly collaborative...Levetiracetam, midazolam, propofol, fentanyl perfusions were initiated...Early identification and diagnosis augment a favorable outcome. Further studies are needed to define risk factors and mechanism of the iodinated contrast neurotoxicity, which may help minimize severe complications.
- |||||||||| Tonic-clonic seizure in pregnancy – a differential diagnosis regarding a case report (Virtual Platform - Poster section) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_525;
Rapid sequence induction with propofol and rocuronium, followed by endotracheal intubation was performed and anaesthetic maintenance was ensured with sevoflurane...As such, despite presenting with a tonic-clonic seizure, when taken into account all clinical signs and diagnostic exams, renewed intracranial bleed and eclampsia were unlikely diagnosis.As no obvious diagnosis was apparent, a more detailed clinical history as ascertained, at which time the patient revealed she had elected to stop all medication 48h prior, including levetiracetam 500mg twice daily.This case highlights the importance of an adequate differential even when an obvious diagnosis is apparent. This is true for all patients but particularly so in the most complex ones.
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg.
Journal: Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs. (Pubmed Central) - Jun 12, 2022
The long-term use of antiepileptic drugs, especially old-generation polytherapy, can increase lipid profiles, homocysteine levels, ADMA, and carotid intima thickness compared to the minimal effect of new antiepileptic generation. A routine follow-up of these markers and a lifestyle modification are recommended to avoid cerebrovascular events as much as possible.
- |||||||||| levetiracetam / Generic mfg.
Retrospective data, Review, Journal: The Safety of Rapid Infusion Levetiracetam: A Systematic Review. (Pubmed Central) - Jun 11, 2022
Rapid infusion of levetiracetam is a beneficial method of administration in an acute care setting where patients need rapid attainment of therapeutic levels of antiepileptic medications. Additional research is needed to ensure that rapid administration of intravenous levetiracetam is as efficacious as the traditional dosing method.
- |||||||||| levetiracetam / Generic mfg.
Journal: Imaging of Synaptic Density in Neurodegenerative Disorders. (Pubmed Central) - Jun 11, 2022
Further, since SV2A is the target of the antiepileptic drug levetiracetam, human blocking studies have characterized specific binding and potential reference regions...The recent availability of new F tracers, F-SynVesT-1 and F-SynVesT-2, will substantially broaden the application of SV2A PET. Future studies are needed in larger patient cohorts to establish the clinical value of SV2A PET and its potential for diagnosis and progression monitoring of neurodegenerative diseases, as well as efficacy assessment of disease-modifying therapies.
- |||||||||| carbidopa/levodopa / Generic mfg., levetiracetam / Generic mfg.
Review, Journal: Evolving Concepts in Our Understanding and Treatment of Holmes Tremor, Over 100 Years in the Making. (Pubmed Central) - Jun 11, 2022
Current treatment options include carbidopa-levodopa, levetiracetam, and trihexyphenidyl, and surgical management such as deep brain stimulation in selected medication-refractory patients. In this review we discuss the pathophysiology, etiology, neuroimaging, and the latest clinical guidelines for care and management of HT.
- |||||||||| levetiracetam / Generic mfg.
Journal: Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery. (Pubmed Central) - Jun 11, 2022
Synaptic vesicle glycoprotein 2A (SV2A) regulates action potential-dependent neurotransmitter release and is commonly known as the primary binding site of an approved anti-epileptic drug, levetiracetam...Taken together, our results demonstrate that sv2a deficiency leads to increased seizure vulnerability and provide valuable insight into the functional importance of sv2a in the brain in general. Furthermore, we provided evidence that the concept of connectivity mapping represents an attractive and powerful approach in the discovery of novel compounds against epilepsy.
- |||||||||| levetiracetam / Generic mfg.
Biomarker, Journal, Adverse drug reaction: A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam. (Pubmed Central) - Jun 8, 2022
To assess the clinical utility of PRS as a predictor, it should be tested in an independent and ideally prospective cohort. Larger sample sizes are required for the identification of significant univariate common genetic signals or rare genetic signals associated with psychiatric LEV ADRs.
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