levetiracetam / Generic mfg. 
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 185 Diseases   81 Trials   81 Trials   6476 News 


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  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Levetiracetam treatment in an experimental model of sciatic nerve injury: A randomized controlled trial. (Pubmed Central) -  Nov 15, 2022   
    There was a significant improvement in the sciatic functional index, histopathological findings, and parameters showing tissue oxidant status in rats with sciatic nerve injury receiving levetiracetam treatment. Further investigations should be performed to evaluate the contribution of levetiracetam as a treatment modality in sciatic nerve injuries.
  • ||||||||||  levetiracetam / Generic mfg.
    ERF mutation in a patient with Noonan-like phenotype, type 1 diabetes mellitus and epilepsy (Rome, Italy) -  Nov 13, 2022 - Abstract #ESPE2022ESPE_1029;    
    Our patient has similar clinical characteristics such as dolicochephaly, a Noonan-like phenotype, and an ERF mutation, supporting a pathogenetic role for ERF in Rasopathies. Moreover, he had ECG anomalies and epilepsy which are frequently reported in these conditions, and type 1 DM, expanding the ERF mutant phenotype.
  • ||||||||||  levetiracetam / Generic mfg.
    NEUROD1 mutation as a cause of neonatal diabetes: the rarest of the rare! (Rome, Italy) -  Nov 13, 2022 - Abstract #ESPE2022ESPE_771;    
    NDM patients with associated neurological abnormalities (especially cerebellar hypoplasia), and sensori-neural hearing loss should undergo genetic testing for NEUROD1. To our knowledge, this is the 4th reported NDM case with NEUROD1 mutation worldwide and the first reported in Africa.
  • ||||||||||  phenobarbital / Generic mfg., levetiracetam / Generic mfg.
    Reducing Risk of Morbidity in Term Infants After Out-of-hospital Birth (Anaheim Convention Center, Hall A, Board # 152) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_2347;    
    We presented two cases of infants born at home who did not receive AAP-recommended newborn evaluation. Timely medical follow-up of infants born at home mitigates preventable neonatal complications that may ultimately impact long-term outcome.
  • ||||||||||  levetiracetam / Generic mfg.
    Stop the PRES: A New MIS-C Complication (Anaheim Convention Center, Hall A, Board # 178) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_2271;    
    This case argues the need for aggressive blood pressure monitoring and management for patients being treated for MIS-C. It is essential that pediatricians do not neglect rising blood pressures in these patients and act early to prevent the onset of PRES.
  • ||||||||||  levetiracetam / Generic mfg., hydrocortisone / Generic mfg.
    An Unusual Presentation of Child Abuse and Subsequent Osmotic Demyelination Syndrome (Anaheim Convention Center, Hall A, Board # 045) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_1849;    
    While the exact etiology of her ODS is not completely clear, her case emphasizes the importance of having a high index of suspicion for potential ODS and creating a broad differential when patients present with abnormal mentation, as well as inconsistent history. Our patient had a favorable outcome, however 39% of patients with ODS die within a few months of symptom onset, and only 60% recover neurologically from the insult, according to reported data.
  • ||||||||||  levetiracetam / Generic mfg.
    PK/PD data, Retrospective data, Journal:  Extensive pharmacokinetic variability of Levetiracetam. ¿Are doctors aware? (Pubmed Central) -  Nov 9, 2022   
    Age and co-medication with strong enzyme-inducing drugs, especially carbamazepine, significantly influence levetiracetam levels. Clinicians at our center did not consider this interaction and prescribed similar doses of levetiracetam when it was used in combination with these drugs or with others, so they probably were not aware of this interaction.
  • ||||||||||  phenobarbital / Generic mfg., levetiracetam / Generic mfg., oxcarbazepine / Generic mfg.
    Retrospective data, Journal:  Impact of epilepsy and its treatment on brain metastasis from solid tumors: A retrospective study. (Pubmed Central) -  Nov 8, 2022   
    Among 42 patients, 26 were administered levetiracetam, followed by oxcarbazepine...Two patients changed ASM due to adverse events and 1 to phenobarbital owing to the interaction with cancer treatment...Furthermore we deemed in patients receiving chemotherapy the choice of ASM should consider possible interactions with antitumor therapies, for this reason newer generation ASMs should be the preferred choice. It is necessary to get close to the DDD before considering an ASM ineffective in seizure control.
  • ||||||||||  levetiracetam / Generic mfg.
    Retrospective data, Journal:  Acute medical workup for new-onset psychosis in children and adolescents: A retrospective cohort. (Pubmed Central) -  Nov 8, 2022   
    Notably, 33 (25.2%; 95% CI: 18.0-33.5) had incidental findings unrelated to psychosis, 14 (10.7%; 95% CI: 6.0-17.3) had findings that required medical intervention but did not explain the psychosis, 12 (9.2%; 95% CI: 4.8-15.5) had a positive urine drug screen, and 4 (3.1%; 95% CI: 0.8-7.6) had a neurological exam consistent with conversion disorder. In conclusion, extensive medical testing in the acute setting for psychosis had a low yield for identifying medical etiologies of new-onset psychotic symptoms.
  • ||||||||||  levetiracetam / Generic mfg.
    Preclinical, Journal:  The differential effect of levetiracetam on memory and anxiety in rats. (Pubmed Central) -  Nov 8, 2022   
    A prudent multi-professional approach is required. LEV may cause memory and locomotor disturbances, but some of these adverse effects seem to be temporary and limited to the effect of acute dose.
  • ||||||||||  lacosamide / Generic mfg., aspirin / Generic mfg., levetiracetam / Generic mfg.
