- |||||||||| levetiracetam / Generic mfg.
Journal: Broadening the phenotypic spectrum of the presumably epilepsy-related SV2A gene variants. (Pubmed Central) - Feb 9, 2023
Adverse reaction to levetiracetam in individuals with various variants of this gene has recently been described...This family case further supports the role of the SV2A gene in autosomal dominant epilepsy. It provides new information on the course of epilepsy in people with variants in the SV2A gene who have never been treated with SV2A agonists and specific neurodevelopmental features of this syndrome.
- |||||||||| levetiracetam / Generic mfg.
Review, Journal: Recent Advances in the Applications of Additive Manufacturing (3D Printing) in Drug Delivery: A Comprehensive Review. (Pubmed Central) - Feb 9, 2023
It provides new information on the course of epilepsy in people with variants in the SV2A gene who have never been treated with SV2A agonists and specific neurodevelopmental features of this syndrome. There has been a tremendous increase in the investigations of three-dimensional (3D) printing for biomedical and pharmaceutical applications, and drug delivery in particular, ever since the US FDA approved the first 3D printed medicine, SPRITAM
- |||||||||| prednisone / Generic mfg., levetiracetam / Generic mfg.
Enrollment closed, Trial completion date, Trial primary completion date: CAN-GT: rAAV-Olig001-ASPA Gene Therapy for Treatment of Children With Typical Canavan Disease (clinicaltrials.gov) - Feb 8, 2023
P1/2, N=24, Active, not recruiting,
Off-label use may be a permissible treatment alternative without underlying evidence, provided it takes place in a well-planned and well-monitored therapeutic setting and the benefits outweigh the potential risks. Enrolling by invitation --> Active, not recruiting | Trial completion date: Mar 2024 --> Aug 2024 | Trial primary completion date: Mar 2023 --> Aug 2023
- |||||||||| levetiracetam / Generic mfg.
Adult-Onset MELAS (Ballroom D3 / D4; In Person) - Feb 7, 2023 - Abstract #ISC2023ISC_1806;
EEG was indicative of focal left posterior temporal seizures which responded well to levetiracetam...An initial high-dose arginine bolus of 0.5gm/kg is recommended on day one, followed by an additional dosage of 0.5gm/kg/day continuous infusion for the next 3-5 days. Fluid therapy is also recommended for stroke-like episodes in order to maintain cerebral perfusion.
- |||||||||| Seizalam (midazolam intramuscular) / Pfizer
Journal: Status Epilepticus in Older Adults: Diagnostic and Treatment Considerations. (Pubmed Central) - Feb 7, 2023
The standard of care for convulsive SE is treatment with an intravenous anesthetic, including midazolam, propofol, ketamine and pentobarbital...Adjunctive strategies may include immunomodulatory treatments, non-pharmacological strategies such as ketogenic diet, neuromodulation therapies and surgery in select cases. Surrogate decision makers should be updated early and often in refractory episodes of SE and informed of the high morbidity and mortality associated with the disease as well as the high probability of subsequent epilepsy among survivors.
- |||||||||| lacosamide / Generic mfg., phenytoin / Generic mfg., levetiracetam / Generic mfg.
Retrospective data, Journal: Treatment of benzodiazepine-refractory status epilepticus: A retrospective, cohort study. (Pubmed Central) - Feb 6, 2023
Also, there is no observed benefit for late posttraumatic seizures. In our cohort of SE, PHT showed higher effectiveness in terminating established SE, as well as refractory SE in the subgroup of patients treated with anaesthetics.
- |||||||||| brivaracetam / Generic mfg.
Journal: Brivaracetam to Treat Partial Onset Seizures in Adults. (Pubmed Central) - Feb 3, 2023
There are approximately 30 antiepileptic agents for clinicians to choose from. Brivaracetam is a novel antiepileptic agent that was approved for use by the FDA in 2016 and is showing promising results as monotherapy and adjunctive therapy in individuals with drug-refractory focal seizures while minimizing adverse drug reactions.
- |||||||||| levetiracetam / Generic mfg., methylprednisolone sodium succinate / Generic mfg., azathioprine / Generic mfg.
Journal: Anti-N-methyl-D-aspartate Receptor Autoimmune Encephalitis: A Case Report. (Pubmed Central) - Jan 28, 2023
Our findings suggested early diagnosis and prompt immunotherapy treatment beneficial for the outcome. ase reports; encephalitis; immunotherapy; methylprednisolone.
- |||||||||| levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg., dexamethasone injection / Generic mfg.
Journal: Loss of Consciousness and Cardiac Arrest as an Atypical Presentation of Tubercular Meningitis: A Case Report. (Pubmed Central) - Jan 28, 2023
Electroencephalogram revealed diffuse right fronto-parietal seizure activity ceasing with midazolam injection, hence levetiracetam was started...The patient was started on anti-tubercular therapy and an injection of dexamethasone was added...Delay in treatment leads to irreversible neurological damage and even death. cardiac arrest; case report; tubercular meningitis; unconsciousness.
