- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Evaluation Of Lamotrigine-induced Hypogammaglobulinemia Identifies Rare IFIH1 Pathogenic Variant (Monitor 06) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_646;
However, genetic evaluation identified a novel presentation of IFIH1 with humoral immunodeficiency but absence of encephalopathy, blood vessel or bone anomalies associated with AGS or SMS. This case demonstrates the importance of a complete evaluation for primary immunodeficiency as genetic testing identified possible underlying innate error of immunity and inherited syndrome.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Patch testing to guide alternative agents in a patient with delayed cutaneous reaction to antiepileptics. (Monitor 03) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_598;
Then at age 32, she was switched from valproic acid to levetiracetam while seeking a pregnancy but developed anxiety, dizziness, and palpitations...Discussion Antiepileptic PT sensitivity varies between 20-80%. This variability is attributed to variable drug concentrations and vehicles, commercially available PT preparations, intrinsic drug factors such as lipophilicity, variable molecular weights, whether the drug or a metabolite is the immunogenic trigger, or secondary to transient potentiating factors that cannot be replicated such as viral infections or autoimmune conditions.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, Xcopri (cenobamate) / SK Bio, Angelini Group, Endo, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Review, Journal: Management of epilepsy during pregnancy and lactation. (Pubmed Central) - Sep 13, 2023
Insufficient data exist to reach strong conclusions about the newest antiseizure medications such as eslicarbazepine, perampanel, brivaracetam, cannabidiol, and cenobamate...In general, breastfeeding does not appear to add any additional long term risks to the child. Creative ways of optimizing registry enrollment and data collection are needed to enhance patient safety.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
An Interesting Case of COVID-19 related Parkinsonism () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1885;
In a predisposed individual, COVID-19 illness can result in parkinsonism. To ascertain if the impact on dopaminergic activity is short-term or long-lasting, more research is required.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg., piracetam / Generic mfg.
Post-hypoxic myoclonus after bilateral pallidal stimulation: A case report () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1045;
Our case demonstrates clinical improvement in myoclonus and functional gains after DBS focused at stimulation contacts with highest beta synchrony, which may correspond to motor pathways relevant for treatment of movement disorders. Stimulation optimization led to reduced periods of broadband activity which may signify the neurophysiologic response to stimulation and requires further investigation.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg., propranolol / Generic mfg.
COVID-19 associated opsoclonus myoclonus ataxia syndrome () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1042;
We hypothesize that opsoclonus myoclonus ataxia syndrome may be a potential parainfectious complication of COVID-19, with severe symptomatology and a potentially reversible course despite the need for multiple medications. Larger studies are needed to confirm the connection and clarify the pathogenesis.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
Progressive myoclonic epilepsy ataxia syndrome associated with NUS1 gene mutation () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_832;
There are less than 25 reported cases of NUS1 pathogenic variant associated with myoclonus, epilepsy, ataxia, intellectual disability syndrome (MEAID syndrome) till date. NUS1 gene was not included as part of proband testing until recently, so we wanted to emphasize through this case that NUS1 gene testing should be included in the genetic screening of undiagnosed phenotypes of myoclonus, myoclonus-ataxia, and progressive myoclonus epilepsy.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
Paroxysmal Kinesigenic Dyskinesia caused by a novel missense variant in NBEA () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_827;
Levetiracetam was tried up to 2000 mg twice daily, which lead to mild reduction of attacks... This case highlights that should be considered in cases of negative PKD and can be treated with oxcarbazepine.
- |||||||||| levetiracetam / Generic mfg.
An atypical presentation of Multiple System Atrophy (MSA) () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_678;
According to the diagnostic criteria for Multiple System Atrophy (MSA) proposed by the Movement Disorder Society in 2022, this patient would fulfill criteria for possible MSA. Although the presence of myoclonus is described in MSA, particularly as minipolymyoclonus, the presence of generalized myoclonus is uncommon, especially as a presentation form as in this case.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Cutaneous toxicity of CAR T-cell therapy: a case of a bullous life-threatening reaction (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2299;
Due to the timing of the onset after CAR-T infusion, the concomitance of CRS grade 4, and the histological findings, we strongly considered the maculopapular rash followed by bullous eruption of our patient as a life- threatening CAR T-cell related toxic cutaneous reaction. More studies and case reports are required to further investigate the possible pathogenic reaction between Car T- cell therapies and skin toxicity.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Postmortem Genetic Testing in Sudden Unexpected Death in Epilepsy. (Pubmed Central) - Aug 28, 2023
While grieving family members struggle with uncertainty about the cause of death, we as clinicians also face similar uncertainties about genetic contributions to SUDEP, especially when the literature is sparse, and the utility of genetic testing is still being worked out. We aim to shed some light on this topic, highlighting areas where data is emerging but also areas where uncertainty remains, keeping our case in mind as we examine this clinically important area.
- |||||||||| zonisamide / Generic mfg.