    JUMPING MOUSTACHES IN A CASE OF STROKE (GALLERY) -  Nov 7, 2022 - Abstract #WSC2022WSC_1473;    
    In this case, right facial EPC were the presenting features of stoke and they lasted for over 3-4 days. In our patient, the left precentral gyral ischemic lesion may be the possible culprit cortical generator leading to facial EPC.
  • ||||||||||  Fycompa (perampanel) / Eisai
    Journal:  Effects of New-Generation Antiepileptic Drug Prophylaxis on Delayed Neurovascular Events After Aneurysmal Subarachnoid Hemorrhage. (Pubmed Central) -  Nov 6, 2022   
    The present study suggests that prophylactic administration of levetiracetam and perampanel was not associated with worse outcomes and that perampanel may have the potential to reduce DCI by preventing microcirculatory disturbances after SAH. Further studies are warranted to investigate anti-DCI effects of a selective α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor antagonist perampanel in SAH patients in a large-scale prospective study.
  • ||||||||||  brivaracetam / Generic mfg.
    Review, Journal:  Narrative review of brivaracetam for genetic generalized epilepsies. (Pubmed Central) -  Nov 5, 2022   
    Further studies are warranted to investigate anti-DCI effects of a selective α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor antagonist perampanel in SAH patients in a large-scale prospective study. According to our review, brivaracetam is a valid treatment alternative in patients with genetic generalized epilepsies capable of improving patients' quality of life by reducing seizure frequency with minimal adverse effects.
  • ||||||||||  levetiracetam / Generic mfg.
    Trial primary completion date:  TRIP: Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease (clinicaltrials.gov) -  Nov 4, 2022   
    P2,  N=28, Recruiting, 
    According to our review, brivaracetam is a valid treatment alternative in patients with genetic generalized epilepsies capable of improving patients' quality of life by reducing seizure frequency with minimal adverse effects. Trial primary completion date: Jan 2023 --> Jun 2023
  • ||||||||||  fludarabine IV / Generic mfg., busulfan / Generic mfg., levetiracetam / Generic mfg.
    Trial completion date, Trial primary completion date:  Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC) (clinicaltrials.gov) -  Nov 3, 2022   
    P=N/A,  N=30, Recruiting, 
    Trial primary completion date: Jan 2023 --> Jun 2023 Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Jun 2022 --> Jun 2023
  • ||||||||||  lacosamide / Generic mfg., phenytoin / Generic mfg., levetiracetam / Generic mfg.
    Preclinical, Journal:  Evaluation of an ex-vivo neonatal extracorporeal membrane oxygenation circuit on antiepileptic drug sequestration. (Pubmed Central) -  Nov 1, 2022   
    Percent drug sequestrations for levetiracetam and lacosamide were less than 20% and for phenytoin were as high as 30% based on the sampling following single bolus dose administration into a neonatal ECMO circuit. Careful consideration of patient clinical status should be taken in consideration when optimizing antiepileptic therapy in neonates receiving ECMO.
  • ||||||||||  ezogabine (XEN496) / Xenon
    Preclinical, Journal:  Efficacy of anti-seizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy. (Pubmed Central) -  Oct 28, 2022   
    Drugs that reduced spiking did not cause any consistent ECoG spectral changes, while drugs that increased spiking all increased power in the slower delta and/or theta bands. These data provide a framework on which to build our understanding of gain-of-function HCN1 DEE pharmacosensitivity in the clinical setting.
  • ||||||||||  Fycompa (perampanel) / Eisai
    Journal:  Anti‑tumor effects of anti‑epileptic drugs in malignant glioma cells. (Pubmed Central) -  Oct 26, 2022   
    The present study investigated four common antiepileptic drugs, perampanel, carbamazepine (CBZ), sodium valproate (VPA) and levetiracetam (LEV), which are expected to have antitumor effects, and determined the most beneficial drug for the treatment of malignant glioma by comparing antitumor effects such as inhibition of cell proliferation and suppression of migration and invasion (using Transwell assays)...Further antitumor effects in combination with temozolomide were investigated using T98G and U‑251MG cell lines, and were confirmed in both cell lines with perampanel and in T98G cells with LEV, but not observed with CBZ and VPA...These effects may reduce cell motility and increase adhesion between cells, suggesting that perampanel treatment suppressed cell migration. In conclusion, the present study suggests that perampanel may be more beneficial in terms of antitumor efficacy than other antiepileptic drugs for the treatment of malignant glioma.
  • ||||||||||  levetiracetam / Generic mfg., brivaracetam / Generic mfg., piracetam / Generic mfg.
    Journal:  Analysis of Two Mixtures Containing Racetams in Their Pharmaceuticals Using Simple Spectrophotometric Methodologies. (Pubmed Central) -  Oct 25, 2022   
    Both procedures were successfully applied for the determination of each drug in bulk powder, checked using laboratory prepared mixtures, and directly applied on commercially available pharmaceutical products without interference. The obtained results revealed a good agreement with those obtained by the reported methods.
  • ||||||||||  Diacomit (stiripentol) / Biocodex, Meiji Seika
    Review, Journal:  Pharmacologic and Dietary Treatments for Epilepsies in Children Aged 1-36 Months: A Systematic Review. (Pubmed Central) -  Oct 23, 2022   
    Little high-quality evidence exists on pharmacologic and dietary treatments for early-life epilepsies. Future research should isolate how treatments contribute to outcomes, conduct etiology-specific analyses, and report patient-centered outcomes such as hospitalization, neurodevelopment, functional performance, sleep quality, and patient and caregiver quality of life.