- |||||||||| SEVERE METABOLIC ACIDOSIS OF UNCOMMON ETIOLOGY: A CASE REPORT () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1826;
As seizures remained refractory despite administration of midazolam 1.5 mg/kg/hr, phenobarbital 30 mg/kg, fosphenytoin 60 mg/kg, levetiracetam 60 mg/kg, and lacosamide 6 mg/kg, decision was made to target burst suppression with pentobarbital...However, 10 hours after initiating pentobarbital, the patient developed distributive shock requiring fluid resuscitation and an epinephrine infusion...Propylene glycol toxicity typically presents with serum hyperosmolality, lactic acidosis, and renal failure. This case highlights the importance of an awareness of common medication solvents and their toxicity profiles.
- |||||||||| levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
PROPHYLAXIS FOR THE PREVENTION OF EARLY POSTTRAUMATIC SEIZURES IN TRAUMATIC BRAIN INJURY () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1665;
Patients who received Levetiracetam prophylaxis had a higher incidence of EPTS compared to patients who received Fosphenytoin prophylaxis. These patients also had a lower presenting GCS, potentially playing a role in the neuropathophysiology of EPTS.
- |||||||||| levetiracetam / Generic mfg.
A CRITICAL CASE OF ZINC DEFICIENCY AND ASSOCIATED SEPSIS () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1565;
Due to his history of seizures, Keppra was discontinued as DRESS syndrome was considered...Case reports describe breastfed preterm patients with similar symptoms that improved with zinc supplementation, however this was not the case for our patient. At this time whole exome sequencing for this patient will be pursued to determine the etiology of his deficiency.
- |||||||||| methotrexate / Generic mfg.
METHOTREXATE-INDUCED SEIZURES IN AN ADULT () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1478;
New-onset seizure activity in an adult initiated on methotrexate should be investigated further, with consideration given to potential drug toxicity. Typical management centers on discontinuation of MTX and supportive care.
- |||||||||| levetiracetam / Generic mfg.
THE IMPACT OF LEVETIRACETAM LOADING DOSES ON SUCCESSFUL SEIZURE CESSATION () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1434;
Among patients treated with loading-doses of levetiracetam > 40 mg/kg, there was a statistically significant increase in maintenance dose of levetiracetam and a trend towards more frequent administration of third-line agents. There was a longer ICU length of stay among patients administered >40 mg/kg loading dose which could have led to increased monitoring and increases in maintenance dosing of levetiracetam among that population.
- |||||||||| levetiracetam / Generic mfg., bumetanide / Generic mfg.
OPTIMIZATION OF MEDICATION PRODUCT FORMULATIONS AT AN ACADEMIC MEDICAL CENTER () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1027;
Conversion of certain doses of levetiracetam and thiamine from IVPB to IVP formulations resulted in a reduction in pharmacy workflow and an overall cost savings to the institution. This comprehensive assessment approach will continue to operate systemwide at UCSF Health, with the goal to transition bumetanide once the item is off shortage.
- |||||||||| Thrombopoietin Receptor Agonist after Anti-CD19 CAR-T Cells: A Case Report (Poster Area) - Jan 24, 2023 - Abstract #EHAEBMTCART2023EHA_EBMT_CART_111;
In this single-case experience, thrombopoietin receptor agonist has proven effective and safe as therapy for prolonged cytopenias after CAR-T infusions. Prospective studies are needed to confirm the potential of this strategy.
- |||||||||| Sylvant (siltuximab) / Jazz, Actemra IV (tocilizumab) / Roche, JW Pharma, Kineret (anakinra) / SOBI
CRS after CAR-T Cell Therapy for MCL: A Case Report (Poster Area) - Jan 24, 2023 - Abstract #EHAEBMTCART2023EHA_EBMT_CART_96;
After 34 days, he was extubated without neurologic deficits, but with myopathy and colonization of resistant Gram-negative bacteria. One month post CAR-T cell therapy, complete remission (CR) was achieved, and the patient was discharged.
- |||||||||| Tecartus (brexucabtagene autoleucel) / Gilead
Unusual Toxicity after Brexucabtagene Autoleucel Treatment (Poster Area) - Jan 24, 2023 - Abstract #EHAEBMTCART2023EHA_EBMT_CART_69;
Since clinical conditions progressively improved, the patient was discharged on day +24. Skin and neurologic toxicities after CART do not always fit within CRS and ICANS grading and their treatment represents an unmet clinical need.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg.
Journal: The medical and surgical treatment of epilepsy in older adults: a national survey. (Pubmed Central) - Jan 23, 2023
Our surveyed physicians differed in their approach to ASM choice as well as perception about surgery in older adults with epilepsy. These findings likely reflect the lack of clinical guidelines dedicated to this population and the deficient implementation of best practices.
