levetiracetam / Generic mfg. 
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  • ||||||||||  Review, Journal:  Antiseizure Drugs and Movement Disorders. (Pubmed Central) -  Aug 6, 2022   
    Although little information is available on the adverse effects or benefits on movement disorders of newer antiseizure drugs (such as brivaracetam, cenobamate, eslicarbazepine, lacosamide, and rufinamide), the evidence collected in this review should guide the choice of antiseizure drugs in patients with concomitant epilepsy and movement disorders. Finally, these notions can lead to a better understanding of the mechanisms involved in the pathophysiology and treatments of movement disorders.
  • ||||||||||  levetiracetam / Generic mfg., ethosuximide / Generic mfg.
    Journal:  Epilepsy in Angelman syndrome (Pubmed Central) -  Aug 6, 2022   
    Finally, these notions can lead to a better understanding of the mechanisms involved in the pathophysiology and treatments of movement disorders. Early genetic diagnosis of AS facilitates the selection of AET.
  • ||||||||||  Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
    Observational data, Journal:  Efficacy and safety of antiseizure medication in post-stroke epilepsy. (Pubmed Central) -  Aug 5, 2022   
    Early genetic diagnosis of AS facilitates the selection of AET. Our data show that antiseizure medications acting via the slow inactivation of sodium channels, such as lacosamide and eslicarbazepine, are well tolerated and might be associated with better seizure control in PSE.
  • ||||||||||  temozolomide / Generic mfg., levetiracetam / Generic mfg.
    Biomarker, Journal:  Impact of various prognostic factors on survival in glioblastoma: tertiary care institutional experience. (Pubmed Central) -  Aug 4, 2022   
    Among various clinical and treatment-related prognostic factors evaluated in our study, younger age at presentation and addition of temozolomide chemotherapy to radiation showed improvement in OS and DFS. The use of the anti-epileptic drug Levetiracetam had an impact on DFS in glioblastoma patients.
  • ||||||||||  phenytoin / Generic mfg., levetiracetam / Generic mfg.
    Review, Journal:  Anti-Epileptic Drugs in Geriatric Neurosurgery: A Review of 669 Neurosurgical Cases. (Pubmed Central) -  Aug 3, 2022   
    AEDs are used as prophylaxis to prevent seizures before most neurosurgical procedures and were commonly prescribed in TBI patients. Phenytoin was found to be the commonest AEDs utilized among the different neurosurgical categories followed by levetiracetam.
  • ||||||||||  vixotrigine (BIIB074) / Biogen, GSK, Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
    Journal:  Pharmacotherapeutic Management of Trigeminal Neuropathic Pain: An Update. (Pubmed Central) -  Jul 31, 2022   
    In real-world clinical practice, baclofen, cannabinoids, eslicarbazepine, levetiracetam, brivaracetam, lidocaine, misoprostol, opioids, phenytoin, fosphenytoin, pimozide, sodium valproate, sumatriptan, tizanidine, tocainide, tricyclic antidepressants, and vixotrigine are sometimes used, either as monotherapy or in combination...While there is no optimal pharmacotherapy for treating trigeminal neuropathy, advancements in our understanding of the underlying mechanisms of this condition and drug development indicate promise for NaV inhibitors, despite the fact that not all patients respond to them and they may have potentially treatment-limiting side effects. Nevertheless, better understanding of NaV channels may be important avenues for future drug development for trigeminal neuropathy.
  • ||||||||||  Fycompa (perampanel) / Eisai, Catalyst Pharma
    Trial completion date, Trial primary completion date:  Effect of Perampanel on Peritumoral Hyperexcitability in HGG (clinicaltrials.gov) -  Jul 23, 2022   
    P1/2,  N=20, Recruiting, 
    These results delineate the need for research on better pharmacologic and non-pharmacologic treatment strategies in dogs with drug-resistant epilepsy. Trial completion date: Mar 2023 --> Jun 2023 | Trial primary completion date: Mar 2023 --> Jun 2023
  • ||||||||||  levetiracetam / Generic mfg.
    First results from the BrainDrugs-Epilepsy Cohort Study of patients with newly diagnosed epileptic seizures (Hall E2 [IN-PERSON, ONLINE]) -  Jul 23, 2022 - Abstract #ECNP2022ECNP_268;    
    In PET we use the synaptic vesicle glycoprotein 2A-binding radioligand [11C]-UCB-J, including displacement paradigms with the commonly used ASM levetiracetam. Hesdorffer DC, Ishihara L, Mynepalli L, 2012...Epilepsia, 51, 48-56.Chen Z, Brodie MJ, Kwan P, 2018. Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30-Year Longitudinal Cohort Study.JAMA Neurol, 75, 279-286.
  • ||||||||||  flunarizine / Generic mfg., levetiracetam / Generic mfg.
    Journal:  Alternating Hemiplegia of Childhood associated with a pathogenic variant of the ATP1A3 gene (Pubmed Central) -  Jul 23, 2022   
    The diagnosis of AHC is complex and is frequently confused with epilepsy, so it is important to correctly perform the diffe rential diagnosis, including anamnesis, tests such as EEG, and careful observation of clinical events that, with the current access to audiovisual technology, becomes more accurate. The genetic analysis is a great diagnostic tool that, when performed in time, avoids other unnecessary tests and therapies.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Effects of levetiracetam on sleep architecture and daytime sleepiness. (Pubmed Central) -  Jul 23, 2022   
    Main disadvantages of the studies are: the small sample size, comparison of the results obtained in healthy volunteers with patients with epilepsy, short observation duration, variations of dosage, different evaluation modalities and concomitant AED therapy. Future prospective studies on subjective and objective effects of Levetiracetam on sleep architecture and daytime sleepiness are needed to better understand its impact on sleep in order to improve epilepsy patients' quality of life, seizure control and sleep disturbances.