Retrospective data, Journal: Evaluation of antiseizure medications including zonisamide in feline idiopathic epilepsy at a referral hospital in Japan. (Pubmed Central) - Aug 28, 2023
Nine cats that were finally treated with phenobarbital (PB) monotherapy reached the primary goal (the seizure frequency after the treatment intervention was less than one seizure every 3 months)...Five cats [PB + diazepam (DZP), ZNS + DZP, and ZNS + levetiracetam + DZP] decreased the seizure frequency and reached the primary goal in all but one cat reached the secondary goal...ZNS may be available to treat idiopathic epilepsy in cats. However, ZNS administration may cause adverse events, such as gastrointestinal toxicity, in cats.
- |||||||||| Spectogram Analysis: More Than Just a Rainbow (Exhibit Hall) - Aug 23, 2023 - Abstract #ASA2023ASA_5286;
Under neuromuscular blockade, the detection of seizures can be challenging. The use of bilateral BIS with spectrogram facilitates the interpretation of EEG waves, enables an early diagnosis and treatment of seizures.
- |||||||||| Post-Operative Seizure: Failure to Avoid Complication in a High Risk Epilepsy Patient (Exhibit Hall) - Aug 23, 2023 - Abstract #ASA2023ASA_4113;
Two minutes after extubation, she began having tonic movements in left upper extremity and left lateral neck deviation, which rapidly progressed to tonic-clonic seizures that did not respond to midazolam, lorazepam, levetiracetam, and lacosamide. She was re-intubated and transferred to the ICU in status epilepticus.
- |||||||||| sevoflurane / Generic mfg., levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg.
Seizures on Emergence: Risk Factors and Perioperative Management (Exhibit Hall) - Aug 23, 2023 - Abstract #ASA2023ASA_3997;
Recurrence of tonic-clonic movements prompted initiation of propofol infusion and levetiracetam bolus administration. We discuss approach to delayed emergence and risk factors for, as well as, management of post-operative seizures.
- |||||||||| pentylenetetrazole (BTD-001) / Balance Therap
Journal: The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not K1.1 channel expression. (Pubmed Central) - Aug 20, 2023
Levetiracetam (LEV) i.p. at a dose of 108?mg/kg was given to third group rats as positive control group (PC) before 20?minutes PTZ administration...K1.1 increased in heart of PTZ animals and turned back to mean control values with magnetic field exposure. Suppressing the expected increase of c-fos protein expression in seizures with magnetic field application but not being able to change the K1.1 expression shows that new studies can be done by increasing the frequency of 1.5 mT magnetic field.
- |||||||||| levetiracetam / Generic mfg.
Journal, Video: The Role of Video-EEG Monitoring in Lesch-Nyhan Syndrome. (Pubmed Central) - Aug 17, 2023
The dystonic movements and epileptic seizures responded to Levetiracetam, but the management of the behavioural disorder remained a challenge...Despite the fact that epilepsy is uncommon in LNS children, it should always be considered as part of the differential diagnosis in movement disorders. Therefore, long-term video-EEG monitoring is recommended as well as a detailed patient history to identify possible clinical/subclinical epileptic seizures that require treatment.
- |||||||||| phenobarbital / Generic mfg., levetiracetam / Generic mfg., topiramate / Generic mfg.
Biomarker, Journal: Prognostic factors for employment outcomes in patients with a history of childhood-onset drug-resistant epilepsy. (Pubmed Central) - Aug 14, 2023
Specific medical, psychosocial, and educational factors may influence the employment outcomes of childhood-onset DRE. Paying attention to ASMs' side effects, adequately preventing the complications of psychiatric disorder symptoms, and providing an environment suitable for each patient condition would promote a fine working status for people with childhood-onset DRE.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma
Trial completion: Effect of Perampanel on Peritumoral Hyperexcitability in HGG (clinicaltrials.gov) - Aug 14, 2023
P1/2, N=12, Completed,
Paying attention to ASMs' side effects, adequately preventing the complications of psychiatric disorder symptoms, and providing an environment suitable for each patient condition would promote a fine working status for people with childhood-onset DRE. Active, not recruiting --> Completed
- |||||||||| levetiracetam / Generic mfg.
Bullous pemphigoid in a patient with complex partial epilepsy and newly onset treatment with levetiracetam (e-Poster Hall) - Aug 8, 2023 - Abstract #EADV2023EADV_1894;
Levetiracetam was discontinued and the patient was started on Prednisone 0.5 mg/kg/day and clobetasol propionate 0.05% cream...Nowadays corticosteroids have been discontinued and azathioprine is being tapered, with no flare-up of skin lesions... Even though the incidence of BP in patients diagnosed with epilepsy or treated with levetiracetam is low, it is important to be aware of this relationship in order to perform an early diagnosis and start treatment as soon as possible, and therefore to improve its prognosis.
- |||||||||| levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg., rifampicin/isoniazid/ethambutol/pyrazinamide / Generic mfg.
Journal: Pediatric intracranial tuberculoma: illustrative case. (Pubmed Central) - Aug 4, 2023
A literature review on pediatric intracranial tuberculoma was performed, which included 48 studies (n = 49). The mean age was 8.8
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