- |||||||||| SOURCE CONTROL (Convention Center Exhibit Hall - Rapid Area 1B) - Aug 4, 2023 - Abstract #CHEST2023CHEST_4835;
- |||||||||| levetiracetam / Generic mfg.
Leve-TOX-cetam (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_4421;
Figure: Figure 1 (a-c) Histologic findings on liver biopsy consistent with drug induced liver injury from levetiracetam. (a) Hematoxylin and eosin (H&E) stain (200x) demonstrating a focal mononuclear cell infiltrate (arrow) with a lobular disarray and normal portal tract (upper right); (b) Reticulin stain (200x) with large area of intralobular collapse (arrows); (c) Trichrome stain (200x) with focal increased portal fibrosis and duct proliferation.
- |||||||||| phenytoin / Generic mfg.
Elevated Liver Enzymes: Is Phenytoin the Culprit? (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_4393;
In severe cases of phenytoin-induced liver toxicity, corticosteroid therapy may be used cautiously and in minimal doses. There are no established guidelines, but discontinuing phenytoin therapy is warranted if liver disease symptoms or elevated liver enzymes are present.
- |||||||||| Invasive Listeria Gastroenteritis Leading to Bacteremia and a CNS Abscess (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3600;
Case Description/ A 64-year-old male with lupus nephritis on prednisone and mycophenolate presented due to word-finding difficulty and headaches...He regained expressive speech and was discharged on IV ampicillin and bactrim, along with oral dexamethasone and keppra for seizure prophylaxis...Figure: Images A and B depict the intra-axial peripherally enhancing lesion centered in the medial posterior left frontal lobe surrounded by vasogenic edema with some areas of tubular appearance measuring approximately 1.6 x 1.9 x 2.2 cm. There is minimal mass effect and no midline shift seen.
- |||||||||| Journal: A 5-Year Study of Antiseizure Medications (ASMs) Monitoring in Patients with Neuropsychiatric Disorders in an Italian Clinical Center. (Pubmed Central) - Jul 29, 2023
The most used ASMs were Valproate (VPA: 54.5%) and Levetiracetam (LEV: 18.6%), followed by Oxcarbazepine (OxCBZ: 8.3%) and Carbamazepine (CBZ: 7.2%), whereas the associations LEV/VPA, Ethosuximide (ESM)/VPA, and CBZ/VPA were the most frequently proposed...For VPA, there was a decrease of mean C(p) across ages, from adolescents to older patients, while the C(p) of LEV, CBZ, OxCBZ, and Topiramate (TPM) showed a slight tendency to increase...Finally, the ASMs subjected to multiple dosing starting from an initial subtherapeutic C(p) increased their level at different time points within a year, reaching the reference range for some of them. In conclusion, the present study suggests that TDM is widely applied to monitor ASMs C(p), finding many of them within the reference range, as a demonstration of its utility in clinical practice.
- |||||||||| levetiracetam / Generic mfg.
Journal: The case for levetiracetam to be included in essential medicine lists. (Pubmed Central) - Jul 26, 2023
In conclusion, the present study suggests that TDM is widely applied to monitor ASMs C(p), finding many of them within the reference range, as a demonstration of its utility in clinical practice. No abstract available
- |||||||||| Ameile (aumolertinib) / Jiangsu Hansoh Pharma, EQRx
A Case of Brain Metastases from Lung Cancer with Epilepsy and ECOG Score of 4 Successfully Treated with Aumolertinib (Exhibit Hall) - Jul 25, 2023 - Abstract #IASLCWCLC2023IASLC_WCLC_1707;
In this case, we reported a right lung adenocarcinoma cT3N3M1 patient with brain metastasis, malignant pleural effusion, and a positive EGFR 19del mutation who obtained a remarkable curative effect and good tolerance,after treatment with aumolertinib. This was the first report successfully applied aumolertinib to an EGFR sensitive lung patient with brain metastases with epilepsy as the initial symptom and in poor physical condition, and suggested the fast and good therapeutic potential of aumolertinib in this population.
- |||||||||| An Awake Craniotomy At 4pm! What A Way To End The Day! (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_3136;
Vital signs are as follows: BP=75/60, HR=46 (bpm), and SpO2= 77%.1.Discuss possible methods of pre-empting and managing airway compromise in patient undergoing "awake" craniotomy.The patient reestablishes spontaneous ventilation, the Mayfield head clamp is removed, and the surgical incision dressed and wrapped. She is then transported to the neurosurgical intensive care unit without further incident.