  • ||||||||||  levetiracetam / Generic mfg., oxcarbazepine / Generic mfg.
    Journal:  LC-MS/MS quantification of levetiracetam, lamotrigine and 10-hydroxycarbazepine in TDM of epileptic patients. (Pubmed Central) -  Jul 23, 2022   
    Future prospective studies on subjective and objective effects of Levetiracetam on sleep architecture and daytime sleepiness are needed to better understand its impact on sleep in order to improve epilepsy patients' quality of life, seizure control and sleep disturbances. This method can be used to monitor drug concentrations and decision-making in epileptic patients.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Novel Variant Expands the Clinical Spectrum of CUX2-Associated Developmental and Epileptic Encephalopathies. (Pubmed Central) -  Jul 20, 2022   
    Additionally, the patient responded well to levetiracetam, and at his last follow-up (5.5 years old), he had discontinued antiepileptic drug treatment and remained seizure-free for 6 months...On the basis of clinical characteristics and genetic analysis, we presented one case diagnosed with DEE67. Our finding expanded the clinical and molecular spectrum of CUX2 variants.
  • ||||||||||  Fycompa (perampanel) / Eisai, Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
    Epilepsy and ataxia: the hidden infection () -  Jul 18, 2022 - Abstract #EAN2022EAN_2667;    
    This case constitutes an atypical presentation of Whipple's disease in which the absence of typical clinical manifestations at an early stage made the diagnosis challenging. It also highlighted the need to investigate systemic complaints in the evaluation of refractory epilepsies without identifiable cause.
  • ||||||||||  cyclophosphamide / Generic mfg., levetiracetam / Generic mfg.
    CNS manifestations of anti-GBM vasculitis: a diagnostic conundrum (B7) -  Jul 18, 2022 - Abstract #EAN2022EAN_2653;    
    This case highlights the diagnostic dilemma of patients presenting with acute neurological symptoms on a background of a rare reno-vascular disease. The rapidly reversible MRA breading and MRI white-matter changes secondary to vasogenic oedema, together with the clinical findings are very typical of PRES.
  • ||||||||||  lacosamide / Generic mfg., levetiracetam / Generic mfg.
    Implications of anaesthetics' utilization in NCSE prognosis (A6) -  Jul 18, 2022 - Abstract #EAN2022EAN_2583;    
    Anesthetics' utilization might be associated with worse outcomes, but a causal relationship is unclear. Larger prospective studies are needed to clarify which situations might benefit from a more aggressive strategy.
  • ||||||||||  felbamate / Generic mfg., levetiracetam / Generic mfg.
    Epilepsy in tubulinopathies: a case with a new de novo mutation in TUBB2A (A5) -  Jul 18, 2022 - Abstract #EAN2022EAN_2483;    
    Despite the incidence of epilepsy seems higher in patients with TUBB2A compared with other tubulinopathies, to date a detailed description is not available. The description of the epilepsy features in other TUBB2A cases might help clarify whether a Developmental and Epileptic Encephalopathy is a consistent phenotype.
  • ||||||||||  Journal:  Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. (Pubmed Central) -  Jul 15, 2022   
    No increased risk was associated with levetiracetam with lamotrigine (8-year cumulative incidence, 1.6%; aHR, 0.9; 95% CI, 0.3-2.5). No consistently increased risks were observed for neurodevelopmental disorders after prenatal exposure to monotherapy with lamotrigine, levetiracetam, carbamazepin, oxcarbazepine, gapapentin, pregabalin, clonazepam, or phenobarbital.
  • ||||||||||  Journal, Adverse events:  Analyzing excipient-related adverse events in antiseizure drug formulations. (Pubmed Central) -  Jul 15, 2022   
    Our study provides a novel approach to analyzing post-market surveillance reports by including excipients. It may be useful to clinicians when evaluating select patient groups that may be refractory to pharmacological treatment or experience worsening adverse events when switching formulations of the same antiseizure medicine.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Influence of Bariatric Surgery on Levetiracetam Clinical Effectiveness: Case Series. (Pubmed Central) -  Jul 15, 2022   
    It may be useful to clinicians when evaluating select patient groups that may be refractory to pharmacological treatment or experience worsening adverse events when switching formulations of the same antiseizure medicine. No abstract available
  • ||||||||||  pentylenetetrazole (BTD-001) / Balance Therap
    Preclinical, Journal:  Bioinformatics guided rotenone adjuvant kindling in mice as a new animal model of drug-resistant epilepsy. (Pubmed Central) -  Jul 15, 2022   
    In conclusion, lamotrigine kindling model is more advantageous than earlier described lamotrigine and corneal kindling models which respond to drug combinations. As a result, pre-clinical drug screening through rotenone kindling may uncover broad spectrum drugs with novel antiseizure mechanisms which is a pressing issue to deal with drug-resistant epilepsy.