- |||||||||| brivaracetam / Generic mfg.
Review, Journal: A review of cognitive and behavioral outcomes of Brivaracetam. (Pubmed Central) - Jan 21, 2023
For patients who are intolerant to levetiracetam and have levetiracetam-related behavioral side effects, switching to BRV could be beneficial. However, heterogeneity between studies resulted in low-quality of evidence, and further trials are needed to confirm the findings.
- |||||||||| levetiracetam / Generic mfg.
PK/PD data, Preclinical, Journal: Effect of date molasses on levetiracetam pharmacokinetics in healthy rats. (Pubmed Central) - Jan 15, 2023
On the other hand, the current study discovered that rats given date molasses for a week had a reduced rate and extent of absorption. As a result, date molasses might increase the risk of epileptic seizures in oral LEV-treated ones.
- |||||||||| levetiracetam / Generic mfg.
Journal: Insulinoma as a cause of seizure-like activity and spontaneous hypoglycaemia. (Pubmed Central) - Jan 11, 2023
Her initial workup was unremarkable, and she was diagnosed with complex partial seizures and commenced on levetiracetam...She underwent surgical resection and remained symptom free at follow-up. This case highlights the importance of blood glucose measurements in patients presenting with neuroglycopenic symptoms and outlines the workup and management of insulinoma.
- |||||||||| Journal: Features of the choice and the use of antiepileptic drugs as analgesics in elderly. (Pubmed Central) - Jan 9, 2023
Variety of antiepileptics used as analgesics have variable efficacy and safety profile in elderly. «Old» antiepileptics (phenobarbital, clonazepam, ethosuximide, carbamazepine, phenytoin, valproate, etc.) and «new» (gabapentin, pregabalin, oxcarbazepine, lamotrigine, levetiracetam, topiramate, zonisamide, tiagabine) are considered in this review with insights on pharmacokinetic features of these drugs in elderly, profile of side effects, parameters of analgesic efficacy.
- |||||||||| levetiracetam / Generic mfg.
Journal, Adverse events: Levetiracetam Associated Behavioral Adverse Events in Neurocritical Care Patients. (Pubmed Central) - Jan 7, 2023
We believe that the incidence of BAEs in our specific patient population cannot solely be attributed to ICU delirium given the lower risk of developing hyperactive delirium in ICU patients as compared to other subtypes. Therefore, monitoring and determination of the benefit versus risk in those experiencing BAEs is highly encouraged.
- |||||||||| FATAL ATRIO-ESOPHAGEAL FISTULA PRESENTING AS NEW ONSET SEIZURES (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_166;
Cerebral air embolism is a devastating complication of AEF that should be suspected in a patient with acute neurologic symptoms and a recent history of catheter ablation. Early recognition of AEF is essential in order to initiate surgical intervention or stenting.
- |||||||||| Review, Journal: Overview of therapeutic options for epilepsy. (Pubmed Central) - Jan 1, 2023
(1) As first-line treatment, vigabatrin is unanimously recommended for infantile spasms and focal seizures before 2 years and is also widely used for seizures over 2 years, as are levetiracetam and carbamazepine. (2) If seizures persist (about 40% of children and adolescents), cannabidiol and everolimus, an inhibitor of the mTOR pathway, have recently been approved as adjunctive therapy to the arsenal of antiseizure medications authorized for this age group and to the ketogenic diet..
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: Association Between Antiepileptic Drugs and Incident Parkinson Disease in the UK Biobank. (Pubmed Central) - Dec 28, 2022
This study, the first to systematically look at PD risk in individuals prescribed the most common AEDs, to our knowledge, found evidence of an association between AEDs and incident PD. With the recent literature demonstrating an association between epilepsy and PD, this study provides further insights.
- |||||||||| levetiracetam / Generic mfg., acyclovir / Generic mfg.
BROADENING THE CLINICAL SPECTRUM OF CADASIL: ACUTE ENCEPHALOPATHY AS AN UNUSUAL PRESENTATION (EXHIBITION) - Dec 23, 2022 - Abstract #ADPD2023ADPD_2160;
CADASIL should be considered in the differential diagnosis of acute unexplained encephalopathies, especially in case MRI white matter changes, previous migraine with aura, or a family history o f stroke and dementia. The encephalopathy is self -limiting but may recur.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
LATE-ONSET MYOCLONIC EPILEPSY AND ITS IMPACT ON DOWN SYNDROME WITH ALZHEIMER DISEASE (EXHIBITION) - Dec 23, 2022 - Abstract #ADPD2023ADPD_1658;
The increase of life expectancy in DS has led to a better knowledge about late onset complications related to DS, such as AD and LOMEDS. This study supports LOMEDS is associated with a poor prognosis due to the worsening of cognitive impairment albeit good antiepileptic response in SD plus AD.
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