- |||||||||| tranexamic acid oral / Generic mfg., esmolol / Generic mfg., levetiracetam / Generic mfg.
Just Another Subarachnoid Hemorrhage? Or Am I Really Up-to-date On What To Do? (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_2910;
The patient was given 1gm of Levetiracetam and 1gm ofTranexamic acid and transferred to a specialized hospital with around the clock interventional neuroradiology and vascular neurosurgical services.What are the clinical severity scales of SAH?...Esmolol was then given...How is the diagnosis made? What are the treatments available?
- |||||||||| tranexamic acid oral / Generic mfg., esmolol / Generic mfg., levetiracetam / Generic mfg.
Just Another Subarachnoid Hemorrhage? Or Am I Really Up-to-date On What To Do? (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_2086;
The patient was given 1gm of Levetiracetam and 1gm ofTranexamic acid and transferred to a specialized hospital with around the clock interventional neuroradiology and vascular neurosurgical services.What are the clinical severity scales of SAH?...Esmolol was then given...How is the diagnosis made? What are the treatments available?
- |||||||||| An Awake Craniotomy At 4pm! What A Way To End The Day! (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_1350;
Vital signs are as follows: BP=75/60, HR=46 (bpm), and SpO2= 77%.1.Discuss possible methods of pre-empting and managing airway compromise in patient undergoing "awake" craniotomy.The patient reestablishes spontaneous ventilation, the Mayfield head clamp is removed, and the surgical incision dressed and wrapped. She is then transported to the neurosurgical intensive care unit without further incident.
- |||||||||| Neuroanesthesia Myths And Dogmas (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_54;
She is then transported to the neurosurgical intensive care unit without further incident. The patient
- |||||||||| levetiracetam / Generic mfg.
Journal: Levetiracetam-associated pancytopenia. (Pubmed Central) - Jul 14, 2023
A PBPK model of LEV was successfully developed to optimize dosing regimens for special populations. No abstract available
- |||||||||| leucovorin calcium / Generic mfg., levetiracetam / Generic mfg., desmopressin / Generic mfg.
Unexplained cerebrospinal fluid findings in GABA transaminase deficiency (Exhibitions Hall (ICC)) - Jul 11, 2023 - Abstract #SSIEM2023SSIEM_615;
It is of note that central DI has been described before in this very rare disorder. Further studies are required to understand the CSF biochemistry.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg., oxcarbazepine / Generic mfg.
Review, Journal: The evidence for repurposing anti-epileptic drugs to target cancer. (Pubmed Central) - Jul 7, 2023
Valproic acid, oxcarbazepine, lacosamide, lamotrigine, and levetiracetam are the drugs that showed potential beneficial outcomes against different cancers. Antiepileptic drugs might be a good option for adjuvant cancer therapy, but there is a need to investigate further their efficacy in cancer therapy clinical trials.
- |||||||||| levetiracetam / Generic mfg.
Subclinical mesial temporal lobe activity in Alzheimer (In-Person) - Jul 6, 2023 - Abstract #AAIC2023AAIC_4120;
Epileptic activity is predominantly found during sleep. Our findings suggest an important role for network hyperexcitability in AD disease pathogenesis.
- |||||||||| levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
Journal: Status Epilepticus. (Pubmed Central) - Jul 5, 2023
Sequelae include focal neurologic deficits, cognitive impairment, and behavioral problems. Pediatricians play an important role in the early recognition and treatment of status epilepticus, thereby preventing the acute and chronic harm that can be associated with status epilepticus.
- |||||||||| levetiracetam / Generic mfg.
Observational data, Journal: Neurodevelopment of babies born to mothers with epilepsy: a prospective observational cohort study. (Pubmed Central) - Jul 5, 2023
Pediatricians play an important role in the early recognition and treatment of status epilepticus, thereby preventing the acute and chronic harm that can be associated with status epilepticus. These data are reassuring for infant development following in utero exposure to monotherapy lamotrigine or levetiracetam but child development is dynamic and future follow-up is required to rule out later emerging effects.
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